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A new study has investigated the impacts of human activity on Antarctic Marine and Coastal. Alongside local effects of fishing, pollution and invasive alien species, global climate change is causing sea temperature rises and ocean acidification. Action is therefore needed at all levels to address these impacts.

In this file photo, job seekers line up to enter Choice Career Fair at the Los Angeles Convention Center on December 1, 2010 in Los Angeles, California. Overall, the number of unemployed Californians ticked up by 1,000 over the month to nearly 1.4 million for August 2014, but the rate remained unchanged, at 7.4 percent. The national unemployment rate is down to 6.1 percent.; Credit: Kevork Djansezian/Getty Images

California's unemployment rate is unchanged for a third month, holding at 7.4 percent in August.

The California Employment Development Department reported Friday that the state added 44,200 nonfarm jobs during the month, bringing the state total to 15.5 million in August.

Last month's gains mean the state has added 1.4 million jobs since February 2010, when the jobless number hit a peak of 12.4 percent.

Overall, the number of unemployed Californians ticked up by 1,000 over the month to nearly 1.4 million. The national unemployment rate is down to 6.1 percent.

Construction posted the largest increase over the month, adding 13,600 jobs. Manufacturing, financial activities, business services, education, health, leisure and government all added jobs in August.

Trade, transportation and utilities, along with information, posted job losses of 8,300.

With the recent 22% rise in the price of uranium, Peter Epstein of Epstein Research considers the upside for Skyharbour's holdings in the Athabasca Basin.

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A new study shows that the West Antarctic Peninsula is experiencing some of the most rapid climate change on Earth, featuring dramatic increases in temperatures, retreats in glaciers and declines in sea ice. The Southern Ocean absorbs nearly half of the carbon dioxide -- the key greenhouse gas linked to climate change -- that is absorbed by all the world's oceans. The study tapped an unprecedented 25 years of oceanographic measurements in the Southern Ocean and highlights the need for more monitoring in the region. The research revealed that carbon dioxide absorption by surface waters off the West Antarctic Peninsula is linked to the stability of the upper ocean, along with the amount and type of algae present. A stable upper ocean provides algae with ideal growing conditions. During photosynthesis, algae remove carbon dioxide from the surface ocean, which in turn draws carbon dioxide out of the atmosphere. From 1993 to 2017, changes in sea ice dynamics off the West Antarctic Peninsula stabilized the upper ocean, resulting in greater algal concentrations and a shift in the mix of algal species. That's led to a nearly five-fold increase in carbon dioxide absorption during the summertime. The research also found a strong north-south difference in the trend of carbon dioxide absorption. The southern portion of the peninsula, which to date has been less impacted by climate change, experienced the most dramatic increase in carbon dioxide absorption, demonstrating the poleward progression of climate change in the region.

Image credit: Drew Spacht/The Ohio State University

NSF documentary about the race against nature to understand and meet the challenges of the rapidly changing Arctic

Hong-Kong-based conglomerate Tencent has rolled out Xiao’e Pinpin, a mini program for...

US-based fintech Namogoo will integrate incentive platform

Source: Streetwise Reports   04/27/2020

Avadel Pharmaceuticals Plc (AVDL:NASDAQ) today announced "positive topline data from its pivotal Phase 3 REST-ON trial assessing the safety and efficacy of FT218, an investigational, once-nightly formulation of sodium oxybate for the treatment of excessive daytime sleepiness and cataplexy in patients with narcolepsy." The firm pointed out that it met all three of the co-primary efficacy endpoints in the study for each of three dosage levels which it claims demonstrates "highly significant, clinically meaningful improvements on the Maintenance of Wakefulness Test, Clinical Global Impression-Improvement and mean weekly cataplexy attacks."

The company's Chief Medical Officer Jordan Dubow, M.D., commented, "We are excited to see these positive topline data from the REST-ON study, where all three dose levels of once-nightly FT218 demonstrated a statistically significant and clinically meaningful improvement on the measures of the two prominent symptoms of narcolepsy, as well as an improvement in overall functioning compared to placebo...Once-nightly FT218 delivered a clinically meaningful response within three weeks of treatment initiation, which was sustained through each treatment period...We think once-nightly FT218, if approved, has the potential to be a meaningful contributor to patient care."

Avadel Pharma's CEO Greg Divis remarked, "The successful outcome of the REST-ON study strengthens our belief that, if approved, once-nightly FT218 has the potential to be a significant advancement for patients in the estimated $1.7 billion twice-nightly sodium oxybate market. Our proprietary market research with physicians and patients informs us that there is a strong interest in a once-nightly sodium oxybate formulation. We look forward to sharing the results from the REST-ON study with the FDA and progressing toward a potential approval that would allow us to bring this important treatment to the patients who need it most. If approved, FT218 would be the first once-nightly therapy to address both excessive daytime sleepiness and cataplexy in patients with narcolepsy."

The REST-ON study is a double-blind, randomized, placebo-controlled Phase 3 trial to assess the efficacy and safety of once-nightly FT218, a formulation of sodium oxybate using Avadel's proprietary Micropump technology for extended-release oral suspension in the treatment of excessive daytime sleepiness and cataplexy in patients suffering from narcolepsy. The company stated that 212 patients were enrolled in the study and result "showed that the 9 g dose of once-nightly FT218 demonstrated a highly significant and clinically meaningful improvement compared to placebo across all three co-primary endpoints."

The company advised that FT218 has been granted Orphan Drug Designation from the U.S. FDA for the treatment of narcolepsy. The firm added that the designation was granted on basis that FT218 may be clinically superior to a formulation of sodium oxybate that is already approved by the FDA for the same indication.

Avadel Pharmaceuticals is biopharmaceutical company headquartered in Dublin, Ireland. The company's primary focus is on the development and potential FDA approval for FT218, which just completed its Phase 3 REST-ON clinical trial for the treatment of narcolepsy patients suffering from excessive daytime sleepiness and cataplexy. The firm also develops and markets sterile injectable drugs for use in hospital settings.

Avadel started off the day with a market capitalization of around $456.2 million with approximately 46.4 million shares outstanding and a short interest of about 14.00%. AVDL shares opened more than 34% higher today at $13.30 (+$3.37, +34.28%) over Friday's $9.83 closing price and reached a new 52-week high price this morning of $13.49. The stock has traded today between $11.90 and $13.49 per share and is currently trading at $12.27 (+$2.44 +24.82%).

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( Companies Mentioned: AVDL:NASDAQ, )

Payment service provider and direct card acquirer ECOMMPAY have...

With the recent 22% rise in the price of uranium, Peter Epstein of Epstein Research considers the upside for Skyharbour's holdings in the Athabasca Basin.

Levels of air pollution significantly increase on the island of Svalbard in the Norwegian Arctic when tourist cruise ships are present, according to a recent study. With shipping levels rising in the region, the researchers recommend that stricter emissions regulations are introduced in order to limit the impact of pollution on the Arctic environment.

Research into mercury has identified two genes in bacteria that appear to be required for turning the metal into its most toxic form, methylmercury. The study adds to a growing body of research that helps us to understand the transformations that mercury undergoes in the environment and the microbes involved in these transformations.

An early-warning system developed by researchers could help forest managers in Europe predict which trees are at greatest risk of bark- beetle infestation. The study looked at the probability of bark-beetle outbreaks on two important conifer-tree species in Slovenia: the Norway spruce (Picea abies) and silver fir (Abies alba). It found that high temperatures, and extreme weather linked to climate change — including droughts and ice storms — weakened trees, making them more vulnerable to attack by bark beetles.

New research has produced a starch-based bioplastic with similar properties to equivalent traditional oil-based plastics. By adding an ammonium salt to thermoplastic starch (TPS) the study demonstrated an improvement in the plasticisation process, rendering it flexible, mouldable and potentially recyclable.

In a recent experiment in Norway, electrical appliance stores increased their sales of energy-efficient tumble driers when consumers were made aware of their cheaper lifetime operating costs by shop staff and a new product labelling system.

A new concrete-reinforcement system, used by the LIFE INSU-SHELL1 project, replaces steel rods with non-corrosive textile structures to reduce the amount of concrete needed in construction. This nearly halves the global warming potential of traditional steel-reinforced concrete which is the largest producer of CO2 emissions in the building industry.

A new study finds that a quarter of fish products labelled as ‘cod’ or ‘haddock’ in Dublin, Ireland, are in fact completely different species of fish. This indicates that fish consumers are being misled by inaccurate labels, which could compromise sustainable fishing and consumption efforts.

A map of science could assist research planning strategies by helping to identify emerging topics. The map — which is based on links to almost 20 million scientific articles that have been published over the past 16 years — clusters and links scientific disciplines by citation-based relationships and serves as a highly detailed and scalable infographic. The authors hope it will be used by research planners to help distinguish — and potentially forecast — the research areas in science which have longevity, and also those which are innovative.

A team of psychologists, kinesiologists and archaeologists at Indiana University and elsewhere are throwing new light on a longstanding archaeological mystery: the purpose of a large number of spherical stone artifacts found at a major archaeological site in South Africa.

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When most people hear the word "pollinator," they think of bees and butterflies. However, certain beetles are known to pollinate plants as well, and new fossil evidence indicates that they were doing so 20 million years ago.

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An extinct reptile related to crocodiles that lived 212 million years ago in present day New Mexico has been named as a new species, Vivaron haydeni, in a paper published this week by Virginia Tech's Department of Geosciences researchers.

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Under pressure from rising food prices, many nations have begun to acquire large tracts of agricultural land in foreign countries, a practice known as ‘land grabbing’. New research has now quantified current levels of land grabbing and demonstrated that it is accompanied by concerning levels of ‘water grabbing’ which could affect water supply in the ‘grabbed’ countries.

The development of Green Infrastructure (GI) in a UK case study has been researched in a recent study. Some issues caused by an imbalance in stakeholder power and conflicting roles played by major stakeholders were identified with the project. Stakeholder participation is central to the concept of GI and the research reiterates the importance for those implementing GI to ensure that participation is effective and balanced.

A team of researchers from Florida State University, Johns Hopkins University and the National Institutes of Health has found existing drug compounds that can both stop Zika from replicating in the body and from damaging the crucial fetal brain cells that lead to birth defects in newborns.

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Using archival documents, a new report published online by JAMA Internal Medicine examines the sugar industry's role in coronary heart disease research and suggests the industry sponsored research to influence the scientific debate to cast doubt on the hazards of sugar and to promote dietary fat as the culprit in heart disease.

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The ability of the Earth’s living systems to store carbon could play a vital role in the mitigation of climate change. A new report suggests that, in coming decades, safeguarding and restoring carbon in ecosystems has the potential to prevent well over 50 gigatonnes (Gt) of carbon entering the atmosphere.

Global population growth since 1850 has been largely enabled by commercial phosphorus and nitrogen fertilisers. The availability of these nutrients for food production relies upon steadily diminishing resources of natural gas and phosphorus rock. A recent study suggests that to secure a long-term affordable food supply, policy intervention is needed to conserve these essential resources.

Reindeer herding has a long history in the Arctic, but climate change and industrial activity are bringing this important economic and cultural tradition to breaking point. In a unique initiative, reindeer herders across the Arctic are leading an international team of scientists in using modern technology to adapt to global change and empower indigenous communities.

UN researchers highlight the need to develop better ways to measure the impacts of climate change on children's health. They suggest more attention be given to impact analysis of different social groups and ages, as well as nutrition.

Contrary to some established views, the local animal population is unlikely to be the major source of resistance diversity for Salmonella Typhimurium DT104 in humans in Scotland, according to a study. The researchers suggest that a broader approach to fighting antibiotic resistance is needed, which goes beyond focusing solely on curbing the use of antibiotics in domestic animal populations.