Malaria parasites invade and replicate within red blood cells (RBCs), extensively modifying their structure and gaining access to the extracellular environment by placing the plasmodial surface anion channel (PSAC) into the RBC membrane. Expression of members of the cytoadherence linked antigen gene 3 (clag3) family is required for PSAC activity, a process that is regulated epigenetically. PSAC is a well-established route of uptake for large, hydrophilic antimalarial compounds and parasites can acquire resistance by silencing clag3 gene expression, thereby reducing drug uptake. We found that exposure to sub-IC50 concentrations of the histone methyltransferase inhibitor chaetocin caused substantial changes in both clag3 gene expression and RBC permeability, reversing acquired resistance to the antimalarial compound blasticidin S that is transported through PSAC. Chaetocin treatment also altered progression of parasites through their replicative cycle, presumably by changing their ability to modify chromatin appropriately to enable DNA replication. These results indicate that targeting histone modifiers could represent a novel tool for reversing epigenetically acquired drug resistance in P. falciparum.

The FBI seizes the internet domain to WeLeakInfo.com, a site that was cataloging billions of records, such as email addresses and passwords, from more than 10,300 data breaches at various companies and service providers.

The records involved conversation logs between Microsoft support agents and customers across the globe, dating back to 2005. Most of the records were redacted of customer contact information, but not all.

The JSE fell on Tuesday as global markets tumbled on the back of a rout in crude oil prices.

The local bourse inched higher on Wednesday as global stocks took a breather following consecutive sessions of weakness.

Stock markets struggled on Friday as hopes of quickly finding a treatment for coronavirus were dashed, analysts said, and more crushing economic data delivered a body blow to confidence.

Equity markets have rallied Monday as countries eased coronavirus lockdown measures, but oil prices tumbled as a supply glut offset output cuts.

The surge in stocks was on the back of positive news from trials being conducted on a potential treatment for the coronavirus. With most economies looking to partially reopen their economies, this brought a jump across most asset classes including commodities.

Unprecedented demand for online services and entertainment during the Covid-19 pandemic lockdowns, along with a scramble for haven investments, have helped set South African stocks on course for a record month.

Stock markets plunged on Thursday after economic growth data confirmed fears of Covid-19's bruising impact on the world economy.

Still, there was disappointment in terms of economic data following the release of the SACCI Business Confidence index data for April which came in at 77.8, compared to a forecast of 89.2.

The rand strengthened against the greenback as it peaked at a session high of R18.30 before it was recorded trading 1.41% firmer at R18.32/$ at 17.00

BACKGROUND:

The ability of the decades-old Boston and Philadelphia criteria to accurately identify infants at low risk for serious bacterial infections has not been recently reevaluated.

Wix Stores has a smooth offering that's strongly geared toward beginners who just want to get off the ground quickly. More advanced users or those who need more in-depth customizability, however, will need to look elsewhere.

Given that GoDaddy's GoCentral Online Store is an add-on service to its web hosting product, you'll find its features a little more limited than much of the competition. But if you're a GoDaddy customer, then it's a great way to start quickly.

Sabric, a financial crime information centre, shares its tips on staying safe over the festive season.

Extremely low or negative yields in global markets make it challenging for investors to generate meaningful returns, says Brian McMillan of Investec Structured Products.

There are three challenges facing investors going forward, HSBC chief market strategist at HSBC Private Bank tells Fin24.

Finance Minister Tito Mboweni’s February Budget speech will be scrutinised for evidence the country is doing enough to preserve its last remaining investment grade rating from Moody’s.

Many investors do not fully understand the tax incentive and structure of a Section 12J venture capital investment, according to a managing director involved in this sector.

Sharing moments of levity and hope from the education world amid the mass disruption of schooling and life from the coronavirus.

Penn Staters across the Commonwealth are embodying the “We Are” spirit by keeping campus food pantries open and shelves stocked to continue to serve students in need during the coronavirus pandemic.

After a successful pilot, a professional development program is looking to expand its lesson-study approach to rural teachers.

Is your favorite music missing on your iPhone or iPad? Maybe you inadvertently turned off syncing or accidentally deleted those tunes. All is not lost; here's how to recover your music.

As the Apple iPod turns 14, we take a look back at its history and influence over the last decade-plus.

Customers in the U.S. should begin noticing in-store changes starting today.

Before there were smartwatches, digital watches were the most high-tech timepieces you could buy. We explore the evolution of the digital watch from 1972 to present day.

Don't settle for the default settings on your Android device. With the right launcher, you can customize the screens and layouts of your phone.

The most popular special education stories of the year examined the broken promises of special education, the aftermath of the lead crisis in Flint, Mich., and how educators lack confidence in their ability to meet the needs of children with disabilities.

Education Week's top English-language learner stories on 2019 explored who's teaching the nation's English-learners and the struggles those educators encounter on the job, how the Trump administration's immigration policies affected students and their families and examined why more schools in the Un

Until now, providing your own router didn't stop ISPs charging you a router rental fee.

The STOP-ROP Multicenter Study Group
Feb 1, 2000; 105:295-310
ARTICLES

In a shocking display of ignorance, pay for performance has become reformers' blitzkrieg. Both common sense and research are being ignored.

Penn State Abington faculty are using the current situation as an opportunity to enrich students academically and support them personally during this period of remote learning. "What may be most inspiring of all is the deep-seated concern for our students that faculty efforts expose,” said Friederike Baer, division head for Arts and Humanities.

Many consumers are facing limited hours and product shortages at their neighborhood grocery stores and naturally are worried about the availability and safety of their food. A Penn State Extension webinar planned for noon to 1 p.m. May 14 will address these concerns, as well as provide suggestions on alternative places and methods for sourcing food.

Parental control app Qustodio is a highly configurable, easy-to-manage tool for keeping track of your child's activity on Windows, Mac, iOS, and Android devices, though it comes at a premium price.

Retail stores, corporate offices, and contact centers in China are closed through February 9 as the coronavirus spreads globally. Apple's online store will remain open, though.

Though it only costs $150, LG's Aristo 4+ phone offers a disappointing experience all around.

We're living through a moment that will be written about in history books. Personal journals, blogs and oral histories could help shape the narrative, according to historians at Penn State Behrend.

The winning writers of Penn State University Libraries Short Stories’ “April Showers” spring 2020 contest have been announced. Representing six Penn State campuses, the latest writing contest challenged Penn State students, faculty and staff across the commonwealth to unleash their best original short stories or poetry on the theme of weather.

Juan Roberto Meléndez-Colón was exonerated, in 2002, after nearly 18 years on death row for a crime he did not commit. He visited Penn State Fayette, The Eberly Campus to share his story on March 5.

Entries from two Penn State students were among winners in categories for professional television journalists as part of the Keystone Media Awards.

The books category has disappeared from the Microsoft Store and you'll no longer be able to access purchased or rented ebooks from July. Expect a full refund, though.

"We have a key word from day one: 'winning'. We are going to keep fighting hard to keep doing that," said Fernando Santos as he prepared for four more years as Portugal coach.

Connected storage is more versatile storage, but that's just one of the many benefits of buying a NAS device. We've tested the top models to tell you which one will work best for your home or small business.

The SA market is losing favour among international investors.

Stockbrokers come in two forms: human and online. And costs, advice and information available to investors differ widely.

Technology like DNA testing and facial recognition has helped me piece together a family history torn apart by war. But honoring Holocaust Remembrance Day is about more than remembering the past.

Behavioral economics applies key principles from psychology and economics to address obstacles to behavior change. The important topic of pediatric firearm injuries has not yet been explored through a behavioral economic lens. Pediatric firearm-related injuries are a significant public health problem in the United States. Despite American Academy of Pediatrics guidelines advising that firearms be stored unloaded, in a locked box or with a locking device, and separate from ammunition, estimates suggest that ~4.6 million children live in homes with at least 1 loaded and unlocked firearm. In this article, we use behavioral economic theory to identify specific cognitive biases (ie, present bias; in-group, out-group bias; and the availability heuristic) that may influence parental decision-making around firearm storage. We illustrate situations in which these biases may occur and highlight implementation prompts, in-group messengers, and increased salience as behaviorally informed strategies that may counter these biases and subsequently enhance safe firearm storage. We also describe other opportunities to leverage the behavioral economic tool kit. By better understanding the individual behavioral levers that may impact decision-making around firearm storage, behavioral scientists, pediatric providers, and public health practitioners can partner to design and test tailored interventions aimed at decreasing pediatric firearm injuries. Further empirical study is warranted to identify the presence of specific biases and heuristics and determine the most effective behavior change strategies for different subpopulations.