and Design and synthesis of novel 8-(azaindolyl)-benzoazepinones as potent and selective ROCK inhibitors By pubs.rsc.org Published On :: RSC Med. Chem., 2024, 15,3862-3879DOI: 10.1039/D4MD00313F, Research ArticleDaniele Pala, David Clark, Christine Edwards, Elisa Pasqua, Laura Tigli, Barbara Pioselli, Piotr Malysa, Fabrizio Facchinetti, Fabio Rancati, Alessandro AccettaThis study reports a novel, potent and selective series of ROCK inhibitors based on 8-(azaindolyl)-benzoazepinones identified through a core-hopping strategy.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
and Correction: computational design, synthesis, and assessment of 3-(4-(4-(1,3,4-oxadiazol-2-yl)-1H-imidazol-2-yl)phenyl)-1,2,4-oxadiazole derivatives as effective epidermal growth factor receptor inhibitors: a prospective strategy for anticancer therapy By pubs.rsc.org Published On :: RSC Med. Chem., 2024, 15,3912-3912DOI: 10.1039/D4MD90040E, Correction Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Nilesh Raghunath Khedkar, Milind Sindkhedkar, Alex JosephThe content of this RSS Feed (c) The Royal Society of Chemistry Full Article
and Anticancer potential of copper(I) complexes based on isopropyl ester derivatives of bis(pyrazol-1-yl)acetate ligands By pubs.rsc.org Published On :: RSC Med. Chem., 2024, Accepted ManuscriptDOI: 10.1039/D4MD00610K, Research Article Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Maura Pellei, Carlo Santini, Miriam Caviglia, Jo' Del Gobbo, Chiara Battocchio, Carlo Meneghini, Simone Amatori, Chiara Donati, Eleonora Zampieri, Valentina Gandin, Cristina MarzanoIn this paper, the isopropyl ester derivatives LOiPr and L2OiPr of bis(pyrazol-1-yl)acetic acid and bis(3,5-dimethyl-pyrazol-1-yl)acetic acid were used as chelators for the preparation of the new Cu(I) phosphane complexes 1-4....The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
and Advances in Detecting Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) Using Molecular Receptors and Nanostructured Assemblies By pubs.rsc.org Published On :: RSC Med. Chem., 2024, Accepted ManuscriptDOI: 10.1039/D4MD00661E, Review ArticleAvijit Kumar DasThe detection and quantification of non-steroidal anti-inflammatory drugs (NSAIDs) are crucial due to their widespread use and potential impact on human health and the environment. This review provides a comprehensive...The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
and Wall Street makes wagers on the likely winners and losers in a second Trump term By www.thehindu.com Published On :: Wed, 13 Nov 2024 16:55:27 +0530 Wall Street is already making big bets on what take two for a White House led by Donald Trump will mean for the economy and markets Full Article Business
and SKDRDP provides desks and benches worth ₹2.75 crore to 507 government primary schools in four districts of Karnataka By www.thehindu.com Published On :: Wed, 13 Nov 2024 12:49:14 +0530 Rajya Sabha MP Veerendra Heggade urges parents to get their wards admitted to government schools as they now have better facilities Full Article Mangaluru
and Free and fair inquiry sought into death of snakebite victim in Srikakulam district By www.thehindu.com Published On :: Wed, 13 Nov 2024 18:10:47 +0530 Son of the victim alleges that local medical and health officials misleading higher-ups regarding the incident Full Article Andhra Pradesh
and Incessant rains cause landslides on Tirumala ghat road By www.thehindu.com Published On :: Wed, 13 Nov 2024 18:56:12 +0530 Full Article Andhra Pradesh
and Target is to to make 30,000 MT of sand available every day in East Godavari district, says Collector By www.thehindu.com Published On :: Wed, 13 Nov 2024 19:25:35 +0530 P. Prasanthi warns boatmen associations of stringent action if they attempt to prevent vehicles transporting sand from the sand reaches Full Article Andhra Pradesh
and Andhra Pradesh Budget reflects aspirations of all sections of people, say legislators By www.thehindu.com Published On :: Wed, 13 Nov 2024 20:10:11 +0530 It has given impetus to the developmental goals outlined in the NDA’s election manifesto, say MLAs on the first day of discussion Full Article Andhra Pradesh
and PAG report points out Andhra Pradesh govt.’s failure to disclose quantum of off-budget borrowings in Budget By www.thehindu.com Published On :: Wed, 13 Nov 2024 20:19:16 +0530 Principal amount outstanding in 2019-20 was ₹67,171 crore, and it touched ₹1,54,797 crore in 2023-24, says the PAG report released by the I&PR Department Full Article Andhra Pradesh
and Andhra Pradesh government deploys drones to detect ganja palnatations By www.thehindu.com Published On :: Wed, 13 Nov 2024 20:21:37 +0530 State collaborates with NCB and Google to map and track cannabis plantations using satellite imagery technology Full Article Andhra Pradesh
and RLDA invites bids for commercial land use in Tirupati railway station By www.thehindu.com Published On :: Wed, 13 Nov 2024 20:29:31 +0530 The station is being developed on a massive scale, providing commuting area on the southern side, in view of the crammed locality on the northern side Full Article Andhra Pradesh
and Andhra Pradesh Govt. weighing options on how to utilise Mahila Samrakshana Karyadarshis, says Home Minister By www.thehindu.com Published On :: Wed, 13 Nov 2024 20:30:46 +0530 Ambiguity in overall control of their duties and service matters resulted in immense distress for the MSKs, says Home Minister Full Article Andhra Pradesh
and Andhra Pradesh govt. reaffirms commitment to ‘irrigating every acre of farmland’ in State through river-interlinking projects By www.thehindu.com Published On :: Wed, 13 Nov 2024 20:43:13 +0530 Full Article Andhra Pradesh
and Police book Sri Reddy for posting ‘defamatory content’ against Chandrababu Naidu, Pawan Kalyan By www.thehindu.com Published On :: Wed, 13 Nov 2024 21:25:39 +0530 Full Article Andhra Pradesh
and Andhra Pradesh High Court strikes down PIL seeking to restrain police from taking action on ‘abusive content on social media’ By www.thehindu.com Published On :: Wed, 13 Nov 2024 21:30:39 +0530 Full Article Andhra Pradesh
and India’s office leasing soars 41% in 2024 amid rent hikes, supply crunch, and GCC growth: Cushman & Wakefield By www.thehindubusinessline.com Published On :: Wed, 13 Nov 2024 09:20:06 +0530 In an interview to businessline, Cushman & Wakefield’s Veera talks about commercial space leasing outlook, trends, and rental and supply trends for the coming months Full Article Real Estate
and Metro Rail services to be extended to Medchal and other parts of northern Hyderabad under Phase-III: Telangana CM By www.thehindu.com Published On :: Wed, 13 Nov 2024 19:18:36 +0530 Full Article Hyderabad
and COP29: India, other developing countries demand fair climate finance commitments By www.thehindu.com Published On :: Wed, 13 Nov 2024 13:33:21 +0530 India, LMDCs advocate for equitable climate finance at COP29, pushing for transparency, fairness, and flexibility in financial commitments Full Article World
and 29th Climate Conference (COP) tracker | Day 2 LIVE: Key speeches, UK NDC, and India’s reaction at 5 p.m. on November 13 By www.thehindu.com Published On :: Wed, 13 Nov 2024 17:01:23 +0530 Vibhuti Garg, an Associate and Senior Energy Specialist with over 13 years of experience in the energy sector, will guide us through the implications of these financial negotiations and the potential impacts on global energy transitions and climate commitments at 5 p.m. on November 13 Full Article Environment
and Synthesis and evaluation of photoaffinity labeling reagents for identifying binding sites of sulfated neurosteroids on NMDA and GABAA receptors By pubs.rsc.org Published On :: RSC Adv., 2024, 14,36352-36369DOI: 10.1039/D4RA07074G, Paper Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Mingxing Qian, Yuanjian Xu, Hong-Jin Shu, Zi-Wei Chen, Lei Wang, Charles F. Zorumski, Alex S. Evers, Steven Mennerick, Douglas F. CoveyPhotoaffinity labels (PALs) for sulfated steroid binding sites on GABAA and NMDA receptors. The PALs have varying profiles of positive and negative modulatory (PAM and NAM) actions.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
and Karnataka bypolls: Channapatna, Shiggaon and Sandur constituencies witness overall turnout of 76.9% till 5 p.m. By www.thehindu.com Published On :: Wed, 13 Nov 2024 10:37:35 +0530 A total of 45 candidates are in the fray in these byelections Full Article Karnataka
and Karnataka Chief Minister Siddaramaiah says no proposal to ease night traffic ban through Bandipur By www.thehindu.com Published On :: Wed, 13 Nov 2024 14:45:12 +0530 Deputy Chief Minister D.K. Shivakumar had stated, in Wayanad in Kerala, that the government would take all possible measures to lift night traffic ban through Bandipur, which had riled wildlife conservationists in Karnataka Full Article Karnataka
and Watch | War over Waqf: Busting myth and misinformation By www.thehindu.com Published On :: Wed, 13 Nov 2024 16:25:12 +0530 How did an incident in a small village in Vijayapura snowball into an issue of national interest? Full Article Karnataka
and PUCL condemns opposition to Dalits’ entry into temple in Mandya village By www.thehindu.com Published On :: Wed, 13 Nov 2024 19:16:27 +0530 Full Article Karnataka
and Illegal export of iron ore from Belekeri port: Karnataka High Court suspends sentence and grants bail to MLA Satish Sail and five other convicts By www.thehindu.com Published On :: Wed, 13 Nov 2024 19:21:10 +0530 Full Article Karnataka
and Union and State governments should set up Sanatana Board, demand seers By www.thehindu.com Published On :: Wed, 13 Nov 2024 19:27:24 +0530 Full Article Karnataka
and Mysuru to host conference on AI and Deeptech By www.thehindu.com Published On :: Wed, 13 Nov 2024 19:45:37 +0530 Full Article Karnataka
and Byelections: Polling passes off peacefully in Sandur By www.thehindu.com Published On :: Wed, 13 Nov 2024 19:51:08 +0530 Full Article Karnataka
and I've found ways and means to break it down: Ashwin on Smith's batting By www.thehindu.com Published On :: Wed, 13 Nov 2024 16:21:04 +0530 The two seasoned campaigners would face off during the Border-Gavaskar Trophy starting November 22 in Perth Full Article Cricket
and Final Call, Trevalius, Densetsu, Once You Go Black and Champions Way catch the eye By www.thehindu.com Published On :: Wed, 13 Nov 2024 17:29:08 +0530 Full Article Races
and Shambala and Kimiko impress By www.thehindu.com Published On :: Wed, 13 Nov 2024 17:34:17 +0530 Full Article Races
and Sharandeep grinds out a half-century on a slow-moving opening day By www.thehindu.com Published On :: Wed, 13 Nov 2024 19:43:55 +0530 The Jharkhand opener exhibits ample patience and a tight defence Full Article Cricket
and Allison Transmission to double Chennai facility with $100 mn+ investment amid rising global demand By www.thehindubusinessline.com Published On :: Thu, 14 Nov 2024 07:33:39 +0530 The expansion aims to double the facility’s size, creating 167 new jobs, and enhance production capacity for automatic transmissions in response to growing global demand Full Article Companies
and Residents raise concerns over water quality and odour from Vellalore dump yard By www.thehindu.com Published On :: Wed, 13 Nov 2024 20:22:04 +0530 Full Article Coimbatore
and The globally-acclaimed Candlelight Concert is now in Chennai. Listen to classical and contemporary music at Museum Theatre, amidst thousands of candles By www.thehindu.com Published On :: Wed, 13 Nov 2024 21:12:01 +0530 The first concert on November 15 will feature tunes from Tamil and Hindi films, followed by tributes to Coldplay, Mozart, Queen, and Abba in the upcoming months Full Article Life & Style
and Exploring urban ecology through stories, verse and flavours By www.thehindu.com Published On :: Wed, 13 Nov 2024 21:27:29 +0530 Full Article Bengaluru
and Jairam Tiger Mahto stands in the way in tough battle for NDA and INDIA blocs in Jharkhand By www.thehindu.com Published On :: Wed, 13 Nov 2024 22:26:16 +0530 Known for raising local issues, the 30-year-old leader hails from Kurmi (Mahtos) community that comprise 22% of the total population, the largest chunk after tribals and plays a decisive role in at least 30 seats Full Article Jharkhand Assembly
and Sharandeep grinds out a half-century on a slow-moving opening day By www.thehindu.com Published On :: Wed, 13 Nov 2024 22:59:37 +0530 The opener exhibits ample patience and a tight defence as Jharkhand reached 136 for three in the 55 overs that were possible after the start of play was delayed by two hours Full Article Cricket
and Parthiv Patel gets dual responsibility with Gujarat Titans: batting and assistant coach By www.thehindu.com Published On :: Thu, 14 Nov 2024 03:51:09 +0530 Parthiv Patel will perform the dual role in the support staff led by head coach Ashish Nehra Full Article Cricket
and South India science drama festival on Thursday and Friday By www.thehindu.com Published On :: Wed, 13 Nov 2024 22:04:59 +0530 Full Article Bengaluru
and Congress demands white paper on government recruitments in Goa since 2019 By www.thehindu.com Published On :: Wed, 13 Nov 2024 22:39:40 +0530 The Congress attack came a day after a woman member of BJP’s mahila morcha was arrested in connection with the jobs scam Full Article India
and CMC organises exhibition and poster competition on diabetes By www.thehindu.com Published On :: Wed, 13 Nov 2024 23:12:15 +0530 Full Article Tamil Nadu
and Tambaram Corporation begins population survey and area mapping for improved coverage of UPHCs By www.thehindu.com Published On :: Wed, 13 Nov 2024 23:18:44 +0530 Full Article Chennai
and Temple sets example by introducing ‘mechanical elephant’ to honour tradition and preserve wildlife By www.thehindu.com Published On :: Wed, 13 Nov 2024 23:41:12 +0530 Inspired by the Irinjadappilly Sri Krishna Temple in Thrissur, the temple trustees collaborated with PETA to bring Sankaranarayan to Kannur Full Article Kerala
and Two men arrested for producing forged demand draft By www.thehindu.com Published On :: Thu, 14 Nov 2024 00:00:36 +0530 Full Article Chennai
and The impact of Pradhan Mantri Ujjwala Yojana in Jammu and Kashmir By www.thehindu.com Published On :: Thu, 14 Nov 2024 00:57:59 +0530 Expanding the network of LPG distribution points in rural areas and extending financial support for refills could further increase clean fuel adoption Full Article Comment
and Demanding security, Tamil Nadu government doctors begin indefinite strike By www.thehindu.com Published On :: Thu, 14 Nov 2024 01:18:08 +0530 Federation of Government Doctors’ Association will decide on the next course of action at an executive committee meeting to be held on November 17, 2024. Full Article Tamil Nadu
and Trump names firebrand lawmaker Matt Gaetz U.S. Attorney General By www.thehindu.com Published On :: Thu, 14 Nov 2024 02:50:05 +0530 Donald Trump posted on social media that Matt Gaetz will end Weaponized Government Full Article World