In this work, we consider a group of robots working together to manipulate a rigid object to track a desired trajectory in $SE(3)$. The robots have no explicit communication network among them, and they do no know the mass or friction properties of the object, or where they are attached to the object. However, we assume they share data from a common IMU placed arbitrarily on the object. To solve this problem, we propose a decentralized adaptive control scheme wherein each agent maintains and adapts its own estimate of the object parameters in order to track a reference trajectory. We present an analysis of the controller's behavior, and show that all closed-loop signals remain bounded, and that the system trajectory will almost always (except for initial conditions on a set of measure zero) converge to the desired trajectory. We study the proposed controller's performance using numerical simulations of a manipulation task in 3D, and with hardware experiments which demonstrate our algorithm on a planar manipulation task. These studies, taken together, demonstrate the effectiveness of the proposed controller even in the presence of numerous unmodelled effects, such as discretization errors and complex frictional interactions.

With all due respect to Greta Thunberg and Billie Eilish, nobody had a better 2019 than Baby Yoda. The real star of the Disney+ flagship Star Wars series The Mandalorian, the little green puppeteering/CGI marvel (aka "the Child") might be the most adorable creature ever created.…

A method for producing fatty acid alkyl esters from biolipids through transesterification and/or esterification reactions uses a flow-through cavitation device for generating cavitation bubbles in a fluidic reaction medium. The fluidic medium is passed through sequential compartments in the cavitation device having varying diameters and inner surface features to create localized reductions in fluid pressure thus vaporizing volatile alcohols and creating an increased surface area and optimized conditions for the reaction to occur at the gas-liquid interface around the bubbles.

This invention relates to an improved process for the preparation of green fatty acid methyl esters (FAME; commonly called as biodiesel) from different triglyceride oils using mixed metal oxides derived from layered double hydroxides (referred here as LDHs) as reusable solid heterogeneous base catalysts. This process uses very low alcohohoil molar ratio and catalyst and/or products are easily separable after the reaction through simple physical processes. The properties of thus obtained biodiesel meet the standard biodiesel values and can directly be used as transport fuel.

An elongated segmented soap bar is segmented longitudinally into a plurality of soap bodies separate and discrete from one another. Adjacent soap bodies are movable with respect to one another between at least two different configurations including at least an arc configuration with the plurality of soap bodies disposed in an arc. At least one coupler couples the plurality of soap bodies together to allow the adjacent soap bodies to move with respect to one another between the at least two different configurations.

The present invention relates to a method of making low colored bis(2-ethylhexyl) furan-2,5-dicarboxylate (BEHFD) plasticizer via mild hydrogenation of highly colored BEHFD.

A lead for providing electrical stimulation of patient tissue includes a distal lead element, at least two proximal lead elements, and a junction coupling the distal lead element to each of the at least two proximal lead elements. The distal lead element includes a plurality of electrodes and a plurality of conductive wires coupled to the plurality of electrodes and extending along a longitudinal axis of the distal lead element. Each of the at least two proximal lead elements includes a plurality of terminals and a plurality of conductive wires coupled to the plurality of terminals and extending along a longitudinal axis of the proximal lead element. The junction includes a circuit arrangement electrically coupling each of the conductive wires of the distal lead element to at least one of the conductive wires of at least one of the at least two proximal lead elements.

A method for engineering and utilizing large DNA vectors to target, via homologous recombination, and modify, in any desirable fashion, endogenous genes and chromosomal loci in eukaryotic cells. These large DNA targeting vectors for eukaryotic cells, termed LTVECs, are derived from fragments of cloned genomic DNA larger than those typically used by other approaches intended to perform homologous targeting in eukaryotic cells. Also provided is a rapid and convenient method of detecting eukaryotic cells in which the LTVEC has correctly targeted and modified the desired endogenous gene(s) or chromosomal locus (loci) as well as the use of these cells to generate organisms bearing the genetic modification.

The present invention relates to a diesel oxidation catalyst comprising a carrier substrate, and a first washcoat layer disposed on the substrate, the first washcoat layer comprising palladium supported on a support material comprising a metal oxide, gold supported on a support material comprising a metal oxide, and a ceria comprising compound, as well as a process for the preparation of such catalyst.

The present invention relates to a catalyst composition for conversion of vegetable oils to hydrocarbon products in the diesel boiling range, comprising a porous support; Group III A or VA element in the range of 1-10 wt %; Group VI B elements in the range of 1 to 20 wt %; Group VIII B elements in range of 0.01 to 10 wt %. The present invention further provides the process for preparing the catalyst composition for conversion of vegetable oils to hydrocarbon products in the diesel boiling range. The present invention also provides the process for conversion of vegetable oils to hydrocarbon products in the diesel boiling range using the catalyst composition or discarded refinery spent hydro-treating catalyst.

The present invention relates to antibody molecules against anticoagulants, in particular dabigatran, and their use as antidotes of such anticoagulants.

Human antibodies, preferably recombinant human antibodies, that specifically bind to human interleukin-12 (hIL-12) are disclosed. Preferred antibodies have high affinity for hIL-12 and neutralize hIL-12 activity in vitro and in vivo. An antibody of the invention can be a full-length antibody or an antigen-binding portion thereof. The antibodies, or antibody portions, of the invention are useful for detecting hIL-12 and for inhibiting hIL-12 activity, e.g., in a human subject suffering from a disorder in which hIL-12 activity is detrimental. Nucleic acids, vectors and host cells for expressing the recombinant human antibodies of the invention, and methods of synthesizing the recombinant human antibodies, are also encompassed by the invention.

The present disclosure describes antibodies that target HM1.24. In various aspects, the antibodies have specific CDR, variable, or full length sequences, have modifications with the parent antibody, or include at least one modification relative to a parent antibody that alters affinity to an FcγR or alters effector function as compared to the parent antibody. Nucleic acids encoding the antibodies and methods of using the antibodies are also disclosed.

The disclosure relates to anti-glial maturation factor beta (“GMF-B”) monoclonal antibodies (mAbs) and fragments thereof, as well as hybridoma lines that secrete antibodies or fragments. Therapeutic and diagnostic uses of such antibodies, including treatment and detection of cancer and dementia, and methods and kits for detecting cells or samples expressing GMF-B, including soluble GMF-B, are also encompassed.

The present invention relates to novel antibodies, particularly antibodies directed against deletion mutants of epidermal growth factor receptor and particularly to the type III deletion mutant, EGFRvIII. The invention also relates to human monoclonal antibodies directed against deletion mutants of epidermal growth factor receptor and particularly to EGFRvIII. Diagnostic and therapeutic formulations of such antibodies, and immunoconjugates thereof, are also provided.

An embodiment is an integrated circuit structure including a first die attached to a second die by a first connector. The first connector includes a solder joint portion between a first nickel-containing layer and a second nickel-containing layer, a first copper-containing layer between the first nickel-containing layer and the solder joint portion, and a second copper-containing layer between the second nickel-containing layer and the solder joint portion.

Monoclonal antibodies (mAbs) having thyroid stimulating activity (TSAb), especially full or considerably agonistic activity, or thyroid blocking activity (TBAb), which are obtainable by genetic immunization of mice, or fragments (F(ab')2, Fab or Fv) or humanized forms of such monoclonal antibodies or single chain forms (SCA; scFv) of such fragments, which antibodies, or their fragments, compete with bovine TSH for epitopes of the human TSHr, compete with autoantibodies from sera from Graves' patients as well as with autoantibodies from sera from patients harboring blocking autoantibodies for epitopes of the human TSHr, bind to conformational epitopes of the human TSHr located in the first 281 amino acids of the human TSHr, and usually also bind to TSFR receptors (TSHr) from different animals. Various uses of such antibodies, or of peptides corresponding to variable regions of such antibodies, are also described and claimed.

The present invention relates to a packing box for accommodation of plate bodies, which comprises a backplane, and a side plate vertically arranged at the periphery of the backplane, the plate body including a main body, and a PCB plate connected through a flexible sheet to the edge of the main body, a positioning member being further arranged in the space enclosed by the backplane and the side plate for preventing the PCB plate from moving relative to the main body. The positioning member of the present invention can prevent the PCB plate from moving relative to the main body of the plate body, playing a role in protecting the circuit on the flexible sheet and having low costs.

A vibrating machine for producing a molded body by compacting a granular raw mixture includes an oscillatable vibrating table configured to receive a molding box. A clamping device is produced by at least two clamping closures, each including: a pivot bracket having a lower end being pivotally mounted on the vibrating table and an upper end including a cranking which is directed outward; a double-acting hydraulic pivot cylinder pivotally mounted on the vibrating table; a two-armed rocker arm pivotally connected to the pivot bracket and including an inner part that cooperates with the molding box and an outer part that cooperates with the hydraulic pivot cylinder; and a compression spring disposed between the cranking and the outer part of the rocker arm such that the rocker arm releases from a position closing the respective clamping closure upon a pressure in the hydraulic pivot cylinder being relieved.

The present disclosure provides antibodies, and antigen-binding fragments thereof that bind to EBOV glycoprotein. The present disclosure further provides hybridoma cell lines and methods for making and using the compositions provided herein.

The invention relates to a human Interleukin-2 (hIL-2) specific monoclonal antibody (mAb), or antigen binding fragment thereof, the binding of which to hIL-2 inhibits binding of hIL-2 to CD25 and the antibody is characterized by any of the parameters: the variable chain of the mAb comprises the amino acid sequence of SEQ ID NO 005 or SEQ ID NO 006; the binding to hIL-2 is characterized by a dissociation constant (KD)≦7.5 nmol/L; the binding to hIL-2 is characterized by an off-rate (Koff)≦1×10−4 s−1 and/or the antibody displays no measurable cross-reactivity to murine IL-2.

Cysteine engineered antibodies useful for the site-specific conjugation to a variety of agents are provided. Methods for the design, preparation, screening, selection and use of such antibodies are also provided.

Antibodies that interact with osteoprotegerin ligand (OPGL) are described. Methods of treating osteopenic disorders by administering a pharmaceutically effective amount of antibodies to OPGL are described. Methods of detecting the amount of OPGL in a sample using antibodies to OPGL are described.

The present disclosure provides compositions and methods of use involving binding proteins, e.g., antibodies and antigen-binding fragments thereof, that bind to the matrix metalloproteinase-9 (MMP9) protein (MMP9 is also known as gelatinase-B), such as where the binding proteins comprise an immunoglobulin (Ig) heavy chain (or functional fragment thereof) and an Ig light chain (or functional fragment thereof).

This invention relates to novel monoclonal antibodies that specifically bind to the alpha-folate receptor. In some embodiments, the antibodies inhibit a biological activity of folate receptor-α (FR-α). The antibodies are useful in the treatment of certain cancers, particularly cancers that have increased cell surface expression of the alpha-folate receptor (“FR-α”), such as ovarian, breast, renal, colorectal, lung, endometrial, or brain cancer. The invention also relates to cells expressing the monoclonal antibodies, antibody derivatives, such as chimeric and humanized monoclonal antibodies, antibody fragments, and methods of detecting and treating cancer using the antibodies, derivatives, and fragments.

A retractable stock guide has a stationary guide rail on which a retractable guide cap is operably supported. The guide rail and cap have two through holes at opposite ends through which two mounting studs extend to attach the stock guide to an associated die member. The holes in the guide cap are ovate, and the heads of the mounting studs are tapered, whereby tightening of the mounting stud shifts the guide cap relative to the guide rail from an aligned, retracted load/unload condition, to an inwardly protruding, extended run condition, wherein the stock strip is slidingly captured between two like stock guides and the mounting surface of the die. Two ball bearing guides can be substituted for the stationary guide rail.

One aspect of the disclosure relates to a die comprising a primary plate and secondary plates. The secondary plates comprise through weld holes formed along a direction. The through weld holes of adjacent secondary plates do not overlap when viewed in the direction along which the though weld holes are formed. The primary plate is coupled to at least one secondary plate abutting the primary plate by first welds located in the through weld holes. The secondary plates abutting each other are coupled by second welds located in the through weld holes.

A device for transporting vehicle bodies, on which standardized holding components are provided. A guide device is provided for at least one continuous drive train which having a driving side and a slack side, and having a first return element and at least one second return element around which the at least one continuous drive train circulates. The at least one continuous drive train supports a plurality of coupling elements which are arranged and aligned in such a manner that they can work together with the standardized holding components provided on the vehicle body.

Provided are an apparatus and a method for rapidly producing a synthetic gas from a bio-diesel byproduct using microwave plasma, in which, while a plasma flame is generated by a plasma generator and waste glycerin, a bio-diesel byproduct, as fuel, is gasified by being supplied to the generated plasma flame of high temperature, the fuel is supplied in various types to increase the contact time or the contact area with the plasma flame and thus promote gasification thereof and the contents of steam and oxygen supplied and the plasma power are controlled to increase the collection amount of combustible gas and thus allow rapid production of the synthetic gas.

A method for obtaining diesel fuel from vegetable or animal oils through the addition of hydrogen in the presence of catalysts under suitable temperature and pressure conditions is described. The method is different from other similar methods in that it involves the use of space velocities of between 5.1 h-1 and 9 h-1, thereby enabling a reduction in the size of the reactor and in hydrogen consumption, as well as lowering construction and operating costs. The invention also relates to the products obtained using said method, which have demonstrated that in additions, even below 10%, they improve the performance of diesel engines, thereby lowering fuel consumption.

A multi-stage reactor system for preparing biodiesel is used to increase efficiency and yield and reduce impurities. A three-stage transesterification reaction for preparing biodiesel can include one high-shear cavitation reactor and two low-shear cavitation reactors, preferably in series, and optionally one or more separation vessels for removing waste and recycling triglyceride feedstock, catalyst and alcohol to the high-shear cavitation reactor.

The present invention relates to the use of at least 120 ppm of a nitrogen-containing detergent as a diesel fuel additive to improve the performance of a diesel engine having a high pressure fuel system.

The present invention provides assays for detecting and measuring the presence or level of anti-TNFα drug therapeutics and autoantibodies in a sample. The present invention is useful for optimizing therapy and monitoring patients receiving anti-TNFα drug therapeutics to detect the presence or level of autoantibodies (e.g., HACA and/or HAHA) against the drug.

In sporadic Alzheimer's disease, neurofibrillary lesion formation is preceded by extensive post-translational modification of the microtubule associated protein tau. Immunoassays have been developed recently that detect tau in biological specimens, thus providing a means for pre-mortem diagnosis of Alzheimer's disease, which has remained elusive. These assays have been improved by the analysis of relevant post-translational modifications, such as phosphorylation, however opportunity for improvement remains. The present invention addresses this issue by disclosing synthetic methylated peptides derived from the tau protein of paired helical filaments and non-diseased control brain. Alzheimer's disease specificity is provided by the presence or absence of methyl moieties on lysine residues and differences between mono-, di-, and tri-methylation. The methylated peptide is useful as an antigen and a binding partner for identifying compounds that interact with the peptide and the methylated tau protein, including antibodies that can distinguish non-diseased brain from that affected by Alzheimer's disease. The resulting antibodies are useful diagnostically and therapeutically. The compounds that specifically bind to methylated tau proteins are useful for eliminating abnormally methylated tau.

An exhaust apparatus for a diesel engine rapidly burns an unburned deposit in an upstream exhaust catalyst with heat of a heater. The exhaust apparatus includes a downstream exhaust cleaner, an upstream exhaust catalyst provided in an exhaust passage, upstream of the downstream exhaust cleaner, a heater disposed at an exhaust inlet of the upstream exhaust catalyst, and an engine starter apparatus. A control unit controls the power supply to the heater and an engine start process is performed by the engine starter apparatus. A start command unit is connected to the control unit. When the engine has been stopped and then the start command unit gives the control unit a start command, the control unit powers the heater without performing an engine start process, thereby keeping the engine stopped for a predetermined period of time after the start command has been given, and subsequently performing the engine start process.

Brian Batchelor, once described by the Daily Echo as ‘the most versatile singer in the South’, has died at the age of 87.

News you don't want to miss for April 15:

1. The number of covid-19 deaths in Alameda County increased from 23 to 36 over a two-day period, SFGate reports.…

A FORMER Aston Villa striker has died after he was Tasered by police.

A SOUTHAMPTON football team has scored big after being newly kitted out.

A LADIES’ night of food and fashion raised £700 for a cancer charity.

Unexpected treat in store for girls in Race For Life

by Mike Vimpany

TRIBUTES have been paid to a “passionate and loving” Southampton mum of five children who has died of cancer aged 33.

One thing WNCW knows about is bluegrass, old time and true country music. It's a part of our electic music format which made this Friday Feature Interview of the Week even more special - when we learned all about the East Tennessee State University Bluegrass, Old Time, and Country Music Studies Program. Interviewed on March 20, 2020 was Program Director Daniel Boner. ETSU is passing on a legacy of music history that will help keep it going strong for the future. Posted by Host and Producer of The Friday Feature- Paul Foster, WNCW Senior Producer, News Director, and Morning Edition Regional Host

Magician and animal trainer Roy Horn, of the legendary Las Vegas duo Siegfied and Roy, died Friday from complications related to COVID-19. Horn tested positive last week. He was 75. "The world has lost one of the greats of magic, but I have lost my best friend," Siegfried Fischbacher said of his partner in a statement. "Roy was a fighter his whole life including during these final days. I give my heartfelt appreciation to the team of doctors, nurses and staff at Mountain View Hospital who worked heroically against this insidious virus that ultimately took Roy's life." Roy Horn was born in Germany in 1944. He and Siegfried began their act in Las Vegas in 1967. In 1989 they began a 14-year run at the Mirage Resort performing illusions with exotic animals, making tigers, lions, even elephants vanish and reappear. In October of 2003, Roy Horn was performing with a 400-pound white tiger named Mantecore when the great cat grabbed him by the throat before a stunned audience and dragged him

Magician and animal trainer Roy Horn, of the legendary Las Vegas duo Siegfied and Roy, died Friday from complications related to COVID-19. Horn tested positive last week. He was 75. "The world has lost one of the greats of magic, but I have lost my best friend," Siegfried Fischbacher said of his partner in a statement. "Roy was a fighter his whole life including during these final days. I give my heartfelt appreciation to the team of doctors, nurses and staff at Mountain View Hospital who worked heroically against this insidious virus that ultimately took Roy's life." Roy Horn was born in Germany in 1944. He and Siegfried began their act in Las Vegas in 1967. In 1989 they began a 14-year run at the Mirage Resort performing illusions with exotic animals, making tigers, lions, even elephants vanish and reappear. In October of 2003, Roy Horn was performing with a 400-pound white tiger named Mantecore when the great cat grabbed him by the throat before a stunned audience and dragged him

Actor Peter Fonda, best-known for his iconic role as a free-spirited motorcycle rider in the 1969 counterculture classic Easy Rider , died Friday at his home in Los Angeles at the age of 79. The cause of his death was respiratory failure due to lung cancer, according to a family statement released to People magazine. "In one of the saddest moments of our lives, we are not able to find the appropriate words to express the pain in our hearts. As we grieve, we ask that you respect our privacy," the Fonda family wrote. "And, while we mourn the loss of this sweet and gracious man, we also wish for all to celebrate his indomitable spirit and love of life," they added. "In honor of Peter, please raise a glass to freedom." Peter Fonda was the only son of Hollywood legend Henry Fonda and socialite Frances Seymour Brokaw. He was also the brother of actress Jane Fonda. Peter Fonda had a brief film career in the mid-1960s before his breakout performance as Wyatt in Easy Rider, costarring Dennis

Starring in the skit for 'The Tonight Show Starring Jimmy Fallon', The Rolling Stones frontman gets onboard to support a non-profit providing for children in need during the coronavirus pandemic.

Hits like "Tutti Frutti," "Long Tall Sally" and "Good Golly Miss Molly" were influential to many groups, especially the Beatles. Continue reading…

Read what stars, including Jimmy Page and Brian Wilson, had to say about the death of the rock legend. Continue reading…