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An engineered exosome for delivering sgRNA:Cas9 ribonucleoprotein complex and genome editing in recipient cells

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Biomater. Sci., 2020, Advance Article
DOI: 10.1039/D0BM00427H, Paper
Yangyang Ye, Xiang Zhang, Fei Xie, Bin Xu, Ping Xie, Ting Yang, Qian Shi, Chen-Yu Zhang, Yujing Zhang, Jiangning Chen, Xiaohong Jiang, Jing Li
CRISPR-Cas9 components delivered by engineered exosomes achieve genome editing in recipient cells.
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Antibiofilm coatings based on protein-engineered polymers and antimicrobial peptides for preventing implant-associated infections

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Biomater. Sci., 2020, Advance Article
DOI: 10.1039/D0BM00155D, Paper
Sergio Acosta, Arturo Ibañez-Fonseca, Conrado Aparicio, J. Carlos Rodríguez-Cabello
Protein-engineered polymers can be used as multivalent platforms for AMP tethering on implant surfaces as cytocompatible coatings with strong antibiofilm properties.
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Enhanced nanoparticle accumulation by tumor-acidity-activatable release of sildenafil to induce vasodilation

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Biomater. Sci., 2020, Advance Article
DOI: 10.1039/D0BM00466A, Paper
Peng Zhang, Yu Zhang, Xiaoya Ding, Chunsheng Xiao, Xuesi Chen
An efficient strategy to selectively promote nanoparticle accumulation in solid tumors was developed by encapsulating sildenafil in cisplatin-incorporated polymeric micelles.
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Messenger RNA/polymeric carrier nanoparticles for delivery of heme oxygenase-1 gene in the post-ischemic brain

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Biomater. Sci., 2020, Advance Article
DOI: 10.1039/D0BM00076K, Paper
Jungju Oh, Sang-Mi Kim, Eun-Hye Lee, Minkyung Kim, Youngki Lee, Seung Hwan Ko, Ji Hoon Jeong, Chang-Hwan Park, Minhyung Lee
Heme oxygenase-1 messenger RNA (HO1-mRNA) was delivered into the post-ischemic brain, using a polymeric carrier. Therapeutic efficacy of HO1-mRNA delivery was compared with that of HO1-plasmid DNA (HO1-pDNA) in ischemia-reperfusion rat models.
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A TRACER culture invasion assay to probe the impact of cancer associated fibroblasts on head and neck squamous cell carcinoma cell invasiveness

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Biomater. Sci., 2020, Advance Article
DOI: 10.1039/C9BM02017A, Paper
Teresa Dean, Nancy T. Li, Jose L. Cadavid, Laurie Ailles, Alison P. McGuigan
A novel 3D in vitro co-culture platform to explore the interactions between cancer-associated fibroblasts and tumour cells that drive increased tumour cell invasion and the impact of matrix density.
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A photothermal-hypoxia sequentially activatable phase-change nanoagent for mitochondria-targeting tumor synergistic therapy

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Biomater. Sci., 2020, Advance Article
DOI: 10.1039/D0BM00003E, Paper
Jia Qu, Dengke Teng, Guoqing Sui, Shihui Guan, Yang Wang, Qimeihui Wang, Yuanqiang Lin, Haitao Ran, Zhigang Wang, Hui Wang
The advantages of PCM@Lip/IT NPs include mitochondrial-targeting, on-demand drug release, and prodrug activation by hypoxia with guidance/monitoring by PA and FL imaging.
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Sustainable release of vancomycin from micro-arc oxidised 3D-printed porous Ti6Al4V for treating methicillin-resistant Staphylococcus aureus bone infection and enhancing osteogenesis in a rabbit tibia osteomyelitis model

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Biomater. Sci., 2020, Advance Article
DOI: 10.1039/C9BM01968E, Paper
Teng Zhang, Qingguang Wei, Hua Zhou, Wenhao Zhou, Daoyang Fan, Xinhong Lin, Zehao Jing, Hong Cai, Yan Cheng, Xiaoguang Liu, Weishi Li, Chunli Song, Yun Tian, Nanfang Xu, Yufeng Zheng, Zhongjun Liu
Sustainable release of vancomycin from micro-arc oxidised 3D-printed porous Ti6A14V for treating MRSA bone infection and enhancing osteogenesis.
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Self-assembled nucleo-tripeptide hydrogels provide local and sustained doxorubicin release

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Biomater. Sci., 2020, Advance Article
DOI: 10.1039/D0BM00134A, Paper
Kiheon Baek, Alexander David Noblett, Pengyu Ren, Laura J. Suggs
Doxorubicin is intercalated within the nanofibril structure of self-assembled nucleo-peptide hydrogels and injection leads to decrease in tumor volume and greater concentration of chemotherapeutic relative to soluble form.
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A pH-responsive dissociable mesoporous silica-based nanoplatform enabling efficient dual-drug co-delivery and rapid clearance for cancer therapy

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Biomater. Sci., 2020, Accepted Manuscript
DOI: 10.1039/D0BM00204F, Paper
Yongju He, Linjie Shao, Ibrahim Usman, Yao Hu, Anqiang Pan, Shuquan Liang, Hui Xu
The dilemma between tumor accumulation and renal clearance has severely limited the efficacy of mesoporous silica-based drug nanocarrier in cancer therapy. Herein, a pH-responsive dissociable mesoporous silica-based nanoplatform with efficient...
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19 F magnetic resonance imaging enabled real-time, non-invasive and precise localization and quantification of the degradation rate of hydrogel scaffolds in vivo

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Biomater. Sci., 2020, Advance Article
DOI: 10.1039/D0BM00278J, Paper
Qinghua Li, Zujian Feng, Huijuan Song, Jianhua Zhang, Anjie Dong, Deling Kong, Weiwei Wang, Pingsheng Huang
19 F MRI is able to precisely monitor the localization and quantify the degradation rate of implantable/injectable hydrogels in real-time and noninvasive manner, with no interference of endogenous background signals and limitation of penetration depth.
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A disulfide based low molecular weight gel for the selective sustained release of biomolecules

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Biomater. Sci., 2020, Advance Article
DOI: 10.1039/D0BM00508H, Paper
Nitin D. Bansode, Kotagudda Ranganath Sindhu, Chloe Morel, Murielle Rémy, Julien Verget, Claudine Boiziau, Philippe Barthélémy
Constructing biocompatible soft materials via supramolecular approaches remains an important challenge for in vivo applications.
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A conductive PEDOT/alginate porous scaffold as a platform to modulate the biological behaviors of brown adipose-derived stem cells

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Biomater. Sci., 2020, Advance Article
DOI: 10.1039/C9BM02012H, Paper
Boguang Yang, Fanglian Yao, Lei Ye, Tong Hao, Yabin Zhang, Lei Zhang, Dianyu Dong, Wancai Fang, Yan Wang, Xiaoyang Zhang, Changyong Wang, Junjie Li
The development of three-dimensional conductive scaffolds is vital to support the adhesion, proliferation and myocardial differentiation of stem cells in cardiac tissue engineering.
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Oral biofilm elimination by combining iron-based nanozymes and hydrogen peroxide-producing bacteria

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Biomater. Sci., 2020, 8,2447-2458
DOI: 10.1039/C9BM01889A, Paper
Yanqiu Wang, Xinyu Shen, Shang Ma, Qianqian Guo, Wei Zhang, Lu Cheng, Liming Ding, Zhuobin Xu, Jing Jiang, Lizeng Gao
Combining nanozymes and bacteria to eliminate dental biofilms in a mixed-species model.
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In situ conversion of rose bengal microbubbles into nanoparticles for ultrasound imaging guided sonodynamic therapy with enhanced antitumor efficacy

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Biomater. Sci., 2020, 8,2526-2536
DOI: 10.1039/C9BM02046B, Paper
Rui Hou, Xiaolong Liang, Xiaoda Li, Xu Zhang, Xiaotu Ma, Fan Wang
Sonosensitizer microbubbles enhance drug accumulation and the antitumor efficacy of sonodynamic therapy by ultrasound mediated micro to nano conversion.
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Tumor localization of oncolytic adenovirus assisted by pH-degradable microgels with JQ1-mediated boosting replication and PD-L1 suppression for enhanced cancer therapy

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Biomater. Sci., 2020, 8,2472-2480
DOI: 10.1039/D0BM00172D, Paper
Haishi Qiao, Xingmei Chen, Qiming Wang, Junmei Zhang, Dechun Huang, Enping Chen, Hongliang Qian, Yinan Zhong, Qi Tang, Wei Chen
Illustration of pH-degradable microgels (MGs) for the simultaneous encapsulation of OA and JQ1 for an enhanced oncolytic viral treatment with JQ1-meidated boosting viral replication and PD-L1 suppression.
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Trastuzumab targeted micellar delivery of docetaxel using dendron–polymer conjugates

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Biomater. Sci., 2020, 8,2600-2610
DOI: 10.1039/C9BM01764J, Paper
Burcu Sumer Bolu, Bianka Golba, Amitav Sanyal, Rana Sanyal
Incorporation of a therapeutic antibody into nanosized drug delivery systems can improve their target specificity.
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Super-assembled core/shell fibrous frameworks with dual growth factors for in situ cementum–ligament–bone complex regeneration

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Biomater. Sci., 2020, 8,2459-2471
DOI: 10.1039/D0BM00102C, Paper
Tian Ding, Jianhua Li, Xingshuang Zhang, Lingqian Du, Yang Li, Dengwang Li, Biao Kong, Shaohua Ge
In this work, a super-assembled framework (SAF) was fabricated to achieve sequential delivery of bFGF and BMP-2 for in situ cementum–ligament–bone complex regeneration.
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Bioinspired inorganic nanoparticles and vascular factor microenvironment directed neo-bone formation

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Biomater. Sci., 2020, 8,2627-2637
DOI: 10.1039/D0BM00041H, Paper
Hwan D. Kim, Jungha Park, Sivashanmugam Amirthalingam, R. Jayakumar, Nathaniel S. Hwang
VEGF-overexpressing human tonsil-derived stem cells (VEGF-hTMSCs) and a whitlockite microenvironment induce vascularized bone tissue formation in biodegradable polymeric scaffolds.
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Assembly of FN-silk with laminin-521 to integrate hPSCs into a three-dimensional culture for neural differentiation

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Biomater. Sci., 2020, 8,2514-2525
DOI: 10.1039/C9BM01624D, Paper
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Carolina Åstrand, Veronique Chotteau, Anna Falk, My Hedhammar
The functionalized recombinant spider silk protein FN-silk can self-assemble into a 3D microfiber network. When combined with recombinant laminin521 it provides a 3D culture system suitable for expansion of hPSCs and following neural differentiation.
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NIR-emitting semiconducting polymer nanoparticles for in vivo two-photon vascular imaging

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Biomater. Sci., 2020, 8,2666-2672
DOI: 10.1039/C9BM02063B, Paper
Xiao-Ting Gong, Wenguang Xie, Jing-Jing Cao, Shengxiang Zhang, Kanyi Pu, Hao-Li Zhang
A NIR-emitting TPF probe (NESPN) was prepared using semiconducting polymers and used for continuously monitoring the whole process of ischemic stroke and subsequent reperfusion. This work provides a new and versatile tool for vascular research and diagnosis of vascular diseases.
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Spatial immobilization of endogenous growth factors to control vascularization in bone tissue engineering

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Biomater. Sci., 2020, 8,2577-2589
DOI: 10.1039/D0BM00087F, Paper
Marta R. Casanova, Catarina Oliveira, Emanuel M. Fernandes, Rui L. Reis, Tiago H. Silva, Albino Martins, Nuno M. Neves
An engineered biofunctional system comprises endogenous BMP-2 and VEGF bound in a parallel pattern. It successfully enabled obtaining the spatial osteogenic and angiogenic differentiation of human hBM-MSCs under basal culture conditions.
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H2S-releasing amphiphilic dipeptide hydrogels are potent S. aureus biofilm disruptors

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Biomater. Sci., 2020, 8,2564-2576
DOI: 10.1039/D0BM00241K, Paper
Yun Qian, Afnan Altamimi, Shaina Alston Yates, Santu Sarkar, Matthew Cochran, Mingjun Zhou, Nicole Levi-Polyachenko, John B. Matson
Hydrogen sulfide (H2S) is an endogenous signaling gas, and exogenous H2S administration has the potential for promoting wound healing. Here we investigate the antimicrobial effects of H2S-releasing hydrogels in the context of burn wound healing.
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A thermo-responsive, self-assembling biointerface for on demand release of surface-immobilised proteins

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Biomater. Sci., 2020, 8,2673-2681
DOI: 10.1039/C9BM01957J, Paper
Angela Saccardo, Mikhail Soloviev, Enrico Ferrari
Engineering of the neuronal SNARE proteins yields chimeric bio-materials that reversibly assemble and disassemble at set temperatures.
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Advances in living cell-based anticancer therapeutics

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Biomater. Sci., 2020, 8,2344-2365
DOI: 10.1039/D0BM00036A, Review Article
He Dong, Xiao Xu, Leikun Wang, Ran Mo
This review summarizes recent advances in the applications of living cells as drug carriers or active drugs for anticancer drug delivery and cancer therapy.
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Interfacing human induced pluripotent stem cell-derived neurons with designed nanowire arrays as a future platform for medical applications

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Biomater. Sci., 2020, 8,2434-2446
DOI: 10.1039/D0BM00182A, Paper
Jann Harberts, Undine Haferkamp, Stefanie Haugg, Cornelius Fendler, Dennis Lam, Robert Zierold, Ole Pless, Robert H. Blick
Nanostructured substrates such as nanowire arrays form a powerful tool for building next-generation medical devices.
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A novel peptide targeting gastrin releasing peptide receptor for pancreatic neoplasm detection

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Biomater. Sci., 2020, 8,2682-2693
DOI: 10.1039/D0BM00162G, Paper
Yuanbiao Tu, Ji Tao, Fang Wang, Peifei Liu, Zhihao Han, Zhaolun Li, Yi Ma, Yueqing Gu
The designed novel peptide GB-6 with targeted GRPR-binding possesses more favorable pharmacokinetic properties and metabolic stability, as well as superior tumor-targeting ability in pancreatic cancer models, relative to BBN7–14.
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Particle-mediated delivery of frataxin plasmid to a human sensory neuronal model of Friedreich's ataxia

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Biomater. Sci., 2020, 8,2398-2403
DOI: 10.1039/C9BM01757G, Communication
Ewa Czuba-Wojnilowicz, Serena Viventi, Sara E. Howden, Simon Maksour, Amy E. Hulme, Christina Cortez-Jugo, Mirella Dottori, Frank Caruso
Multilayered particles in gene therapy for Friedreich's ataxia induce a 27 000-fold increase in frataxin gene expression in a patient-derived cell model.
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An intelligent vancomycin release system for preventing surgical site infections of bone tissues

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Biomater. Sci., 2020, Advance Article
DOI: 10.1039/D0BM00255K, Paper
Yuan Li, Guang Li, Xiaoling Sha, Litao Li, Kuo Zhang, Daohong Liu, Yanfei Hao, Xu Cui, Lei Wang, Hao Wang
An intelligent anti-bacterial system can be constructed on implants during surgery.
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A versatile ultrafine and super-absorptive H+-modified montmorillonite: application for metabolic syndrome intervention and gastric mucosal protection

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Biomater. Sci., 2020, Advance Article
DOI: 10.1039/D0BM00474J, Paper
Qiwen Wang, Jie Shen, Enqi Mo, Haotian Zhang, Jianwei Wang, Xiurong Hu, Jun Zhou, Hongzhen Bai, Guping Tang
An H+-modified montmorillonite (H-MMT) was prepared using an acid modification method to obtain powerful absorption ability as a theranostic platform for both metabolic syndrome and gastric mucosa protection.
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Optically controlled hybrid metamaterial of plasmonic spiky gold inbuilt graphene sheets for bimodal imaging guided multimodal therapy

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Biomater. Sci., 2020, Advance Article
DOI: 10.1039/D0BM00312C, Paper
Kunnumpurathu Jibin, Jayaram S. Prasad, Giridharan Saranya, Sachin J. Shenoy, Kaustabh K. Maiti, Ramapurath S. Jayasree
Gold–graphene nanohybrid for simultaneous dual-imaging guided triple therapy as a new paradigm in light-triggered cancer theranostics. The material demonstrates excellent therapeutic efficacy and treatment monitoring features.
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A transport system based on a quantum dot-modified nanotracer is genetically and developmentally stable in pregnant mice

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Biomater. Sci., 2020, Advance Article
DOI: 10.1039/D0BM00311E, Paper
Open Access
Hye Jin Kim, Ji Sun Park, Se Won Yi, Minyeon Go, Hye-Ryun Kim, Su Jin Lee, Jong Min Park, Dong Hyun Cha, Sung Han Shim, Keun-Hong Park
The use of nanoscale materials (NMs) could cause problems such as cytotoxicity, genomic aberration, but the impacts of NM exposure during pregnancy remain uncharacterized in the context of clinical applications.
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Serum miRNAs are differentially altered by ethanol and caffeine consumption in rats

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Toxicol. Res., 2019, 8,842-849
DOI: 10.1039/C9TX00069K, Paper
M. Martinez, I. M. U. Rossetto, R. M. S. Arantes, F. S. N. Lizarte, L. F. Tirapelli, D. P. C. Tirapelli, L. G. A. Chuffa, F. E. Martinez
Alcoholism is a multifactorial disease with high risk for dependence determined by genetic background, environmental factors and neuroadaptations.
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Gynura divaricata ameliorates hepatic insulin resistance by modulating insulin signalling, maintaining glycolipid homeostasis and reducing inflammation in type 2 diabetic mice

By pubs.rsc.org
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Toxicol. Res., 2019, 8,928-938
DOI: 10.1039/C9TX00191C, Paper
Xuan Dong, Shu-Xiang Zhao, Bing-Qing Xu, Yu-Qing Zhang
Oral lyophilized powder of Gynura divaricata, an edible medicinal plant, can alleviate both hyperglycaemia and hepatic insulin resistance in type 2 diabetic mice.
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Lipoic acid antagonizes paraquat-induced vascular endothelial dysfunction by suppressing mitochondrial reactive oxidative stress

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Toxicol. Res., 2019, 8,918-927
DOI: 10.1039/C9TX00186G, Paper
Li Pang, Ping Deng, Yi-dan Liang, Jing-yu Qian, Li-Chuan Wu, Ling-ling Yang, Zheng-ping Yu, Zhou Zhou
α-Lipoic acid antagonizes paraquat toxicity.
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Thyroid endocrine status and biochemical stress responses in adult male Wistar rats chronically exposed to pristine polystyrene nanoplastics

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Toxicol. Res., 2019, 8,953-963
DOI: 10.1039/C9TX00147F, Paper
Fatemeh Amereh, Akbar Eslami, Simin Fazelipour, Mohammad Rafiee, Mohammad Ismail Zibaii, Mohammad Babaei
At this time, little is known about the long-term effects of micro(nano)plastics on public health. In the present study, early warning signs of thyroid endocrine disruption were noticed in adult Wistar rats from the ingestion of virgin polystyrene nanoparticles.
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Biogenic Aspergillus tubingensis silver nanoparticles’ in vitro effects on human umbilical vein endothelial cells, normal human fibroblasts, HEPG2, and Galleria mellonella

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Toxicol. Res., 2019, 8,789-801
DOI: 10.1039/C9TX00091G, Paper
Cristiane Angélica Ottoni, Durvanei Augusto Maria, Priscila Jane Romano de Oliveira Gonçalves, Welington Luiz de Araújo, Ana Olívia de Souza
Biogenic silver nanoparticles are ecofriendly and offers valuable possibilities of applications in several industrial areas.
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Effects of moderate red wine on cardiovascular risk factors in diabetics: a systematic review and meta-analysis of randomized controlled trials

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Toxicol. Res., 2019, 8,979-987
DOI: 10.1039/C9TX00227H, Paper
Saavia Alice Naame, Decheng Li, Ruixue Huang
Diabetes mellitus is of major public health concerns; its incidence is continuously increasing.
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Astilbin attenuates cerebral ischemia/reperfusion injury by inhibiting the TLR4/MyD88/NF-κB pathway

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Toxicol. Res., 2019, 8,1002-1008
DOI: 10.1039/C9TX00222G, Paper
Jing Li, Zhaowei Gu, Yue Liu, Yu Wang, Min Zhao
Ischemic stroke is the second most common cause of death worldwide and cerebral ischemia/reperfusion (I/R) injury also leads to serious tissue damage.
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Astaxanthin reduces perfluorooctanoic acid cytotoxicity in Saccharomyces cerevisiae

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Toxicol. Res., 2019, 8,1009-1015
DOI: 10.1039/C9TX00215D, Paper
S. J. Sudharshan, Raghavendra Tirupathi, Madhu Dyavaiah
Perfluorooctanoic acid (PFA) has been identified as an environmental contaminant of high concern for human health.
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Nanoparticle induced barrier function assessment at liquid–liquid and air–liquid interface in novel human lung epithelia cell lines

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Toxicol. Res., 2019, 8,1016-1027
DOI: 10.1039/C9TX00179D, Paper
Open Access
Lars Leibrock, Sandra Wagener, Ajay Vikram Singh, Peter Laux, Andreas Luch
To answer questions about nanoparticle toxicity, translocation and biokinetics following inhalation exposure, in vitro models should have functional barrier properties to mimic the in vivo situation as closely as possible.
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Application of the direct peptide reactivity assay (DPRA) to inorganic compounds: a case study of platinum species

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Toxicol. Res., 2019, 8,802-814
DOI: 10.1039/C9TX00242A, Paper
Jocelyn D. C. Hemming, Mark Hosford, Martin M. Shafer
The in chemico Direct Peptide Reactivity Assay (DPRA) was developed as a non-animal, relatively high throughput, screening tool for skin sensitization potential.
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Benzoquinone alters the lipid homeostasis in Saccharomyces cerevisiae

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Toxicol. Res., 2019, 8,1035-1041
DOI: 10.1039/C9TX00139E, Paper
Abhishek Raj, Vasanthi Nachiappan
BQ exposure inhibited cell growth, increased the ROS-mediated apoptosis, and altered the phospholipids that resulted in membrane proliferation.
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Only 13% of industrial units resume ops after Odisha eases lockdown

By www.business-standard.com
Published On :: Fri, 08 May 2020 17:29:00 +0530

Micro units in the state have not been able to resume operations to catch up with their larger peers


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Amarinder Singh asks administration to ensure welfare of migrant workers

By www.business-standard.com
Published On :: Fri, 08 May 2020 17:53:00 +0530

The chief minister asked the industry ministry to "aggressively" pursue the development of the four industrial parks already announced by the state government in the budget for this fiscal.


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Export contraction in April could surpass March's steep 25-year decline

By www.business-standard.com
Published On :: Fri, 08 May 2020 19:02:00 +0530

Major forex earning sectors cite lack of labour, funds and key supplies


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Vizag gas leak: NGT orders LG Polymers to deposit Rs 50 cr pending probe

By www.business-standard.com
Published On :: Fri, 08 May 2020 20:07:00 +0530

NGT bench set up fact-finding committee, to be headed by former AP High Court judge


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Gujarat eases labour laws, offers land to firms shifting base from China

By www.business-standard.com
Published On :: Fri, 08 May 2020 20:28:00 +0530

The state government also offered land and infrastructure for companies and projects that were looking to shift base from China to other destinations


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Govt hikes borrowing limit by over 50% to Rs 12 trn as virus grips economy

By www.business-standard.com
Published On :: Fri, 08 May 2020 20:56:00 +0530

Sources say the Centre has asked RBI to do whatever to keep yields in check, which may result in massive secondary market bond purchases


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Covid-19: Relief for NRIs, foreign visitors as tax residency rules eased

By www.business-standard.com
Published On :: Sat, 09 May 2020 02:08:00 +0530

The government imposed a lockdown on March 24 and is yet to open up travel, including international flights.


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Covid-19: Chhattisgarh CM asks Rs 30,000 cr package for state from PM

By www.business-standard.com
Published On :: Sat, 09 May 2020 13:01:00 +0530

CM Baghel has urged the prime minister to release Rs 10, 000 crore immediately, out of the total amount.


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