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Two youngsters from Kochi determined to smash their disabilities on the badminton court

Atul Krishna and Jyothish Kumar defy physical limitations to excel in badminton, inspiring with their determination and talent.




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State affected due to lack of support from Centre during disasters: Kerala CM

Union government’s attitude reflects a desire for Kerala to suffer, says Pinarayi Vijayan




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Day 1 of Modi 3.0: PM signed file to release Kisan Nidhi, Cabinet approves 3 cr homes

PM Kisan Nidhi provides income support to 14.5 crore small and marginal farmers




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Disaster management Bill tabled in LS; Opposition says Bill encroaches on States’ jurisdiction

Centre asserts that there is no interference in the rights of the States as disaster management is the first responsibility of the States.




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Govt extends interest equalisation scheme for exporters till September 30

This extension aims to promote the country’s outbound shipments and provide exporters with interest benefits.




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TN: Textile industry seeks govt support for powerloom modernisation




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Data | In Andhra Pradesh, rich districts such as West Godavari and Visakhapatnam, performed poorly on social indicators

Rich districts featured at the bottom half when categorised on health and education related parameters




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A peep into the history of the Naval Coast Battery-Visakhapatnam

Used as a supply route during the Second World War, the Vizag coast became home to army camps and eventually, to safeguard India’s maritime interests following Chinese aggression, became the site for the Naval Coast Battery




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Sea kayaking coaching camp in Visakhapatnam

Sea kayaking coaching camp to be held in Rushikonda, Visakhapatnam, on October 12




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COP29 day 2 highlights: U.N. chief cautions world leaders, says ‘pay up or face climate-led disaster for humanity’

More than 75 leaders are expected in Baku over two days but the heads of some of the most powerful and polluting economies are not attending this year’s summit




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SAAP Chairman urges Chief Minister to re-allot land in Visakhapatnam

The land, meant for introducing water games, was used by former Chief Minister Y.S. Jagan Mohan Reddy for constructing a helipad for his palace, Ravi Naidu says




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On paper characterisation of droplet and evaporation study using impedance spectroscopy

Anal. Methods, 2024, Advance Article
DOI: 10.1039/D4AY00303A, Paper
O. Kare Siva Prakasam, Akashlina Basu, Koel Chaudhury, Soumen Das
A paper chip employs an impedance method to determine the characteristics of the droplet. We compare the traditional evaporation method with the electrical method to study the evaporation of various liquids.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Field method for preservation of total mercury in waters, including those associated with artisanal scale gold mining

Anal. Methods, 2024, Advance Article
DOI: 10.1039/D3AY02216A, Paper
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
David C. P. King, Michael J. Watts, Elliott M. Hamilton, Robert J. G. Mortimer, Mike Coffey, Odipo Osano, Maureene Auma Ondayo, Marcello Di Bonito
A method was developed for sampling and preserving total Hg from water samples, recovering >75% Hg over 4 weeks of storage. The method was assessed using water samples at artisanal gold mining sites in Kenya.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry




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How to Disable JavaScript in Almost Any Browser

In 2022 I think it’s still important as a web developer to test your how your websites look and function when users disable JavaScript in their browser. Developing in this way used to be a cornerstone of Progressive Enhancement and can be handy on both desktop or mobile.

I still find myself wanting disabling JavaScript on pages I visit. Sometimes it’s to test a page I’m working on, but in other instances it’s simply to visit a web page that’s not functioning correctly and I want to see if JavaScript is the culprit.

The post How to Disable JavaScript in Almost Any Browser appeared first on Impressive Webs.




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Lead optimisation of OXS007417: in vivo PK profile and hERG liability modulation to optimise a small molecule differentiation agent for the potential treatment of acute myeloid leukaemia

RSC Med. Chem., 2024, 15,3495-3506
DOI: 10.1039/D4MD00275J, Research Article
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Thomas J. Cogswell, Laia Josa-Culleré, David Zimmer, Sébastien R. G. Galan, Morgan Jay-Smith, Kate S. Harris, Carole J. R. Bataille, Thomas R. Jackson, Douzi Zhang, Stephen G. Davies, Paresh Vyas, Thomas A. Milne, Graham M. Wynne, Angela J. Russell
The optimisation of a class of AML differentiation agents is described to show improved potency, solubility and stability, reduced off target toxicity, and tumour regression in a murine model in vivo.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Discovery and optimisation of pyrazolo[1,5-a]pyrimidines as aryl hydrocarbon receptor antagonists

RSC Med. Chem., 2024, 15,3477-3484
DOI: 10.1039/D4MD00266K, Research Article
Raitis Bobrovs, Svetlana Terentjeva, Ninni Elise Olafsen, Zilvinas Dambrauskas, Antanas Gulbinas, Toivo Maimets, Indrek Teino, Aigars Jirgensons, Jason Matthews, Kristaps Jaudzems
The aryl hydrocarbon receptor (AHR) is a versatile ligand-dependent transcription factor involved in diverse biological processes, from metabolic adaptations to immune system regulation.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Property-based optimisation of PROTACs

RSC Med. Chem., 2024, Accepted Manuscript
DOI: 10.1039/D4MD00769G, Opinion
James Scott, Iacovos Michaelides, Markus Schade
PROTACs are an emerging therapeutic approach towards targeted protein degradation. This article examines the leading examples of this modality that are in clinical development through the prism of their physicochemical...
The content of this RSS Feed (c) The Royal Society of Chemistry




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A practical guide for the assay-dependent characterisation of irreversible inhibitors

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00707G, Review Article
Lavleen K. Mader, Jessica E. Borean, Jeffrey W. Keillor
Kinetic evaluations for assay dependent characterization of irreversible inhibitors.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Guidelines for green urbanisation

The Ministry of Urban Development has proposed environmental guidelines for construction projects in urban areas. Nidhi Adlakha reports




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Flat organisation believers: Can you imagine a world without managers?

What does a manager do that we keep hiring new ones or keep promoting more of them? Which managerial layer is the most important?




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CBSE disaffiliates 21 schools over ‘dummy admissions’




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Three arrested for raping intellectually disabled research scholar from Odisha




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Accessibility for disabled persons is a human and a fundamental right: SC judgment

The court asked the government to enable the creation of public and private spaces, services and products of an ‘universal design’ which could be accessed by everyone, regardless of their ability, age, or status




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Coming to grips with mega disasters

Rooted in research, the book reveals the existential threats we face and charts the roadmap ahead




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My Farm, a farm-to-table set-up in Visakhapatnam, is an example of responsible farming

Locally-grown vegetables find their way to My Farm, a farm-to-table set-up near Visakhapatnam, that adopts permaculture to promote sustainability as a way of life




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A natural farm from wasteland at Andhra University in Visakhapatnam

The Andhra University Avani Organics Gardening Hub in Visakhapatnam has grown into a thriving natural farm and is building a community of urban dwellers that is transforming a wasteland into a patch of green




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Rupee rises one paisa to close at 83.96 against U.S. dollar

At the interbank foreign exchange market, Rupee opened at 83.92 and finally settled for the day at 83.96 (provisional)




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Rupee rises 1 paisa to 83.95 against U.S. dollar

The Reserve Bank of India's (RBI) decision to keep policy rates unchanged also played a part in the rupee's range-bound movement




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Rupee slips 1 paisa to 84.07 against U.S. dollar in early trade

On Thursday, the rupee weakened by 4 paise to close at 84.06 against the U.S. dollar.




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Rupee gains 1 paisa to 84.06 against U.S. dollar in early trade

Sustained outflow of foreign funds and an upward momentum in the crude oil prices weighed on the local unit, forex traders said




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IndusInd Bank shares plunge 17%; Mcap erodes by ₹15,572 crore amid disappointing earnings

Total income rose to ₹14,871 crore in the quarter under review, from ₹13,530 crore in the same period a year ago, IndusInd Bank said in a regulatory filing




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Rupee opens on flat note, rises 1 paisa to 84.07 against U.S. dollar in early trade

The rupee rises slightly against dollar amid strong dollar and foreign fund outflows; RBI intervention expected to support local currency




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Rupee settles on flat note, rises 1 paisa to 84.07 against U.S. dollar

Meanwhile, the dollar index, which gauges the greenback's strength against a basket of six currencies, was trading 0.08% lower at 103.91




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Rupee rises 1 paisa to close at 84.10 against U.S. dollar

Rupee recovers slightly against U.S. dollar amid election uncertainty, FII outflows, and volatile global markets




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Free salon for persons with disabilities inaugurated in Vellore




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Hindu Tamil Thisai journalist Kalyanasundaram dies at 50




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BJP leader Tamilisai Soundararajan calls for ‘strong alliance of like-minded parties’ to defeat DMK in 2026

BJP’s Tamilisai Soundararajan says that it is not necessary that only parties with similar ideologies should form an alliance




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For the festive season, designers are working with artisans to create clothes with a conscience

As gifting and dressing up for the festive season begins, consumers are increasingly looking at sustainable, environment friendly choices



  • Life & Style

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Editorial. Little or no lessons learnt from natural disasters

Population as well as economic activities in vulnerable areas should be kept to a minimum. Yet, governments have promoted the opposite, including tourism




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Alone in the Abyss / directed by: Claudie Ottawa ; produced by: Manon Barbeau, Patricia Bergeron, Manon Barbeau, Yves Bisaillon, Ravida Din ; production agencies: Corporation Wapikoni mobile (Montreal), National Film Board of Canada (Montreal)

Montreal : National Film Board of Canada, 2018




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Master plan soon to develop Srisailam and tourism in Nallamala, says Andhra Pradesh Chief Minister Chandrababu Naidu

A committee comprising three Cabinet Ministers will be constituted for the purpose, says Chandrababu Naidu; he warns of severe action against those resorting to character assassination of women and children




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TDP leaders from Anantapur disappointed after being snubbed for nominated posts

Having swept all 14 Assembly seats and two MP seats in the undivided district, there were several contenders from the TDP and JSP for the nominated posts




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Srisailam temple witnesses high devotee influx amid Karthika Masam

Devotees are allowed darshan from 4.30 a.m. to 4 p.m. and from 5.30 p.m. to 11 p.m.




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Andhra Pradesh govt.. to deploy ‘kisan drones’ in agriculture sector this year

The drones would be mainly helpful in spraying fertilizer and pesticides, and said all villages in the State are targeted to be covered in three years, says Minister Atchannaidu




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Tackling learning disabilities head-on

With understanding, empathy, and evidence-based interventions, we can create an education system that truly leaves no child behind




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Canada ends fast-track visa programme for international students, Indians to be affected

From now on, students need to apply through the regular study permit stream, which accepts Guaranteed Investment Certificates as proof of financial support




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Schools disaffiliated by CBSE in Delhi continue functioning as usual; students, parents say they don’t know about the derecognition

The students from Classes 1 to 9 may not be directly impacted, those set to appear for their Board examinations may have little choice except to shift to another school in the middle of the year




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Will the end of SDS Visa derail Indian students’ Canadian dreams?

Canadian government discontinues SDS visa, impacting Indian students with longer processing times, higher fees, and complex procedures.




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Rupee falls 1 paisa to all-time low of 84.38 against U.S. dollar in early trade

Forex traders said the rupee is likely to remain under pressure unless there is a softening in the dollar index or a slowdown in foreign fund outflows




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Asian markets drop as Trump worries kick in after China disappoints