es As Its Population Ages, Japan Quietly Turns to Immigration By www.migrationpolicy.org Published On :: Mon, 27 Mar 2017 15:35:24 -0400 One of the most rapidly aging societies in the world, Japan is looking to immigration to address increased labor shortages—albeit slowly and largely without public debate. This country profile offers a brief overview of Japan’s migration history and examines the current immigration system, in particular policies and programs to bring in foreign workers, particularly on a temporary basis. Full Article
es As Colombia Emerges from Decades of War, Migration Challenges Mount By www.migrationpolicy.org Published On :: Wed, 12 Apr 2017 10:06:18 -0400 Colombia has more internally displaced persons (IDPs) than any other country in the world, the result of a 52-year civil war. Beyond improving the lives of its 7.3 million IDPs, the country faces a number of crucial migration issues as it works to achieve stability in the wake of an historic peace accord signed in late 2016. This country profile examines historical trends and current and future migration challenges in Colombia. Full Article
es The Philippines: Beyond Labor Migration, Toward Development and (Possibly) Return By www.migrationpolicy.org Published On :: Tue, 11 Jul 2017 15:12:29 -0400 In the Philippines, a pervasive culture of migration has led millions to seek opportunities abroad, particularly since an economic downturn in the 1970s. The government has long embraced exporting labor as official economic policy, but over time, the focus has shifted: first to protecting workers overseas and much more recently to linking migration and development. This article explores the evolution of Filipino migration policy and trends. Full Article
es Afghanistan: Displacement Challenges in a Country on the Move By www.migrationpolicy.org Published On :: Tue, 14 Nov 2017 15:42:47 -0500 Nearly 6 million Afghans fled after violence erupted in the late 1970s, primarily to Iran and Pakistan. While millions returned after the collapse of the Taliban in 2001, the security situation has since deteriorated and the government struggles to meet the needs of vulnerable populations, particularly the internally displaced. This country profile explores Afghanistan’s complex migration and displacement history as well as ongoing challenges. Full Article
es Australia: A Welcoming Destination for Some By www.migrationpolicy.org Published On :: Mon, 12 Feb 2018 12:34:51 -0500 Immigration has driven economic and social development in Australia for more than two centuries. Even as more than one-fourth of the country’s population is foreign born and Australia ranks third among top refugee resettlement countries worldwide, controversy surrounding its hardline treatment of asylum seekers arriving by boat has cast a shadow on its reputation as a welcoming country, as this article explores. Full Article
es Using Fear of the “Other,” Orbán Reshapes Migration Policy in a Hungary Built on Cultural Diversity By www.migrationpolicy.org Published On :: Wed, 09 Oct 2019 11:41:59 -0400 The recent rise in xenophobia in Hungary stands in marked contrast with the country's rich migration history. After 390,000 migrants and asylum seekers arrived in 2015, the government of Viktor Orbán issued policies to significantly limit migration and enacted a law criminalizing humanitarian assistance to migrants. This country profile examines Hungary’s migration past and present, tracing the country’s multicultural heritage to the current wave of anti-immigrant sentiment. Full Article
es Central American Development: Two Decades of Progress and Challenges for the Future By www.migrationpolicy.org Published On :: Wed, 01 Aug 2012 00:00:00 -0400 This report summarizes the economic and social development policy achievements of Central American countries over the past 20 years, as well as the notable obstacles to development that remain. The author identifies long-term challenges and outlines how they can be incorporated into a new development agenda. Full Article
es Migration and Environmental Change: Assessing the Developing European Approach By www.migrationpolicy.org Published On :: Wed, 01 May 2013 00:00:00 -0400 This policy brief explores the relationship between environmental change and migration to Europe in light of recent scholarship challenging the notion that environmental change triggers mass migration. It presents an overview of European policy response in this area and summarizes the spectrum of proposed solutions. Full Article
es A New Era in Refugee Protection and Migration Management? Looking Forward After UN Summit on Refugees and Migrants By www.migrationpolicy.org Published On :: Wed, 28 Sep 2016 12:42:48 -0400 MPI experts discuss the outcomes from the UN Summit on Large Movements of Refugees and Migrants and President Obama's Leaders Summit on the Global Refugee Crisis and what it means for international cooperation on refugee protection and management of migration flows. Full Article
es When Disaster Strikes: Responding to Migrants Caught in Crises By www.migrationpolicy.org Published On :: Wed, 05 Sep 2018 12:08:35 -0400 Migrants displaced by crisis do not benefit from international protection the way that refugees do. This article examines the experiences of labor migrants amid manmade and natural disasters in the Central African Republic, Côte d’Ivoire, Lebanon, Libya, South Africa, and Thailand, as well as stakeholder responses. Research demonstrates the agency and resilience of migrants, who develop flexible solutions in the face of crisis. Full Article
es Indonesia: A Country Grappling with Migrant Protection at Home and Abroad By www.migrationpolicy.org Published On :: Mon, 17 Sep 2018 11:13:07 -0400 Indonesia, which has a long history as a major origin for migrant labor in the Asia-Pacific and beyond, more recently has reluctantly found itself a transit and destination country, including for asylum seekers. Still, policymakers remain focused on protection of its nationals abroad rather than on assuring the status of Chinese and other foreigners in the country. This country profile explores Indonesia's rich migration history. Full Article
es How One Woman Fled Domestic Violence During COVID-19 Pandemic By feeds.socialpsychology.org Published On :: 2020-05-01T06:47:43-04:00 Source: USA Today - Top StoriesWhen the coronavirus initially hit Colorado in early March, many flocked to grocery stores and cleared shelves, preparing to hunker down in their homes. But for Jeara and her four young children, those first days of the pandemic were different: They were settling into a domestic violence shelter after an incident involving her husband days earlier. Full Article
es Nearly 20,000 Teens in Georgia Receive Licenses Without a Road Test By feeds.socialpsychology.org Published On :: 2020-05-06T09:32:10-04:00 Source: CNN - Top StoriesThe sweaty palms on the steering wheel. The repeated exclamations of "Sorry!" The nervous glances from the examiner. They're all part of the dreaded road test, which, for decades, has been a rite of passage for every U.S. teenager to obtain a driver's license. Yet now, due to the coronavirus pandemic, nearly 20,000 teens in Georgia have received licenses without taking an official road test, and Wisconsin will soon follow suit. Full Article
es Color Boost: How Vivid Hues in Your Home Can Lift Your Mood By feeds.socialpsychology.org Published On :: 2020-05-06T09:32:56-04:00 Source: CNN - Top StoriesHow do colors make us feel? This question has guided color specialist Leatrice Eiseman since childhood. As the executive director of the Pantone Color Institute, she leads color trends and forecasts as well as the decision-making behind the company's annual "Color of the Year" (the choice for 2020, Classic Blue, is proving to be an apt calming color for an already anxious year). Full Article
es Calls to European Domestic Violence Hotlines Soar Amid Lockdowns By feeds.socialpsychology.org Published On :: 2020-05-08T02:05:16-04:00 Source: Reuters - World NewsCalls to domestic violence hotlines in Europe are up by as much as three-fifths as alcohol and drug abuse combine with close confinement in coronavirus lockdowns to fuel abuse of the most vulnerable, the World Health Organization has said. Full Article
es Research Uses Artificial Intelligence to Measure Human Emotions By feeds.socialpsychology.org Published On :: 2020-05-08T02:06:17-04:00 Source: Psych CentralNew research presented online at the Cognitive Neuroscience Society annual meeting shows how data-driven computational methods are being used to understand and detect emotions. Investigators believe their findings have the potential to overturn old ideas about the structure of emotions across humanity. Full Article
es After 6 More Months, 31 Million New Domestic Violence Cases, Warns U.N. By feeds.socialpsychology.org Published On :: 2020-05-08T13:31:53-04:00 Source: Yahoo News - Top HeadlinesWomen and children are experiencing unprecedented levels of abuse and violence at home as stress and anxiety continue to mount due to the pandemic. Data from the United Nations reveal a 600% increase in the number women who have experienced partner violence, and projections suggest that if coronavirus lockdowns continue for six more months, there will be an estimated 31 million additional domestic violence cases around the world. Full Article
es French Philosopher Latour Urges No Return to Pre-Lockdown Normal By feeds.socialpsychology.org Published On :: 2020-05-08T13:32:04-04:00 Source: Reuters - World NewsWhat if rather than hurrying back to a pre-lockdown "business as usual" to revive economies hammered by the coronavirus pandemic, countries built a new normal where the fight against climate change was paramount? Full Article
es Reaching a “Fair Deal” on Talent: Emigration, Circulation, and Human Capital in Countries of Origin By www.migrationpolicy.org Published On :: Tue, 02 Feb 2016 10:39:57 -0500 While skilled migration brings widely acknowledged economic benefits for destination countries and migrants, its impact on countries of origin has been the subject of more debate. Despite a growing consensus that origin countries can benefit from emigration and the circulation of skills, enabling this potential to be fully exploited remains a challenge. This report examines initiatives that develop skills and human capital. Full Article
es Emigration Trends and Policies in China: Movement of the Wealthy and Highly Skilled By www.migrationpolicy.org Published On :: Fri, 05 Feb 2016 11:28:44 -0500 This report analyzes the evolution of Chinese emigration from the 1970s, when market-oriented reforms began reducing barriers to movement beyond the country's borders, to the present day. High-skilled and high-value emigration is rising fast. Despite liberalized exit controls, low-skilled labor migration is stagnant as a result of complicated and expensive recruitment procedures. Full Article
es Emigration from Portugal: Old Wine in New Bottles? By www.migrationpolicy.org Published On :: Mon, 08 Feb 2016 17:35:30 -0500 While emigration increased after Portugal plunged into an economically turbulent period amid the global financial crisis, the country's image as the poster child for post-crisis outmigration may be misplaced. This report explores the scale, drivers, and impact of emigration from Portugal since the turn of the millennium, and examines how the country can stem emigration and promote the return of emigrants. Full Article
es Achieving Skill Mobility in the ASEAN Economic Community: Challenges, Opportunities, and Policy Implications By www.migrationpolicy.org Published On :: Thu, 11 Feb 2016 10:15:00 -0500 This report by MPI and the Asian Development Bank lays out a realistic roadmap toward freer movement among skilled professionals within the ASEAN Economic Community (AEC), encouraging cooperation among ASEAN Member States in recognizing foreign qualifications and making government investments in training and educations systems that prepare workers in accordance with common standards. Full Article
es The Germany-Turkey Migration Corridor: Refitting Policies for a Transnational Age By www.migrationpolicy.org Published On :: Thu, 18 Feb 2016 10:53:32 -0500 This Transatlantic Council on Migration report describes how the migration of nationals between Germany and Turkey has developed over recent decades; examines the economic, social, and political factors behind this development; and discusses the policy implications and lessons that can be drawn. Full Article
es Spain: New Emigration Policies Needed for an Emerging Diaspora By www.migrationpolicy.org Published On :: Thu, 10 Mar 2016 09:48:06 -0500 This report discusses Spain’s changing migration patterns in the wake of dramatic economic downturn, paying special attention to the effects of the emigration of young, native-born Spaniards. The report also focuses on policies geared toward engaging the increasing number of Spaniards abroad, finding that much of Spain's policy towards diasporas predates the 1980s. Full Article
es The Long Road Ahead: Status Report on the Implementation of the ASEAN MRAs on Professional Services By www.migrationpolicy.org Published On :: Mon, 13 Mar 2017 17:36:06 -0400 While it has been years since the Association of Southeast Asian Nations signed accords to facilitate the movement of professionals in seven occupations, implementation of these Mutual Recognition Arrangements remains "painfully slow and uneven across countries." This final report in an MPI-Asian Development Bank series explores MRA implementation by sector, and offers recommendations to help achieve the goal of greater skill mobility in Southeast Asia. Full Article
es Regional Enforcement: A Profile of Migrants Deported from the United States and Mexico to the Northern Triangle By www.migrationpolicy.org Published On :: Fri, 28 Aug 2015 12:13:52 -0400 Marking the release of an MPI report, speakers on this webinar present an overview of regional immigration enforcement trends, including U.S. and Mexican apprehensions and deportations of both children and adults, along with a demographic, socioeconomic, and criminal profile of child and adult deportees. Full Article
es Migrants Deported from the United States and Mexico to the Northern Triangle: A Statistical and Socioeconomic Profile By www.migrationpolicy.org Published On :: Mon, 31 Aug 2015 15:46:25 -0400 This report examines the rising numbers of apprehensions and deportations of Central American children and adults by the United States and Mexico, and provides a demographic, socioeconomic, and criminal profile of deportees to El Salvador, Guatemala, and Honduras. The report traces how rising Mexican enforcement is reshaping regional dynamics and perhaps ushering in changes to long-lasting trends in apprehensions. Full Article
es Regional Enforcement: A Profile of Migrants Deported from the United States and Mexico to the Northern Triangle By www.migrationpolicy.org Published On :: Thu, 03 Sep 2015 18:28:05 -0400 This webinar includes an overview of regional immigration enforcement trends, including U.S. and Mexican apprehensions and deportations of Central American migrants, along with a demographic, socioeconomic, and criminal profile of child and adult deportees. Full Article
es Reception and Reintegration Services in Central America: Ending the Deportee Revolving Door By www.migrationpolicy.org Published On :: Fri, 04 Dec 2015 10:23:08 -0500 A webinar releasing a report examining deportations to Central America and reception and reintegration services in El Salvador, Guatemala, and Honduras. Full Article
es Stopping the Revolving Door: Reception and Reintegration Services for Central American Deportees By www.migrationpolicy.org Published On :: Fri, 04 Dec 2015 17:59:04 -0500 For a growing population of migrants deported from Mexico and the United States to Central America, the conditions upon return typically are worse than when they left, setting up a revolving-door cycle of migration, deportation, and remigration. This report provides a detailed profile of reception and reintegration services offered in El Salvador, Guatemala, and Honduras to deported migrants, examining their challenges and opportunities for improvement. Full Article
es Reception and Reintegration Services in Central America: Ending the Deportee Revolving Door By www.migrationpolicy.org Published On :: Fri, 11 Dec 2015 12:52:32 -0500 A webinar releasing a report examining deportations to Central America and reception and reintegration services in El Salvador, Guatemala, and Honduras. Full Article
es Mexican Immigrants in the United States By www.migrationpolicy.org Published On :: Thu, 17 Mar 2016 10:05:23 -0400 Mexican immigration to the United States has slowed in recent years, and since the Great Recession more Mexican immigrants have returned to Mexico than have migrated to the United States. Mexicans, however, remain the largest origin group in the country, accounting for 28 percent of all immigrants. See how Mexican immigrants compare to the overall foreign- and U.S.-born populations on key indicators with this Spotlight article. Full Article
es Inmigrantes Centroamericanos en los Estados Unidos By www.migrationpolicy.org Published On :: Wed, 19 Apr 2017 15:53:25 -0400 La migración centroamericana a los Estados Unidos comenzó en gran números en los años ochenta, impulsada por la inestabilidad política, los desastres naturales y las dificultades económicas. Aproximadamente 3,4 millones de centroamericanos vivieron en los Estados Unidos en 2015, principalmente de El Salvador, Guatemala y Honduras. Dónde viven en los Estados Unidos, su competencia en inglés, su estado legal, las vías de inmigración, y más, están cubiertos en este artículo. Full Article
es La Situación de Cambio Constante entre EE UU y México: Tendencias y Políticas de Migración, Incluyendo Menores No Acompañados By www.migrationpolicy.org Published On :: Wed, 23 Aug 2017 15:25:50 -0400 Una llamada en español que analiza las dinámicas cambiantes y las cuestiones políticas relacionadas con la migración a través de México a los Estados Unidos. Full Article
es La Situación de Cambio Constante entre EE UU y México: Tendencias y Políticas de Migración, Incluyendo Menores No Acompañados By www.migrationpolicy.org Published On :: Fri, 01 Sep 2017 12:31:52 -0400 Durante este seminario, ponentes presentaron hallazgos de un reciente informe que utiliza datos de agencias gubernamentales mexicanas, entrevistas con funcionarios clave y relatos de la sociedad civil para examinar el marco legal para la protección de menores no acompañados y su aplicación, al igual que las brechas entre este marco y su aplicación durante los procesos de detención, interrogación y alojamiento. El presidente de MPI, Andrew Selee, también expuso cómo el cambio en la dinámica política en Estados Unidos puede afectar las cuestiones migratorias con México, así como los efectos en la relación bilateral en medio de tensiones sobre el muro fronterizo, la renegociación del acuerdo del TLCAN y una cifra significativa de repatriaciones de migrantes mexicanos. Full Article
es Vanishing Frontiers: The Forces Driving Mexico and the United States Together By www.migrationpolicy.org Published On :: Thu, 17 May 2018 10:04:04 -0400 Marking the release of MPI President Andrew Selee's book, this discussion explores the emerging trends in migration, economic interdependence, technology innovation, and cultural exchange that are transforming the relationship between the United States and Mexico. Full Article
es Promising Strategies for Reintegration of Migrants Returning to Mexico and Central America By www.migrationpolicy.org Published On :: Mon, 07 Jan 2019 10:55:18 -0500 Authors of a year-long study of reception and reintegration services in Mexico and the Northern Triangle discuss the findings of their fieldwork, including the differing reintegration needs of individual migrant groups, promising reception and reintegration programs, ongoing challenges for origin communities, and policy recommendations to improve reintegration strategies. Full Article
es Despite Trump Invitation to Stop Taking Refugees, Red and Blue States Alike Endorse Resettlement By www.migrationpolicy.org Published On :: Tue, 28 Jan 2020 22:52:44 -0500 Forty-two governors, Republican and Democrat alike, have affirmed their consent for continued refugee resettlement, bypassing an invitation from the Trump administration to stop accepting refugees. These actions, which reportedly surprised the White House, suggest there may be limits to the Trump immigration agenda when it comes to refugees, as this Policy Beat explores. Full Article
es As Lesvos Battles Migration Crisis Fatigue, the Value of Centralized Migration Decision-Making Is Questioned By www.migrationpolicy.org Published On :: Wed, 11 Sep 2019 12:42:46 -0400 As Greece's Aegean islands continue to grapple with migrants arriving on their shores, decisions regarding the needs of newcomers are negotiated in Brussels and Athens, far removed from the situation on the ground. Meanwhile, local communities have had successes in hosting migrants, as this article drawing on observations from the hospitality center and refugee camp on Lesvos explores. Full Article
es Suicide Risk Assessment in Youth and Young Adults With Type 1 Diabetes By care.diabetesjournals.org Published On :: 2020-01-20T12:00:30-08:00 OBJECTIVE To describe sociodemographic and clinical characteristics of youth and young adults with type 1 diabetes who endorsed suicidal ideations as part of routine depression screening and the results of their suicide risk assessments. RESEARCH DESIGN AND METHODS The Patient Health Questionnaire–9 was used to assess depressive symptoms and suicide/death ideation in 550 youth and young adults with type 1 diabetes ages 10–24 years. Only individuals who endorsed suicidal/death ideations (n = 49) completed a standardized suicide risk assessment protocol and safety planning. RESULTS Nine percent of individuals endorsed suicidal/death ideation and of those, 83.4% reported clinically elevated depressive symptoms; 16% made a previous suicide attempt. No youth (n = 39) or young adults (n = 11) disclosed current plans or preparations for suicide, but five who expressed suicidal ideation acknowledged the lethality of insulin for an attempt. Three previously used insulin to attempt suicide. The overwhelming majority of individuals were classified as being low risk for future suicide attempt/completion. None were hospitalized as a part of the suicide risk assessment, and no suicide completions have occurred. CONCLUSIONS The findings of this study provide initial insight into the behaviors and cognitions of youth and young adults with type 1 diabetes who experience suicidal and death ideations. Comprehensive suicide risk assessment and safety planning are feasible during routine type 1 diabetes clinic appointments. Full Article
es Randomized Study to Evaluate the Impact of Telemedicine Care in Patients With Type 1 Diabetes With Multiple Doses of Insulin and Suboptimal HbA1c in Andalusia (Spain): PLATEDIAN Study By care.diabetesjournals.org Published On :: 2020-01-20T12:00:30-08:00 OBJECTIVE To assess the impact of a telemedicine visit using the platform Diabetic compared with a face-to-face visit on clinical outcomes, patients’ health-related quality of life (HRQoL), and physicians’ satisfaction in patients with type 1 diabetes. RESEARCH DESIGN AND METHODS PLATEDIAN (Telemedicine on Metabolic Control in Type 1 Diabetes Mellitus Andalusian Patients) (NCT03332472) was a multicenter, randomized, 6-month follow-up, open-label, parallel-group controlled study performed in patients with type 1 diabetes with suboptimal metabolic control (HbA1c <8% [<64 mmol/mol]), treated with multiple daily injections. A total of 388 patients were assessed for eligibility; 379 of them were randomized 1:1 to three face-to-face visits (control cohort [CC]) (n = 167) or the replacement of an intermediate face-to-face visit by a telemedicine visit using Diabetic (intervention cohort [IC]) (n = 163). The primary efficacy end point was the mean change of HbA1c levels from baseline to month 6. Other efficacy and safety end points were mean blood glucose, glucose variability, episodes of hypoglycemia and hyperglycemia, patient-reported outcomes, and physicians’ satisfaction. RESULTS At month 6, the mean change in HbA1c levels was –0.04 ± 0.5% (–0.5 ± 5.8 mmol/mol) in the CC and 0.01 ± 0.6% (0.1 ± 6.0 mmol/mol) in the IC (P = 0.4941). The number of patients who achieved HbA1c <7% (<53 mmol/mol) was 73 and 78 in the CC and IC, respectively. Significant differences were not found regarding safety end points at 6 months. Changes in HRQoL between the first visit and final visit did not differ between cohorts, and, regarding fear of hypoglycemia (FH-15 score ≥28), statistically significant differences observed at baseline remained unchanged at 6 months (P < 0.05). CONCLUSIONS The use of telemedicine in patients with type 1 diabetes with HbA1c <8% (<64 mmol/mol) provides similar efficacy and safety outcomes as face-to-face visits. Full Article
es Diabetes INSIDE: Improving Population HbA1c Testing and Targets in Primary Care With a Quality Initiative By care.diabetesjournals.org Published On :: 2020-01-20T12:00:30-08:00 OBJECTIVE To improve outcomes of patients with adult type 2 diabetes by decreasing HbA1c undertesting, reducing the proportion of patients with poor glycemic control, and lowering mean HbA1c levels using a quality improvement (QI) program. RESEARCH DESIGN AND METHODS Six years of outpatient electronic health record (EHR) data were analyzed for care gaps before and 2 years after implementing a QI initiative in an urban academic medical center. QI strategies included 1) individual provider and departmental outcome reports, 2) patient outreach programs to address timely follow-up care, 3) a patient awareness campaign to improve understanding of achieving clinical goals, 4) improving EHR data capture to improve population monitoring, and 5) professional education. RESULTS Analysis (January 2010 to May 2018) of 7,798 patients from Tulane Medical Center (mean age 61 years, 57% female, 62% black, 97% insured) with 136,004 visits showed target improvements. A Cox proportional hazards model controlling for age, sex, race, and HbA1c level showed a statistically significant reduction in HbA1c undertesting >6 months (hazard ratio 1.20 ± 0.07). Statistical process control charts showed 15.5% relative improvement in the patient proportion with HbA1c >9% (75 mmol/mol) from 13% to 11% (P < 10–6) following QI interventions and a 2.1% improvement of population mean HbA1c from 7.4% (57 mmol/mol) to 7.2% (55 mmol/mol) (P < 10–6). CONCLUSIONS Multidisciplinary QI teams using EHR data to design interventions for providers and patients produced statistically significant improvements in both care process and clinical outcome goals. Full Article
es Sex Difference in Effects of Low-Dose Aspirin on Prevention of Dementia in Patients With Type 2 Diabetes: A Long-term Follow-up Study of a Randomized Clinical Trial By care.diabetesjournals.org Published On :: 2020-01-20T12:00:30-08:00 OBJECTIVE To evaluate and compare the efficacy of long-term use of low-dose aspirin for the prevention of dementia in men and women. RESEARCH DESIGN AND METHODS This study is a follow-up cohort study of the Japanese Primary Prevention of Atherosclerosis With Aspirin for Diabetes (JPAD) trial, which was a randomized, open-label, standard care–controlled trial examining the effects of low-dose aspirin on cardiovascular events. We followed up 2,536 Japanese patients with type 2 diabetes (T2D) enrolled in the JPAD trial from 2002 to 2017. The primary outcome of this post hoc analysis was the incidence of dementia, which was defined by the prescription of antidementia drugs or admission due to dementia. RESULTS Among the originally enrolled patients, 2,121 (84%) retained their original allocation. During a median follow-up of 11.4 years, 128 patients developed dementia. The overall effect of low-dose aspirin on the prevention of dementia adjusted for age, sex, and other established risk factors was not significant (hazard ratio [HR] 0.82, 95% CI 0.58–1.16). However, a significant reduction was seen in the risk of dementia in women (HR 0.58, 95% CI 0.36–0.95), but not in men (HR 1.27, 95% CI 0.75–2.13) (Pinteraction = 0.03). CONCLUSIONS Long-term use of low-dose aspirin may reduce the risk for dementia in women with T2D. Full Article
es Late Relapse of Diabetes After Bariatric Surgery: Not Rare, but Not a Failure By care.diabetesjournals.org Published On :: 2020-02-20T11:55:29-08:00 OBJECTIVE To characterize the status of cardiometabolic risk factors after late relapse of type 2 diabetes mellitus (T2DM) and to identify factors predicting relapse after initial diabetes remission following bariatric surgery to construct prediction models for clinical practice. RESEARCH DESIGN AND METHODS Outcomes of 736 patients with T2DM who underwent Roux-en-Y gastric bypass (RYGB) or sleeve gastrectomy (SG) at an academic center (2004–2012) and had ≥5 years’ glycemic follow-up were assessed. Of 736 patients, 425 (58%) experienced diabetes remission (HbA1c <6.5% [48 mmol/mol] with patients off medications) in the 1st year after surgery. These 425 patients were followed for a median of 8 years (range 5–14) to characterize late relapse of diabetes. RESULTS In 136 (32%) patients who experienced late relapse, a statistically significant improvement in glycemic control, number of diabetes medications including insulin use, blood pressure, and lipid profile was still observed at long-term. Independent baseline predictors of late relapse were preoperative number of diabetes medications, duration of T2DM before surgery, and SG versus RYGB. Furthermore, patients who relapsed lost less weight during the 1st year after surgery and regained more weight afterward. Prediction models were constructed and externally validated. CONCLUSIONS While late relapse of T2DM is a real phenomenon (one-third of our cohort), it should not be considered a failure, as the trajectory of the disease and its related cardiometabolic risk factors is changed favorably after bariatric surgery. Earlier surgical intervention, RYGB (compared with SG) and more weight loss (less late weight regain) are associated with less diabetes relapse in the long-term. Full Article
es Intellectual Disability in KATP Channel Neonatal Diabetes By care.diabetesjournals.org Published On :: 2020-02-20T11:55:29-08:00 OBJECTIVE Neonatal diabetes has been shown to be associated with high neuropsychiatric morbidity in a genotype-phenotype–dependent manner. However, the specific impact of different mutations on intellectual functioning is still insufficiently characterized. Specifically, only a small number of subjects with developmental delay have been comprehensively assessed, creating a knowledge gap about patients carrying the heaviest burden. RESEARCH DESIGN AND METHODS We assessed the intellectual functioning and mental health of the complete Norwegian population with KATP channel neonatal diabetes. Eight sulfonylurea-treated children (five with the p.V59M genotype [KCNJ11]) were assessed using age-matched control subjects with type 1 diabetes. The investigations included a physical and motor developmental examination, cerebral MRI, psychometrical examination, and questionnaires assessing intellectual capabilities and psychiatric morbidity. RESULTS A strong genotype-phenotype correlation was found, revealing the p.V59M genotype as highly associated with substantial intellectual disability, with no significant correlation with the time of sulfonylurea initiation. Consistent with previous studies, other genotypes were associated with minor cognitive impairment. Cerebral MRI verified normal brain anatomy in all but one child. CONCLUSIONS We here presented a comprehensive assessment of intellectual functioning in the largest cohort of p.V59M subjects to date. The level of intellectual disability revealed not only changes the interpretation of other psychological measures but downplays a strong protective effect of sulfonylurea. Within the scope of this study, we could not find evidence supporting an early treatment start to be beneficial, although a weaker effect cannot be ruled out. Full Article
es Screening for Glucose Perturbations and Risk Factor Management in Dysglycemic Patients With Coronary Artery Disease--A Persistent Challenge in Need of Substantial Improvement: A Report From ESC EORP EUROASPIRE V By care.diabetesjournals.org Published On :: 2020-03-20T11:50:34-07:00 OBJECTIVE Dysglycemia, in this survey defined as impaired glucose tolerance (IGT) or type 2 diabetes, is common in patients with coronary artery disease (CAD) and associated with an unfavorable prognosis. This European survey investigated dysglycemia screening and risk factor management of patients with CAD in relation to standards of European guidelines for cardiovascular subjects. RESEARCH DESIGN AND METHODS The European Society of Cardiology’s European Observational Research Programme (ESC EORP) European Action on Secondary and Primary Prevention by Intervention to Reduce Events (EUROASPIRE) V (2016–2017) included 8,261 CAD patients, aged 18–80 years, from 27 countries. If the glycemic state was unknown, patients underwent an oral glucose tolerance test (OGTT) and measurement of glycated hemoglobin A1c. Lifestyle, risk factors, and pharmacological management were investigated. RESULTS A total of 2,452 patients (29.7%) had known diabetes. OGTT was performed in 4,440 patients with unknown glycemic state, of whom 41.1% were dysglycemic. Without the OGTT, 30% of patients with type 2 diabetes and 70% of those with IGT would not have been detected. The presence of dysglycemia almost doubled from that self-reported to the true proportion after screening. Only approximately one-third of all coronary patients had completely normal glucose metabolism. Of patients with known diabetes, 31% had been advised to attend a diabetes clinic, and only 24% attended. Only 58% of dysglycemic patients were prescribed all cardioprotective drugs, and use of sodium–glucose cotransporter 2 inhibitors (3%) or glucagon-like peptide 1 receptor agonists (1%) was small. CONCLUSIONS Urgent action is required for both screening and management of patients with CAD and dysglycemia, in the expectation of a substantial reduction in risk of further cardiovascular events and in complications of diabetes, as well as longer life expectancy. Full Article
es Glucosamine Use, Inflammation, and Genetic Susceptibility, and Incidence of Type 2 Diabetes: A Prospective Study in UK Biobank By care.diabetesjournals.org Published On :: 2020-03-20T11:50:34-07:00 OBJECTIVE Glucosamine is a widely used supplement typically taken for osteoarthritis and joint pain. Emerging evidence suggests potential links of glucosamine with glucose metabolism, inflammation, and cardiometabolic risk. We prospectively analyzed the association of habitual glucosamine use with risk of type 2 diabetes (T2D) and assessed whether genetic susceptibility and inflammation status might modify the association. RESEARCH DESIGN AND METHODS This study analyzed 404,508 participants from the UK Biobank who were free of diabetes, cancer, or cardiovascular disease at baseline and completed the questionnaire on supplement use. Cox proportional hazards models were used to evaluate the association between habitual use of glucosamine and risk of incident T2D. RESULTS During a median of 8.1 years of follow-up, 7,228 incident cases of T2D were documented. Glucosamine use was associated with a significantly lower risk of T2D (hazard ratio 0.83, 95% CI 0.78–0.89) after adjustment for age, sex, BMI, race, center, Townsend deprivation index, lifestyle factors, history of disease, and other supplement use. This inverse association was more pronounced in participants with a higher blood level of baseline C-reactive protein than in those with a lower level of this inflammation marker (P-interaction = 0.02). A genetic risk score for T2D did not modify this association (P-interaction = 0.99). CONCLUSIONS Our findings indicate that glucosamine use is associated with a lower risk of incident T2D. Full Article
es Targeting CXCR1/2 Does Not Improve Insulin Secretion After Pancreatic Islet Transplantation: A Phase 3, Double-Blind, Randomized, Placebo-Controlled Trial in Type 1 Diabetes By care.diabetesjournals.org Published On :: 2020-03-20T11:50:34-07:00 OBJECTIVE Reparixin is an inhibitor of CXCR1/2 chemokine receptor shown to be an effective anti-inflammatory adjuvant in a pilot clinical trial in allotransplant recipients. RESEARCH DESIGN AND METHODS A phase 3, multicenter, randomized, double-blind, parallel-assignment study (NCT01817959) was conducted in recipients of islet allotransplants randomized (2:1) to reparixin or placebo in addition to immunosuppression. Primary outcome was the area under the curve (AUC) for C-peptide during the mixed-meal tolerance test at day 75 ± 5 after the first and day 365 ± 14 after the last transplant. Secondary end points included insulin independence and standard measures of glycemic control. RESULTS The intention-to-treat analysis did not show a significant difference in C-peptide AUC at both day 75 (27 on reparixin vs. 18 on placebo, P = 0.99) and day 365 (24 on reparixin vs. 15 on placebo, P = 0.71). There was no statistically significant difference between treatment groups at any time point for any secondary variable. Analysis of patient subsets showed a trend for a higher percentage of subjects retaining insulin independence for 1 year after a single islet infusion in patients receiving reparixin as compared with patients receiving placebo (26.7% vs. 0%, P = 0.09) when antithymocyte globulin was used as induction immunosuppression. CONCLUSIONS In this first double-blind randomized trial, islet transplantation data obtained with reparixin do not support a role of CXCR1/2 inhibition in preventing islet inflammation-mediated damage. Full Article
es What math professors and k-12 teachers think of each other By blogs.ams.org Published On :: Mon, 18 Nov 2019 14:00:32 +0000 By Michael Pershan, St. Ann’s School I. What do primary/secondary math educators think of the teaching that happens in colleges? And — the other way around — what do mathematics professors think of primary and secondary math teaching? I’m nearing … Continue reading → Full Article Communication Graduate Education K-12 Education
es The Future of Enrichment: Math Contests or Math Circles? By blogs.ams.org Published On :: Mon, 13 Jan 2020 07:36:00 +0000 by Doug O’Roark Executive Director, Math Circles of Chicago The New York Times recently published an article entitled “The Right Answer? 8,186,699,633,530,061 (An Abacus Makes It Look Almost Easy)”. Its lead photograph features over 100 children seated at desks, facing … Continue reading → Full Article K-12 Education Mathematics Education Research Outreach Student Experiences extra-curricular math circles math contests math festivals