Grup Yorum's Ibrahim Gokcek died two days after suspending his “death fast."

Turkey supports the embattled Tripoli government against rebel forces from the east led by Gen. Khalifa Hifter.

Prague Daily Monitor

The details are still unclear but early Saturday evening a car crash involving multiple vehicles was reported on the D10 close to Březina near Mladá Boleslav. Firefighters reported 27 cars involved. Micheala Fliegerova, the spokesperson for the police reported over 30 participants were involved in the crash.

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A combination of three drugs suppressed the coronavirus within seven days when used on patients in Hong Kong, nearly twice as fast as a single medicine did, in a result seen as a leading hope in the fight against the pandemic, a study has found.The findings of the research, led by University of Hong Kong academics and published in The Lancet on Saturday, could signal progress in the search for a standard form of therapy for Sars-CoV-2, the virus that causes the Covid-19 disease.It discovered…

North Korea is close to completing a missile storage facility near Pyongyang Sunan International Airport. The facility is "almost certainly related to North Korea's expanding ballistic missile program," the Beyond Parallel website at the Center for Strategic and International Studies reported Tuesda...

Colorado Springs is the beachhead. But it's always been clear In-N-Out Burger planned to feed its fanatical following along the Front Range by building more than just the one restaurant coming to that city in 2020.

Five Frontier Corps (FC) soldiers and one officer were martyred after their vehicle was targeted with an improvised explosive device (IED) near the Pakistan-Iran border, the military's media wing said on Friday.

In a tweet, the Inter-Services Public Relations (ISPR) said the security personnel were returning from patrolling in Buleda — 14 kilometres from the Pakistan-Iran border — to "check possible routes used by terrorists in the mountainous terrain of Makran".

As they were returning, their vehicle was targeted with a remote controlled IED, it added.

The martyred were identified as Major Nadeem, Naik Jamshed, Lance Naik Khizar Hayat, Lance Naik Taimor, Sepoy Nadeem and Sepoy Sajid.

In December 2019, one FC soldier was martyred and two others were injured in an exchange of fire with terrorists after they raided an FC checkpost in North Waziristan.

"Terrorists raided an FC post in North Waziristan district near the Pak-Afghan border," an ISPR statement had said.

"During the exchange of fire, two terrorists were killed," it had added.

Tata Value Homes Limited (TVHL), a 100% subsidiary of Tata Housing Development Company Limited, today strengthened its presence in South India by developing Spanish themed residential township at Sriperumbudur, near Chennai. The company plans to Invest around Rs 300 crore in setting up this township. Inspired by Spanish living, Santorini is designed by architects F+A. The township is spread across lush greenery at Sriperumbudur, one of the fastest growing corridors in Chennai. Speaking on the project Brotin Banerjee, MD & CEO, Tata Housing Development Co. Ltd., said, with rapid urbanisation and influx of global lifestyle trends more and more affluent home buyers are looking for homes to reflect the financial […]

AN3444 Driving LEDs with Constant Current and Sequential Linear LED Drivers

A glass bead has been brought down to its coldest possible quantum state using a new method that may one day allow us to observe an object in two places at once

An extinct variety of date palm tree has been grown from ancient seeds preserved in the Judean desert for 2000 years, the oldest seeds ever germinated

A study of what will happen to glaciers in the Alps under various climate scenarios suggests they will almost completely disappear if we keep pumping out carbon dioxide

Earth’s continents may have been shifting for 2.5 billion years, according to a study of ancient rocks that finds plate tectonics evolved far earlier than we thought

This week, watch as Westworld breaks out of the park and into LA, discover why vision is so important and listen as a drama exploits the weirdness of sound

Nearly 90 cases of the novel coronavirus have been recorded among employees of Polyus Krasnoyarsk, a unit of Russia's largest gold producer Polyus , the regional branch of Russia's consumer health watchdog said on Saturday.

Title: Nearly 100 Sickened by E.Coli-Tainted Romaine Lettuce
Category: Health News
Created: 4/27/2018 12:00:00 AM
Last Editorial Review: 4/30/2018 12:00:00 AM

Title: Nearby Lightning Shut Down a Woman's Brain Implant
Category: Health News
Created: 5/1/2018 12:00:00 AM
Last Editorial Review: 5/1/2018 12:00:00 AM

Title: Even Living Near a Farm Might Help Prevent Allergies
Category: Health News
Created: 5/1/2018 12:00:00 AM
Last Editorial Review: 5/1/2018 12:00:00 AM

Title: Nearly 700 at LA Universities Remain Under Measles Quarantine
Category: Health News
Created: 4/29/2019 12:00:00 AM
Last Editorial Review: 4/29/2019 12:00:00 AM

Title: Nearly 700,000 Infant Rocking Sleepers Recalled Due to Infant Deaths
Category: Health News
Created: 4/29/2019 12:00:00 AM
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Title: Newly Discovered Illness May Cause Nearly 1 in 5 Dementias, Experts Say
Category: Health News
Created: 4/30/2019 12:00:00 AM
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Title: As Finals Draw Near, College Kids' Diets Worsen
Category: Health News
Created: 5/3/2019 12:00:00 AM
Last Editorial Review: 5/3/2019 12:00:00 AM

Title: In COVID Crisis, Nearly Half of People in Some U.S. States Are Going Hungry
Category: Health News
Created: 4/28/2020 12:00:00 AM
Last Editorial Review: 4/28/2020 12:00:00 AM

Title: Antibodies Found in Nearly All People Infected by New Coronavirus: Study
Category: Health News
Created: 5/8/2020 12:00:00 AM
Last Editorial Review: 5/8/2020 12:00:00 AM

Title: U.S. Jobless Rate at Nearly 15 Percent as Coronavirus Cases Top 1.2 Million
Category: Health News
Created: 5/8/2020 12:00:00 AM
Last Editorial Review: 5/8/2020 12:00:00 AM

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Category: Health News
Created: 4/16/2020 12:00:00 AM
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Title: Pot Use Among U.S. Seniors Nearly Doubled in 3 Years
Category: Health News
Created: 2/24/2020 12:00:00 AM
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ABSTRACT

Staphylococcus aureus can colonize the human host and cause a variety of superficial and invasive infections. The success of S. aureus as a pathogen derives from its ability to modulate its virulence through the release, sensing of and response to cyclic signaling peptides. Here we provide, for the first time, evidence that S. aureus processes and secretes small linear peptides through a specialized pathway that converts a lipoprotein leader into an extracellular peptide signal. We have identified and confirmed the machinery for each step and demonstrate that the putative membrane metalloprotease Eep and the EcsAB transporter are required to complete the processing and secretion of the peptides. In addition, we have identified several linear peptides, including the interspecies signaling molecule staph-cAM373, that are dependent on this processing and secretion pathway. These findings are particularly important because multiple Gram-positive bacteria rely on small linear peptides to control bacterial gene expression and virulence.

IMPORTANCE Here, we provide evidence indicating that S. aureus secretes small linear peptides into the environment via a novel processing and secretion pathway. The discovery of a specialized pathway for the production of small linear peptides and the identification of these peptides leads to several important questions regarding their role in S. aureus biology, most interestingly, their potential to act as signaling molecules. The observations in this study provide a foundation for further in-depth studies into the biological activity of small linear peptides in S. aureus.

This season’s flu vaccine was 45% effective overall and 55% effective among children and teens, the Centers for Disease Control and Prevention reported in February.

The entry/fusion complex (EFC) consists of 11 conserved proteins embedded in the membrane envelope of mature poxvirus particles. Poxviruses also encode proteins that localize in cell membranes and negatively regulate superinfection and syncytium formation. The vaccinia virus (VACV) A56/K2 fusion regulatory complex associates with the G9/A16 EFC subcomplex, but functional support for the importance of this interaction was lacking. Here, we describe serially passaging VACV in nonpermissive cells expressing A56/K2 as an unbiased approach to isolate and analyze escape mutants. Viruses forming large plaques in A56/K2 cells increased in successive rounds of infection, indicating the occurrence and enrichment of adaptive mutations. Sequencing of genomes of passaged and cloned viruses revealed mutations near the N terminus of the G9 open reading frame but none in A16 or other genes. The most frequent mutation was His to Tyr at amino acid 44; additional escape mutants had a His-to-Arg mutation at amino acid 44 or a duplication of amino acids 26 to 39. An adaptive Tyr-to-Cys substitution at amino acid 42 was discovered using error-prone PCR to generate additional mutations. Myristoylation of G9 was unaffected by the near-N-terminal mutations. The roles of the G9 mutations in enhancing plaque size were validated by homologous recombination. The mutants exhibited enhanced entry and spread in A56/K2 cells and induced syncytia at neutral pH in HeLa cells despite the expression of A56/K2. The data suggest that the mutations perturb the interaction of G9 with A56/K2, although some association was still detected in detergent-treated infected cell lysates.

IMPORTANCE The entry of enveloped viruses is achieved by the fusion of viral and cellular membranes, a critical step in infection that determines host range and provides targets for vaccines and therapeutics. Poxviruses encode an exceptionally large number of proteins comprising the entry/fusion complex (EFC), which enables infection of diverse cells. Vaccinia virus (VACV), the prototype member of the poxvirus family, also encodes the fusion regulatory proteins A56 and K2, which are displayed on the plasma membrane and may be beneficial by preventing reinfection and cell-cell fusion. Previous studies showed that A56/K2 interacts with the G9/A16 EFC subcomplex in detergent-treated cell extracts. Functional evidence for the importance of this interaction was obtained by serially passaging wild-type VACV in cells that are nonpermissive because of A56/K2 expression. VACV mutants with amino acid substitutions or duplications near the N terminus of G9 were enriched because of their ability to overcome the block to entry imposed by A56/K2.

Actuation remains a significant challenge in soft robotics. Actuation by light has important advantages: Objects can be actuated from a distance, distinct frequencies can be used to actuate and control distinct modes with minimal interference, and significant power can be transmitted over long distances through corrosion-free, lightweight fiber optic cables....

Imants G. Priede, Rhoderick W. Burgass, Manolis Mandalakis, Apostolos Spyros, Petros Gikas, Finlay Burns, and Jim Drewery

Whereas upper ocean pelagic sharks are negatively buoyant and must swim continuously to generate lift from their fins, deep-sea sharks float or swim slowly buoyed up by large volumes of low-density oils in their livers. Investigation of the Pressure, Volume, Temperature (PVT) relationships for liver oils of 10 species of deep-sea Chondrichthyes shows that the density difference between oil and seawater, remains almost constant with pressure down to full ocean depth (11 km, 1100 bar); theoretically providing buoyancy far beyond the maximum depth of occurrence (3700 m) of sharks. However, , does change significantly with temperature and we show that the combined effects of pressure and temperature can decrease buoyancy of oil by up to 10% between the surface and 3500 m depth across interfaces between warm southern and cold polar waters in the Rockall Trough in the NE Atlantic. This increases drag more than 10 fold compared with neutral buoyancy during horizontal slow swimming (0.1 m s^–1) but the effect becomes negligible at high speeds. Chondrichthyes generally experience positive buoyancy change during ascent and negative buoyancy change during descent but contrary effects can occur at interfaces between waters of different densities. During normal vertical migrations buoyancy changes are small, increasing slow-speed drag by no more than 2–3 fold. Equations and tables of density, pressure and temperature are provided for squalene and liver oils of Chimaeriformes (Harriotta raleighana, Chimaera monstrosa, Chimaera monstrosa), Squaliformes (Centrophorus squamosus, Deania calcea, Centroscymnus coelolepis, Centroscyllium fabricii, Etmopterus spinax) and Carcharhiniformes (Apristurus laurussonii, Galeus murinus).