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Although CEACAM1 (CC1) glycoprotein resides at the interface of immune liver injury and metabolic homeostasis, its role in orthotopic liver transplantation (OLT) remains elusive. We aimed to determine whether/how CEACAM1 signaling may affect hepatic ischemia-reperfusion injury (IRI) and OLT outcomes. In the mouse, donor liver CC1 null mutation augmented IRI-OLT (CC1-KO→WT) by enhancing ROS expression and HMGB1 translocation during cold storage, data supported by in vitro studies where hepatic flush from CC1-deficient livers enhanced macrophage activation in bone marrow–derived macrophage cultures. Although hepatic CC1 deficiency augmented cold stress–triggered ASK1/p-p38 upregulation, adjunctive ASK1 inhibition alleviated IRI and improved OLT survival by suppressing p-p38 upregulation, ROS induction, and HMGB1 translocation (CC1-KO→WT), whereas ASK1 silencing (siRNA) promoted cytoprotection in cold-stressed and damage-prone CC1-deficient hepatocyte cultures. Consistent with mouse data, CEACAM1 expression in 60 human donor liver biopsies correlated negatively with activation of the ASK1/p-p38 axis, whereas low CC1 levels associated with increased ROS and HMGB1 translocation, enhanced innate and adaptive immune responses, and inferior early OLT function. Notably, reduced donor liver CEACAM1 expression was identified as one of the independent predictors for early allograft dysfunction (EAD) in human OLT patients. Thus, as a checkpoint regulator of IR stress and sterile inflammation, CEACAM1 may be considered as a denominator of donor hepatic tissue quality, and a target for therapeutic modulation in OLT recipients.

Organ shortage continues to limit the lives of patients who require liver transplantation. While extending criteria for liver organs provides a needed resource, tissue damage from prolonged ischemic injury can result in early allograft dysfunction and consequent rejection. In this issue of the JCI, Nakamura et al. used a mouse transplantation model with prolonged ex vivo cold storage to explore liver graft protection. The authors found that liver grafts with absent carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) exhibited increased ischemia-reperfusion injury inflammation and decreased function in wild-type recipients. The authors went on to correlate CEACAM1 levels with postreperfusion damage in human liver transplant recipients. Notably, this study identified a potential biomarker for liver transplant donor graft quality.

IBM today announced the first clients to tap into its IBM Q™ early-access commercial quantum computing systems to explore practical applications important to business and science. They include: JPMorgan Chase, Daimler AG, Samsung, JSR Corporation, Barclays, Hitachi Metals, Honda, Nagase, Keio University, Oak Ridge National Lab, Oxford University and University of Melbourne.

IBM announced today that Southern Connecticut State University (SCSU) has integrated IBM Watson Analytics to help create new services and programs based on data-driven insights to improve students’ academic achievement and development.

IBM today announced that Mammoth Resorts, the leading four-season mountain resort operator in California, is using Watson Customer Engagement solutions on the IBM Cloud to create customized offers that are helping to drive record numbers of visitors to the resort every year.

IBM y la Universidad Autónoma de Baja California (UABC) firman Convenio de Colaboración que incluye conceptos de Iniciativa Académica, Reclutamiento, Investigación, Responsabilidad Social y Proyectos Especiales. Formación de profesionales en las nuevas necesidades de las organizaciones: expertos en cómputo en la nube, analistas de big data, desarrolladores de soluciones móviles y de redes sociales aplicadas a negocios

Emmy Nominee Leslye Headland to write, produce, and serve as showrunner for new untitled Star Wars series for Disney+.

The team at NSKN names (now Board and Dice) sent me a review copy of Teotihuacan and I’ve had the opportunity to play several times in the months since, across all player counts, including solo against the Teotibot.

Scholars tell us that Teotihuacan was, in its prime, the largest city in the Americas as well as the sixth largest city in the world. It’s only fitting that a prominent board game designer should make it the focal point of a compelling strategy game. Daniele Tascini is that designer, and in Teotihuacan, players take on the role of noble families working to build the great city and its Pyramid of the Sun while accruing wealth and glory.

Odysseas Stamoglou is the artist behind the illustrations and tile carvings in this game. A casual glance from a player like myself (who is not steeped in deep knowledge of Mesoamerican art but has visited the Teotihuacan ruins) observes that the illustrations are reminiscent of the decorations found on structures and items from the famed city. With a bit of research I was able to track down further information on the genesis of and inspiration for the artwork, as explained by Odysseas in a BoardGameGeek.com (BGG) thread:

“All the symbols, masks and murals you see in the game are original Teotihuacano art, with some minor adjustments. The temple icons as well as the various patterns you see are not just random decorations. For example, the red pyramid, associated with the pyramid of the Sun has the fire god as its symbol. The red patterns and decorations are symbols associated with the fire god (like triangles, pointed or romboid shapes, etc). So I went out of my way to make sure each visual element is thematic and as true to the theme as possible. The great pyramid symbol and the dice icons are invented, following the style of Teotihuacan with goggle eyes and headdress for the Pyramid and Maya signs for the dice. I used the mural of the Great Goddess as inspiration for the pyramid symbol.”

Clearly, Odysseas has put a lot of time and effort into his work here and it reinforces the game’s theme extremely well. The theme and the artwork are woven together beautifully. It might have been nice to include custom dice that feature thematic Mesoamerican etchings in place of ordinary pips, but that can drive up the retail price of the game, so it may have already been discussed and dismissed by the design team as too costly. I would also like to see obsidian incorporated into the theme somehow (perhaps in a future expansion?) as that was prominent in Teotihuacan art.

Components for the game include cardboard and wooden tokens, a large main board, 4 sets of dice, and beautifully made tiles (construction material feels and looks similar to dominos) used for building the pyramid. I really love the color palette used on the main and action boards. Player aids would be nice and such an obvious plus that it’s hard to understand why they were overlooked. The good news is that there has been a collaborative effort on BGG to create effective player aids; we downloaded the latest version from beonyourway (shown below; https://boardgamegeek.com/filepage/177055/yet-another-teotihuacan-player-aid) and found them to be very useful.

Getting into the gameplay, Teotihuacan is predominantly a worker placement game (with set collection aspects) that features dice deployed as workers utilizing a rondel. Players begin the game with 3 worker dice each and take turns moving a worker die they control 1-3 spaces around the main board, from one action board to another, completing the desired action(s) on the action board their worker lands on and earning any associated victory points.

Most actions also allow the player to increase the numeric value of the worker die by 1 and when the die reaches 6 in value, the worker “ascends”, allowing the player to choose from a selection of valuable bonuses (including the acquisition of a 4^th worker die) and resetting the die back to 1 in value. The actions represented on the various action boards include earning resources (cocoa, stone, wood, gold), constructing the pyramid, decorating the pyramid, building houses, worshipping to advance on temples and earn discovery tiles, and securing technology.

Extra actions or bonuses may be granted to a player when they have more than one die on an action board at the time they complete the action on that board – this is usually a result of moving a die to an action board where the player previously moved a die but some discovery tile bonuses allow players to move more than one worker die at a time, which can also lead to the accumulation of multiple dice belonging to one player on an action board. It’s not exclusively take, take, take in Teotihuacan. Players must give up resources in order to complete most actions. Additionally, they must pay resources – specifically cocoa - at the end of each phase or “eclipse” of the game (payment is proportionally to the number of worker dice they control and the numeric value of those dice) as well as whenever they wish to take an action where other players currently have worker dice positioned (payment is proportional to the number of other players who have worker dice already on that action board).

Almost every game has gone down the same for me– I find creative ways to pull out far ahead of the other players in the beginning, but I usually struggle with building an engine and eventually their engines take off and they overcome me. I couldn’t even pull off a win against the Teotibot on the easiest level. I finally had a win last week by focusing heavily on the construction action board, as three of the technologies gave bonuses for that action.

There are many ways to score points in Teotihuacan and it opens up a lot of avenues for creatively driving point accrual. The many options also allow for replay experiences that feel like a different game each time. Of course, a multitude of choices can also lead to analysis paralysis and Teotihuacan can suffer from this, dragging the playing time out typically anywhere from 90 to 120 minutes on average in our house.

Strategy tip: players need to be flexible and adapt tactics each game, taking  into consideration the action board arrangement and the available technologies on the alchemy action board.

Teotihuacan is the only game in my collection with a Mesoamerican theme, one of the few incorporating a rondel, and as an added plus, it includes solo mode.  It has so much to offer including a well-researched and implemented theme, a consistent intellectual challenge across all player counts, and quality components. All of these features suggest it would be a great addition to any game library, but it’s the ever-changing gameplay created by the variable action board placement and technologies that really compelled me to give Teotihuacan a permanent home in my game collection.

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Publisher: NSKN Games (now Board and Dice)
Players: 1-4
Actual Playing Time (vs the guideline on the box): 90-120 minutes
Game type: Worker Placement, Rondel, Set Collection

Rating:

Jenni’s rating scale:
OUI: I would play this game again; this game is ok. I probably would not buy this game myself but I would play it with those who own it and if someone gave it to me I would keep it.
OUI OUI: I would play this game again; this game is good. I would buy this game.
OUI OUI OUI: I LOVE THIS GAME. I MUST HAVE THIS GAME.
NON: I would not play this game again. I would return this game or give it away if it was given to me

Studio Universal na znovuotevření kin nečeká. Premiéru animovaného hitu Trollové: Světové turné pustilo na placených digitálních kanálech. Strategie se vyplatila a hollywoodský gigant zvažuje, že by kinům v budoucnu odepřel jejich exkluzivní právo promítat filmy měsíce před uvedením na jiných platformách.

Well, in just a few short days I am off to Japan on what I think is a very well-deserved vacation! The dogs will be on vacation, too, on their first ever trip to a boarding facility. I put a lot of care into choosing a place for them and I am optimistic that everything will work out well in my absence. Nervous, but optimistic. It will be really good for all of us, I think, since I have never boarded them and need to lighten up and it will be a good "out in the world" experience for the browns. Cutting the cord... I will report back on how everyone does.

Last week at Doga Maizy was such a pill that this week I put in an untested rookie. Probert was up to the challenge and made a LOVELY Doga companion. He taught a wonderful class and he just might be my new Doga co-teacher.

My boyfriend brought over this poster for Probert this weekend and hung it above his crate. Probert came in from playing outside to see it for the first time, walked straight into his crate and stood there staring at it. I think he likes it!

In this episode Michelle from Iriss interviews Dr Donald Macaskill, Chief Executive of Scottish Care.

Donald worked for many years in the health and social care sectors across the United Kingdom specialising in learning disability and older people's work. A particular professional focus has been issues related to bereavement, palliative care and individual rights.

For thirteen years he ran his own equality and human rights consultancy focusing on adult protection, risk and personalisation. From 2012-2015 he managed Scottish Care's self-directed support project, People as Partners, then worked as Scottish Care's Joint National Workforce Lead. From 1st April 2016 he became the CEO of Scottish Care, the representative body for care providers in the independent sector.

We hear about the people, projects, books, music and much more that inspire him.

Freshly Squeezed aims to 'squeeze' information and inspiration from key influencers in social services in Scotland.

Transcript of episode

Music Credit: Make your dream a reality by Scott Holmes

The benefits of open access (OA) are undeniable and increasingly evident across all academic disciplines and scientific research: making academic publications1 freely and openly accessible and reusable provides broad visibility for authors, a better return on investment for funders, and greater access to knowledge for other researchers and the general public. And yet, despite OA’s obvious … Read More "Why Sharing Academic Publications Under “No Derivatives” Licenses is Misguided"

The post Why Sharing Academic Publications Under “No Derivatives” Licenses is Misguided appeared first on Creative Commons.

Current job opportunities/vacancies at CELCIS as well as jobs with other organisations and agencies working in residential child care.

UNStudio has completed renovations of the Hanwha headquarters in Seoul — all without disrupting the building’s normal business operations. The impressive feat was achieved thanks to efficient and low-impact construction methods that the international design firm dubs “remodeling in place.” In addition to renovated interior spaces and a redesigned landscape, the Hanwha headquarters is now home to a completely new, energy-generating facade with integrated solar panels to express the company’s identity as an ambitious global leader in the solar panel industry. [...]

By Isaac Cabe  Published: May 07th, 2020 

In light of the ongoing COVID-19 pandemic, Princeton is evaluating scenarios for campus operations next academic year. While no decisions have been made yet, the Academic Year 2021 Coordinating Committee is preparing for a number of options based on federal and state health guidelines.

Princeton faculty members Rubén Gallo, M. Zahid Hasan, Amaney Jamal, Ruby Lee, Margaret Martonosi, Tom Muir, Eve Ostriker, Alexander Smits, Leeat Yariv, James Stone and Muhammad Qasim Zaman have been named members of the American Academy of Arts and Sciences. Visiting faculty member Alondra Nelson also was elected to the academy.

Princeton professors Anne Case, Jennifer Rexford, Suzanne Staggs and Elke Weber have been named members of the National Academy of Sciences in recognition of their distinguished and continuing achievements in original research.

Princeton will decide in early July whether the undergraduate teaching program will be online or residential in the fall term. The University is exploring ways to safely and responsibly reopen Princeton’s laboratories, libraries and other facilities when state law permits. 

Hotels, casinos virtually empty as China market still restricted

Destin Vacation Just me and Mom JuneJuly 2010Day 1Got up at 0410 and drove down using our GPS. Ate at Shoney's for breakfast before leaving. We got to Destin around 1400. We felt so good that we went grocery shopping. We stopped by our beach for

Mexico Vacation March 2014Day 1 March 8thFlight was good. We got chocolates at the North Carolina on our layover there then on to Cancun. We were transferred to Akumal Beach Resort in Akumal where our room was on the 3rd floor of Building 6. Awe

“Those people shot him to kill him. It’s a miracle that my son is alive,” Carmen Cruz said of the Feb. 6 incident in which her son, 26-year-old Erick Diaz-Cruz, was wounded in a confrontation with Immigration and Customs Enforcement agents in Gravesend.

Success Academy Charter Schools, which teaches 18,000 students across 45 schools in the city, will move to online learning starting Mar. 19, though officials didn’t specify how long the shutdown will last.

Amid a public health emergency, it's unconscionable for California to allow dozens of state-owned homes to stay empty.

Ralph Lawler discusses what it's like to see the NBA season suspended, a promising Clippers season put on hold, and the world change while on vacation.

It may be tempting to book precious time off even with the world as unsettled as it is. But this year, your trip may be more financially protected.

Your credit card company can help when goods and services are not received. Be careful though.