Jerad Eickhoff took his latest first step on Sunday morning at Spectrum Field. He threw a bullpen session, his first since sustaining a setback last month following carpal tunnel surgery in October.
To date, the imaging and diagnosis of hepatocellular carcinoma (HCC) rely on CT/MRI, which have well-known limitations. Glypican-3 (GPC3) is a cell surface receptor highly expressed by HCC but not by normal or cirrhotic liver tissue. Here we report initial clinical results of GPC3-targeted PET imaging with [68Ga]Ga-DOTA-RYZ-GPC3 (RAYZ-8009), a peptide-based GPC3 ligand in patients with known or suspected HCC. Methods: [68Ga]Ga-RAYZ-8009 was obtained after labeling the peptide precursor with 68Ga from a 68Ge/68Ga generator and heating at 90°C for 10 min followed by sterile filtration. After administration of [68Ga]Ga-RAYZ-8009, a dynamic or static PET/CT scan was acquired between 45 min and 4 h after administration. Radiotracer uptake was measured by SUVs for the following tissues: suspected or actual HCC or hepatoblastoma lesions, non–tumor-bearing liver, renal cortex, blood pool in the left ventricle, and gastric fundus. Additionally, tumor–to–healthy-liver ratios (TLRs) were calculated. Results: Twenty-four patients (5 patients in the dynamic protocol; 19 patients in the static protocol) were scanned. No adverse events occurred. Two patients had no lesion detected and did not have HCC during follow-up. In total, 50 lesions were detected and analyzed. The mean SUVmax of these lesions was 19.6 (range, 2.7–95.3), and the mean SUVmean was 10.1 (range, 1.0–49.2) at approximately 60 min after administration. Uptake in non–tumor-bearing liver and blood pool rapidly decreased over time and became negligible 45 min after administration (mean SUVmean, <1.6), with a continuous decline to 4 h after administration (mean SUVmean, 1.0). The opposite was observed for HCC lesions, for which SUVs and TLRs continuously increased for up to 4 h after administration. In individual lesion analysis, TLR was the highest between 60 and 120 min after administration. Uptake in the gastric fundus gradually increased for up to 45 min (to an SUVmax of 31.3) and decreased gradually afterward. Conclusion: [68Ga]Ga-RAYZ-8009 is safe and allows for high-contrast imaging of GPC3-positive HCC, with rapid clearance from most normal organs. Thereby, [68Ga]Ga-RAYZ-8009 is promising for HCC diagnosis and staging. Further research is warranted.
Oregon, Ohio State, Georgia and Miami lead the first edition of the 2024-25 College Football Playoff rankings, the selection committee announced.
Making the Most of Today’s Cloud-First Approach to Running HPC and AI Workloads With Penguin Scyld Cloud Central™ Bursting to cloud has long been used to complement on-premises HPC capacity […]
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The wealthiest person on Earth has taken the next step toward a commercial brain interface
Health officials in Britain have detected the country's first confirmed human case of a new strain of mpox that has been spreading throughout Africa.
The U.S. Army has awarded a $435 million contract for Repkon USA to build the nation's only TNT production facility in a rural community in Graham, Ky.
NASA engineers fired the engines on the X-59 research aircraft in advance of planned test flights to determine if the aircraft can reduce sonic booms and make supersonic flight over land quieter.
The three NASA astronauts that were part of the SpaceX Crew-8 aboard Crew Dragon Endeavour will speak publicly today for the first time since their mission returned to earth late last month.
SpaceX successful launched a South Korean communication satellite from Kennedy Space Center in Florida on Monday afternoon.
Rhode Island today became the first state in the nation adopt the Next Generation Science Standards.
Rhode Island may become the first state to adopt the Next Generation Science Standards. The state board will vote later today.
The principal of a school in Kentucky went back to the drawing board on his school's schedule after hearing author Daniel Pink talk about what children really need.
Students returning to schools in Virginia and New York this fall will be required to participate in mental-health education as part of their health and physical education courses.
Alabama lawmakers passed a charter school law last year, becoming the 43rd state to adopt one.
The Pittsburgh Penguins traded Lars Eller to the Washington Capitals on Tuesday afternoon.
In Tuesday night's Republican primary in West Virginia, Robert Karnes, a West Virginia Republican state senator who lashed out at teachers during their nine-day strike, lost to pro-labor candidate Bill Hamilton.
UConn women’s basketball freshman Sarah Strong earned the first Big East Freshman of the Week honors of her career on Monday after a pair of impressive performances in the Huskies’ Week 1 wins. Strong was the No. 1 recruit in the Class of 2024 and lived up to her elite billing with a game-high 17 points in her college debut against Boston University on Thursday. She also led the team with six ...
EAU CLAIRE— This weekend saw the first basketball games for Blugold men’s and women’s basketball during the Market & Johnson Blugold Tip-Off Tournament. The games were the first to be played at the Sonnentag Event Center, a part of the new $122 million multi-purpose facility which opened earlier this year. The event center has a capacity of 3,500 people for sporting events as compared to the ...
The early polygraph machine was considered the most scientific way to detect deception—but that was a myth
Building on previous efforts, the Kingdom of Morocco will offer technical assistance to the Republic of Guinea through a South-South Cooperation Tripartite Agreement signed today at FAO headquarters by FAO [...]
Today we celebrate the cultural heritage, health benefits and economic importance of tea.
Read the series on how FAO increased efficiency, effectiveness and transparency to better support its Members in the transformation of agrifood systems.
The firebrand politician once quipped that she would like to be remembered as a woman who ‘had guts’
In March 1895, Boston and New York City began an epic and highly competitive race to become the first American city with a working subway system.
This video from the Illustris project simulates 13 billion years of the universe in just two minutes
Thomas Edison's 1902 trick film, "Hindoo Fakir," depicts an Indian fakir-yogi performing a magic act.
As part of Project Mercury, NASA prepared to send a chimpanzee, Ham, into space to test the effects of space on a living creature.
An exhibit about the first ladies reopens at the National Museum of American History, including dresses worn at inaugural balls.
Discover how Ella Jenkins' joyful songs and storytelling have inspired generations of young listeners, while her commitment to advocacy has profoundly affected the world of music and beyond. --------- For more videos from Smithsonian Magazine: https://www.smithsonianmag.com/videos/ Digital Editorial Director: Brian Wolly Director of Programming: Nicki Marko Supervising Producer & Scriptwriter: Michelle Mehrtens Producer & Editor: Sierra Theobald Motion Designer: Ricardo Jaimes
http://j.mp/z7WXi2 Researchers and scientists work together to find a way to play recordings made by the studio of inventor Alexander Graham Bell
Follow us to the very first Thanksgiving celebration, where the Pilgrims and the Wampanoag came together for a historic feast.
The technology, enabled by thorium atoms, could keep time more accurately than atomic clocks and enable new discoveries about gravity, gravitational waves and dark matter
On this day in 1690, "Publick Occurrences Both Forreign and Domestick" attracted colonial officials' ire by repeating a scandalous rumor and condemning a British alliance with the Mohawk
In the dusty landscape surrounding the city of Marfa, a huge 3D printer is constructing 43 new rooms and 18 residential homes as part of an expansion of El Cosmico
The Fish and Wildlife Service will consider granting federal protections to the Bethany Beach firefly, which is rapidly losing its coastal habitat to development and climate change
The brain diagram, called a connectome, could revolutionize researchers' understanding of the human brain, which has many parallels with a fruit fly's
Best known for "The Vegetarian," the novelist and poet was praised for her "intense poetic prose that confronts historical traumas and exposes the fragility of human life"
Scientists converted the patient’s own cells into blood sugar-regulating cell clusters before injecting them back into her abdomen—and one year later, she still doesn't need insulin injections
The success is a giant leap toward the company's goal to take humans and cargo all the way to Mars on the world's biggest and most powerful launch vehicle
The final 3D atlas of the sky will help scientists study dark matter and dark energy, which make up 96 percent of the universe but remain mysterious
Opening next spring, the new venue will have exhibits and a barbecue bean-themed ball pit play area for kids
Each of the 11 dolphins sampled exhaled at least one suspected particle of microplastic, which researchers say “highlights how extensive environmental microplastic pollution is”