A molecule comprising a lipid, a peptide and a linker to bind the lipid to the peptide which have specific amino acid sequence to bind to Epidermal Growth Factor Receptor (EGFR) of tumor cells, and a liposomal composition which is targeted by the molecule, and method for preparing thereof is disclosed.

The present invention relates to Chimeric Antigen Receptors (CAR) that are recombinant chimeric proteins able to redirect immune cell specificity and reactivity toward selected membrane antigens, and more particularly in which extracellular ligand binding is a scFV derived from a CD123 monoclonal antibody, conferring specific immunity against CD123 positive cells. The engineered immune cells endowed with such CARs are particularly suited for treating lymphomas and leukemia.

The present invention relates to Chimeric Antigen Receptors (CAR) that are recombinant chimeric proteins able to redirect immune cell specificity and reactivity toward selected membrane antigens, and more particularly in which extracellular ligand binding is a scFV derived from a BCMA monoclonal antibody, conferring specific immunity against BCMA positive cells. The engineered immune cells endowed with such CARs are particularly suited for treating lymphomas, multiple myeloma and leukemia.

Provided herein are methods for the prognosis of prostate cancer progression in a patient by analyzing the gene expression in a tumor sample obtained from the patient the prognosis of prostate cancer progression in a patient by analyzing the gene expression in a tumor sample obtained from the patient. In particular, gene expression levels of GCOM1, MEX3D, TRPM4, ATPAF1, PTRF, GLYATL1, FLNA, OBSCN, STRA13, WHSCl, ARFGAP3, KDM2A, FAM83H, CLDN7, CNOT6, and B3GNT9 are measured. Kits containing means for the measurement of gene expression as described herein and methods for treatment of prostate cancer are also provided.

The present invention concerns cancer biomarkers. In particular, the invention concerns HGF as a biomarker for patient selection and patient prognosis in cancer, as well as methods of therapeutic treatment, articles of manufacture and methods for making them, diagnostic kits, methods of detection and methods of advertising related thereto.

The present invention relates to a plant-based wrapping paper for wrapping food. The plants (raw materials) may be fruits, herbs, medicinal plants, tea, vegetables and/or spices. The invention further relates to a method for producing said wrapping paper, its use for wrapping food or its use as packaging material.

The present invention is directed to novel organoleptic compounds, a process of augmenting, enhancing or imparting taste to a material selected from the group consisting of a foodstuff, a chewing gum, a dental product, an oral hygiene product and a medicinal product comprising the step of incorporating an olfactory acceptable amount of such novel organoleptic compounds, and a process of improving, enhancing or modifying a fragrance composition through the addition of an olfactory acceptable amount of such novel organoleptic compounds.

Pancake mixes comprising at least one type of whole grain flour, at least one natural sweetener, at least one fat and a leavening system are provided herein. Packaged food products comprising single-serving containers containing said pancake mixes, as well as methods of preparing pancakes, are also provided. The pancakes described herein are preferably 100% whole grain and free from preservatives and/or artificial colorings.

This disclosure describes a simple, low cost method to produce a modular dry mix that can easily be modified and customized to produce a wide range of easy to aerate, no ice cream machine needed, ice cream and frozen dairy and non-dairy desserts and products made by this process. The method relies on successive simultaneous particle size reduction and blending steps without the use of traditional mix drying operations. The formulations produced by this process are modular and allow quick and simple ingredient substitutions to create distinct finished products. The process yields mixes that produce stronger, more stable foams that don't leave an oily mouth feel. The disclosure also includes a formulation and process used to make ice cream, and related frozen dairy and non-dairy desserts at room temperature in one step where the ingredients do not need to be aged, or homogenized, and aeration occurs without the need for simultaneous cooling or freezing. The process allows the end-user to control and vary the texture, freezing rate, melting point and eating qualities of the product without the use of traditional, home or industrial ice cream machines and a product made by this process. A product produced from this mix consists of a (protein-concentrate and emulsifier)—stabilized, protein-based foam created by combining a powder mix with one or a combination of a large range of above freezing temp liquids then immediately whisking the mixture at room temp to a target overrun without pre-aging, and then freezing that product statically till desired hardness is achieved. The main execution of this process involves the use of dry powders that are transported and sold dry and then reconstituted by the end user before they are combined without pre-treatment, freezing homogenization or aging. The manufacturing process offers significant advantages over current dry mix production methods which require significant upfront investment and produce hard to customize mixes. The formulation and finished product making portions of the invention offer significant improvement over existing manufacturing methods for frozen desserts and dessert mixes that require simultaneous freezing and aeration in terms of cost, convenience, customizability, shelf-stability and environmental impact.

A formulation consisting of a food-grade dye and a plant aroma cocktail is uptaken by plants and flowers and fruit. The improved aroma profile and color make the plant or it's flowers or it's fruit more desirable for consumption or viewing with an enhanced aroma.

It has unexpectedly been found that Pichia spp. strains have advantageous properties useful in the beer fermentation process. In particular, Pichia spp. yeast strains can be combined with normal beer yeast strains and different hop varieties in a fermentation process to produce synergistic effects—namely, the increased production of esters in the fermentation product. More specifically, the yeast can be used to produce increased levels of isoamyl acetate, isobutyl acetate, ethyl propionate, ethyl valerate, ethyl butyrate, ethyl decanoate and ethyl octanoate in beer. In addition, the Pichia spp. strain interacts differently with different hop varieties, so the flavor profile of beer can be tuned by using different combinations of Pichia spp. strains and hops. The present invention relates to a method of brewing beer using a Pichia spp. yeast strain and at least one hop variety, a beer obtainable by such a method and use of a Pichia spp. yeast strain according to the present invention.

The invention relates to a guiding device for guiding an oblong intermediate element while joining at least two decorative elements by means of this intermediate element.

A conveyance system that transports fabric comprises a work space having a surface that the fabric can be transports across, and at least one budger that moves and/or provide force to the fabric in a servo controlled motion.

A carpet and method for producing same that comprises an enhanced seam suitable for separation of an installation portion of the carpet and sacrificial edge portions of the produced carpet.

Methods for etching a substrate in a plasma processing chamber having at least a primary plasma generating region and a secondary plasma generating region separated from said primary plasma generating region by a semi-barrier structure. The method includes generating a primary plasma from a primary feed gas in the primary plasma generating region. The method also includes generating a secondary plasma from a secondary feed gas in the secondary plasma generating region to enable at least some species from the secondary plasma to migrate into the primary plasma generating region. The method additionally includes etching the substrate with the primary plasma after the primary plasma has been augmented with migrated species from the secondary plasma.

Fertilizer granules and methods of producing fertilizer granules. The fertilizer granules are formed from a fertilizer composition, such as a phosphate fertilizer, includes a fibrous material for the purpose of increasing the granule strength preventing or reducing attrition or dusting formation during storage, transport, and/or handling of the fertilizer. Dust formation can be reduced fifty percent or more. The base fertilizer composition can include a phosphate fertilizer, such as monoammonium phosphate (MAP) or diammonium phosphate (DAP), and optionally one or more micronutrients or secondary nutrients, such as elemental sulfur. The fibrous material is pulp or paper sludge, for example.

The invention is directed to manufacture of fertilizer having commercial levels of nitrogen supplemented with organic substances. The process treats organic matter with acid causing hydrolysis of organic polymers after which the mix is injected with nitrogen. The resultant sterilized and liquefied organic matter is disbursed over recycled material for the production of granules. Because the process allows for the controlled addition of acids and ammonia, desired levels of components can be achieved. The process is scalable, odor controlled and safe thereby allowing for the location of biosolid processing facilities in most any location. Further, the fertilizer of the invention provides a dual nitrogen-release profile when applied to crops. After application to soil, fertilizer of the invention releases an immediate bolus of nitrogen, similar to traditional ammonium sulfate, followed by continued slow release of nitrogen typically over a season.

A travel distance estimation device is provided. The travel distance estimation device includes an estimated velocity determination unit that successively estimates an estimated velocity of a movable object based on an acceleration integrated value and a velocity initial value a travel distance calculation unit that successively calculates an estimated travel distance of the movable object based on the estimated velocity, and a past velocity correction unit that determines corrected past velocities by correcting pre-correction past estimated velocities so that the corrected past velocities are continuous with the velocity initial value determined this time. The pre-corrected past estimated velocities are the estimated velocities that were successively determined. The travel distance estimation device further includes a travel distance correction unit that recalculates based on the corrected past velocities an estimated travel distance.

A method of health management of a monitored system includes collecting component condition indicator data used to calculate a plurality of component health indicators. Component fault severity and potential failure modes are determined utilizing the component condition indicator data. The potential failure modes are ranked in order of likelihood to isolate the failure mode. A system of health management for monitored apparatus includes a fault severity module to derive a plurality of component health indicators from collected component condition indicator data, the plurality of component health indicators indicative of fault severity of a plurality of components. A fault isolation module separately derives a ranked listing of potential fault/failure modes utilizing the component condition indicator data. The system further includes a communication portion to which the plurality of component health indicators and the ranked listing of fault/failure modes are transmitted for review and/or action by cognizant personnel.

A flotation system for a recreational board such as a stand up paddleboard includes an elongated substrate that is sized and shaped to releaseably wrap around the perimeter of a recreational board. The elongated substrate is constructed of a buoyant material such as foam, and defines a plurality of apertures that can be used to store items such as beverages and personal belongings. The elongated substrate is releaseably attached to the board by a variety of fastening means, and serves to increase stability and buoyancy of the board, and to protect the board.

A craft includes a rigid hull (1) that consists of a V-shaped bottom (5) and a bridge (4) on which a load can rest. The hull includes plating consisting of compartmentalized pneumatic floats (2), the rear compartments (32) of which are combined with an inflation and deflation system so as to vary the buoyancy of the craft. The craft also includes a submergible hull (1), the central cavity (9) of which is formed between the bottom (5) and the bridge (4) and is open at the rear so as to be automatically filled or emptied, the central cavity (9) containing at least one bag (10) that is combined with an inflation and deflation system enabling the buoyancy to be varied and consequently the level of immersion of the stern (7) to be changed as needed.

A method of operating a clothes dryer having a treating chamber for receiving a laundry load, an air system for supplying and exhausting air from the treating chamber, a heating element for heating the air supplied to the treating chamber, and a controller implementing a cycle of operation, wherein the controller estimates a cycle time of a drying cycle of operation.

A method of producing an endodontic file that involves grinding in a plane substantially parallel to the longitudinal axis of a rotating dental instrument blank. By grinding the dental instrument blank in this manner, the torsional strength of the resulting endodontic file is not eroded during its production, thereby providing a file that is less susceptible to breakage during its use.

A multi-purpose balance exercise device designed to be used in multiple positions and for diverse exercises. For example, various embodiments allow for the multipurpose device to be use as an aerobic step device as well as the ability to easily adjust the device to various heights to easily decrease the level of difficulty of the device for use during various exercises. The balance exercise device can provide a polarity of handles and grab points both horizontally and vertically, which allow for an enhanced number of exercises or movements using either the top and/or bottom of the device. The balance exercise device includes a flexible bladder filled with air, other gases, or gels attached to a substantially rigid base. The base can include an interior within which features such as handles are disposed to provide a gripping or lifting exercise to which the balance exercise device can be used.

A combination massage table with one or more resistance bands (hereinafter, a combination table) is disclosed. In some embodiments, the combination table may comprise: a massage table; the one or more resistance bands; and a means for attaching the one or more resistance bands to the massage table; such that a client using the combination table receives at least one improved health benefit as compared against massage therapy without any resistance band use. Furthermore, methods for using the combination table are disclosed. Such methods may comprise: preparing the combination table for use; preparing the client so the client is laying on top of an upper surface of the combination table; and massaging the client while the client at least intermittently engages one or more resistance bands that are attached to the combination table; wherein in the at least intermittent engagement of the one or more resistance bands while the client is being massaged results in the at least one improved health benefit to the client.

A training apparatus with adjustable travel distance includes a base frame including a pair of guide rails extending along a transverse axis, a pair of sliding units each including a pedal coupled to and slidable along one respective guide rail and a stopper located on one lateral side of the pedal, and a pair of travel distance adjusting units each including a guiding member mounted in the base frame and extending along the transverse axis and a rear position-limiting member mounted on the guiding member for stopping against the stopper of one respective pedal and position adjustable relative to the guiding member along the transverse axis to adjust the travel distance of the respective pedal.

A group of tertiary amine azides are useful as hypergolic fuels for hypergolic bipropellant mixtures. The fuels provide higher density impulses than monomethyl hydrazine (MMH) but are less toxic and have lower vapor pressures that MMH. In addition, the fuels have shorter ignition delay times than dimethylaminoethylazide (DMAZ) and other potential reduced toxicity replacements for MMH.

Compositions and methods relating to gas generants used in inflatable restraint systems. The gas generant grains formed via spray drying techniques of the present disclosure provide superior performance, including high burn rates and high gas yields. Further, processing of the gas generant grain products can be streamlined. Such gas generants include by way of non-limiting example, guanidine nitrate, basic copper nitrate, and a secondary oxidizer, such as potassium perchlorate.

A composition capable of producing either solid propellant grains, liquid or gel monopropellants, all of which are electrically ignitable and capable of sustained controllable combustion at ambient pressure. Additional compositions capable of sustained controllable combustion at elevated pressures are described. Applications for the compositions disclosed herein are provided, and include among other applications use in small micro thrusters, large core-burning solid propellant gains, shaped explosives charges for military application, and pumpable liquids and gel monopropellants or explosives for military, commercial mining or gas and oil recovery. In alternative embodiments the above compositions may also incorporate an energetic nitrate polymer, bum rate modifiers, and/or metal fuel(s). The HIPEP formulation makes it possible to ignite and sustain combustion at ambient and vacuum conditions (a) without continuous electrical power and (b) while providing faster bum rates.

Disclosed is a high performance hydrocarbon fuel characterized by a hydrogen content greater than 14.3% by weight, a hydrogen to carbon atomic ratio greater than 2.0 and/or a heat of combustion greater than 18.7 KBtu/lb. The disclosed fuels generally have a paraffin content that is at least 90% by mass and a C12-C20 isoparaffin content of at least 40% by mass.

A household appliance (100) comprises a cabinet (105) accommodating a drum for loading items to be dried and a drying air circuit for circulating drying air through the drum for drying the items therein. The drying air circuit comprises air heating elements (415) for heating the drying air fed to the drum, and the cabinet is provided with a worktop (110) defining a surface (130) having a plurality of apertures (135) in fluid communication with an air conveying system (205,225,230) adapted to deliver a flow of air through said apertures. The air conveying system comprises an air duct (230) thermally coupled to the air heating elements in such a way as to cause heat generated by the air heating elements to heat the air to be delivered through the apertures in the drying surface.

A heating appliance including a metal substrate, at least a part of which is covered with a self-cleaning coating including at least one oxidation catalyst selected from the platinoid oxides, and at least one dopant of said oxidation catalyst selected from the rare-earth oxides. The self-cleaning coating is a bilayer coating including: an inner layer at least partially covering the metal substrate and including the dopant; and an outer layer in contact with the ambient air and including the oxidation catalyst. Also provided is a method for producing such a heating appliance.

A system and method for using color to indicate a state of a home appliance, such as an iron. The iron has a sole plate and a water tank in fluid communication with the sole plate, a heater for heating the sole plate, a sensor for sensing a temperature of the sole plate, a user interface for setting a desired temperature for the sole plate, and a controller in communication with user interface and the sensor for controlling the heater. An illumination device under the control of the controller is provided to illuminate the water tank, particularly the interior thereof, in a color that is representative of a state of the iron, such as a power condition of the iron and/or a temperature of the sole plate.

Appliances, methods and systems in which steam can be applied to a fabric and a heated surface can be used to press and/or dry the fabric.

A work stopping apparatus according to this invention includes a swing unit pivotable about a first pivot shaft between an abutment position and a retracted position, and a driving unit pivoting the swing unit. The swing unit includes a swing portion and a movable portion including a work abutment portion. The movable portion is pivotable about a second pivot shaft parallel to the first pivot shaft. A distance between the first pivot shaft and the work abutment portion becomes short along with pivoting motion of the swing unit from the abutment position to the retracted position.

Devices, cartridges, and method are described herein for emulating smoking wherein a device generates an aerosol for inhalation by a subject by heating a viscous material that can have a tactile response in the mouth or respiratory tract, while reducing Hoffman analytes and mutagenic compounds delivered to the user as compared to a common tobacco cigarette.

A luminance controller according to example embodiments includes a gamma set selector to select a reference gamma set from among first through N-th gamma sets respectively corresponding to first through N-th reference luminances, based on a target luminance of a display panel; an initialization voltage selector to select an initialization voltage corresponding to the reference gamma set, from among first through N-th initialization voltage offsets respectively corresponding to the first through N-th gamma sets; a common voltage selector to select a common voltage corresponding to the reference gamma set from among first through N-th common voltage offsets respectively corresponding to the first through N-th gamma sets; and a determiner to determine a target initialization voltage based on the target luminance and the initialization voltage, and to determine a target common voltage based on the target luminance and the common voltage.

A portable folding support structure for safely tethering an individual comprises a portable cart sized to fit through a residential doorway, having wheels and a motor that actuates at least one of the wheels. A hand-operated throttle and steering device control the cart. The cart comprises an extendable anchoring plate to prevent rolling. A substantially horizontal jib with the cart comprises a harness point for receiving a safety cable to which an individual is attached to allow safe cleaning practices and to minimize fall risk. A foldable outrigger provides stability to the cart and an anchoring pad attaches to a distal region of the outrigger to promote stability. A textile liquid-absorbing surface is positionable about an outer surface of a glass balcony to inhibit cleaning liquids from spilling below the level of the liquid-absorbing surface.

Aspects of the invention relate to a roof comprising at least an inclined surface and a rim marking a transition to another surface extending horizontally or at a different inclination, the inclined surface and the rim being covered by roof elements. The roof further comprising at least one anchor for attaching an anchor rope to. The anchor is secured to the roof beneath the roof element or elements covering the rim and the roof elements covering the rim are spaced apart from the roof elements covering the inclined surface so as to allow access to the anchor from outside the roof.

A safety line anchor system is provided and includes an elongate member including a threaded stud at one end for threading the member on to a threaded opening in a trench plate, a flange fixed to the stud end of the member above the stud base, the flange having two or more openings provided there through for accepting two or more stabilization bolts, a freely rotable platform attached to the end of the elongate member opposite the stud end, the platform including two or more slots cut there through for accepting safety line attachments, and a crane handle fixed to the rotable platform, the crane handle for accepting a crane hook.

A load balancing descending device for controlling the descent of a user descending on a rope carrying a load is provided. The rope has a decreasing rope free end as the user descends. The load balancing descending device comprises a first plate and a second plate. A first pin is positioned between the first plate and the second plate with the first pin spacing the first plate from and pivotally connecting the first plate to the second plate and the combined first plate and second plate having a first side and a second side. A second pin is positioned between the first plate and the second plate with the second pin spaced from the first pin. An attachment mechanism is formed in the first side of the combined first plate and second plate for attaching a user and/or load. The rope is wrapped in a serpentine manner about the first pin and the second pin between the first plate and the second plate with the rope free end exiting the combined first plate and second plate from the second side. As the user descends the rope, the length and weight of the rope free end decreases thereby causing the load balancing descending device to rotate moving the rope free end in a general direction from the first side toward the second side and automatically balancing the weight of the user and load against the weight of the rope free end in order to maintain a controlled rate of descent.

This maintenance trolley (17) for the air intake (9) of the nacelle of an aircraft turbojet engine is notable in that it comprises a base (19) and a platform (23) cantilever-mounted on this base (19) and designed to enter said air intake (9) without contact therewith.

Apparatus and methods are disclosed, such as a method that includes precharging channel material of a string of memory cells in an unselected sub-block of a block of memory cells to a precharge voltage during a first portion of a programming operation. A programming voltage can then he applied to a selected memory cell in a selected sub-block of the block of memory cells during a second portion of the programming operation. The selected memory cell is coupled to a same access line as an unselected memory cell in the unselected sub-block. Additional methods and apparatus are disclosed.

In one embodiment, a server of a first wireless communication network receives a wireless communication originated by a terminal of the first wireless communication network, the wireless communication containing a current geographic location of the terminal as determined by the terminal. The server may then determine acceptable communication parameters for the terminal to communicate on the first wireless communication network, e.g., based on preventing transmission by the terminal that might interfere with operation of one or more unintended receivers. The server then generates an instruction message for the terminal based on the acceptable communication parameters, and transmits the instruction message toward the terminal to cause the terminal to only continue transmitting according to acceptable communication parameters.

In one embodiment, a device of a first wireless communication network determines a link budget from a terminal in the first communication network to an unintended receiver for a communication from the terminal to an intended receiver in the first wireless communication network, based on the communication being configured with initial communication parameters. The device also determines whether one or more adjusted communication parameters would result in reducing a received power at the unintended receiver being below a link budget threshold, while still satisfying a receive sensitivity of the intended receiver. If so, the device causes the terminal to transmit the communication using the adjusted communication parameters. In one embodiment, the device is the terminal, and causing comprises transmitting as the terminal. In another embodiment, the device is a server of the first communication network, and causing comprises instructing the terminal to transmit the communication using the adjusted communication parameters.

A technique for emulating virtual port control of airtime fairness for wireless stations using per station Enhanced Distributed Channel Access (EDCA) parameters. Specific parameters are received for each of a plurality of stations connected to the access point. An EDCA field of a beacon that stores a general EDCA parameter is set to an empty state. The beacon is broadcast to a plurality stations on the wireless communication network and within range of an access point. The beacon comprises a BSSID (Basic Service Set Identifier) for use by the plurality of stations to connect with the access point for access to the wireless communication network. The beacon also comprises an empty EDCA field. In response to broadcasting the empty EDCA parameter, receiving a direct inquiry from each of the plurality of stations for the general EDCA parameter. Each of the plurality of stations is responded to with a direct communication of a specific parameter corresponding to each station. A transmission is received from at least one of the stations complying with the specific parameter.

The sensing method a first vehicle user equipment (UE) for collision avoidance in a wireless communication network comprises receiving a set of scheduling assignment (SA) information allocated to a set of second vehicle UEs, decoding the set of SA information, each of which includes SA information to each of the set of second vehicle UEs, performing energy sensing operation for resources to be used by each of the set of second vehicle UEs to determine additional potential SA transmission and data transmission from the set of second vehicle UEs over the resources, determining available resources for the data transmission from the first vehicle UE based on the performed energy sensing and SA sensing, skipping a channel sensing operation on at least one subframe that is used for the data transmission from the first vehicle UE, and transmitting data among resources identified as unused in next transmissions from second vehicle UEs.

A remote maintenance system includes a maintenance management apparatus connected to a user apparatus and a communication relay apparatus connected to a remote-controlled apparatus. The maintenance management apparatus transmits, to the communication relay apparatus, message data whose destination is unique identification information of a mobile communication network assigned in advance to the communication relay apparatus. The communication relay apparatus notifies the maintenance management apparatus of an IP address that is dynamically assigned to itself upon reception of the message data. The maintenance management apparatus transmits, to the communication relay apparatus, information on remote operation received from the user apparatus whose destination is the notified IP address. The communication relay apparatus relays, to the remote-controlled apparatus, the information on the remote control received from the maintenance management apparatus.

A tool for measuring, marking, or cutting material, the tool formed of a rigid sheet of transparent material having a plurality of lines formed thereon, and a plurality of windows formed in the lines to enable viewing of material underlying the tool. The windows can be outlined in opaque lines, and alternating windows can be filled with contrasting transparent colors.

The present invention is directed to a system of devices and a method for preparing a tooth to receive a restoration. The system includes a dental instrument for removal of portions of a tooth in the mouth of a patent and an overlay for guiding the dental instrument during the step of tooth removal. The overlay is designed for temporary installation into the mouth of the patient to guide the dental instrument to remove tooth material. The overlay has one or more sets of guide walls, with a predetermined configuration capable of contacting one or more guide projections of the dental instrument, and a receptacle capable of receiving and attaching to the dental instrument.