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DIGITAL-TO-ANALOG CONVERTER AND HIGH-VOLTAGE TOLERANCE CIRCUIT

A digital-to-analog converter (DAC) and a high-voltage tolerance circuit are provided. The DAC includes a high-voltage tolerance circuit. The high-voltage tolerance circuit is configured to generate a reference voltage, and select the reference voltage or a first power-source voltage to control the node voltage of each branch of an operational amplifier circuit of the high-voltage tolerance circuit according the logical signal level of an input signal.




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ADAPTIVE DIGITAL QUANTIZATION NOISE CANCELLATION FILTERS FOR MASH ADCS

For continuous-time multi-stage noise shaping analog-to-digital converters (CT MASH ADCs), quantization noise cancellation often requires accurate estimation of transfer functions, e.g., a noise transfer function of the front end modulator and a signal transfer function of the back end modulator. To provide quantization noise cancellation, digital quantization noise cancellation filters adaptively tracks transfer function variations due to integrator gain errors, flash-to-DAC timing errors, as well as the inter-stage gain and timing errors. Tracking the transfer functions is performed through the direct cross-correlation between the injected maximum length linear feedback shift registers (LFSR) sequence and modulator outputs and then corrects these non-ideal effects by accurately modeling the transfer functions with programmable finite impulse response (PFIR) filters.




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Composition for enhancing the production of crystal agglomerates from a precipitation liquor

The present invention relates to compositions and methods to increase the output of a high quality product from the precipitation liquor crystallization process exemplified through the aluminum hydroxide recovery processes such as the Bayer process. The invention is a method of increasing the size of precipitates from a liquor. The invention in one embodiment relates to the use of a crystal growth modifier compositions added to the precipitation process to increase the particle size distribution of the precipitated alumina trihydrate.




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Production of low sodium salt with balanced mineral content

A process is provided for preparing a salt product with reduced sodium content including the step of providing a concentrated brine, which is typically seawater, to which has been added potassium chloride. The mixture is transferred to a crystallizer unit where at least a portion of the mix is transferred to the crystallizer through a washing column. Liquid is evaporated from the crystallizer such that crystals form, crystals are passed from the crystallizer through said washing column to a separating unit such that in the passing through the washing column the crystals are rinsed with the brine portion being transferred as a counter current through the column. The inventive process is characterized by recycling of the brine from which the salt crystallizes, thus all main ingredients of the mixed input brine reach a steady equilibrium concentration in the mother liquor in the crystallizer. These will then precipitate as crystals, as more of the respective substances gets added to the mother liquor through inflow of mixed input brine. None of the liquor is purged out of the system as in conventional salt crystallizers. All the components in the feed are substantially contained in the product from the crystallizer either as crystalline material or soluble ingredients.




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RESONATOR AND RESONANCE DEVICE

A resonator is provided that suppresses frequency variations with etching without decreasing the strength of vibration arms. The resonator includes a base portion, a first vibration portion extending from the base portion in a first direction and having a first width, and a second vibration portion extending from the base portion in the first direction with a first gap between the first and second vibration portions and having the first width. The first and second vibration portions perform out-of-plane bending vibration with opposite phases at a predetermined frequency. The predetermined frequency varies in accordance with the first width and the first gap. The ratio of the first gap to the first width is within a range that causes an absolute value of rates of variations in the predetermined frequency with respect to variations in the first width and in the first gap to be not more than about 100 ppm.




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RESONANCE DEVICE

A resonance device is provided with a reduced size and also suppresses the occurrence of deformation and breakage during operation. The resonance device includes a lower substrate, an upper substrate that defines a vibration space between the lower substrate and the upper substrate, a protruding portion that is formed on an inner surface of the lower or upper substrates. Moreover, a resonator is disposed in the vibration space and includes a base portion and vibration arms that extend in parallel to one another from the base portion along the inner surface of the lower substrate or the inner surface of the upper substrate and that vibrate in a vertical direction toward the inner surface of the lower substrate or the inner surface of the upper substrate.




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MUSIC PERFORMANCE SYSTEM AND METHOD THEREOF

A method for processing a music performance, the method comprising the steps of: receiving a first media signal from a media source; analysing the first media signal to extract any media signal characteristics; creating a reference media signal by suppressing at-least a predominant sound source of the first media signal; reproducing the reference media signal while receiving a users media signal from an input device to generate a second media signal; analysing the second media signal to extract any media signal characteristics; processing the characteristics of the second media signal in isolation or in combination with the characteristics of the first media signal; and generating feedback for the music performance based upon the processed media signals.




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DRUMSTICK GRIP AND PERFORMANCE ENHANCEMENT

The specification discloses a novel drumstick configuration with an enhanced grip and performance characteristics. Included in the drumstick are a plurality of preferably continuous circumferential longitudinally spaced-apart grooves disposed in an outer surface of an elongate body portion. The grooves each contain a grip-enhancing material which has an upper surface disposed slightly above the outer surface of the body portion to enhance the grip and general performance characteristics of the drumstick.




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Latency enhanced note recognition method in gaming

The present invention relates to the field of audio recognition, in particular to computer implemented note recognition methods in a gaming application. Furthermore, the present invention relates to improving latency of such audio recognition methods. One of the embodiments of the invention described herein is a method for note recognition of an audio source. The method includes: dividing an audio input into a plurality of frames, each frame having a pre-determined length, conducting a frequency analysis of at least a set of the plurality of frames, based on the frequency analysis, determining if a frame is a transient frame with a frequency change between the beginning and end of the frame, comparing the frequency analysis of each said transient frame to the frequency analysis of an immediately preceding frame and, based on said comparison, determining at least one probable pitch present at the end of each transient frame, and for each transient frame, outputting pitch data indicative of the probable pitch present at the end of the transient frame.




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Device for enhancing a corner structure

In an embodiment, an interchangeable corner hanger to ornament framing protruding corner structures is provided. The interchangeable corner hanger includes a horizontal portion and a vertical portion. The horizontal portion is designed to rest on an exposed edge of a corner structure, and the vertical portion is designed to hang over the corner of the corner structure and rest against a wall upon which the trim is attached. The vertical portion has a length sufficient to stabilize the corner hanger without the use of other adhesives or attachments. In an embodiment, the vertical portion is configured to allow one or more interlocking elements to be suspended from the vertical portion. For example, the vertical portion may include an interlocking pattern configured to accept a complimentary interlocking pattern on an interlocking element. Further interlocking elements may be attached to the interlocking element.




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Truss and column structures incorporating natural round timbers and natural branched round timbers

Trusses comprising natural round timbers as top and bottom cords are provided. Also provided are truss and column assemblies comprising natural branched round timber columns connected to a truss.




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One-piece dovetail veneer tie and wall anchoring system with in-cavity thermal breaks

A dovetail anchoring system for cavity walls is disclosed and includes a sheetmetal dovetail anchor and one-piece sheetmetal dovetail veneer tie. The anchoring system is used in conjunction with building structures that have a masonry outer wythe anchored to a poured masonry inner wythe. A thermally-isolating coating is optionally applied to the high-strength veneer tie, which is interconnected with the wall anchor. The thermally-isolating coating is selected from a distinct grouping of materials, that are applied using a specific variety of methods, in one or more layers and cured and cross-linked to provide high-strength adhesion. The thermally-coated veneer ties provide an in-cavity thermal break that severs the thermal threads running throughout the cavity wall structure, reducing the U- and K-values of the anchoring system by thermally-isolating the metal components.




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Thermally coated wall anchor and anchoring systems with in-cavity thermal breaks for cavity walls

Thermally-isolating wall anchors and reinforcement devices and anchoring systems employing the same are disclosed for use in masonry cavity walls. A thermally-isolating coating is applied to the wall anchor, which is interconnected with a wire formative veneer tie. The thermally-isolating coating is selected from a distinct grouping of materials, that are applied using a specific variety of methods, in one or more layers and cured and cross-linked to provide high-strength adhesion. The thermally-coated wall anchors provide an in-cavity thermal break that severs the thermal threads running throughout the cavity wall structure, reducing the U- and K-values of the anchoring system by thermally-isolating the metal components.




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SYSTEM AND METHOD FOR DELIVERING AN ANTI-ADHESIVE SUBSTANCE TO A BODY CAVITY

A system and method for creating a medicated atmosphere in an organ, or body cavity is disclosed. The system includes a flexible nebulization catheter that can be manipulated during use, a device for the introduction of the nebulization catheter, a medication delivery apparatus configured to control delivery of a medication to the catheter, a gas delivery apparatus in communication with the catheter, a gas pressure relief apparatus configured to relieve pressure in the organ or body cavity, and a central controller. The system may include a liquid source having a mixture of hyaluronic acid and heparin that, in conjunction with the nebulizing catheter, are designed to generate an aerosol with a particle size of 10-25 microns in a body cavity. The method includes providing an aerosol of anti-adhesive medication to an organ or body cavity while controlling overall pressure in the organ or cavity.




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PATIENT INTERFACE ASSEMBLY WITH SELF-ADJUSTING ANCHOR POINTS

A patient interface assembly having an improved support for use in securing a patient interface device to the head of a patient overcomes the shortcomings of conventional headgear. The improved support provides a self-adjusting anchor point situated anterior to the ear of the patient that provides enhanced stability in mounting the patient interface device to the patient.




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NON-INVASIVE SYSTEMS AND METHODS FOR IDENTIFYING RESPIRATORY DISTURBANCES EXPERIENCED BY A SUBJECT

An example method for detecting respiratory disturbances experienced by a subject can include receiving an airflow signal and at least one of an acoustic or vibration signal, where the airflow, acoustic, and/or vibration signals are associated with the subjects breathing. At least one feature can be extracted from the airflow signal and at least one feature can be extracted from at least one of the acoustic or vibration signal. Based on the extracted features, at least one respiratory disturbance can be detected. The respiratory disturbance can be flow limited breath or inspiratory flow limitation (“IFL”).




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BREATHING ASSISTANCE APPARATUS

A mask with cushion that has an outer film is disclosed. The film may be self-skinning or a film formed about or glued to the cushion body. In another form the cushion may be formed with at least a portion having a plurality of adjacent voids having honeycomb-like structure.




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APPLIANCE INCLUDING AN ANTENNA USING A PORTION OF APPLIANCE AS A GROUND PLANE

An appliance, such as an oven, includes a housing having an internal compartment and an RF antenna. At least a portion of the housing comprises an electrically conductive portion. The antenna includes an active component and a connection to the electrically conductive portion, which serves as a ground plane of the antenna. The housing may include a door assembly having a window that includes the electrically conductive portion in the form of a transparent conductive layer. The door assembly may be detachable and the connection to the antenna may be made by way of capacitive coupling. In an alternative arrangement, the housing includes a light fixture for illuminating the internal compartment, wherein the active component of the antenna is disposed in the light fixture.




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LOW THERMAL IMPEDANCE STRUCTURE IN A PHASED ARRAY

An antenna system including: a metal base plate; an antenna element arranged on and extending away from the front side of the base plate; a circuit board including a ground plane, adjacent to, and in thermal contact with the base plate; a plurality of electrical components on the circuit board including a power amplifier and an I/O connector; a metal support plate separated from, parallel to, and facing the base plate, with the circuit board located between the base and support plates; a plurality of thermally conductive standoffs thermally connecting the base plate to the support plate; and a master board including an I/O connector mating with the I/O connector on the circuit board and electrically connecting the circuit board to the master board, the master board located between the circuit board and the support plate and including signal paths for routing signals to the circuit board.




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MAGNETICALLY ENHANCED LOW TEMPERATURE-HIGH DENSITY PLASMA-CHEMICAL VAPOR DEPOSITION PLASMA SOURCE FOR DEPOSITING DIAMOND AND DIAMOND LIKE FILMS

A magnetically enhanced low temperature high density plasma chemical vapor deposition (LT-HDP-CVD) source has a hollow cathode target and an anode, which form a gap. A cathode target magnet assembly forms magnetic field lines substantially perpendicular to the cathode surface. A gap magnet assembly forms a magnetic field in the gap that is coupled with the cathode target magnetic field. The magnetic field lines cross the pole piece electrode positioned in the gap. The pole piece is isolated from ground and can be connected to a voltage power supply. The pole piece can have negative, positive, floating, or RF electrical potentials. By controlling the duration, value, and sign of the electric potential on the pole piece, plasma ionization can be controlled. Feed gas flows through the gap between the hollow cathode and anode. The cathode can be connected to a pulse power or RF power supply, or cathode can be connected to both power supplies. The cathode target and substrate can be inductively grounded.




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MAGNETICALLY ENHANCED HIGH DENSITY PLASMA-CHEMICAL VAPOR DEPOSITION PLASMA SOURCE FOR DEPOSITING DIAMOND AND DIAMOND-LIKE FILMS

A magnetically enhanced HDP-CVD plasma source includes a hollow cathode target and an anode. The anode and cathode form a gap. A cathode target magnet assembly forms magnetic field lines that are substantially perpendicular to a cathode target surface. The gap magnet assembly forms a cusp magnetic field in the gap that is coupled with the cathode target magnetic field. The magnetic field lines cross a pole piece electrode positioned in the gap. This pole piece is isolated from ground and can be connected with a voltage power supply. The pole piece can have a negative, positive, or floating electric potential. The plasma source can be configured to generate volume discharge. The gap size prohibits generation of plasma discharge in the gap. By controlling the duration, value and a sign of the electric potential on the pole piece, the plasma ionization can be controlled. The magnetically enhanced HDP-CVD source can also be used for chemically enhanced ionized physical vapor deposition (CE-IPVD). Gas flows through the gap between hollow cathode and anode. The cathode target is inductively grounded, and the substrate is periodically inductively grounded.




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Electrically and Magnetically Enhanced Ionized Physical Vapor Deposition Unbalanced Sputtering Source

An electrically and magnetically enhanced ionized physical vapor deposition (I-PVD) magnetron apparatus and method is provided for sputtering material from a cathode target on a substrate, and in particular, for sputtering ceramic and diamond-like coatings. The electrically and magnetically enhanced magnetron sputtering source has unbalanced magnetic fields that couple the cathode target and additional electrode together. The additional electrode is electrically isolated from ground and connected to a power supply that can generate positive, negative, or bipolar high frequency voltages, and is preferably a radio frequency (RF) power supply. RF discharge near the additional electrode increases plasma density and a degree of ionization of sputtered material atoms.




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ENHANCEMENT OF PENETRATION AND ACTION

The present invention relates, inter alia, to dermal systems comprising at least one light source and at least one pharmaceutically and/or cosmetically active ingredient. The dermal systems can be employed in order to enhance the penetration and action of the pharmaceutically and/or cosmetically active ingredient.




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BRANCH CURRENT MONITOR WITH RECONFIGURATION

A branch current monitor that includes reconfiguration.




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CAPACITANCE DETECTION APPARATUS AND INPUT APPARATUS

A voltage of a first capacitor is compared with a threshold voltage and a signal corresponding to the comparison result is generated at each of a first timing during a period after the transfer of a positive charge has ended and before the transfer of a negative charge starts and a second timing during a period after the transfer of the negative charge has ended and before the transfer of the positive charge starts. In each of the case where a positive charge is transferred and the case where a negative charge is transferred, operations (digitization of an integrated value and a feedback operation) of a delta sigma modulator are performed.




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DETERMINING POSITION OF RADIO FREQUENCY COIL IN MAGNETIC RESONANCE IMAGING SYSTEM

A method for determining a position of an RF coil in a magnetic resonance imaging (MRI) system is disclosed. As an example, a center of a field of view (FOV) to be scanned may be adjusted to a magnetic field center of an MRI system, and coordinate values in a coordinate system for shape-characteristic points of the FOV may be determined, where an origin of the coordinate system is located at the magnetic field center of the MRI system. A preset gradient magnetic field may be applied to the FOV, and coil units respectively covering the shape-characteristic points may be determined. An effective region may be obtained by connecting the determined coil units according to the shape of the FOV, and a coil unit located in the effective region may be determined as an effective coil unit for imaging the FOV by the MRI system.




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MAGNETIC RESONANCE IMAGING APPARATUS AND RF COIL APPARATUS

According to one embodiment, magnetic resonance imaging apparatus includes a transmission coil, a plurality of reception channels, transmission/reception circuitry, and processing circuitry. The transmission coil transmits an RF wave to a subject. The reception channels receive MR signals generated from the subject. The transmission/reception circuitry controls the transmission coil to change the flip angle of a nucleus contained in the subject and excited by the transmitted RF wave. The processing circuitry determines whether the reception channels include an impaired channel, based on the comparison between the distributions of the signal values of the received MR signals with respect to the changing flip angles among the reception channels.




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SYSTEM AND METHOD FOR MAGNETIC RESONANCE IMAGING

A system and method for magnetic resonance imaging is provided. The method includes dividing k-space into a plurality of regions along a dividing direction; scanning an object using a plurality of sampling sequences; acquiring a plurality of groups of data lines; filling the plurality of groups of data lines into the plurality of regions of the k-space; and reconstructing an image based on the filled k-space.




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MICROELECTROMECHANICAL GYROSCOPE WITH REJECTION OF DISTURBANCES AND METHOD OF SENSING AN ANGULAR RATE

A gyroscope includes a substrate, a first structure, a second structure and a third structure elastically coupled to the substrate and movable along a first axis. The first and second structure are arranged at opposite sides of the third structure with respect to the first axis A driving system is configured to oscillate the first and second structure along the first axis in phase with one another and in phase opposition with the third structure. The first, second and third structure are provided with respective sets of sensing electrodes, configured to be displaced along a second axis perpendicular to the first axis in response to rotations of the substrate about a third axis perpendicular to the first axis and to the second axis.




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Drilling-Resistance Measuring Device for Use Underwater

The invention relates to a drilling-resistance measuring device (10) and to a method for material testing in a humid environment or underwater. The drilling-resistance measuring device (10) comprises a housing (1), in which a drive and a drill chuck (3) coupled to the drive are arranged, in which drill chuck a drilling needle (4) is or can be releasably held, wherein the housing (1) has a drilling-needle outlet opening (5') enclosed by a drilling-needle outlet guide (5), through which drilling-needle outlet opening the drilling needle (4) extends out of the housing (1). The drilling-resistance measuring device (10) comprises at least one water-tight bellows (6), which is arranged in the interior of the housing (1) around the drilling needle (4) between the drill chuck (3) and the drilling-needle outlet guide (5), wherein moisture or water can enter the bellows (6) through the drilling-needle outlet opening (5').




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MICRO-ELECTROMECHANICAL APPARATUS HAVING CENTRAL ANCHOR

A micro-electromechanical (MEMS) apparatus includes a substrate, two first anchors, a frame, and two elastic members. The substrate is provided with a reference point thereon. The frame surrounds the two first anchors, and each of the elastic members connects the corresponding first anchor and the frame. Each of the first anchors is disposed near the center of the MEMS apparatus to decrease an effect caused by warpage of the substrate. The MEMS apparatus can be applied to an MEMS sensor having a rotatable mass, such as a three-axis accelerometer or a magnetometer, to improve process yield, reliability, and measurement accuracy.




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USE OF FLUORESCENT POLYMERS IN MARKING COMPOSITIONS FOR THE DIAGNOSTIC DETERMINATION OF CLEANING PERFORMANCE

The present invention generally relates to fluorescent marking compositions and their use to determine whether a surface has been cleaned. More particularly, the marking compositions comprise fluorescent polymers.




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MEMORY WITH ENHANCEMENT TO PERFORM RADIATION MEASUREMENT

Techniques are described that includes using a memory to store data within a system. The techniques include lowering a supply voltage applied to said memory and ceasing use of the memory to store data within the system. The techniques further include reading values from the memory with the supply voltage being lowered. The techniques further include determining a radiation level from an amount of corrupted ones of the values.




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SUPERCONDUCTING NANOWIRE AVALANCHE PHOTODETECTORS WITH REDUCED CURRENT CROWDING

Superconducting nanowire avalanche photodetectors (SNAPs) have using meandering nanowires to detect incident photons. When a superconducting nanowire absorbs a photon, it switches from a superconducting state to a resistive state, producing a change in voltage that can be measured across the nanowire. A SNAP may include multiple nanowires in order to increase the fill factor of the SNAP's active area and the SNAP's detection efficiency. But using multiple meandering nanowires to achieve high fill-factor in SNAPs can lead to current crowding at bends in the nanowires. This current crowding degrades SNAP performance by decreasing the switching current, which the current at which the nanowire transitions from a superconducting state to a resistive state. Fortunately, staggering the bends in the nanowires reduces current crowding, increasing the nanowire switching current, which in turn increases the SNAP dynamic range.




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Pre-burning, dry process methodology and systems for enhancing mettallurgical solid fuel properties

Measurements are taken of moisture, BTU/lb (British Thermal Units per pound), ash, forms of sulfur, volatile material, grindability, and absorption properties of any of a wide variety of mine-run solid fuels. Using that information, a dry electromagnetic process technology has been developed that can be controlled and monitored to selectively alter and enhance metallurgical solid fuel properties. Specific changes include altering the mechanical structure and chemical composition of solid fuels such as coal, coal coke or petroleum coke, increasing the BTU/lb to optimum levels, decreasing all forms of sulfur, and decreasing ash, while maintaining the BTU/lb of the fuels. A new family of solid fuel designer coals not found in nature can be produced via these methods and apparatus.




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Use of 1,1-diethoxyethane for increasing knocking resistance of automotive gasoline

The present invention relates to the use of 1,1-diethoxyethane for increasing the knocking resistance of low-boiling gasoline with an initial boiling point (IBP) of 80° C. to 120° C. by at least 40 units (Research Octane Number).




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Gasoline fuel composition for improved performance in fuel injected engines

A method for improving performance of fuel injectors, and a method for cleaning fuel injectors for an internal combustion engine. The methods include operating the engine on a fuel composition comprising a major amount of fuel and from about 1 to about 200 ppm by weight based on a total weight of the fuel of a reaction product of (i) a hydrocarbyl substituted compound containing at least one tertiary amino group and (ii) a halogen substituted C2-C8 carboxylic acid, ester, amide, or salt thereof, wherein the reaction product as made is substantially devoid of free anion species.




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The Complex Hustle of Oakland's BART Dancers

Turf dancing has become ubiquitous on the trains, providing steady income, a creative platform, and a built-in audience. On a recent Friday, Yaameen Muhammad stood on the West Oakland BART platform, the afternoon sun reflecting off his neon-yellow high-tops.…



  • Arts & Culture/Arts Feature

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METHODS FOR PREDICTING THE SURVIVAL TIME OF PATIENTS SUFFERING FROM CANCER

The present invention relates to methods for predicting the survival time of patients suffering from cancer. Said methods are based on the quantification and analysis of the cell free nucleic acids that are present in a sample from the patient and typically include the determination of the level of the mutant nucleic acid which contains a mutation of interest, the calculation of the mutation load for said mutation of interest, the calculation of the DNA integrity index or a combination thereof.




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METHODS AND COMPOSITIONS RELATING TO FUSIONS OF ALK FOR DIAGNOSING AND TREATING CANCER

Disclosed are methods and compositions for detecting the presence of a cancer in a subject and assessing the efficacy of treatments for the same. The disclosed method use reverse transcription polymerase chain reaction (RT-PCR) and multiplex polymerase chain reaction techniques as well as Template Exchange Extension Reaction (TEER) to detect the presence of point mutations, truncations, or fusions of anaplastic lymphoma kinase.




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CANCER PROGRESSION OBSERVATION INDEX GENE GROUP AND METHOD OF DETECTING THE GENE GROUPS

A method of detecting a cancer progression observation index gene group, comprising: a) preparing a plurality of AKR/J mice in which an oncogene is inserted into a thymocyte; b) dividing the AKR/J mice into three groups, raising the first group of the AKR/J mice after high-dose ionizing radiation of 0.8 Gy/min, raising the second group of the AKR/J mice after low-dose ionizing radiation of 0.7 mGy/hr, and raising the third group of the AKR/J mice in a general environment; c) obtaining a thymus of a dead mouse of the first or second group of the AKR/J mice throughout the b) operation and diagnosing cancer when a weight of the thymus is increased to twice or more than before radiation; d) extracting thymuses by sacrificing the first to third groups of the AKR/J mice at the time at which the third group of the AKR/J mice initially die; and e) selecting only a thymus having no change in weight compared to the organs of the same-aged non-irradiated AKR/J mice from the organs extracted in d) and detecting a gene of the organ whose weight is increased or decreased by a factor of two or more through gene analysis.




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Enhancing Flow Cytometry Discrimination with Geometric Transformation

In flow cytometry, particles (2) can be distinguished between populations (8) by combining n-dimensional parameter data, which may be derived from signal data from a particle, to mathematically achieve numerical results representative of an alteration (48). An alteration may include a rotational alteration, a scaled alteration, or perhaps even a translational alteration. Alterations may enhance separation of data points which may provide real-time classification (49) of signal data corresponding to individual particles into one of at least two populations.




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PERSONALIZED THERAPY OF INFLAMMATION-ASSOCIATED CANCER USING METHODS OF ASSESSING THE SUSCEPTIBILITY OF A SUBJECT TO THE TREATMENT WITH EGFR INHIBITORS/ANTAGONISTS

The present invention relates to in vitro methods of assessing the susceptibility or responsiveness of a subject to the treatment with an epidermal growth factor receptor (EGFR) inhibitor/antagonist, wherein the subject has been diagnosed or suspected of suffering from inflammation-associated. These methods comprise determining the level of expression of EGFR in myeloid cells in a sample from the subject, wherein an expression of EGFR in the myeloid cells is indicative of the subject being susceptible to the treatment with an EGFR inhibitor/antagonist. The invention also relates to EGFR inhibitors/antagonists for use in the treatment or amelioration of inflammation-associated cancer. The invention furthermore provides in vitro methods of prognosing the survival time, progression-free survival time or disease course of a subject that has been diagnosed or suspected of suffering from from inflammation-associated cancer. In addition thereto, the invention relates to in vitro diagnostic methods of assessing the proneness of a subject to develop inflammation-associated cancer in which the expression of EGFR is determined in myeloid cells from the subject.




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MATERIALS AND METHODS FOR DIAGNOSIS, PROGNOSIS AND ASSESSMENT OF THERAPEUTIC/PROPHYLACTIC TREATMENT OF PROSTATE CANCER

A method to detect prostate cancer comprising contacting a sample of prostate cells from the patient with a set of detectably labeled probes under hybridization conditions and determining the presence of chromosomal abnormalities in prostate tumor tissue, PIN (intra-epithelial neoplasia), histologically benign tissue and benign prostatic hyperplasia (BPH); a method to combine immunofluorescence and FISH (IF-FISH) to facilitate the assessment of chromosomal abnormalities; a set of probes; and a kit comprising the set of probes and instructions for diagnosing prostate cancer in a patient.




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METHODS FOR DIAGNOSIS AND PROGNOSIS OF CANCER

We have discovered a protein in humans, herein referred to as collagen like gene (CLG) product (SEQ ID NOS: 12 and 13), that is expressed in human prostate cancer and breast cancer cell lines but not in normal adult, placenta, lung, liver, skeletal muscle, kidney or pancreas tissues. We have also discovered that the level of CLG mRNA expression correlates positively with the metastatic potential of the cancer cell lines tested.




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CANCER BIOMARKERS AND METHODS OF USE THEREOF

The present invention provides detection methods for detecting a pre-cancerous epithelial cell signature. The present invention further provides reagents for use in the detection methods. A subject detection method is useful in various imaging, diagnostic, prognostic, and patient monitoring methods, which are also provided.




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APPLYING PHASE SEPARATION OF A SOLVENT MIXTURE WITH A LOWER CRITICAL SOLUTION TEMPERATURE FOR ENHANCEMENT OF COOLING RATES BY FORCED AND FREE CONVECTION

A method and system for cooling a device (preferably a micro-device), comprising cooling the device by using a lower critical solution temperature (LCST) mixture. Enhancement of heat transfer rates is achieved during phase separation of a two-component system (two-component mixture) with a LCST. Convective heat transfer rates in small diameter pipes and over a vertical (hot) plate are demonstrated.




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LOW CAPACITANCE SURGE SUPPRESSION DEVICE

A surge suppression device includes a micro electromechanical system (MEMS) switch electrically connected to a current path. Additionally, the surge suppression device includes a transient voltage suppression (TVS) device electrically connected in series to the MEMS switch. The surge suppression device is configured to protect electronic components from voltage surges or current surges.




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COMPONENT CARRIER AND GUIDING SYSTEM FOR TUNABLE, ENHANCED CHASSIS AIRFLOW

An enhanced airflow chassis system includes a component chassis that defines a chassis enclosure including a chassis entrance and component slots. First component carriers are mounted to first components and positioned in each of the component slots. Each first component carrier defines first component carrier airflow apertures that direct airflow entering the chassis entrance to the first component mounted to that first component carrier. A backplane located in the chassis enclosure opposite the component slots from the chassis entrance defines backplane airflow apertures and includes a component connector located adjacent each of the component slots that is connected to the first component mounted to the component carrier positioned in that component slot. A chassis venting member positioned between at least two of the component slots defines chassis venting member airflow apertures that direct airflow entering the chassis entrance through the chassis enclosure to a subset of the backplane airflow apertures.




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Reader's Letter: St John's Ambulance volunteers are working tirelessly

75 YEARS AGO this week St John Ambulance volunteers played a vital role delivering first aid and providing support to both the public and the armed forces on VE Day.