led Canadian Blood Services discovery research lab contributes to new knowledge on neutrophils By www.blood.ca Published On :: Thu, 29 Aug 2024 14:37:37 +0000 Canadian Blood Services discovery research lab contributes to new knowledge on neutrophils Plasma Transfusion Blood Thursday, August 29, 2024 Abby Wolfe Dr. Donald R. Branch’s work as a discovery scientist at Canadian Blood Services focuses on immunotherapy, seeking to further enhance understanding of the cellular and molecular mechanisms involved in autoimmune diseases. Based in Toronto, Dr. Branch’s laboratory develops models of rheumatoid arthritis, Alzheimer’s disease, immune thrombocytopenia (ITP) and multiple sclerosis in mice. These models are particularly useful in examining how cells affected by these conditions respond to current therapeutic agents like intravenous immunoglobulin – a blood product made from human plasma commonly known as IVIg – and investigating potential alternative therapeutics. Over the years, Dr. Branch’s lab research findings have included the discovery of a special reagent that makes identification of antibodies easier by “zapping" autoantibodies, answers around unexpected side effects of IVIg therapy, and insights around recipients’ responses to bone marrow transplantation. It has also earned him numerous awards and accolades, including four from AABB, the Association for the Advancement of Blood & Biotherapies. Dr. Don Branch, Canadian Blood Services senior scientist New knowledge about neutrophils Recently, contributions from Dr. Branch’s lab helped a U.K.-based team of researchers discover new information about how neutrophil function and activity is regulated. Neutrophils are a type of white blood cell that are part of the body’s normal immune response. A person’s neutrophil levels may be affected by infections as well as chronic or acute illnesses. Patients who have very low neutrophil counts and/or persistent infections may receive a boost to their neutrophil levels via granulocyte transfusion therapy. However, in some diseases, overactivation of neutrophils can also create an inflammatory environment and harm healthy tissue. The research has been published in the high-impact scientific journal, Nature. This publication has filled a gap in knowledge about the mechanisms involved in maintaining balance between neutrophils’ infection-fighting power and inflammation-causing potential. As Dr. Branch describes: “This research by Dr. Brown and team shows that the myeloid inhibitory C-type lectin enzyme, which is known as MICL, controls neutrophil activity in rheumatoid arthritis. It is likely that MICL also regulates neutrophil activity in general. This suggests that if therapeutics can be designed to target MICL, they may be useful in controlling inflammation and infection. It is a fundamental finding that will change our understanding of the biology of neutrophils.” Discovery research, like the study to which Don and Ruqayyah contributed, is essential to improving patient care in the long run. New biomedical insights are essential to crafting new drugs and new therapeutic approaches in a rational way. Dr. William (Bill) Sheffield, Canadian Blood Services senior scientist and associate director of research Discovery research expertise leads to new collaboration The special mouse model that Dr. Branch’s lab uses is known as K/BxN. In this model, two mouse populations are selectively bred to produce offspring whose genetic material carry an antibody that destroys bone cartilage. An arthritis-causing serum containing this destructive antibody can then be obtained from the mice for use as a reagent in research. This process is termed “serum-transfer arthritis” and has been used by many investigators in the study of treatments that may alleviate the condition. Knowledge of Dr. Branch’s lab’s expertise in this area prompted a connection to the team of researchers at the Universities of Exeter and Aberdeen in the U.K. for this study. Says Dr. Branch, “In 2021, I supported a successful application to Canadian Blood Services’ Blood Efficiency Accelerator Program (BEAP) by Dr. Maria Fernandes, a researcher from Héma-Québec who works with neutrophils. Through this collaboration, Dr. Fernandes was aware that I work on rheumatoid arthritis with K/BxN mice, and she also knew that Dr. Gordon Brown in the U.K. was looking to collaborate with a researcher in this area for some planned neutrophil research. My lab, which included postdoctoral fellow Dr. Ruqayyah Almizraq at the time, contributed to Dr. Brown’s research by providing the sera from our K/BxN mice. With this sera, Dr. Brown and his collaborators were able to induce rheumatoid arthritis and show that it could be resolved by removing the inhibition of a specific enzyme.” Science that is never boring The Branch lab is currently using these same mouse models to investigate whether a recombinant protein called IgG1 Fc hexamer could be an effective replacement for IVIg in the treatment of autoimmune conditions like rheumatoid arthritis and ITP. While early results are promising, continued work is needed. In fact, back in 2018, Dr. Branch was asked in a previous R.E.D. blog post to describe what he found to be the most exciting part of science. Reflecting on the same question now, he reiterates that his response still rings true after 50 years in the field: The most exciting part of science is that when you do good science, you get more questions than you get answers, which means it is never boring. There is no end to imagination; new ideas, theories, experiments and discoveries occur often and provide a level of excitement to which many other professions cannot attest. Dr. Donald (Don) Branch, Canadian Blood Services senior scientist Canadian Blood Services – Driving world-class innovation Through discovery, development and applied research, Canadian Blood Services drives world-class innovation in blood transfusion, cellular therapy and transplantation—bringing clarity and insight to an increasingly complex healthcare future. Our dedicated research team and extended network of partners engage in exploratory and applied research to create new knowledge, inform and enhance best practices, contribute to the development of new services and technologies, and build capacity through training and collaboration. Find out more about our research impact. The opinions reflected in this post are those of the author and do not necessarily reflect the opinions of Canadian Blood Services nor do they reflect the views of Health Canada or any other funding agency. Related blog posts Senior scientist wins prestigious award for discovering a ‘gold standard’ reagent used in transfusion medicine Tuesday, March 28, 2023 Aldis Brennan Dr. Donald Branch, Canadian Blood Services senior scientist, has received the Dale A. Smith Memorial Award for his discovery of the ZZAP reagent. This award, from the Association for the Advancement of Blood & Biotherapies (AABB), recognizes the application of technology to the practice of transfusion medicine or biotherapies. Transfusion Blood Read full story, Senior scientist wins prestigious award for discovering a ‘gold standard’ reagent used in transfusion medicine Interactive lab tour helps undergraduate students learn from Canadian Blood Services senior scientist and team Thursday, March 16, 2023 Beth Binnington, Senior Research Assistant Students from the Undergraduate Pathology Alliance at Western University posed insightful questions to researchers during an interactive visit to the research laboratory of Dr. Donald Branch, Canadian Blood Services senior scientist in February 2023. Plasma Transfusion Blood Read full story, Interactive lab tour helps undergraduate students learn from Canadian Blood Services senior scientist and team Meet the researcher: Dr. Donald Branch Wednesday, February 28, 2018 Dr. Kendra Hodgkinson For this instalment of “Meet the researcher”, we met with Dr. Donald Branch, a scientist at Canadian Blood Services who studies infectious diseases and immunology. How long have you been with Canadian Blood Services? I started with the Canadian Red Cross at the Edmonton Blood Centre in December 1985... Plasma Transfusion Blood Read full story, Meet the researcher: Dr. Donald Branch Full Article
led Teledyne Acquires Electronics Company Micropac Industries By www.defensedaily.com Published On :: Mon, 04 Nov 2024 20:54:34 +0000 Teledyne Technologies [TDY] on Monday said it has acquired Micropac Industries [MPAD] in a $57.3 million deal that adds electronic components used in space, military, industrial, and medical applications. The […] Full Article Business/Financial highlights
led Teledyne To Acquire Two Acquire Two Aerospace And Defense Businesses From Excelitas By www.defensedaily.com Published On :: Wed, 06 Nov 2024 21:44:18 +0000 Teledyne Technologies [TDY] on Wednesday said it has agreed to acquire two business units from Excelitas Technologies Corp. for $710 million in cash, one based in the United Kingdom that […] Full Article Business/Financial International highlights
led Bridging the Skilled Trades Gap to Accelerate the Energy Transition By www.achrnews.com Published On :: Tue, 08 Oct 2024 13:00:00 -0400 In the midst of a historic energy transition, the HVAC is facing a workforce shortage, and it needs to get creative to find solutions. Full Article
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led HVAC Manufacturers turn to Voice Controlled Comfort By www.achrnews.com Published On :: Mon, 30 Apr 2018 07:33:00 -0400 Technology is redefining how consumers control their homes. That includes everything from lighting to mood music to heating and air conditioning. Full Article
led A Capital Cost and Energy Saving Approach to Chilled Water HVAC with Zero Emissions Potential By www.achrnews.com Published On :: Fri, 09 Aug 2024 14:00:00 -0400 The proposed new approach to chilled water HVAC systems promises to provide significant capital cost savings, energy cost savings, and a path to eliminate CO2 emissions. Full Article
led Hacking the Edges of Knowledge: LLMs, Vulnerabilities, and the Quest for Understanding By seclists.org Published On :: Sat, 02 Nov 2024 18:10:19 GMT Posted by Dave Aitel via Dailydave on Nov 02[image: image.png] It's impossible not to notice that we live in an age of technological wonders, stretching back to the primitive hominids who dared to ask "Why?" but also continually accelerating and pulling everything apart while it does, in the exact same manner as the Universe at large. It is why all the hackers you know are invested so heavily in Deep Learning right now, as if someone got on a megaphone at Chaos... Full Article
led Episode 388: Bob Kepford on Decoupled Content Management Systems By traffic.libsyn.com Published On :: Tue, 12 Nov 2019 19:06:58 +0000 Bob Kepford discusses Decoupled CMS. Many CMS practitioners are adopting a decoupled approach to improve scale, allow for more specialized roles, and to separate data collection from delivery. Host Jeff Doolittle spoke with Kepford about what makes a Decoupled CMS different. Full Article
led SE Radio 623: Michael J. Freedman on TimescaleDB By se-radio.net Published On :: Wed, 03 Jul 2024 00:04:00 +0000 Michael J. Freedman, the Robert E. Kahn Professor in the Computer Science Department at Princeton University, as well as the co-founder and CTO of Timescale, spoke with SE Radio host Gavin Henry about TimescaleDB. They revisit what time series data means in 2024, the history of TimescaleDB, how it integrates with PostgreSQL, and they take the listeners through a complete setup. Freedman discusses the types of data well-suited for a timeseries database, the types of sectors that have these requirements, why PostgreSQL is the best, Pg callbacks, Pg hooks, C programming, Rust, their open source contributions and projects, data volumes, column-data, indexes, backups, why it is common to have one table for your timeseries data, when not to use timescaledb, IoT data formats, Pg indexes, how Pg works without timescaledb, sharding, and how to manage your upgrades if not using Timescale Cloud. Brought to you by IEEE Computer Society and IEEE Software magazine. Full Article
led What’s Next for Bangladesh’s Student-Led Revolution? By www.yesmagazine.org Published On :: Wed, 21 Aug 2024 21:25:27 +0000 A Bangladesh-born labor explores the South Asian nation’s prospects to transition to a stable democracy now that the dust has settled from Prime Minister Sheikh Hasina’s ouster. Full Article Democracy Social Justice Activism YES! Presents: Rising Up with Sonali Student Activism Bangladesh
led 'Incredibly special' - Mary Earps makes history as new waxwork is revealed By www.bbc.com Published On :: Mon, 11 Nov 2024 13:07:35 GMT Nope you're not seeing double! Take a look at the new wax figure of Mary Earps at Madame Tussauds. Full Article
led Watch Newsround - signed and subtitled By www.bbc.com Published On :: Tue, 12 Nov 2024 12:01:22 GMT A signed version of Newsround is available to watch every weekday for children who use British Sign Language. Full Article
led Five power quality devices that every commercial plant must have installed By electrical-engineering-portal.com Published On :: Mon, 20 Apr 2020 06:36:53 +0000 Nowadays everybody speaks about power quality. For many reasons, I would say. Electrical energy is now polluted more than ever, and consumers are more sensitive to power disruptions and fluctuations than a small flower to the stronger wind. But, it... Read more The post Five power quality devices that every commercial plant must have installed appeared first on EEP - Electrical Engineering Portal. Full Article Energy and Power Power Quality Protection automatic transfer switch backup generator isolation transformer power quality power source surge protection surge protection device ups utility source voltage regulators
led Practical design knowledge in harmonics distortion and power factor correction (PFC) By electrical-engineering-portal.com Published On :: Mon, 30 Aug 2021 06:42:26 +0000 Nowadays, if you do not consider harmonics distortion when designing a new network, you missed the whole point of the network design. Yes, really. The sooner you realize that harmonics problems are on the rise, the better. Modern power networks... Read more The post Practical design knowledge in harmonics distortion and power factor correction (PFC) appeared first on EEP - Electrical Engineering Portal. Full Article Low Voltage Medium Voltage Power Quality Power Substation 3rd harmonic 5th harmonic 7th harmonic capacitor current transformer detuning even harmonics harmonics harmonics distortion harmonics level non-linear loads odd harmonics pfc system power factor correction rectifier resonance resonant frequency total harmonic distortion transformer variable-speed drives
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led The Future of MOS-Controlled Thyristor (MCT) By electrical-engineering-portal.com Published On :: Tue, 01 Jan 2013 10:17:22 +0000 The MCT is type of power semiconductor device that combines the capabilities of thyristor voltage and current with MOS gated turn-on and turn-off. It is a high power, high frequency, low conduction drop and a rugged device, which is more... Read more The post The Future of MOS-Controlled Thyristor (MCT) appeared first on EEP - Electrical Engineering Portal. Full Article Electronics high power igbt mct mos-controlled thyristor semiconductor silicon silicon carbide
led A detailed checklist for the installation and commissioning of Gas-Insulated Substations (GIS) By electrical-engineering-portal.com Published On :: Mon, 17 Jul 2023 05:41:49 +0000 Gas-insulated substations (GIS) are critical components of modern electrical power systems, providing efficient and compact solutions for the transmission and distribution of electricity. These substations utilize sulfur hexafluoride (SF6) gas as an insulating and arc-quenching medium, offering several advantages over... Read more The post A detailed checklist for the installation and commissioning of Gas-Insulated Substations (GIS) appeared first on EEP - Electrical Engineering Portal. Full Article Maintenance Power Substation Premium Content Testing and Commissioning color coding contact resistance test control cabinet wiring electrical tests gas handling gas insulated substation gas leak testing gas pressure gis gis drawing inspections and tests interlock schemes interlocking mechanical interlocking proper wiring schematic drawing review sf6 testing procedures thorough installation verification
led The “Cost of Doing Business” study unveiled by KnowHow and the R.I.A By www.randrmagonline.com Published On :: Thu, 19 Sep 2024 14:30:00 -0400 Just in time for 2025 planning, KnowHow and the R.I.A. reveal their “Cost of Doing Business” Study, an extensive look at all facets of successfully running a restoration business, examining the best (and worst) factors to move your company forward today! Full Article
led Financial knowledge & portfolio complexity in Singapore By soundcloud.com Published On :: Fri, 14 Feb 2020 01:43:42 +0000 Financial literacy in Singapore has not been analysed in much detail, despite the fact that this is one of the world’s most rapidly aging nations. In this podcast, Professor of Finance Benedict Koh from the SMU Lee Kong Chian School of Business, discusses the key findings of his research jointly conducted with Olivia Mitchell from the University of Pennsylvania and Susann Rohwedder, Senior Economist at the RAND Corporation and Associate Director of the RAND Center for the Study of Aging. Using a unique new data-set and nationally representative survey - the Singapore Life Panel, they conducted an analysis of older Singaporeans’ financial literacy. Here, Professor Koh discusses his key findings, including: Do older Singaporeans score better on financial knowledge compared to their counterparts in the United States? What are the empirical linkages between financial literacy and retirement preparedness in Singapore? And is financial literacy positively associated with greater wealth and diversity of portfolios? Full Article
led How climate killed corals By blogs.agu.org Published On :: Mon, 18 May 2020 15:11:58 +0000 New study shows multiple factors joined forces to devastate the Great Barrier Reef in 2016. The post How climate killed corals appeared first on GeoSpace. Full Article Geophysical Research Letters climate climate change coral coral bleaching coral reef corals featured global warming Great Barrier Reef ocean science weather
led PepsiCo to Debut Coffee-Cola Called Pepsi Cafe By www.packagingstrategies.com Published On :: Mon, 06 Jan 2020 00:00:00 -0500 Pepsi Cafe will come in two flavors: original and vanilla. The coffee-infused cola beverage has nearly twice as much caffeine as regular Pepsi. Full Article
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led Sun Chemical Showcases UV-LED Printing Solutions at BOBST Grand Opening Event By www.packagingstrategies.com Published On :: Wed, 09 Oct 2024 16:38:04 -0400 Sun Chemical’s SolarWave Integra and SolarWave FSP are both UV-LED curing ink solutions designed to meet diverse printing needs. Full Article
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led Graduation Caps, Gowns Made of Recycled Coca-Cola Bottles By www.packagingstrategies.com Published On :: Wed, 01 May 2019 00:00:00 -0400 Graduates of the 2020 high school class in Atlanta, Georgia, are going to be wearing their graduation garb made of recycled plastic bottles. Coca-Cola began collecting plastic bottles at its headquarters as part of Earth Day activities. The goal is to gather 7,000 bottles, enough to make graduation outfits for 200 graduates. Full Article
led California Requires Plastic Beverage Containers to Contain 15% Recycled Plastic by 2022 By www.packagingstrategies.com Published On :: Tue, 29 Sep 2020 00:00:00 -0400 California passes first-in-the-nation law requiring plastic beverage containers to contain an increasing amount of recycled material — 15% by 2022. Full Article
led Winpak Collaborates with NOVA to Utilize Recycled PE in Flexible Packaging By www.packagingstrategies.com Published On :: Mon, 04 Nov 2024 00:00:28 -0500 Winpak will utilize NOVA’s recycled polyethylene (rPE) to manufacture and distribute high-quality packaging materials for the protection of perishable foods, beverages, and personal care products. Full Article
led METTLER TOLEDO Product Inspection Opens Headquarters of the Americas By www.packagingstrategies.com Published On :: Fri, 03 Aug 2018 00:00:00 -0400 The new 265,000 sq. ft. of office and manufacturing space is the new Product Inspection Headquarters of the Americas, and houses all of the Product Inspection business units. Full Article
led EnvyPak Envelopes Mailed at Lower Rate Without Affixed Label By www.packagingstrategies.com Published On :: Mon, 27 Aug 2018 00:00:00 -0400 EnvyPak received a new ruling from the United States Postal Service that provides lower automation letter rates for a specially formatted, poly envelope that now doesn't require an affixed mailing label, can be sealed with glue applied by lettershops and is fully machine-insertable. Full Article
led Tetra Pak and Lactalis Develop Carton Made of Recycled Polymers By www.packagingstrategies.com Published On :: Thu, 31 Oct 2024 15:15:28 -0400 This material has been certified by ISCC PLUS as originating from the recycling process of used beverage cartons in Spain and is allocated to the package based on a mass balance attribution method. Full Article
led Mondelēz partners with Amcor to use recycled packaging for Cadbury sharing bars By www.packagingstrategies.com Published On :: Wed, 06 Nov 2024 00:00:00 -0500 Sold in the UK and Ireland, the Cadbury core sharing bars will be wrapped in 80% certified recycled plastic packaging, which can be attributed to plastic sourced from advanced recycling technology. Full Article
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led METTLER TOLEDO will host an informational Educational Center at 2015 PROCESS EXPO By www.packagingstrategies.com Published On :: Mon, 29 Jun 2015 00:00:00 -0400 METTLER TOLEDO has invited experts from BRC, SQF, IFS, and FSSC22000 to join food safety experts from METTLER TOLEDO to discuss their latest updates and address a wide range of other food safety topics. Full Article
led Amcor Capsules touts recycled tin in capsules for wine, spirits and sparkling foils By www.packagingstrategies.com Published On :: Wed, 08 May 2024 00:00:00 -0400 The strategic move away from primary content and toward recycled tin helps Amcor Capsules deliver its vision for a more responsible wine and spirits packaging industry. Full Article
led Shurtape Adds rPET Recycled Packaging Tapes to Its Sustainable Products LineUp By www.packagingstrategies.com Published On :: Mon, 05 Aug 2024 00:00:00 -0400 Made with 90% post-consumer recycled PET film, the new tapes offer a way to dramatically reduce the use of virgin plastics in case sealing operations. Full Article
led Greif Launches Recycled, Recyclable Barrier-Coated Paperboard for Food Industry By www.packagingstrategies.com Published On :: Tue, 05 Nov 2024 12:04:45 -0500 The coating is applied directly inline, eliminating the need for a separate offline coating process. Full Article
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