Legislation to provide funds to poor and rural school districts will likely die in the legislative session this year.

Former San Jose Sharks goalie James Reimer was placed on NHL waivers today by the Anaheim Ducks.

Campaigns to get rid of police in schools catch a wave of momentum in some communities, but activists still face deep resistance from educators nationally.

Notre Dame sophomore guard Hannah Hidalgo is on the Women’s Basketball Coaches Association (WBCA) Wade Watch List. She's among 15 players being watched as a potential winner of the oldest, most prestigious player of the year award. She was a Region I finalist for…

We recently demonstrated that transient attenuation of Toll-like receptor 4 (TLR4) in dorsal root ganglion (DRG) neurons, can both prevent and reverse pain associated with chemotherapy-induced peripheral neuropathy (CIPN), a severe side effect of cancer chemotherapy, for which treatment options are limited. Given the reduced efficacy of opioid analgesics to treat neuropathic, compared with inflammatory pain, the cross talk between nociceptor TLR4 and mu-opioid receptors (MORs), and that MOR and TLR4 agonists induce hyperalgesic priming (priming), which also occurs in CIPN, we determined, using male rats, whether (1) antisense knockdown of nociceptor MOR attenuates CIPN, (2) and attenuates the priming associated with CIPN, and (3) CIPN also produces opioid-induced hyperalgesia (OIH). We found that intrathecal MOR antisense prevents and reverses hyperalgesia induced by oxaliplatin and paclitaxel, two common clinical chemotherapy agents. Oxaliplatin-induced priming was also markedly attenuated by MOR antisense. Additionally, intradermal morphine, at a dose that does not affect nociceptive threshold in controls, exacerbates mechanical hyperalgesia (OIH) in rats with CIPN, suggesting the presence of OIH. This OIH associated with CIPN is inhibited by interventions that reverse Type II priming [the combination of an inhibitor of Src and mitogen-activated protein kinase (MAPK)], an MOR antagonist, as well as a TLR4 antagonist. Our findings support a role of nociceptor MOR in oxaliplatin-induced pain and priming. We propose that priming and OIH are central to the symptom burden in CIPN, contributing to its chronicity and the limited efficacy of opioid analgesics to treat neuropathic pain.

Building on previous efforts, the Kingdom of Morocco will offer technical assistance to the Republic of Guinea through a South-South Cooperation Tripartite Agreement signed today at FAO headquarters by FAO [...]

FAO has recently released Fish: Know it, cook it, eat it, a genre-defying cookbook that infuses international recipes with insights into the global fish trade; blends scientific facts and cultural history; melds nutritional information [...]

So what exactly factors into how we end up being right or left-handed? In this one-minute video, Ask Smithsonian host Eric Schulze breaks down the science of being a southpaw.

The octopus places the arm in its mouth, treating it like food.

Our host, Eric Schulze, explains how science is tackling this puzzling question from space.

New DNA analysis adds to growing research indicating the famous Pacific island did not collapse from overuse of resources before the arrival of Europeans

Researchers still don't know what the open-mouth facial expression means or whether it's akin to smiling in humans—but several animals make a similar face during play

For the second year in a row, Grazer bested the massive male named Chunk to take the crown in the single elimination online popularity contest at Katmai National Park and Preserve

The Shipwreck Treasure Museum in Cornwall, England, is selling its collection, which includes items connected to nearly 150 shipwrecks

Steve Lazarides' personal collection of prints, original works, handwritten press releases and burner phones sold at auction for around $1.4 million

Mary, a 54-year-old Asian elephant at the Berlin Zoo, is the “queen of showering,” but her companion Anchali seems to have figured out how to exploit that habit to play pranks

The 1951 artwork, "La Grande Dame (The Cat Woman)," stands over six feet tall and features paintings of "hybrid creatures and lush dreamscapes"

From Setsubun in Japan to Fèt Gede in Haiti, these festivals relish in the macabre

Dominic April fell in love with forging after his career in the military came to an end in 2015. Now operating a blacksmith studio near Quebec City, he hopes to help other veterans dealing with PTSD find creativity and purpose.

By raising her son to be curious about the natural world, this mother helped shape the trajectory of the National Museum of Natural History

Families of Norton Elementary School won’t be seeing their kids return anytime soon. Repairs are going to take longer than expected and students are expected to be back in the school by the start of the next school year.

With P.E.I's only full-time blood oncologist leaving at the end of November, Health P.E.I. was planning to transfer his patients to Dr. Philip Champion. Now Champion says he intends to retire in the spring.

Three weeks after the death of another beluga whale at Marineland, the Ontario government is speaking publicly about its ongoing investigation of the park, saying water troubles are under control after a recent investment.

A jury has found a Naramata, B.C., man guilty on two counts of second-degree murder in the deaths of two brothers. Wade Cudmore, 35, was one of two men accused in the May 2021 drug deal killings of Kamloops, B.C., brothers Erick and Carlo Fryer.

Not only does Mary the Asian elephant prefer to shower herself, but she's really good at it. So good, in fact, that her dexterous bath-time ritual is the subject of a new study about animal tool use. 

M G Bennett & Associates designs machine to help test U.K. 's oldest major suspension bridge

Monarch250 to bring affordable cancer treatment option to more cancer centers

Twins from Maine Grow Up Tinkering, Become Prime Defense Contractors

On 12 May, 130 people in Atlanta, Georgia, participate in a hike at to benefit trafficked and exploited women across our world.

Paul and Vivienne, volunteers from the UK, recently visited a centre for asylum seekers in one of Sweden’s large cities and share about their experiences.

After listening to the Gospel a self-proclaimed atheist encouraged Christians to go tell others this Good News.

Kids' Games in Pakistan challenge children to take a step of action in their lives and to consider others above themselves.

After a trip to repair war damaged churches in the east, construction workers share their experience in order to inspire others to go.

A local Chinese mother teaches Cantonese to three Pakistani mothers before they all watch the film 'Magdalena: Released from Shame' together.

The experiences of Costa Rican OMer Yamileth Morales have given her God's heart for people isolated by HIV and AIDS.

Countries that score highest on an international measure of student achievement tend to have these three things in common when it comes to professional development for teachers.

Special education advocates argue the push for liability protection is a veiled attempt to seek waivers from the Individuals with Disabilities Education Act, the nation's primary special education law.

Ensuring and tracking your financial progress, no matter what path your life takes, is easier than navigating careers or relationships. But good habits have to be set up early, says Laura du Preez.

Alexandra Persiko, interim director of global partnerships in Penn State Global, received a Fulbright IEA award in 2024, notable not only because she was one of 14 university administrators across the U.S. to garner such an award this year, but also because of her unique connection to the program through her mother, Alice Ann, who completed a Fulbright student program in Germany in 1957.

Special education advocates argue the push for liability protection is a veiled attempt to seek waivers from the Individuals with Disabilities Education Act, the nation's primary special education law.

This week, SA Money Report drills down into the 'game changing' oil find off the coast of Namibia, and how this factors into the recent court battles over seismic blasting on the SA West Coast.

This week, SA Money Report journeys in the heart of war, and comes back with a tale about Naspers' exposure in Russia, and its ties to VKontakte, whose 38-year-old CEO Vladimir Kiriyenko was sanctioned by the US.

Pason lost his family when he fled Myanmar. By playing football with OM team members, he finds friendship and hope.

The Department of Education has denied 99 percent of applications for public service loan forgiveness under a temporary expanded program funded by Congress, a report finds.

Leaders from OM Latin America discuss the challenges and opportunities of ministry in the region during their annual meetings in September.

Christa planned to travel around Europe for fun, but OM mobilised her to instead share Jesus with people in Europe, Turkey and India.

Android 15 was released globally in August and since then, original equipment manufacturers (OEMs) such as OnePlus, Oppo and Realme have introduced their iterations of the new operating system (OS) for their smartphones and other devices. The update is said to bring support for true adaptive refresh rate (ARR) which leverages discrete VSync steps to adapt to the frame rate of the on-screen content without changing the current display mode.

Google has announced the silent rollout of its Quick Share app for ARM-powered devices running Windows 11 or later. Users can now easily send and receive photos, documents, and more data between nearby Android devices and ARM-based Windows PCs including the new Snapdragon X Elite laptops.