Nearly 1 in 5 U.S. kids are obese, according to the latest national data.

(MENAFN) On Friday, a high-ranking official of the Moroccan Health Ministry stated that as many as three COVID-19 cases were passed away, pushing the ... ......

(MENAFN)An official with the health ministry in Morocco said on Friday that three more coronavirus patients have died due to coronavirus i... ......

Tripadvisor’s annual list of best hotels has been published. Click through for the top 15 hotels in Turkey that won Travellers’ Choice 2018 awards with the votes of the website’s users.

Forbes magazine has announced the top 25 highest grossing Turkish TV series of the year. Click through for the full list...

One of the issues which accommodation teams in the Education Sector will be grappling with will be students trying to terminate their accommodation contracts early because of the Coronavirus outbreak. The impact this will have on the institution&rsq...

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Educational institutions are having to navigate through unchartered territory with regards to their student accommodation, implementing the recent government guidance in relation to Covid-19 to ensure the safety of both staff and students. Although ...

[U.S. House] Washington, DC -Rep. Ilhan Omar (D-MN) led a letter to General Stephen J. Townsend today calling for increased transparency and public accountability of civilian causalities from the United States Defense Department's Africa Command (AFRICOM). The letter was signed by Rep. Adam Smith, Chair, House Committee on Armed Services; Rep. Adam Schiff, Chair, House Permanent Select Committee on Intelligence; Rep. Eliot Engel, Chair, House Committee on Foreign Affairs; Rep. André Carson, Chair, Subcommittee on Counterterrori

Bank branches attacked with gunfire, petrol bombs.

WeChat, the Chinese messaging app, is systematically monitoring the content sent by international users to build up its censorship algorithms applied against accounts registered in China, a new study has found.Researchers at Citizen Lab, an academic research lab at the University of Toronto, determined that WeChat screens images and documents shared by accounts registered outside China after they are sent, then adds the digital signature – or “hash” – of any files deemed sensitive to a…

Prague Daily Monitor

Tuesday saw a small return of winter to the Czech Republic. Temperatures dropped during the morning as clouds cleared. Soon heavy winds followed and reaped destruction on infrastructure. At the height of the destruction there were almost 18,000 households across the country with electricity outages during the day. The worst outages were felt in Southern Moravia according to E.ON. Meteorologists are also warning people to be safe in the mountains as wet snow can break branches and fell trees.

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Samuel Murithi’s decision to grow the niche crops pays off as demand for the two vegetables picks up, thanks to their health benefits

He was described as a leader who remained calm in a raging storm.

A former Pakistani child bride, who was wrongly accused of killing her husband at 13 and subsequently spent almost two decades in prison, is making history by being the first victim of a miscarriage of justice to seek compensation from the state, say legal human rights experts.   This March, Rani Tanveer, who was released in […]

The post Former Child Bride Holds Pakistan to Account for Wrongful Imprisonment in Historic Legal Challenge appeared first on Inter Press Service.

The profile photo on the Kensington Royal Twitter and Instagram pages was changed to an image of The Duke and Duchess of Cambridge and their children

Former Prime Minister Saad Hariri Thursday dismissed as not useful the meeting held the previous day at Baabda Palace to discuss the economic financial rescue plan which he and his parliamentary Future bloc boycotted.

How Do I Login To myMICROCHIP Account

The world is experiencing what some may think is a “typical” black swan event: rare, extremely impactful, and only retrospectively predictable. 

This working paper proposes flood footprint and accountability to coordinate risk management projects through appropriate spatial planning at river basin scale.

A new book from Jim Al-Khalili makes cutting-edge physics easily understandable and makes it clear why he fell in love with the subject as a teenager

The fossilised remains of the food found in one of the few remaining coastal Neanderthal sites in Europe show they ate plenty of seafood, fish and nuts

Title: zafirlukast (Accolate)
Category: Medications
Created: 4/19/1999 12:00:00 AM
Last Editorial Review: 11/21/2019 12:00:00 AM

Title: FDA to Regulate E-Cigarettes Just Like Tobacco
Category: Health News
Created: 4/28/2011 11:01:00 AM
Last Editorial Review: 4/28/2011 12:00:00 AM

Title: Tobacco Companies Must Put New Warnings on Packaging, Court Says
Category: Health News
Created: 5/1/2018 12:00:00 AM
Last Editorial Review: 5/2/2018 12:00:00 AM

Title: FDA OKs Restricted Sales of 'Heat-Not-Burn' Tobacco Devices
Category: Health News
Created: 4/30/2019 12:00:00 AM
Last Editorial Review: 5/1/2019 12:00:00 AM

ABSTRACT

The availability of energy has significant impact on cell physiology. However, the role of cellular metabolism in bacterial pathogenesis is not understood. We investigated the dynamics of central metabolism during virulence induction by surface sensing and quorum sensing in early-stage biofilms of the multidrug-resistant bacterium Pseudomonas aeruginosa. We established a metabolic profile for P. aeruginosa using fluorescence lifetime imaging microscopy (FLIM), which reports the activity of NADH in live cells. We identified a critical growth transition period during which virulence is activated. We performed FLIM measurements and direct measurements of NADH and NAD⁺ concentrations during this period. Here, planktonic (low-virulence) and surface-attached (virulence-activated) populations diverged into distinct metabolic states, with the surface-attached population exhibiting FLIM lifetimes that were associated with lower levels of enzyme-bound NADH and decreasing total NAD(H) production. We inhibited virulence by perturbing central metabolism using citrate and pyruvate, which further decreased the enzyme-bound NADH fraction and total NAD(H) production and suggested the involvement of the glyoxylate pathway in virulence activation in surface-attached populations. In addition, we induced virulence at an earlier time using the electron transport chain oxidase inhibitor antimycin A. Our results demonstrate the use of FLIM to noninvasively measure NADH dynamics in biofilms and suggest a model in which a metabolic rearrangement accompanies the virulence activation period.

IMPORTANCE The rise of antibiotic resistance requires the development of new strategies to combat bacterial infection and pathogenesis. A major direction has been the development of drugs that broadly target virulence. However, few targets have been identified due to the species-specific nature of many virulence regulators. The lack of a virulence regulator that is conserved across species has presented a further challenge to the development of therapeutics. Here, we identify that NADH activity has an important role in the induction of virulence in the pathogen P. aeruginosa. This finding, coupled with the ubiquity of NADH in bacterial pathogens, opens up the possibility of targeting enzymes that process NADH as a potential broad antivirulence approach.

We wish to thank J. Britton and co-workers for responding to our editorial and giving us an opportunity to clarify our position as well as correct a few misunderstandings. We definitely share the same goal, which is to relieve Europe and the rest of the world from the terrible results of the tobacco epidemic. We also do not "blankly oppose e-cigarettes"; however, we strongly advocate against a harm reduction strategy including e-cigarettes as well as heated tobacco products [1]. As clinicians we all see reluctant smokers where e-cigarettes can be tried as a last resort for getting off cigarette smoking, but that is of little relevance for a general harm reduction strategy. We also agree that the UK has achieved a lot in the area of smoking cessation but would argue that this has been achieved by impressive tobacco control, not by the use of e-cigarettes, and that a country such as Australia, which has banned nicotine-containing e-cigarettes, has achieved similar results.

The respiratory community is united in its desire to reduce and eliminate the harm caused by tobacco smoking, which is at present on course to kill one billion people in the 21st century. The stated policy of the European Respiratory Society is to strive "constantly to promote strong and evidence-based policies to reduce the burden of tobacco related diseases". In our view, the recent ERS Tobacco Control Committee statement on tobacco harm reduction [1], though well-intentioned, appears to be based on a number of false premises and draws its conclusions from a partial account of available data. It also presents a false dichotomy between the provision of "conventional" tobacco control and harm reduction approaches. We therefore respond, in turn, to the seven arguments presented against the adoption of harm reduction in the Committee's statement.

BACKGROUND AND OBJECTIVES:

A previous single-county study found that retail stores usually asked young-looking tobacco customers to show proof-of-age identification, but a large proportion of illegal tobacco sales to minors occurred after the customers had shown identification proving they were too young to purchase tobacco. We sought to investigate these findings on a larger scale.

Tobacco use is a persistent public health issue. It kills up to half its users and is the cause of nearly 90% of all lung cancers. The main psychoactive component of tobacco is nicotine, primarily responsible for its abuse-related effects. Accordingly, most pharmacotherapies for smoking cessation target nicotinic acetylcholine receptors (nAChRs), nicotine’s major site of action in the brain. The goal of the current review is twofold: first, to provide a brief overview of the most commonly used behavioral procedures for evaluating smoking cessation pharmacotherapies and an introduction to pharmacokinetic and pharmacodynamic properties of nicotine important for consideration in the development of new pharmacotherapies; and second, to discuss current and potential future pharmacological interventions aimed at decreasing tobacco use. Attention will focus on the potential for allosteric modulators of nAChRs to offer an improvement over currently approved pharmacotherapies. Additionally, given increasing public concern for the potential health consequences of using electronic nicotine delivery systems, which allow users to inhale aerosolized solutions as an alternative to smoking tobacco, an effort will be made throughout this review to address the implications of this relatively new form of nicotine delivery, specifically as it relates to smoking cessation.

Advances in small RNA sequencing have revealed the enormous diversity of small noncoding RNA (sRNA) classes in mammalian cells. At this point, most investigators in diabetes are aware of the success of microRNA (miRNA) research and appreciate the importance of posttranscriptional gene regulation in glycemic control. Nevertheless, miRNAs are just one of multiple classes of sRNAs and likely represent only a minor fraction of sRNA sequences in a given cell. Despite the widespread appreciation of sRNAs, very little research into non-miRNA sRNA function has been completed, likely due to some major barriers that present unique challenges for study. To emphasize the importance of sRNA research in cardiometabolic diseases, we highlight the success of miRNAs and competitive endogenous RNAs in cholesterol and glucose metabolism. Moreover, we argue that sequencing studies have demonstrated that miRNAs are just the tip of the iceberg for sRNAs. We are likely standing at the precipice of immense discovery for novel sRNA-mediated gene regulation in cardiometabolic diseases. To realize this potential, we must first address critical barriers with an open mind and refrain from viewing non-miRNA sRNA function through the lens of miRNAs, as they likely have their own set of distinct regulatory factors and functional mechanisms.

Background:

Percent density (PD) is a strong risk factor for breast cancer that is potentially modifiable by lifestyle factors. PD is a composite of the dense (DA) and nondense (NDA) areas of a mammogram, representing predominantly fibroglandular or fatty tissues, respectively. Alcohol and tobacco use have been associated with increased breast cancer risk. However, their effects on mammographic density (MD) phenotypes are poorly understood.

Background:

Despite smoking being a well-established risk factor for pancreatic cancer, there is a need to further characterize pancreatic cancer risk according to lifespan smoking patterns and other smoking features, such as tobacco type. Our aim was to deeply investigate them within a large European case–control study.

Tobacco smoking is the primary risk factor for lung cancer, driven by the addictive nature of nicotine and the indisputable carcinogenicity of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) as well as other compounds. The integration of lung cancer chemoprevention with smoking cessation is one potential approach to reduce this risk and mitigate lung cancer mortality. Experimental data from our group suggest that kava, commonly consumed in the South Pacific Islands as a beverage to promote relaxation, may reduce lung cancer risk by enhancing NNK detoxification and reducing NNK-derived DNA damage. Building upon these observations, we conducted a pilot clinical trial to evaluate the effects of a 7-day course of kava on NNK metabolism in active smokers. The primary objective was to compare urinary total 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL plus its glucuronides, major metabolites of NNK) before and after kava administration as an indicator of NNK detoxification. Secondary objectives included determining kava's safety, its effects on DNA damage, tobacco use, and cortisol (a biomarker of stress). Kava increased urinary excretion of total NNAL and reduced urinary 3-methyladenine in participants, suggestive of its ability to reduce the carcinogenicity of NNK. Kava also reduced urinary total nicotine equivalents, indicative of its potential to facilitate tobacco cessation. Plasma cortisol and urinary total cortisol equivalents were reduced upon kava use, which may contribute to reductions in tobacco use. These results demonstrate the potential of kava intake to reduce lung cancer risk among smokers.

Cruciferous vegetables have been of special interest due to the rich presence of bioactive compounds such as sulforaphane which show promising potential on cancer prevention and therapy as an epigenetic dietary strategy. Abnormal epigenetic alteration as one of the primary contributors to tumor development is closely related to breast cancer initiation and progression. In the present study, we investigated the effect of dietary broccoli sprouts (BSp), a common cruciferous vegetable, on prevention of estrogen receptor (ER)-negative mammary tumors at three different temporal exposure windows using a spontaneous breast cancer mouse model. Our findings indicate that maternal BSp treatment exhibited profound inhibitory and preventive effects on mammary cancer formation in the nontreated mouse offspring. The BSp diet administered to adult mice also showed suppressive effects on mammary cancer but was not as profound as the maternal BSp preventive effects. Moreover, such protective effects were linked with differentially expressed tumor- and epigenetic-related genes, as well as altered global histone acetylation, DNA methylation, and DNA hydroxymethylation levels. We also found that the expression changes of tumor-related genes were associated with the levels of histone methylation of H3K4 and H3K9 in the gene promoter regions. In addition, BSp-enriched sulforaphane was shown to increase protein expression of tumor suppressor genes such as p16 and p53 and inhibit the protein levels of Bmi1, DNA methyltransferases, and histone deacetylases in ERα-negative breast cancer cell lines. Collectively, these results suggest that maternal exposure to key phytochemicals may contribute to ER-negative mammary tumor prevention in their offspring through epigenetic regulations.

Honouring real estate developers who are relentless in their pursuit to be socially and environmentally responsible.

Anything that encourages more people to enable two-step verification can only be a good thing.

After more than three long years, the Justice Department has finally lived up to its name by dropping charges against my former boss, former National Security Adviser and retired Army Lt. Gen. Michael Flynn. He should have never been prosecuted.

PUBG Mobile update 0.18.0 released this week but a bug appears to be causing a lot of grief for players unable to play since downloading the latest patch

Nintendo today confirmed earlier reports of account breaches dating back over the past few weeks. The gaming giant issued an update (via Nintendo Japan) noting that around 160,000 Nintendo Accounts were impacted, which found multiple being used to purchase digital items without the owner’s consent. Along with the purchasing powers, the offending parties may have […]

In her first on-camera interview since the former vice president “unequivocally” denied the sexual assault allegation, Reade says she's willing to be questioned under oath.

Analysis: As the president declares victory over the coronavirus amid a rising death toll, his clear focus on extricating himself from responsibility becomes clearer.

Shopping for face masks? We consulted medical experts on how to shop for face masks and rounded up those adhering to the CDC's guidelines.

Super Bowl champion quarterback Joe Flacco underwent neck surgery last month and is expected to be out until September, according to multiple reports.

With the COVID-19 coronavirus causing a global pandemic, a look back at the scientists who figured out viruses and their relationship to disease

The Trump administration is drafting a legal blueprint for mining on the moon under a new U.S.-sponsored international agreement called the Artemis Accords, people familiar with the proposed pact told Reuters.