Many children experience the death of a parent during childhood. The long-term consequences of this life event, including school performance, and the importance of the psychosocial circumstances of the home have not been well elucidated in previous studies.

Both maternal and paternal deaths during childhood were associated with lower grades and school failure. Many of the associations (and especially for death due to external causes) were associated with socioeconomic disadvantage and psychosocial problems in the family. (Read the full article)

There is wide variation in pediatric subspecialty supply in the United States. The impact of this variation in supply on utilization and child and family disease burden is not known.

Among children with special health care needs, living in a county with lower subspecialty supply was associated with lower perceived need for subspecialty care, lower subspecialty utilization, and no meaningful differences in examined measures of child and family disease burden. (Read the full article)

Research in the aftermath of large-scale terrorist attacks shows that exposed children experience numerous negative psychological sequelae, including increased emotional difficulties, posttraumatic stress, and significant attack-related life disruptions.

Most research on terrorism-exposed youth examines large-scale terrorism. Limited work examines reactions to terrorism of the scope of the marathon attack, and the extraordinary manhunt and shelter-in-place warning was an unprecedented experience. Understanding adjustment after these events is critical. (Read the full article)

Vaccinating youth is among the nation’s highest health care priorities. Despite proven health benefits, human papillomavirus vaccination rates remain low.

This is the first known study to test whether vaccination of high-risk adolescents is related to their or their parents’ previous knowledge levels. In the results presented, neither parental nor adolescent knowledge is related to subsequent adolescent vaccination. (Read the full article)

Uptake of rotavirus vaccines has increased steadily since introduction. Despite their demonstrated impact, rotavirus vaccine coverage is lower than for other vaccines recommended in infancy and disease continues to occur.

We observed higher rotavirus detection rates among patients from provider locations with lower rotavirus vaccine coverage; providers who do not offer rotavirus vaccine to age-eligible children may create pockets of susceptible children that serve as reservoirs of ongoing disease transmission. (Read the full article)

Diabetic ketoacidosis (DKA) is a common and serious first manifestation of diabetes mellitus in children. During initial evaluation, the venous blood pH is frequently used to make the diagnosis and classify the severity of DKA.

This study demonstrates that the serum bicarbonate concentration is a simple and accurate predictor of DKA and its severity and can be used in lieu of venous pH measurement, especially in resource-poor settings where access to pH measurement is limited. (Read the full article)

Research demonstrates that substance use, beliefs about use, and influence from family and friends can put young adults at risk for DUI and RWDD. Much of this research is cross-sectional and focuses on risk factors identified in young adults.

This longitudinal study emphasizes the importance of prevention efforts in early adolescence at multiple levels to reduce high school DUI/RWDD, because marijuana beliefs and marijuana use by peers and family members during middle school were associated with high school DUI/RWDD. (Read the full article)

It was far too easy to accidentally start an app subscription if you own an iPhone with Touch ID. Apple just solved the problem with a pop-up.

Multidrug resistant strains belonging to the Enterobacter cloacae complex (ECC) group, and especially those belonging to clusters C-III, C-IV and C-VIII, have increasingly emerged as a leading cause of healthcare-associated infections, with colistin used as one of the last line of treatment. However, colistin-resistant ECC strains have emerged. The aim of this study was to prove that MgrB, the negative regulator of PhoP/PhoQ two-component regulatory system, is involved in colistin resistance in ECC of cluster C-VIII, formerly referred to as Enterobacter hormaechei subsp. steigerwaltii. An in vitro mutant (Eh22-Mut) was selected from a clinical isolate of Eh22. The sequencing analysis of its mgrB gene showed the presence of one nucleotide deletion leading to the formation of a truncated protein of six instead of 47 amino acids. Wild-type mgrB gene from Eh22, as well as that of a clinical strain of Klebsiella pneumoniae used as controls, were cloned and the corresponding recombinant plasmids were used for complementation assays. Results showed a fully restored susceptibility to colistin, and confirmed for the first time that mgrB gene expression plays a key role in acquired resistance to colistin in ECC strains.

Chromosomal and plasmid-borne AmpC cephalosporinases are a major resistance mechanism to β-lactams in Enterobacteriaceae and Pseudomonas aeruginosa. The new β-lactamase inhibitor avibactam effectively inhibits class C enzymes and can fully restore ceftazidime susceptibility. The conserved amino acid residue Asn³⁴⁶ of AmpC cephalosporinases directly interacts with the avibactam sulfonate. Disruption of this interaction caused by the N³⁴⁶Y amino acid substitution in Citrobacter freundii AmpC was previously shown to confer resistance to the ceftazidime-avibactam combination (CAZ-AVI). The aim of this study was to phenotypically and biochemically characterize the consequences of the N³⁴⁶Y substitution in various AmpC backgrounds. Introduction of N³⁴⁶Y into Enterobacter cloacae AmpC (AmpC_cloacae), plasmid-mediated DHA-1, and P. aeruginosa PDC-5, led to 270-, 12,000-, and 79-fold decreases in the inhibitory efficacy (k₂/K_i) of avibactam, respectively. The kinetic parameters of AmpC_cloacaeand DHA-1 for ceftazidime hydrolysis were moderately affected by the substitution. Accordingly, AmpC_cloacaeand DHA-1 harboring N³⁴⁶Y conferred CAZ-AVI resistance (MIC of ceftazidime of 16 µg/ml in the presence of 4 µg/ml of avibactam). In contrast, production of PDC-5 N³⁴⁶Y was associated with a lower MIC (4 µg/ml) since this β-lactamase retained a higher inactivation efficacy by avibactam in comparison to AmpC_cloacaeN³⁴⁶Y. For FOX-3, the I³⁴⁶Y substitution did not reduce the inactivation efficacy of avibactam and the substitution was highly deleterious for β-lactam hydrolysis, including ceftazidime, preventing CAZ-AVI resistance. Since AmpC_cloacaeand DHA-1 display substantial sequence diversity, our results suggest that loss of hydrogen interaction between Asn³⁴⁶ and avibactam could be a common mechanism of acquisition of CAZ-AVI resistance.

HubSpot CRM does a great job delivering a high-quality CRM for small business customers. With a fast-growing portfolio of new platforms and features, HubSpot might also evolve into an end-to-end martech ecosystem for many customers.

Jessica L. Barrington-Trimis
May 1, 2020; 145:e20191652-e20191652
ARTICLES

While we wait for Apple Arcade to launch for iOS devices, Google is preparing its own app/game subscription service for Android called Play Pass.

Comixology Unlimited lets you dive into more than 20,000 digital comics for just $5.99 per month. Make the most of your subscription by starting with these 10 titles.

THE SPFL were tonight criticised for giving Scotland’s clubs hope that league reconstruction was a possibility in their controversial end-of-season resolution.

PARTICK Thistle today branded the SPFL a "disgrace" for failing to inform them that league reconstruction had been abandoned and revealed they are "deeply angered" by Ladbrokes Premiership clubs scuppering the plans.

Former Hearts chairman Leslie Deans has urged the club to take legal action against the SPFL as well as those who voted to end the season early, effectively relegating the Jambos.

Vinod K. Bhutani
Jan 1, 1999; 103:6-14
ARTICLES

The cable is capable of delivering 72Tbps of bandwidth to South America and will be reserved for Gmail, YouTube, Search, and Google Cloud data transmission.

038 - Romanian club handed deferred sanction

042 - Decisions made after Beşiktaş JK and Fenerbahçe SK appeal initial decision

053 - UEFA Club Financial Control Body investigatory chamber takes measures

An atheist's curiosity leads him to hear about God.

Secretary of State Jeffrey Bullock has suspended the Delaware medical license and controlled substance privileges of Gregory Villabona, in light of allegations of unprofessional conduct related to the prescription and distribution of opioid medications.

Delaware’s Public Advocate today issued a letter to the White House asking the Trump administration to deny a request for emergency bailouts for aging coal and nuclear power plants owned by a large regional energy supplier.

Secretary of State Jeffrey Bullock has suspended the Delaware medical license and controlled substance prescribing privileges of Ifeanyi Udezulu for repeatedly failing to adhere to state regulations for the safe prescribing of opioid medications.

Post the NTO implementation, the dynamics have tilted in favour of the broadcasters.

Alejandro Dominguez, president of the South American football body, CONMEBOL said that he was surprised by FIFA's decision to allow five substitutes when the sport resumes after coronavirus pandemic.

BJP leader Pankaja Munde has said that she was not upset over not being nominated by the party for the upcoming Legislative Council election.

NEW CASTLE (July 24, 2018) – Following a 14-month review of Delaware’s opioid use disorder treatment system, a research team from the Johns Hopkins Bloomberg School of Public Health and the Bloomberg American Health Initiative today recommended four major strategies to achieve the state’s goal of a system of care that is accessible, evidence-based, individualized, […]

NEW CASTLE (Oct. 2, 2018) – The Department of Health and Social Services’ Division of Substance Abuse and Mental Health (DSAMH) last week launched its online referral network – Delaware Treatment and Referral Network (DTRN) – allowing Delaware health care providers seeking substance use disorder treatment or mental health services for their patients to make […]

WILMINGTON (Oct. 3, 2018) – As a way to engage more Delawareans suffering from substance use disorder in treatment, while also meeting their accompanying needs for housing, employment, education and other wraparound services, the Department of Health and Social Services (DHSS) today launched its START Initiative with a press conference and a daylong forum for […]

NEW CASTLE (March 26, 2019) – As a new support for individuals and families impacted by the effects of mental health and substance use disorders, the Division of Substance Abuse and Mental Health (DSAMH) and its partners have opened the Bridge Clinic near New Castle to provide screening and referrals to treatment, as well as […]

DOVER (May 9, 2019) – On May 8, 2019, the medical license and controlled substance registrations of Nihar B. Gala, MD, were permanently revoked by the Delaware Board of Medical Licensure and Discipline. The revocation was a result of allegations of unprofessional conduct related to the prescription of opioids to a patient at high risk […]

DOVER (Aug. 1, 2019) – On July 30, 2019, the medical license and controlled substance registration of Damon Cary, MD, were suspended temporarily by the Delaware Board of Medical Licensure and Discipline. The suspension was the result of a request made by the Delaware Attorney General’s Office following investigations into the prescribing and treatment practices […]

DHSS Secretary Dr. Kara Odom Walker says, “In the midst of the opioid crisis we are facing in Delaware and across the country, (these facilities) are another resource we can use to better serve our Medicaid clients in need of treatment for substance use disorder.” NEW CASTLE (Aug. 5, 2019) – The Department of Health […]

The partnership between Reliance Retail Whatsapp - inked on Wednesda -and could mean more competition for the likes of BigBasket and Grofers and others like Amazon and Flipkart looking to get a share of the food and groceries pie.

The union said it was unfair to direct BSNL alone to buy local 4G equipment, largely untested and of substandard quality, from inexperienced companies while letting private operators buy from global players.

Anticipating a huge surge in demand, it came out with a new software for online receipt and settlement of claims and deployed the software on March 29.

As of February 29, 2020; equities outperformed gold over the trailing 10-, 15- and 20-years, delivering annualised 10.39%, 13.89% and 12.0% respectively compared with 8.16%, 12.59% and 11.49% respectively delivered by gold.

Authorities have cracked down on Seoul’s night life after reports of a young clubber infecting people with Covid-19 in South Korea’s capital. The nation now fears a new wave of infections after easing social distancing rules.
Read Full Article at RT.com

The letter has urged, mainly for wage subsidy to large employers, on the lines of the Netherlands and Australia .

The e-way bill generated on or before March 24 and expiring during the March 20-April 15 period would now be valid till May 31.

Kolkata Kight Riders co-owner and Bollywood superstar Shah Rukh Khan on Saturday said he is hopeful of the COVID-19 pandemic subsiding and a deferred IPL going ahead with all the necessary health precautions in place.

The Trump administration responded with a plan to authorise as much as $12 billion in aid

Efforts of all the countries to stop the damage to the Ozone layer seem to be paying off as the damage to the Ozone layer above Antarctica has recovered.

The English Premier League season could be cancelled if teams did not agree to play the remaining 92 fixtures in neutral venues amid the COVID-19 pandemic, League Managers Association (LMA) chief executive Richard Bevan said Wednesday.

Teams will be allowed up to five substitutions per match, instead of the usual three, as a temporary measure to help cope with potential fixture congestion in the aftermath of the novel coronavirus outbreak, FIFA said Friday.

In terms of wireless broadband subscribers, Jio is on top with 376.57 million users, followed by Airtel with 142.34 million subscribers and Vodafone Idea with 117.93 users.