An overview of the biggest business developments in SA and beyond.

OM France marks OM’s 60th anniversary, inviting International Director, Lawrence Tong, to grace this special occasion.

OM Chile responds quickly to help local churches provide relief after a forest fire in Valparaíso kills 15 people and destroys 3,000 homes in April.

Delaware to receive nearly $70 million to fight the opioid crisis Delaware Attorney General Kathy Jennings today announced the final approval of $17.3 billion in opioid agreements with drug makers Teva and Allergan and pharmacies CVS and Walgreens. Following successful state sign-on and subdivision sign-on periods, the defendants have committed to the deal and will start releasing funds […]

July 19, 2017 Wilmington – The Delaware Department of Labor’s Fox Valley has postponed a meeting to receive public comment on proposed updates to the state’s Prevailing Wage regulations. A new date for the meeting has yet to be set. A separate meeting to receive public comment on proposed updates to the state’s Workplace Fraud regulations […]

On September 24, 2018, the Division of Industrial Affairs will accept public comment on proposed changes to Delaware’s Prevailing Wage Regulations from 4:00 to 6:00 pm at the Department of Labor’s Harold Stafford Training Center located at 19 Lea Boulevard, Wilmington, DE 19802. Members of the public may receive a copy of the proposed regulations […]

The Delaware Department of Labor is currently conducting its Annual Prevailing Wage Survey for state-funded construction projects. On January 4, 2019, the Department mailed over 3000 survey forms to contractors. Completed survey forms must be postmarked or returned to the Department of Labor no later than February 8, 2019 for the data to be used […]

The Division of Industrial Affairs (DIA) at the Department of Labor (DOL) is currently conducting its Annual Prevailing Wage Survey for state-funded construction projects – over 3,800 survey forms will be mailed out to contractors on December 27, 2021. The completed survey forms must be postmarked or returned to DIA for the data to be […]

The Division of Industrial Affairs (DIA) at the Department of Labor (DOL) is currently conducting its Annual Prevailing Wage Survey for state-funded construction projects. On January 4, 2023, the Department mailed over 4000 survey forms to contractors. The completed survey forms must be postmarked or returned to DIA for the data to be used in […]

The Department is currently conducting its Annual Prevailing Wage Survey for state-funded construction projects. On December 20, 2023, the Department mailed over 4500 survey forms to contractors and various interested parties. The completed survey forms must be postmarked or returned no later than February 8, 2024, to the Department of Labor for the data to […]

NEW CASTLE (2 de Noviembre, 2022) – La División de Servicios de Manutención de Niños (DCSS) anunció hoy una nueva asociación con TD Bank. A partir del 14 de Noviembre de 2022, los cheques en papel de la División de Servicios de Manutención Infantil ya no se emitirán en PNC Bank. El Jueves 20 de […]

The new SAS developer portal has a permanent home Say sayonara to the old SAS developer portal. We recently shut it down. The new portal is live and has a new home. The old and new sites were living side by side while we finished up some development work. Now [...]

SAS launches a revamped developer portal was published on SAS Users.

The 7th Street Boating and Fishing Area on the Christina River has officially reopened to Wilmington's Eastside community, with DNREC, in partnership with the city, celebrating the $2.9 million project with a ribbon-cutting ceremony in John Barbiarz Park, where the popular facility is located.

A man recently took to Reddit, seeking help identifying an unknown Devanagari text he found at a flea market in Germany.

The couple, together for nine years, had announced the wedding date in January and were eagerly looking forward to their long-awaited special day.

Santa Fe Hybrid makes 231 hp and 271 lb-ft of torque Santa Fe Hybrid averaged 31 mpg combined over mostly highway miles Comfy seats, clever storage, and a spacious cargo area with the third-row folded make it a good family hauler My teen daughter’s a videographer. Whenever I test a big car, fast car, cool car, anything that’s not...

MANILA, Philippines — A new typhoon barreled across an agricultural region in the northeastern Philippines on Monday after thousands were evacuated to safety while still struggling to recover from the devastation caused by three successive storms in the last three weeks. Typhoon Toraji slammed into northeastern Aurora province and was forecast to blow over the mountainous Luzon region, where President Ferdinand Marcos Jr. — just the day before — inspected the damage from the last storm and led the distribution of food packs to residents in Cagayan and Ilocos provinces. Marcos skipped this week's Asia-Pacific Cooperation forum in Peru to oversee recovery efforts from back-to-back storms. After making landfall in Aurora on Monday morning with sustained winds of up to 130 kilometers (81 miles) per hour and gusts of up to 180 kph (112 mph), the typhoon was expected to barrel northwestward across Luzon, weaken as it crosses a mountain range and then blow into the South China Sea. Interior Secretary Jonvic Remulla on Sunday ordered the forcible evacuation of people in 2,500 villages expected to be lashed by Toraji, locally named Nika, warning that the rain-soaked Luzon mountains, valleys and plains were more susceptible to flash floods and landslides. With the typhoon approaching fast, there was little time to move large numbers of people to safety, he said. "We understand if some would want to stay, but we have to get them out," Remulla told reporters. The military said its disaster-response forces have been deployed near high-risk areas and were standing by for new contingencies. It added that it suspended combat drills in the north due to the weather. "Our commitment remains steadfast in safeguarding and assisting our countrymen specially in times of disaster," Armed Forces of the Philippines spokesperson Col. Francel Margareth Padilla said. Schools were shut down, inter-island ferry services and domestic flights were suspended in provinces in or near the path of the typhoon, the 14th weather disturbance to batter the Philippine archipelago this year. Forecasters said they were monitoring another brewing storm in the Pacific that could affect the country if it strengthens. The last two typhoons and a tropical storm caused more than 160 deaths, damaged thousands of houses and farmlands and affected more than 9 million people, including hundreds of thousands who fled to emergency shelters, after dumping from one to two months' worth of rain in just 24 hours in some cities and towns. Overwhelmed, the Philippines received help from Southeast Asian countries led by Singapore, along with longtime treaty ally the United States, to transport food, water and other aid to hard-hit northern provinces. The Philippine archipelago is often battered by typhoons and earthquakes and has more than a dozen active volcanoes, making it one of the most natural disaster-prone countries in the world. In 2013, Typhoon Haiyan, one of the strongest recorded tropical cyclones, left more than 7,300 people dead or missing, flattened entire villages and caused ships to run aground and smash into houses in the central Philippines.

The Philippines ordered evacuations ahead of Typhoon Ofel (international name: Usagi) on Wednesday, as the UN disaster office sought $32.9 million in aid for the country after storms that killed more than 150 people.

La enseñanza bíblica en profundidad de John MacArthur lleva la verdad transformadora de la Palabra de Dios a millones de personas cada día.

La enseñanza bíblica en profundidad de John MacArthur lleva la verdad transformadora de la Palabra de Dios a millones de personas cada día.

La enseñanza bíblica en profundidad de John MacArthur lleva la verdad transformadora de la Palabra de Dios a millones de personas cada día.

La enseñanza bíblica en profundidad de John MacArthur lleva la verdad transformadora de la Palabra de Dios a millones de personas cada día.

La enseñanza bíblica en profundidad de John MacArthur lleva la verdad transformadora de la Palabra de Dios a millones de personas cada día.

La enseñanza bíblica en profundidad de John MacArthur lleva la verdad transformadora de la Palabra de Dios a millones de personas cada día.

La enseñanza bíblica en profundidad de John MacArthur lleva la verdad transformadora de la Palabra de Dios a millones de personas cada día.

La enseñanza bíblica en profundidad de John MacArthur lleva la verdad transformadora de la Palabra de Dios a millones de personas cada día.

La enseñanza bíblica en profundidad de John MacArthur lleva la verdad transformadora de la Palabra de Dios a millones de personas cada día.

La enseñanza bíblica en profundidad de John MacArthur lleva la verdad transformadora de la Palabra de Dios a millones de personas cada día.

La enseñanza bíblica en profundidad de John MacArthur lleva la verdad transformadora de la Palabra de Dios a millones de personas cada día.

La enseñanza bíblica en profundidad de John MacArthur lleva la verdad transformadora de la Palabra de Dios a millones de personas cada día.

This month, the International Monetary Fund (IMF) had an opportunity to end one of its most reviled policies and lift billions of dollars of debt off the backs of crisis-stricken developing countries. It chose not to. The IMF’s ostensible mission is to promote financial stability by providing loans to countries facing economic challenges or crises. […]

MANILA, Philippines — Interior Secretary Jonvic Remulla touted local government units’ (LGUs) preemptive evacuation in response to Typhoon Nika (International name: Toraji), saying they took “lessons” from Severe Tropical Storm Kristine (International name: Trami). In a phone interview aired on People’s Television Network on Wednesday morning, Remulla said LGUs evacuated around 8,000 families from geohazard zones identified by the Department of Environment and Natural Resources as Nika crossed Northern Luzon. “If they didn’t evacuate, perhaps, 100 would have died because many of the houses there were really destroyed,” he said in Filipino. Nika left the Philippine Area of Responsibility at […]...

Keep on reading: Remulla: Preemptive evacuation a ‘lesson’ from Storm Kristine

The ongoing, escalating violence in Lebanon forces millions of Lebanese civilians to face daily bombardment, repeated orders of evacuation, routine destruction of critical infrastructure, and limited access to basic services. With the death toll and rates of displacement on the rise, humanitarian organizations fear that the upcoming winter season is expected to exacerbate these harsh […]

Last week, UN member states adopted the Pact of the Future – and its two annexes: the Global Digital Compact and the Declaration for Future Generations. These action-oriented documents are envisaged to counter emerging threats to development and acceleration of progress on Agenda 2030. Nonetheless, there remains little political prioritization of reproductive justice on this agenda. […]

Chris Evans hopes to become a great dad somedayChris Evans has recently discussed about fatherhood and marital relation with Alba Baptista. Speaking at upcoming Red One movie premiere on November 11, Evans responded to the question about becoming a superhero father like his co-star Dwayne Johnson...

Scientists warn of vastly higher impacts on billions of people’s livelihood and cost to the global economy by the accelerating losses in the world’s snow and ice regions, aka the cryosphere. Over 50 leading cryosphere scientists released an annual report on the status of the world’s ice stores on Tuesday (November 12) at the UN […]

The TA will focus on evaluating the wind potential of various site/s for government investment in wind energy. A feasibility analysis of viable wind sites will be carried out, which will inform the government on the scale of wind projects and how best to develop this potential. The TA will also fund the equipment for measuring wind speeds and directions to confirm site selection and build capacity for wind energy development in the EA.

Never underestimate what a single gopher can achieve in a day: one of the burrowing mammals helped boost soil fungi in an area blanketed by ash from the explosive eruption of Mount St Helens in Washington state

Some 550 years ago, a Venetian monk named Fra Mauro set out to create a world map. Rather than myth and religion, it was based on solid evidence for the first time

Never underestimate what a single gopher can achieve in a day: one of the burrowing mammals helped boost soil fungi in an area blanketed by ash from the explosive eruption of Mount St Helens in Washington state

Isotopic analysis of horse teeth from a medieval burial site suggest that the animals were imported to England from Scandinavia or the Alps, perhaps for use in battle or jousting

Ancient Egyptians may have relied on a vertical shaft that could be filled with water, along with a network of water channels and filtration structures, to build the Step Pyramid of Djoser 4500 years ago

Title: Pious Parasites: Medieval Monks Battled Nasty Gut Germs
Category: Health News
Created: 8/19/2022 12:00:00 AM
Last Editorial Review: 8/19/2022 12:00:00 AM

Title: Too Few U.S. Cities Have Good Hurricane Evacuation Plans
Category: Health News
Created: 8/26/2022 12:00:00 AM
Last Editorial Review: 8/26/2022 12:00:00 AM

Objective:

In this study, we sought to comprehensively evaluate GPT-4 (Generative Pre-trained Transformer)’s performance on the 2022 American Board of Family Medicine’s (ABFM) In-Training Examination (ITE), compared with its predecessor, GPT-3.5, and the national family residents’ performance on the same examination.

BACKGROUND:Practice on fasting prior to extubation in critically ill patients is variable. Efficacy of fasting in reducing gastric volume has not been well established. The primary objective of this study was to assess the effect of 4 h of fasting on prevalence of empty stomach using gastric ultrasonography in critically ill subjects who are fasted for extubation. The secondary objectives were to evaluate the change in gastric volumes during 4 h of fasting and to determine factors associated with empty stomach after fasting.METHODS:This was a single-center, prospective, observational study on adult ICU subjects who were enterally fed for at least 6 h continuously and mechanically ventilated. Gastric ultrasound was performed immediately prior to commencement of fasting, after 4 h of fasting, and after nasogastric (NG) aspiration after 4 h of fasting. An empty stomach was defined as a gastric volume ≤ 1.5 mL/kg.RESULTS:Forty subjects were recruited, and 38 (95%) had images suitable for analysis. The prevalence of empty stomach increased after 4 h of fasting (25 [65.8%] vs 31 [81.6%], P = .041) and after 4 h of fasting with NG aspiration (25 [65.8%] vs 34 [89.5%], P = .008). There was a significant difference in median (interquartile range) gastric volume per body weight between before fasting and 4 h after fasting (1.0 [0.5–1.8] mL/kg vs 0.4 [0.2–1.0] mL/kg, P < .001). No patient factors were associated with higher prevalence of empty stomach after 4 h of fasting.CONCLUSIONS:Most mechanically ventilated subjects had empty stomachs prior to fasting for extubation. Fasting for 4 h further increased the prevalence of empty stomach at extubation to > 80%.

Purpose Low-income children experience disproportionately high rates of dental caries and challenges in accessing dental care compared to their higher-income peers. The purpose of this scoping review was to examine the prevalence of dental caries and dental service utilization among Special Supplemental Nutrition Program for Women, Infants, and Children (WIC) enrolled children.Methods The literature search and review were conducted between September 2023 and February 2024. The review followed the PRISMA-ScR reporting guidelines and included three databases: PubMed, CINAHL, and Dentistry & Oral Sciences Source. The study focused on children aged one to five participating in WIC within the United States (US) and aimed to determine the prevalence of dental service utilization and dental caries in the targeted population.Results This review includes twelve articles that are quantitative observational studies conducted from February 2001 to February 2023. Most of the studies were conducted in WIC programs in the Southern and Midwest regions of the US. Dental caries rates decreased by 61.8% from 2004 to 2016, with the highest prevalence in 2004, and the lowest prevalence in 2016. Dental service utilization among WIC children increased by 56.9% from 1992 to 2020.Conclusion There has been an increase in dental service utilization among WIC-enrolled children, with an overall decrease in dental caries over the last two decades. However, the prevalence of dental caries remains disproportionately high for children enrolled in WIC when compared to non-participants. To develop effective dental interventions for children enrolled in WIC, it is fundamental to identify the unique determinants of dental caries in this population.

The regulation of drug-metabolizing enzymes and transporters by cytokines has been extensively studied in vitro and in clinic. Cytokine-mediated suppression of cytochrome P450 (CYP) or drug transporters may increase or decrease the systemic clearance of drug substrates that are primarily cleared via these pathways; neutralization of cytokines by therapeutic proteins may thereby alter systemic exposures of such drug substrates. The Food and Drug Administration recommends evaluating such clinical drug interactions during clinical development and has provided labeling recommendations for therapeutic proteins. To determine the clinical relevance of these drug interactions to dose adjustments, trends in steady-state exposures of CYP-sensitive substrates coadministered with cytokine modulators as reported in the University of Washington Drug Interaction Database were extracted and examined for each of the CYPs. Coadministration of cytochrome P450 family 3 subfamily A (CYP3A) (midazolam/simvastatin), cytochrome P450 subfamily 2C19 (omeprazole), or cytochrome P450 subfamily 1A2 (caffeine/tizanidine) substrates with anti-interleukin-6 and with anti-interleukin-23 therapeutics led to changes in systemic exposures of CYP substrates ranging from ~ –58% to ~35%; no significant trends were observed for cytochrome P450 subfamily 2D6 (dextromethorphan) and cytochrome P450 subfamily 2C9 (warfarin) substrates. Although none of these changes in systemic exposures have been reported as clinically meaningful, dose adjustment of midazolam for optimal sedation in acute care settings has been reported. Simulated concentration-time profiles of midazolam under conditions of elevated cytokine levels when coadministered with tocilizumab, suggest a ~six- to sevenfold increase in midazolam clearance, suggesting potential implications of cytokine–CYP drug interactions on dose adjustments of sensitive CYP3A substrates in acute care settings. Additionally, this article also provides a brief overview of nonclinical and clinical assessments of cytokine–CYP drug interactions in drug discovery and development.