Mr. Saragoza has been endorsed by Marquis Who's Who as a leader in the music industry

Everywhere Wireless provided its Gigabit+ Internet to keep Trainers from around the world connected

Dovanna, an iconic fashion model of the 1980s, is presented by projected images from her work with photographers Robert Maplethorpe, Pierre & Gilles and Andrew Brucker. Opening attire by Marc Jacobs.

Coeval Now Includes Internet Speeds up to 1,000 Mbps in All Units and Common Areas

Technology meets efficiency in servicing Fortune 500 tenants at the 35-story office tower in Chicago's Loop

Criminal defense lawyers at Goldman Wetzel take their victory in the Hernando County government center designed by attorney Summer Goldman's father.

The Washington Post and Chicago Tribune will include special title pages as part of an international campaign to mark the 80th anniversary of the outbreak of WWII

Crow writes meticulously researched, entertaining novels of romance, history and mystery in an engaging you-are-there style that allows readers to live the history.

Independent Bakery Sells Out of ''Social Distancing' Gift Boxes Following Howie Mandel Show

Designer Sportswear Company from Chicago "D2 Wear" has teamed up with FashionBar for a sportswear apparel fashion show on July 28th at 3:00 pm at the Northbrook mall, Illinois; Admission is free for visitors.

Unlike other solutions, AuthorONE delivers explainable, actionable results.

It’s time to say ‘Bula’ as Indian filmmakers make plans for filming in Fiji.

On Dec. 17, 2019, the Department of Justice filed a complaint in the U.S. District Court for the Northern District of Illinois on behalf of Captain and Judge Advocate Derrick Strong against the City of Chicago Fire Department (CFD), alleging that the City violated the Uniformed Services Employment and Reemployment Rights Act of 1994 (USERRA) when it failed to provide Strong with an opportunity, after his return from active duty military service, to take a promotional examination that he missed while deployed.

The Securities and Exchange Commission today announced that Louis Gracia and Vanessa Horton have been named Associate Directors of the Investment Adviser/Investment Company (IA/IC) examination program in the agency's Chicago Regional Office. Together, Mr…

Using just CSS to produce a hexagonal shape menu with no extra markup and no images.

A CSS ONLY Dragonfly Slide Show with permanent image changes.

Using just a definition list to produce a horizontal sliding menu with diagonal lists suitable for the iPad etc..

Conservation measures for aquatic species throughout the Pacific Northwest rely heavily on maintaining forested riparian zones. A key rationale for this strategy is that the presence of standing and downed trees next to streams will provide a continuous source of wood, which is an important structural component of aquatic habitat.

iHEARTMEDIA Top 40 WKSC (KISS 1035)/CHICAGO is rolling out the red carpet for the thousands of bartenders and servers who are sidelined with no work due to COVID-19 impacting their businesses … more

iHEARTMEDIA/CHICAGO stations will honor CHICAGOLAND teachers and nurses in a weeklong celebration, kicking off on National Teachers Day on Tuesday, MAY 5th and culminating on International … more

HUBBARD RADIO/SEATTLE has announced that CAT THOMAS will become the Brand & Content Director at Top 40 KQMV (MOVIN 92.5) and AC KRWM (WARM 106.9), transferring from HUBBARD’s … more

HUBBARD RADIO Classic Rock WDRV (97.1 THE DRIVE)/CHICAGO's morning guys SHERMAN & TINGLE partnered with the AMERICAN NURSES FOUNDATION to present “Healthcare Heroes," a … more

Chinese-Australian students have come under increasing scrutiny, raising debate about the role of culture, coaching colleges and notions of childhood in an increasingly competitive school environment. Are Chinese parents too pushy, their focus too narrow and the children too obedient? Or are there lessons to be learnt from Chinese students to ensure everyone shares in the success?

En 2016, la route du photographe finlandais Konsta Punkka croisait celle de deux pumas. Il se situait alors au cœur de la Patagonie, au Chili, dans le vaste parc national Torres del Paine. Spécialiste des clichés d’aventure et d’animaux dans leur habitat naturel, le photographe a passé une dizaine de jours à suivre les félins pour tirer de […]

I took this shot about a year ago when I had a very different editing style. A ton of faded blacks and, believe it or not, a subtle green tint (unknowingly inherited from the preset I was using at the time). Re-editing it now, I’m happy with the way my style has evolved, though I can already sense that I’m on the brink of evolving it again. And I’m okay with that. ???? (at London, United Kingdom)

Andrew Rickmann posted a photo:

A Dragonfly seen at the ponds at Rodley Nature Reserve.

Andrew Rickmann posted a photo:

Dragon boat racing on the Thames in Abingdon.

Annotations are what set visual communication and journalism apart from just visualization. They often consist of text, but some of the most useful annotations are graphical elements, and many of them are very simple. One type I have a particular fondness for is the diagonal reference line, which has been used to provide powerful context […]

We study the bi-commutators $[T_1, [b, T_2]]$ of pointwise multiplication and Calder'on-Zygmund operators, and characterize their $L^{p_1}L^{p_2} o L^{q_1}L^{q_2}$ boundedness for several off-diagonal regimes of the mixed-norm integrability exponents $(p_1,p_2) eq(q_1,q_2)$. The strategy is based on a bi-parameter version of the recent approximate weak factorization method.

THE SHOW WILL GO ON…

The invention concerns a new process for the preparation of crystalline form of agomelatine from a solution of agomelatine in a solvent, characterized in that the agomelatine is crystallized by instantaneous precipitation from said solution, at a temperature equal to or below −10° C.

The present invention relates to oligomer compounds (oligomers) for the treatment and prevention of acute myeloid leukemia, which target GLI2 mRNA in a cell, leading to reduced expression of GLI2.

Compounds and methods related to the activation of the TrkB receptor are provided. The methods include administering a 7,8-dihydroxyflavone derivative with modified flavone or heterocyclic ring to a subject in need thereof. Methods and compounds for the treatment of disorders including neurologic disorders, neuropsychiatric disorders, and metabolic disorders (e.g., obesity) are provided.

The invention relates to 17-hydroxy-17-pentafluoroethyl-estra-4,9(10)-dien-11-aryl derivatives of formula I with progesterone-antagonizing action and methods of production thereof, use thereof for the treatment and/or prevention of diseases and use thereof for producing medicinal products for the treatment and/or prevention of diseases, in particular uterine fibroids (myomata, uterine leiomyomata), endometriosis, heavy menstrual bleeding, meningiomata, hormone-dependent breast cancers and menopause-associated complaints or for fertility control and emergency contraception.

The invention relates to compounds of formula (I): wherein R is ethyl, propyl or allyl, and pharmaceutically acceptable salts, solvates or amino acid conjugates thereof. The compounds of formula (I) are useful as FXR agonists.

The present invention provides a compound which functions as a selective vitamin D receptor modulator and has action-selectivity or tissue-selectivity such that it does not induce hypercalcemia but causes other effects. There is provided a compound represented by formula (I), a solvate thereof or a prodrug thereof. wherein m and n each independently represent 1 or 0;R represents a hydrogen atom or an alkyl group;Y represents an ethane-1,1-diyl group or an ethyne-1,2-diyl group; andZ1 represents a hydrogen atom and Z2 represents a hydroxyalkoxy group, orZ1 and Z2 jointly form a methylene group.

The present invention relates to the use of selective adenosine A1 agonists, in particular the dicyanopyridines of formula (I), for the treatment and/or prophylaxis of glaucoma and ocular hypertension as well as the their use for the production of a medicament for the treatment and/or prophylaxis of glaucoma and ocular hypertension.

The disclosure relates to BAX activators and therapeutic uses relates thereto. In certain embodiments, the disclosure relates to methods of treating or preventing cancer, such as lung cancer, comprising administering a therapeutically effective amount of a pharmaceutical composition comprising a compound disclosed herein or pharmaceutically acceptable salt to a subject in need thereof.

Cyclic CRF antagonist peptides having improved properties of “drugability”. The peptides are 33 residues in length with a lactam bond between the residues in position 22 and 25; however, they may be N-terminally shortened by up to 3 residues.

To provide a diagnostic and therapeutic medicament, a bombesin analog peptide antagonist conjugate is provided which has general Formula (I), wherein A is a metal chelator comprising at least one radionuclide metal, B is a spacer linked to N-terminal of C or a covalent bond and C is a bombesin analog peptide antagonist having a sequence as claimed, where further x is an integer from 1 to 3 and n is an integer from 1 to 6. [A-(B)n]x—C (I)

Whether the growth hormone (GH)/Insulin-like growth factor 1(IGF-I) axis exerts cardioprotective effects remains controversial; and the underlying mechanism(s) for such actions are unclear. Here we tested the hypothesis that growth-hormone releasing hormone (GHRH) directly activates cellular reparative mechanisms within the injured heart, in a GH/IGF-I independent fashion. Following experimental myocardial infarction (MI), rats were randomly assigned to receive, during a 4 week period, either placebo (n=14), rat recombinant GH (rrGH, n=8) or JI-38 (n=8; 50 μg/Kg/day), a potent GHRH-agonist. JI-38 did not elevate serum levels of GH or IGF-I, but markedly attenuated the degree of cardiac functional decline and remodeling after injury. In contrast, GH administration markedly elevated body weight, heart weight, circulating GH and IGF-I, but did not offset the decline in cardiac structure and function. Whereas, both JI-38 and GH augmented levels of cardiac precursor cell proliferation, only JI-38 increased anti-apoptotic gene expression. The receptor for GHRH was detectable on myocytes supporting direct activation of cardiac signal transduction. Collectively, these findings demonstrate that within the heart GHRH-agonists can activate cardiac repair following MI, suggesting the existence of a potential signaling pathway based on GHRH in the heart. The phenotypic profile of the response to a potent GHRH agonist has therapeutic implications.

An improved rearward-hinged and forward-hinged, rotatable and tiltable receiving table for a agricultural bale transport vehicle that selectively tilts and rotates a layer of bales resting thereupon 90 degrees relative to a preceding bale layer on the transport vehicle to criss-cross tie a load of bales (a plurality of layers of bales) together in a load stack offloaded from the transport vehicle to the field for later pickup and movement or deposit in a bale storage area. Preferably, the bale transport vehicle is a mid-size or big bale stack wagon having a Mil-Stak® bale loader previously installed or concurrently being installed. The invention enables the lifting, tilting, rotating, and depositing of one mid-size or big bale or a plurality of mid-size or big bales from a rearward-hinged and forward-hinged bale receiving table of the bale transport vehicle onto a rear-hinged stack load table for consolation into a load with other layers of bales for transport from the field. The invention allows selective 90 degree rotation of a layer of bales relative to a preceding layer of bales of the bale stack on the rear-hinged stack load table.

Disclosed are new members of a class of non-lipid small molecule inhibitors which interfere with the interaction between phosphoinositol-3,4,5-triphosphate (PIP3) and pleckstrin homology (PH) domains. These molecules target a broad range of PIP3-dependent signaling events in vitro and exert significant anti-tumor activity in vivo, with improved activity and selectivity toward particular PH domains. The small molecule inhibitors of the invention can be used alone or together with tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) or other cancer medicament to treat cancer. Small molecule inhibitors of the invention act synergistically in combination with TRAIL and with other Akt inhibitors in treating cancer. Pharmaceutical compositions and methods for treating cancer are provided.

Non-naturally occurring peptides are provided that act as a Src SH2 domain antagonist of cardiotonic steroids. Pharmaceutical compositions comprising the peptides are also provided along with vectors encoding the peptides. Methods of treating a Src-associated disease and reducing Src activity in a cell are further provided and include administering or contacting a cell with an effective amount of the peptide.

The present invention concerns cancer biomarkers. In particular, the invention concerns HGF as a biomarker for patient selection and patient prognosis in cancer, as well as methods of therapeutic treatment, articles of manufacture and methods for making them, diagnostic kits, methods of detection and methods of advertising related thereto.

The present invention relates to in vitro methods of assessing the susceptibility or responsiveness of a subject to the treatment with an epidermal growth factor receptor (EGFR) inhibitor/antagonist, wherein the subject has been diagnosed or suspected of suffering from inflammation-associated. These methods comprise determining the level of expression of EGFR in myeloid cells in a sample from the subject, wherein an expression of EGFR in the myeloid cells is indicative of the subject being susceptible to the treatment with an EGFR inhibitor/antagonist. The invention also relates to EGFR inhibitors/antagonists for use in the treatment or amelioration of inflammation-associated cancer. The invention furthermore provides in vitro methods of prognosing the survival time, progression-free survival time or disease course of a subject that has been diagnosed or suspected of suffering from from inflammation-associated cancer. In addition thereto, the invention relates to in vitro diagnostic methods of assessing the proneness of a subject to develop inflammation-associated cancer in which the expression of EGFR is determined in myeloid cells from the subject.

New Liverpool signing Adam Lallana believes England's World Cup failure will make him mentally tougher.

Playing Agony feels like penance for all your past gaming sins.

Square Enix have confirmed that Dragon Quest XI is still in development for the Nintendo Switch but it may be a long way off.

THE continued success of the Allied forces was being acknowledged on the pages of the Daily Echo 100 years ago this week following the latest communications from the various theatres of conflict across Europe.