Andy Murray's sensational year comes to a fitting conclusion today with a knighthood in the New Year's honours list – but he insists he doesn't want to be called 'Sir Andy'.

This curry is one of our most-loved vegan dishes when we do food events - people always come back for more. It's a great-tasting, one-pot meal that could also be eaten with rice to make it go further

Jenni Murray has hosted BBC Woman's Hour at the BBC's studios throughout the coronavirus crisis but will have to start doing so at home once she turns 70 because she will be classified vulnerable.

PETE JENSON: A neutral evaluation of Jose Mourinho's career would probably conclude that his finest hour came in 2010 when he guided Inter Milan to their first European Cup in 45 years.

The Premier League will consider relegating the bottom three clubs based on current league position if there is no resumption to the 2019/20 season.

Schools are meant for making better citizens out of our children but in the Dewas district of Madhya Pradesh, they are forging and reinforcing caste-bondages instead. Inclusive education seems a far cry in the villages of Dewas, reports Shuriah Niazi.

New ideas and initiatives are emerging from the liaison between the press and the advertisers. Advertorials and advertising features are manifestations of this relationship, says Deepti Mahajan.

Maoist surrenders have seen a quantum jump this year, with 472 surrenders being reported until October 31 against 283 for the whole of 2013.

Ayushmann Khurrana has teamed up with his friend and composer Rochak Kohli for a special song titled 'Ma' dedicated to all the hardworking mothers.

Honda is planning to sell the outgoing Honda City sedan alongside the new models at the same time. This news was confirmed according to a report by Autocar India. Moreover, the new Honda City is likely to get a suffix in

In a recent report, Andhra Pradesh has confirmed the death of two coronavirus patients who had no travel history. The Andhra Pradesh Police reported that the virus spread through currency notes, where it turned out to be the ‘culprit' carrying the

Archives, Room Use Only - TK9956.E77 1911

Archives, Room Use Only - TK5275.F54 1927

Archives, Room Use Only - TK5543.M87 1911

If it's not a good year to have a young quarterback because of the lack of on-field work this offseason, the Bengals are in trouble. Their oldest quarterback is Ryan Finley, who is 25. Their most experienced quarterback is Finley, who had three starts, no wins and 87 attempts as a rookie. The Bengals released [more]

Ayushmann Khurrana all set to release a dedication to 'Ma' on Mot...

Ayushmann Khurrana unveiled his song 'Ma', a soothing tribute to all the mothers out there celebrating the day

Earthquake strikes Sussex/Surrey border | Meridian - ITV News  ITV News

'Surrey swarm' quakes 'not caused by oil extraction'  BBC News

'Surrey swarm' earthquakes not caused by nearby oil extraction, study suggests  Science Daily

Surrey named as one of the UK's earthquake hotspots  Surrey Live

Protein-engineering methods have been exploited to produce a surrogate system for the extracellular neurotransmitter-binding site of a heteromeric human ligand-gated ion channel, the glycine receptor. This approach circumvents two major issues: the inherent experimental difficulties in working with a membrane-bound ion channel and the complication that a heteromeric assembly is necessary to create a key, physiologically relevant binding site. Residues that form the orthosteric site in a highly stable ortholog, acetylcholine-binding protein, were selected for substitution. Recombinant proteins were prepared and characterized in stepwise fashion exploiting a range of biophysical techniques, including X-ray crystallography, married to the use of selected chemical probes. The decision making and development of the surrogate, which is termed a glycine-binding protein, are described, and comparisons are provided with wild-type and homomeric systems that establish features of molecular recognition in the binding site and the confidence that the system is suited for use in early-stage drug discovery targeting a heteromeric α/β glycine receptor.

Over 170 molecules have been detected in space, from simple diatomic molecules like CO to complex organic molecules with over 70 atoms, such as fullerene. […]

The post Astronomers explore the rich chemistry surrounding an evolved star appeared first on Smithsonian Insider.

Suzan Murray, chief veterinary medical officer at the Smithsonian’s National Zoological Park, recently returned from Hanoi, where she led a team of scientists training pathologists from Laos, Cambodia and Vietnam to better sample, recognize and detect wildlife diseases in hopes of preventing emerging pandemic disease.

The post Q&A: National Zoo veterinarian Suzan Murray is working to halt pandemic disease in hotspots around the world appeared first on Smithsonian Insider.

stronomers have used NASA's Chandra X-ray Observatory to find evidence our Milky Way Galaxy is embedded in an enormous halo of hot gas that extends for hundreds of thousands of light years.

The post Chandra X-ray Observatory shows Milky Way is surrounded by halo of hot gas appeared first on Smithsonian Insider.

With roughly 5,500 individuals remaining in the wild, the black rhino population is critically endangered. To help save these iconic African giants, at risk for […]

The post A Planet in Peril: Q&A with Suzan Murray of the Smithsonian Global Health Program appeared first on Smithsonian Insider.

Eric Peterman, Mindaugas Valius, and Rytis Prekeris

During mitotic cell division, the actomyosin cytoskeleton undergoes several dynamic changes that play key roles in progression through mitosis. While the regulators of cytokinetic ring formation and contraction are well-established, proteins that regulate cortical stability during anaphase and telophase have been understudied. Here, we describe a role for CLIC4 in regulating actin and actin-regulators at the cortex and cytokinetic cleavage furrow during cytokinesis. We first describe CLIC4 as a new component of the cytokinetic cleavage furrow that is required for successful completion of mitotic cell division. We also demonstrate that CLIC4 regulates the remodeling of sub-plasma membrane actomyosin network within the furrow by recruiting MST4 kinase and regulating ezrin phosphorylation. This work identifies and characterizes new molecular players involved in regulating cortex stiffness and blebbing during late stages of cytokinetic furrowing.

Bipasha Dey and Richa Rikhy

Cell shape morphogenesis from spherical to polygonal occurs in epithelial cell formation in metazoan embryogenesis. In syncytial Drosophila embryos, the plasma membrane incompletely surrounds each nucleus and is organized as a polygonal epithelial-like array. Each cortical syncytial division cycle shows circular to polygonal plasma membrane transition along with furrow extension between adjacent nuclei from interphase to metaphase. In this study, we assess the relative contribution of DE-cadherin and Myosin II at the furrow for polygonal shape transition. We show that polygonality initiates during each cortical syncytial division cycle when the furrow extends from 4.75 to 5.75 µm. Polygon plasma membrane organization correlates with increased junctional tension, increased DE-cadherin and decreased Myosin II mobility. DE-cadherin regulates furrow length and polygonality. Decreased Myosin II activity allows for polygonality to occur at a lower length than controls. Increased Myosin II activity leads to loss of lateral furrow formation and complete disruption of polygonal shape transition. Our studies show that DE-cadherin-Myosin II balance regulates an optimal lateral membrane length during each syncytial cycle for polygonal shape transition.

Coral reefs are home to some of the most colorful, diverse life on the planet. And yet, for all their fame as biodiversity hotspots, it’s […]

The post Coral reef eavesdropping unveils burrowed, romantic male singers appeared first on Smithsonian Insider.

Canada-based digital transaction processor Carta Worldwide teamed with

Cancer-causing chemicals that occur naturally in foods are far more numerous in the human diet than synthetic carcinogens, yet both types are consumed at levels so low that they currently appear to pose little threat to human health, a committee of the National Research Council said in a report released today.

Despite being used for several decades, test-based incentives have not consistently generated positive effects on student achievement, says a new report from the National Research Council.

Research to date on the effect of capital punishment on homicide rates is not useful in determining whether the death penalty increases, decreases, or has no effect on these rates, says a new report from the National Research Council.

Educational and business leaders want todays students both to master school subjects and to excel in areas such as problem solving, critical thinking, and communication

Cardiac arrest strikes almost 600,000 people each year, killing the vast majority of those individuals, says a new report from the Institute of Medicine. Every year in the U.S., approximately 395,000 cases of cardiac arrest occur outside of a hospital setting, in which less than 6 percent survive.

A new report from the National Academies of Sciences, Engineering, and Medicine calls for an international, multi-institutional comprehensive campaign of research, observation, and analysis activities that would help improve understanding and prediction of the Gulf of Mexico’s Loop Current System (LCS).

The Gulf Research Program (GRP) of the National Academies of Sciences, Engineering, and Medicine today announced 11 grant awards totaling $341,283 to assist in the recovery of Gulf Coast scientific research efforts impacted by hurricanes Harvey and Irma.

A systemwide change to the culture and climate in higher education is needed to prevent and effectively respond to sexual harassment, says a new report from the National Academies of Sciences, Engineering, and Medicine.

The Gulf Research Program (GRP) of the National Academies of Sciences, Engineering, and Medicine today announced 11 grant awards totaling $287,565 to assist in the recovery of Gulf of Mexico region scientific research efforts impacted by hurricanes Harvey and Irma.

Following recommendations from a National Academies of Sciences, Engineering, and Medicine report released earlier this year, the National Academies’ Gulf Research Program (GRP) is developing a long-term research campaign to improve understanding and prediction of the Gulf of Mexico Loop Current System (LCS).

The Gulf Research Program (GRP) of the National Academies of Sciences, Engineering, and Medicine today announced a new funding opportunity to provide up to $2.5 million in grants to foster innovative approaches that support its ongoing efforts to improve understanding and prediction of the Gulf of Mexico Loop Current System (LCS).

Current evidence supports the classification of the contemporary red wolf as a distinct species of wolf, although additional genomic evidence from historic wolf specimens could change that assessment, says Evaluating the Taxonomic Status of the Mexican Gray Wolf and the Red Wolf, a new report from the National Academies of Sciences, Engineering, and Medicine.

A new report from the National Academies of Sciences, Engineering, and Medicine recommends ways to make supply chains -- the systems that provide populations with critical goods and services, such as food and water, gasoline, and pharmaceuticals and medical supplies – more resilient in the face of hurricanes and other disasters, drawing upon lessons learned from the 2017 hurricanes Harvey, Irma, and Maria.

The Gulf Research Program (GRP) of the National Academies of Sciences, Engineering, and Medicine today announced $2 million in grant awards for seven new projects through its Understanding Gulf Ocean Systems (UGOS) Grants 2 competition.

The opioid epidemic in the U.S. is driving a simultaneous epidemic of infectious diseases — including HIV, hepatitis C virus (HCV) and bacterial infections, and sexually transmitted infections — but workforce shortages, stigma, and financial and policy barriers are preventing the integration of opioid use disorder (OUD) and infectious disease services, says a new report from the National Academies of Sciences, Engineering, and Medicine.

; Credit: Kaba/Flickr

Tuesday's drought news makes you question whether waiting so long in the drive-thru line will continue to be worth it.

First, today's dryku:
Burger prices rise
Will we turn to other foods?
Burritos' do too

Food:

• Have you noticed the increased food prices at the grocery store? Well, now you're going to see it at your fast food joints too. In-N-Out and Chipotle are having to raise prices on their food. Starbucks has also.

In-N-Out raised the cost of its hamburgers and cheeseburgers by a dime and their famous Double-Double jumped 15 cents to $3.45. French fries were unchanged but soft drinks went up a nickel. (San Gabriel Valley Tribune)

Oil and Water:

• They don't mix, but they separate pretty well. The New York Times looks at how an oil field in the Central Valley also pumps 760,000 gallons of water each day that it sells to a local water district. Article goes on to look at the fight over water use in fracking. (NY Times)

Looting:

• The lowering water levels at Lake Oroville have revealed more prehistoric artifacts. Volunteers are helping rangers by keeping tabs on looters who are digging up the relics. My favorite factoid is about how meth heads are among the many culprits. Does smoking meth cause an uncontrollable digging impulse?

Though many who disturb artifacts may not know any better, others can be troublesome. Among them are insomniac "tweakers" high on methamphetamine. "They just dig and dig like little squirrels," Dobis said. (LA Times)

Witches:

• Dowsers have been the media darlings of the current drought year. Benjamin Radford pokes at the practice and points out why we should trust our suspicions about the water-finding trick. He also gives a history lesson about all the things dowsing has been used to find: water, oil, jewels, murderers... (Discovery)

Maps and charts:

• Finally, I leave you with Weather Underground's latest roundup of water statistics. This year is dry but not the worst on record. Reservoirs are still holding a decent amount of water, especially Pyramid Lake. What's up with that? I'm going to have to look into that. (Weather Underground)

And how has your community been affected by the drought? Share your story with a photo on Twitter or Instagram. Tag it #mydrought. For more details on our photo project, click here.

This content is from Southern California Public Radio. View the original story at SCPR.org.