COVID-19 Impacts on the Trucking Industry , released by the American Transportation Research Institute

Most general aviation (GA) airports are minimally staffed and rarely employ environmental specialists, and the National Environmental Policy Act (NEPA) can be overwhelming to work through for those not familiar with the requirements. The TRB Airport Cooperative Research Program's ACRP Research Report 211: Guidance for Using the Interactive Tool for Understanding NEPA at General Aviation Airports , and the accompanying interactive tool that was developed, will help airport staff from GA airports understan...

Although general aviation airports have historically been funded by federal, state, and local entities, the private sector is increasingly playing a larger role. This involvement has ranged on a continuum from service and management contracts to singular projects at airports that involve leasing mechanisms to long-term leases and the whole-scale private development of general aviation airports. In an era of declining resources and increasingly scrutinized public expenditures, private-sector involvement i...

TRB's Transit Cooperative Research Program (TCRP) has issued a request for proposals to develop a comprehensive, evidenced-based guide for bus operator workforce management from pre-employment through retirement. The guide should present both best practices and innovative practices that enhance and sustain public transit and support bus operators who provide fixed-route, flexible-route, and on-demand services. Proposals are due August 11, 2020 at 5:00 PM Eastern.

Introduction of unmanned aircraft systems (UAS) will pose safety, economic, operational, regulatory, community, environmental, and infrastructure challenges to airports. These risks are further complicated by the dynamic nature of UAS technological development. Experiences and lessons learned from recent major aviation system changes demonstrate the critical importance of ensuring that airports have the resources needed to avoid adverse impacts and maximize benefits as early as possible. This pre-publica...

Incompatible land uses can threaten the safe utility of airports and expose people living and working nearby to potentially unacceptable levels of noise or safety risk. At the state level, all 50 states have enacted some form of airport zoning legislation since the 1950s. The majority of states (90 percent) have enacted laws mandating or enabling local governments to adopt, administer, and enforce airport zoning regulations. The TRB Airport Cooperative Research Program's ACRP Research Report 206: Guidebo...

The needs of airports may vary depending on the types of operations typically conducted at the airport, as well as the type of weather common to the airport. The TRB Airport Cooperative Research Program's ACRP Syntheis 105: Airport Surface Weather Observation Options for General Aviation Airports aims to provide the operators of general aviation (GA) airports a comprehensive source of information about airport-based weather observation options so they may make informed decisions to support the specific o...

Please include the full title on your forms and the authors last name first. Finished Literature River Rose and the Magical Christmas (Clarkson, Kelly); River Rose and the Magical Lullaby (Clarkson, Kelly) Moved Literature Fantasy (Genres); Vampire Chronicles, The: The Queen of the Damned (Rice, Anne) Closed Literature (Open for application) None on this update. […]

Just when it seemed like robots couldn't get any cooler, Cornell University researchers have created a soft robot muscle that can regulate its temperature through sweating.

Arterial cardiovascular events are the leading cause of death in patients with JAK2V617F myeloproliferative neoplasms (MPNs). However, their mechanisms are poorly understood. The high prevalence of myocardial infarction without significant coronary stenosis or atherosclerosis in patients with MPNs suggests that vascular function is altered. The consequences of JAK2V617F mutation on vascular reactivity are unknown. We observe here increased responses to vasoconstrictors in arteries from Jak2V617F mice resulting from a disturbed endothelial NO pathway and increased endothelial oxidative stress. This response was reproduced in WT mice by circulating microvesicles isolated from patients carrying JAK2V617F and by erythrocyte-derived microvesicles from transgenic mice. Microvesicles of other cellular origins had no effect. This effect was observed ex vivo on isolated aortas, but also in vivo on femoral arteries. Proteomic analysis of microvesicles derived from JAK2V617F erythrocytes identified increased expression of myeloperoxidase as the likely mechanism accounting for their effect. Myeloperoxidase inhibition in microvesicles derived from JAK2V617F erythrocytes suppressed their effect on oxidative stress. Antioxidants such as simvastatin and N-acetyl cysteine improved arterial dysfunction in Jak2V617F mice. In conclusion, JAK2V617F MPNs are characterized by exacerbated vasoconstrictor responses resulting from increased endothelial oxidative stress caused by circulating erythrocyte-derived microvesicles. Simvastatin appears to be a promising therapeutic strategy in this setting.

Whether mutations in cancer driver genes directly affect cancer immune phenotype and T cell immunity remains a standing question. ARID1A is a core member of the polymorphic BRG/BRM-associated factor chromatin remodeling complex. ARID1A mutations occur in human cancers and drive cancer development. Here, we studied the molecular, cellular, and clinical impact of ARID1A aberrations on cancer immunity. We demonstrated that ARID1A aberrations resulted in limited chromatin accessibility to IFN-responsive genes, impaired IFN gene expression, anemic T cell tumor infiltration, poor tumor immunity, and shortened host survival in many human cancer histologies and in murine cancer models. Impaired IFN signaling was associated with poor immunotherapy response. Mechanistically, ARID1A interacted with EZH2 via its carboxyl terminal and antagonized EZH2-mediated IFN responsiveness. Thus, the interaction between ARID1A and EZH2 defines cancer IFN responsiveness and immune evasion. Our work indicates that cancer epigenetic driver mutations can shape cancer immune phenotype and immunotherapy.

An in-depth understanding of immune escape mechanisms in cancer is likely to lead to innovative advances in immunotherapeutic strategies. However, much remains unknown regarding these mechanisms and how they impact immunotherapy resistance. Using several preclinical tumor models as well as clinical specimens, we identified a mechanism whereby CD8+ T cell activation in response to programmed cell death 1 (PD-1) blockade induced a programmed death ligand 1/NOD-, LRR-, and pyrin domain–containing protein 3 (PD-L1/NLRP3) inflammasome signaling cascade that ultimately led to the recruitment of granulocytic myeloid-derived suppressor cells (PMN-MDSCs) into tumor tissues, thereby dampening the resulting antitumor immune response. The genetic and pharmacologic inhibition of NLRP3 suppressed PMN-MDSC tumor infiltration and significantly augmented the efficacy of anti–PD-1 antibody immunotherapy. This pathway therefore represents a tumor-intrinsic mechanism of adaptive resistance to anti–PD-1 checkpoint inhibitor immunotherapy and is a promising target for future translational research.

BACKGROUND Since December 2019, an outbreak of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged in Wuhan, and is now becoming a global threat. We aimed to delineate and compare the immunological features of severe and moderate COVID-19.METHODS In this retrospective study, the clinical and immunological characteristics of 21 patients (17 male and 4 female) with COVID-19 were analyzed. These patients were classified as severe (11 cases) and moderate (10 cases) according to the guidelines released by the National Health Commission of China.RESULTS The median age of severe and moderate cases was 61.0 and 52.0 years, respectively. Common clinical manifestations included fever, cough, and fatigue. Compared with moderate cases, severe cases more frequently had dyspnea, lymphopenia, and hypoalbuminemia, with higher levels of alanine aminotransferase, lactate dehydrogenase, C-reactive protein, ferritin, and D-dimer as well as markedly higher levels of IL-2R, IL-6, IL-10, and TNF-α. Absolute numbers of T lymphocytes, CD4+ T cells, and CD8+ T cells decreased in nearly all the patients, and were markedly lower in severe cases (294.0, 177.5, and 89.0 × 106/L, respectively) than moderate cases (640.5, 381.5, and 254.0 × 106/L, respectively). The expression of IFN-γ by CD4+ T cells tended to be lower in severe cases (14.1%) than in moderate cases (22.8%).CONCLUSION The SARS-CoV-2 infection may affect primarily T lymphocytes, particularly CD4+ and CD8+ T cells, resulting in a decrease in numbers as well as IFN-γ production by CD4+ T cells. These potential immunological markers may be of importance because of their correlation with disease severity in COVID-19.TRIAL REGISTRATION This is a retrospective observational study without a trial registration number.FUNDING This work is funded by grants from Tongji Hospital for the Pilot Scheme Project, and partly supported by the Chinese National Thirteenth Five Years Project in Science and Technology for Infectious Disease (2017ZX10202201).

Regenerative pain medicine, which seeks to harness the body’s own reparative capacity, is rapidly emerging as a field within pain medicine and orthopedics. It is increasingly appreciated that common analgesic mechanisms for these treatments depend on neuroimmune modulation. In this Review, we discuss recent progress in mechanistic understanding of nociceptive sensitization in chronic pain with a focus on neuroimmune modulation. We also examine the spectrum of regenerative outcomes, including preclinical and clinical outcomes. We further distinguish the analgesic mechanisms of regenerative therapies from those of cellular replacement, creating a conceptual and mechanistic framework to evaluate future research on regenerative medicine.

Facioscapulohumeral muscular dystrophy (FSHD) results from expression of the full-length double homeobox 4 (DUX4-FL) retrogene in skeletal muscle. However, even in cases of severe FSHD the presence of DUX4 is barely detectable. In this issue of the JCI, Bosnakovski et al. used an inducible, muscle-specific human DUX4 to reproduce the low-level, sporadic DUX4 expression of human FSHD muscle as well the myopathology seen in human FSHD disease. Notably, dysregulated fibroadipogenic progenitors accumulated in affected muscles, thus providing a mechanism for the replacement of muscle by fibrosis and fat.

Are accountants destined to be the anthropologists of the cyber era? Gillian Tett appears to suspect such. Continue reading →

Chuck Todd tells Andrea Mitchell that Hillary Clinton will win the African-American and Hispanic vote in spite of the intellectual appeal of Bernie Sanders to liberal white voters Continue reading →

Chris Hedges speaks the truth about American politics while Robert Reich shows that he is still an establishment Democrat after all, like Bernie Sanders. Continue reading →

we know how politics works in the United States. Whoever—whatever political party gets into government is going to merge with the bureaucracy pretty damn fast. It will be in a position where it has some levers in its hand. And so, as a result, corporate lobbyists will move in to help control those levers. So it doesn’t make much difference in the end. What does make a difference is political accountability, a general deterrence set to stop political organizations behaving in a corrupt manner. Continue reading →

Now that’s a name I haven’t heard in a long time…

The post Heads up: TEMUERA MORRISON will be THE MANDALORIAN’s Boba Fett appeared first on The Beat.

PSA Peugeot Citroën and IBM today announced a partnership to help various industries within the Internet of Things economy to analyze data to deliver new services from connected vehicles.

IBM and Nutanix today announced a multi-year initiative to bring new workloads to hyperconverged deployments.

IBM and Telestream announced today at IBC 2017 a game-changing solution for high-speed capture and production of live, broadcast quality video from remote locations for faster production turnaround. Telestream Vantage powered by Aspera combines Aspera’s FASPStream high-speed streaming technology and Telestream Lightspeed Live Capture media processing platform to enable production teams to work on live video feeds from remote locations in near real time.

IBM today announced the first clients to tap into its IBM Q™ early-access commercial quantum computing systems to explore practical applications important to business and science. They include: JPMorgan Chase, Daimler AG, Samsung, JSR Corporation, Barclays, Hitachi Metals, Honda, Nagase, Keio University, Oak Ridge National Lab, Oxford University and University of Melbourne.

IBM today shipped the first of its breakthrough IBM Z mainframe from its factory in Poughkeepsie, NY. The IBM Z is the world's most powerful and secure transaction system capable of running more than 12 billion encrypted transactions per day - equivalent to 400 Cyber Mondays.

Today, Allianz and IBM concluded an agreement in Munich regarding support for the operation of Allianz's data centers. IBM will be acting as the global provider of IT operation services for Allianz in effect from April 1, 2014, supporting the transformation of the company's global IT infrastructure.

IBM Watson Health and Tiatros Inc, a digital health company, today announced that the Tiatros-enabled post-traumatic stress disorder programs achieved up to 73% completion rate for veterans who begin the PTSD sessions. The Tiatros Post Traumatic Growth for Veterans is a Tiatros psychotherapy program designed as a secure social network to support veterans suffering from post-traumatic stress disorder. The program connects veterans with their peers online, in a platform that is designed to reduce barriers to access and deliver evidence-based cognitive behavioral therapy that is personalized to each individual, with help from Watson APIs.

IBM announced today that Mediacorp, Singapore’s largest media company, has completed a digital transformation of its broadcast operations using IBM Hybrid Cloud solutions as part of the move to a new office building in Singapore’s one-north district. The Mediacorp broadcast operations team can now more quickly, seamlessly and efficiently deliver video and audio content to consumers across different platforms, including new mobile apps, interactive televisions and other connected devices.

As companies look to embrace Artificial Intelligence (AI) to gain competitive advantage and increase productivity, IBM today unveiled a new data science and machine learning platform and an elite consulting team to help them accelerate their AI journeys.

IBM anunció hoy que un 40% de los principales bancos e instituciones financieras en el país cuentan con protección de fraudes en línea que se sustentan en la solución Trusteer de IBM, con la cual la seguridad de los clientes está respaldada al realizar transacciones electrónicas.

IBM anunció hoy la primera plataforma de servicios basada en IBM Watson y construida en IBM Cloud para aumentar la inteligencia humana y ayudar a mejorar las operaciones de los proveedores de servicios a través de tecnologías cognitivas.

El Grupo BBVA acaba de formalizar un acuerdo con IBM para que esta firma asuma la operación y transformación de la infraestructura tecnológica actual de BBVA y el procesamiento de datos en América Latina y EE.UU., actualmente gestionada por su filial ATA en México.

IBM anunció una iniciativa pionera en la industria para construir sistemas de computación cuántica universal comercialmente disponibles. Los sistemas y servicios cuánticos “IBM Q” se entregarán mediante la plataforma IBM Cloud.

Científicos de IBM (NYSE: IBM) desarrollaron un nuevo enfoque para simular moléculas en una computadora cuántica, lo que podrá un día ayudar a revolucionar la química y la ciencia de los materiales. Los científicos utilizaron con éxito un procesador cuántico de siete bits para abordar el problema de la estructura molecular del hidruro de berilio (BeH2), la molécula más grande simulada en una computadora cuántica hasta la fecha. Los resultados muestran una ruta de exploración para los sistemas cuánticos a corto plazo para realzar nuestra comprensión de las reacciones químicas complejas que podrían conducir a aplicaciones prácticas.

Los inventores de IBM (NYSE: IBM) recibieron un récord de 9,043 patentes en 2017, lo que marca el 25º año consecutivo de liderazgo en Estados Unidos y supera el hito de 100.000 patentes. Las nuevas patentes se otorgaron a un grupo diverso de más de 8,500 investigadores, ingenieros, científicos y diseñadores de IBM en 47 países, Latinoamérica incluida, región que contribuyó con cerca de 100 patentes al registro de 2017.

IBM anunció dos nuevas soluciones de almacenamiento empresarial completamente basadas en tecnología flash, las cuales ofrecen avanzada eficiencia e incremento en desempeño, así como una sobresaliente confiabilidad para ayudar a reducir costos, y acelerar infraestructuras y aplicaciones con manejo intensivo de datos.

Un nuevo estudio de IBM pone en entredicho algunas de las creencias que se tienen acerca de la generación del Milenio. Según el estudio elaborado por la Compañía, los nacidos en la Era Digital no son “ni perezosos, ni egoístas, ni superficiales” y aconseja a las empresas detenerse a conocer qué motiva a cada empleado para poder así maximizar sus cualidades únicas.

IBM fue reconocido como líder de software de almacenamiento en el Cuadrante Mágico de Gartner para Software de Recuperación y Respaldo en Centro de Datos1. En sus “cuadrantes mágicos”, los analistas de Gartner evalúan tecnología y soluciones con la “capacidad de ejecución” y una “visión completa”.

Como parte de las celebraciones del 90 aniversario de IBM en México, la empresa realizó por primera vez en el país, los días 7 y 8 de octubre en el Campus Tecnológico de IBM en Guadalajara, el festival de hackeo para desarrolladores cognitivos: HackaPalooza.

IBM y organizaciones aliadas lanzaron la iniciativa global 'Call for Code', el esfuerzo más grande y ambicioso para reunir a desarrolladores del sector académico y empresarial, para resolver uno de los problemas más acuciantes de la sociedad de nuestro tiempo: prevenir, responder y recuperarse de desastres naturales.

Seguridad, aplicaciones estratégicas y analítica móvil son clave para que las organizaciones inteligentes mejoren sus resultados

Apple e IBM lanzaron hoy la primera ola de soluciones IBM MobileFirst para iOS, una nueva clase de apps creadas para los negocios y con soporte para servicios de Cloud, que llevan las capacidades Big Data y Analítica de IBM a los usuarios de iPhone e iPad en las empresas.