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Design and synthesis of novel 8-(azaindolyl)-benzoazepinones as potent and selective ROCK inhibitors

RSC Med. Chem., 2024, 15,3862-3879
DOI: 10.1039/D4MD00313F, Research Article
Daniele Pala, David Clark, Christine Edwards, Elisa Pasqua, Laura Tigli, Barbara Pioselli, Piotr Malysa, Fabrizio Facchinetti, Fabio Rancati, Alessandro Accetta
This study reports a novel, potent and selective series of ROCK inhibitors based on 8-(azaindolyl)-benzoazepinones identified through a core-hopping strategy.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Correction: computational design, synthesis, and assessment of 3-(4-(4-(1,3,4-oxadiazol-2-yl)-1H-imidazol-2-yl)phenyl)-1,2,4-oxadiazole derivatives as effective epidermal growth factor receptor inhibitors: a prospective strategy for anticancer therapy

RSC Med. Chem., 2024, 15,3912-3912
DOI: 10.1039/D4MD90040E, Correction
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Nilesh Raghunath Khedkar, Milind Sindkhedkar, Alex Joseph
The content of this RSS Feed (c) The Royal Society of Chemistry




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Anticancer potential of copper(I) complexes based on isopropyl ester derivatives of bis(pyrazol-1-yl)acetate ligands

RSC Med. Chem., 2024, Accepted Manuscript
DOI: 10.1039/D4MD00610K, Research Article
Open Access
Maura Pellei, Carlo Santini, Miriam Caviglia, Jo' Del Gobbo, Chiara Battocchio, Carlo Meneghini, Simone Amatori, Chiara Donati, Eleonora Zampieri, Valentina Gandin, Cristina Marzano
In this paper, the isopropyl ester derivatives LOiPr and L2OiPr of bis(pyrazol-1-yl)acetic acid and bis(3,5-dimethyl-pyrazol-1-yl)acetic acid were used as chelators for the preparation of the new Cu(I) phosphane complexes 1-4....
The content of this RSS Feed (c) The Royal Society of Chemistry




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Advances in Detecting Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) Using Molecular Receptors and Nanostructured Assemblies

RSC Med. Chem., 2024, Accepted Manuscript
DOI: 10.1039/D4MD00661E, Review Article
Avijit Kumar Das
The detection and quantification of non-steroidal anti-inflammatory drugs (NSAIDs) are crucial due to their widespread use and potential impact on human health and the environment. This review provides a comprehensive...
The content of this RSS Feed (c) The Royal Society of Chemistry




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Wall Street makes wagers on the likely winners and losers in a second Trump term

Wall Street is already making big bets on what take two for a White House led by Donald Trump will mean for the economy and markets




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SKDRDP provides desks and benches worth ₹2.75 crore to 507 government primary schools in four districts of Karnataka

Rajya Sabha MP Veerendra Heggade urges parents to get their wards admitted to government schools as they now have better facilities




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Free and fair inquiry sought into death of snakebite victim in Srikakulam district

Son of the victim alleges that local medical and health officials misleading higher-ups regarding the incident




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Incessant rains cause landslides on Tirumala ghat road




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Target is to to make 30,000 MT of sand available every day in East Godavari district, says Collector

P. Prasanthi warns boatmen associations of stringent action if they attempt to prevent vehicles transporting sand from the sand reaches




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Andhra Pradesh Budget reflects aspirations of all sections of people, say legislators

It has given impetus to the developmental goals outlined in the NDA’s election manifesto, say MLAs on the first day of discussion




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PAG report points out Andhra Pradesh govt.’s failure to disclose quantum of off-budget borrowings in Budget

Principal amount outstanding in 2019-20 was ₹67,171 crore, and it touched ₹1,54,797 crore in 2023-24, says the PAG report released by the I&PR Department




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Andhra Pradesh government deploys drones to detect ganja palnatations

State collaborates with NCB and Google to map and track cannabis plantations using satellite imagery technology




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RLDA invites bids for commercial land use in Tirupati railway station

The station is being developed on a massive scale, providing commuting area on the southern side, in view of the crammed locality on the northern side




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Andhra Pradesh Govt. weighing options on how to utilise Mahila Samrakshana Karyadarshis, says Home Minister 

Ambiguity in overall control of their duties and service matters resulted in immense distress for the MSKs, says Home Minister




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Andhra Pradesh govt. reaffirms commitment to ‘irrigating every acre of farmland’ in State through river-interlinking projects




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Police book Sri Reddy for posting ‘defamatory content’ against Chandrababu Naidu, Pawan Kalyan




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Andhra Pradesh High Court strikes down PIL seeking to restrain police from taking action on ‘abusive content on social media’




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India’s office leasing soars 41% in 2024 amid rent hikes, supply crunch, and GCC growth: Cushman & Wakefield

In an interview to businessline, Cushman & Wakefield’s Veera talks about commercial space leasing outlook, trends, and rental and supply trends for the coming months




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Metro Rail services to be extended to Medchal and other parts of northern Hyderabad under Phase-III: Telangana CM




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COP29: India, other developing countries demand fair climate finance commitments

India, LMDCs advocate for equitable climate finance at COP29, pushing for transparency, fairness, and flexibility in financial commitments




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29th Climate Conference (COP) tracker | Day 2 LIVE: Key speeches, UK NDC, and India’s reaction at 5 p.m. on November 13

Vibhuti Garg, an Associate and Senior Energy Specialist with over 13 years of experience in the energy sector, will guide us through the implications of these financial negotiations and the potential impacts on global energy transitions and climate commitments at 5 p.m. on November 13




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Synthesis and evaluation of photoaffinity labeling reagents for identifying binding sites of sulfated neurosteroids on NMDA and GABAA receptors

RSC Adv., 2024, 14,36352-36369
DOI: 10.1039/D4RA07074G, Paper
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Mingxing Qian, Yuanjian Xu, Hong-Jin Shu, Zi-Wei Chen, Lei Wang, Charles F. Zorumski, Alex S. Evers, Steven Mennerick, Douglas F. Covey
Photoaffinity labels (PALs) for sulfated steroid binding sites on GABAA and NMDA receptors. The PALs have varying profiles of positive and negative modulatory (PAM and NAM) actions.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Karnataka bypolls: Channapatna, Shiggaon and Sandur constituencies witness overall turnout of 76.9% till 5 p.m.

A total of 45 candidates are in the fray in these byelections




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Karnataka Chief Minister Siddaramaiah says no proposal to ease night traffic ban through Bandipur

Deputy Chief Minister D.K. Shivakumar had stated, in Wayanad in Kerala, that the government would take all possible measures to lift night traffic ban through Bandipur, which had riled wildlife conservationists in Karnataka




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Watch | War over Waqf: Busting myth and misinformation

How did an incident in a small village in Vijayapura snowball into an issue of national interest?




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PUCL condemns opposition to Dalits’ entry into temple in Mandya village




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Illegal export of iron ore from Belekeri port: Karnataka High Court suspends sentence and grants bail to MLA Satish Sail and five other convicts




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Union and State governments should set up Sanatana Board, demand seers




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Mysuru to host conference on AI and Deeptech




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Byelections: Polling passes off peacefully in Sandur




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I've found ways and means to break it down: Ashwin on Smith's batting

The two seasoned campaigners would face off during the Border-Gavaskar Trophy starting November 22 in Perth




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Final Call, Trevalius, Densetsu, Once You Go Black and Champions Way catch the eye




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Shambala and Kimiko impress




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Sharandeep grinds out a half-century on a slow-moving opening day

The Jharkhand opener exhibits ample patience and a tight defence




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Allison Transmission to double Chennai facility with $100 mn+ investment amid rising global demand

The expansion aims to double the facility’s size, creating 167 new jobs, and enhance production capacity for automatic transmissions in response to growing global demand




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Residents raise concerns over water quality and odour from Vellalore dump yard




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The globally-acclaimed Candlelight Concert is now in Chennai. Listen to classical and contemporary music at Museum Theatre, amidst thousands of candles

The first concert on November 15 will feature tunes from Tamil and Hindi films, followed by tributes to Coldplay, Mozart, Queen, and Abba in the upcoming months



  • Life & Style

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Exploring urban ecology through stories, verse and flavours




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Jairam Tiger Mahto stands in the way in tough battle for NDA and INDIA blocs in Jharkhand

Known for raising local issues, the 30-year-old leader hails from Kurmi (Mahtos) community that comprise 22% of the total population, the largest chunk after tribals and plays a decisive role in at least 30 seats




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Sharandeep grinds out a half-century on a slow-moving opening day

The opener exhibits ample patience and a tight defence as Jharkhand reached 136 for three in the 55 overs that were possible after the start of play was delayed by two hours




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Parthiv Patel gets dual responsibility with Gujarat Titans: batting and assistant coach

Parthiv Patel will perform the dual role in the support staff led by head coach Ashish Nehra




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South India science drama festival on Thursday and Friday




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Congress demands white paper on government recruitments in Goa since 2019

The Congress attack came a day after a woman member of BJP’s mahila morcha was arrested in connection with the jobs scam




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CMC organises exhibition and poster competition on diabetes




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Tambaram Corporation begins population survey and area mapping for improved coverage of UPHCs




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Temple sets example by introducing ‘mechanical elephant’ to honour tradition and preserve wildlife

Inspired by the Irinjadappilly Sri Krishna Temple in Thrissur, the temple trustees collaborated with PETA to bring Sankaranarayan to Kannur




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Two men arrested for producing forged demand draft




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The impact of Pradhan Mantri Ujjwala Yojana in Jammu and Kashmir

Expanding the network of LPG distribution points in rural areas and extending financial support for refills could further increase clean fuel adoption




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Demanding security, Tamil Nadu government doctors begin indefinite strike

Federation of Government Doctors’ Association will decide on the next course of action at an executive committee meeting to be held on November 17, 2024.




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Trump names firebrand lawmaker Matt Gaetz U.S. Attorney General

Donald Trump posted on social media that Matt Gaetz will end Weaponized Government