as

[ASAP] Inhibitory Effect of Cannabidiol on the Activation of NLRP3 Inflammasome Is Associated with Its Modulation of the P2X7 Receptor in Human Monocytes

Journal of Natural Products
DOI: 10.1021/acs.jnatprod.0c00138




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[ASAP] A Grand Challenge. 3. Unbiased Phenotypic Function of Metabolites from Australia Plants <italic toggle="yes">Gloriosa superba</italic> and <italic toggle="yes">Alangium villosum</italic> against Parkinson

Journal of Natural Products
DOI: 10.1021/acs.jnatprod.9b00880




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[ASAP] Advances in the Biosynthesis of Pyranocoumarins: Isolation and <sup>13</sup>C-Incorporation Analysis by High-Performance Liquid Chromatography–Ultraviolet–Solid-Phase Extraction–Nuclear Magnetic Resonance Data

Journal of Natural Products
DOI: 10.1021/acs.jnatprod.9b00607




as

[ASAP] Stoechanones A and B, Phytotoxic Copaane Sesquiterpenoids Isolated from <italic toggle="yes">Lavandula stoechas</italic> with Potential Herbicidal Activity against <italic toggle="yes">Amaranthus retroflexus<

Journal of Natural Products
DOI: 10.1021/acs.jnatprod.0c00182




as

Fun and games with JavaScript

#484 — April 17, 2020

Unsubscribe  :  Read on the Web

???? If you're bored this weekend at all, consider joining the latest Ludum Dare — it's an online game jam that's been taking place for 18 years and more JavaScript entries are appreciated against all the Unity crowd ????

JavaScript Weekly

Writing an 'Emulator' in JavaScript (and Interfacing with Multiple UIs) — This is really neat. Tania built a Chip-8 interpreter in JavaScript and has gone into quite a bit of detail about what was involved here. Lots of neat bits and pieces to pick up from this.

Tania Rascia

jQuery 3.5.0 Released — I know many of you will groan, but I’m delighted when I see a new jQuery release. It’s still so heavily used. No headline features though, this is a security fix for a cross-site scripting vulnerability, plus some tweaks and fixes in preparation for jQuery 4.0 (yes!)

Timmy Willison (jQuery Foundation)

Build a Game of Battleship with TypeScript & Java. Free Course — Join over 2000 developers creating a game of Battleship with TypeScript, Spring Cloud Stream (Java), and PubSub+. This free 30-minute course is a great way to learn the basics of messaging and event-driven architecture with the Aurelia framework.

Solace sponsor

Profiling React.js Performance — Goes into detail on aspects of the React Profiler API, React’s new experimental Interaction Tracing API, and measuring custom metrics using the User Timing API.

Addy Osmani

Userscripts are Fun and Still Very Much Relevant — ‘Userscripts’ are basically JavaScript programs that run in the context of other Web pages so you can add your own features. They were really popular for a while but still exist and are still a neat use case for using JavaScript to improve your Web experience.

Eldad Bercovici

Another Look at What's New in ECMAScript 2020 — We linked to Dr Axel’s roundup recently, but here’s another take, looking at dynamic imports, nullish coalescing, optional chaining, BigInt, and more.

Ianis T.

⚡️ Quick Releases

???? Jobs

JavaScript Developer at X-Team (Remote) — Join the most energizing community for developers. Work from anywhere with the world's leading brands.

X-Team

Senior JavaScript Developer (Warsaw, Relocation Package) — Open source rich text editor used by millions of users around the world. Strong focus on code quality. Join us.

CKEditor

Find a Job Through Vettery — Vettery specializes in tech roles and is completely free for job seekers. Create a profile to get started.

Vettery

???? Tutorials

How To Create a Particle Trail Animation in JavaScript — Particle animations are particularly (sorry) striking.. and in this article, Anna Prenzel shows how to easily create your own such effects with Anime.js.

Smashing Magazine

Strategies for Migrating to TypeScript — A quick overview of some strategies for migrating code bases from JavaScript over to TypeScript.

Dr. Axel Rauschmayer

Developing in a Monorepo While Still Using Webpack — Second part in a series discussing things the team at Etsy learned during the migration of a home-grown, Require.js-based build system to webpack, which took over a year.

Salem Hilal

A More Productive Way to Build Your JavaScript Apps — Write better code, debug it, and test it – all in one place. Try WebStorm. No configuration required.

WebStorm sponsor

▶  Let's Build a Digital Circuit Simulator in JavaScript — A special episode of the Low Level JavaScript series takes us on a brief journey into the world of digital logic.

Low Level JavaScript

How To Set Up an Express API Backend Project with PostgreSQL — A pretty extensive walkthrough of creating an HTTP API using Express with Node.js and Postgres on the backend, then deploying it all on Heroku.

Chidi Orji

Speed Up Your Angular App: 14 Optimization Tips — Tips on how to make your Angular app smaller, faster, and more responsive.

Marcelo Ricardo de Oliveira

Class-Related Types in TypeScript

Dr. Axel Rauschmayer

????▶ A Fireside Chat on the State of Microservices on April 21 — We recently helped The Software House with a developer survey (thanks to those who took it!) and now they’re doing a live chat on the state of microservices next Tuesday featuring Yan Cui, Alessando Vozza, and others.

The Software House

???? Code & Tools

Puppeteer 3.0: It Now Supports Firefox — Best known for as a way to headlessly control Chrome from Node, Puppeteer has recently seen some competition in the form of the cross-browser Playwright recently. But, no fear, Puppeteer is stepping up and can now work cross-browser too. We also learn Puppeteer is migrating to TypeScript.

Mathias Bynens

Open-Source Serverless CMS Powered by React, Node.js and GraphQL API — Build dynamic websites and apps with Webiny. 100% powered by JavaScript. Deploy your sites to AWS Lambda.

Webiny Serverless CMS sponsor

Rome: An Experimental JavaScript Toolchain — A compiler, linter, formatter, bundler, testing framework and more. Started by Sebastian McKenzie (of Babel and Yarn fame), Rome is now a project from the React Native team at Facebook. Related repo.

Facebook

Vime: A New, Modern Media / Video Player for the Web — Aims to be a ‘modern alternative to Video.js and Plyr’: “The idea behind Vime is we want you to control the player, not the other way around.” Modular, tree-shakable, and with potential for a plugin ecosystem. GitHub repo.

Rahim Alwer

Vuln Cost: An Open Source Security Scanner for VS Code — Free Snyk-powered VS Code extension that finds security vulnerabilities in npm packages, providing feedback in-line with your code, such as how many vulnerabilities a package has.

snyk

ip-num: A Library to Work with ASN, IPv4, and IPv6 Numbers — Happy in both Node and the browser.

dadepo

Flip: Animated Flip Counter Plugin to Add a Countdown to a Website — Adds an animated dynamic countdown timer to a page. No dependencies, responsive and mobile friendly, and fits any language, locale, or time zone.

Rik Schennink

The Perfect Partner to MongoDB Atlas. Try It for Free

Studio 3T sponsor

A JavaScript API for Controlling 'Simpsons: Hit & Run' — Including this as a bit of fun if you fancy noodling on something odd. Remote controlling games from JS seems neat, although I suspect just getting this running would take a while..

Tavis Ormandy




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How tiny dependencies can topple the JavaScript Jenga tower

#486 — May 1, 2020

Unsubscribe  :  Read on the Web

JavaScript Weekly

???? I18n Ally: An All-in-One i18n Extension for VS Code — Got some internationalization work to do? I18n Ally gives you inline annotations, automated translations via Google Translate (which you can review), progress indication, etc. Supports React, Angular, Vue and other frameworks.

Anthony Fu

How a Few Lines of Code Broke Lots of Packages — Just under a week ago, people were reporting that create-react-app was broken. The culprit? A tiny change in a tiny dependency: is-promise. Luckily a fix was out very quickly and the creator of is-promise reflects on what happened here. Liran Tal also has some analysis of the situation.

Forbes Lindesay

Identify Front-End Issues Like JavaScript or Network Errors Fast — Datadog’s algorithmic alerts will proactively alert on any client-side issues such as JavaScript and network errors. Optimize the load time of your front-end resources, and detect any UI issues that affect critical user journeys. Try it free with Datadog Synthetics.

Datadog sponsor

Q: A JavaScript 'Quantum Circuit' Simulator — Bring quantum computing to your browser with this JavaScript simulation. If you were never quite sure what your JavaScript code was going to do, now you can formally explore the concept ????

Stewart Smith

Quick bytes:

???? Jobs

Find a Job Through Vettery — Vettery specializes in tech roles and is completely free for job seekers. Create a profile to get started.

Vettery

Senior Full-Stack Developer (Malmö/Sweden) — Every day is different from the next. Join our upbeat Team and work on exciting, major projects using a modern JavaScript stack.

Ortelius AB

???? Tutorials

A Guide to window.location — A breakdown that covers most of the methods and properties available on the DOM’s window.location object.

samantha ming

Implementing Dark Mode in React Apps Using styled-components

Blessing Krofegha

▶  Let's Build a Financial Dashboard App with React (Webinar On‑Demand) — Join TJ VanToll as he walks you through building a responsive Bootstrap-themed Stocks Portfolio app. Check it out today.

Progress KendoReact sponsor

Getting Started with NuxtJS — Learn how to create Vue.js-powered server-side rendered apps with NuxtJS including configuring an app and deploying it on Heroku.

Timi Omoyeni

▶  Learn Svelte: A 16-Part Course on Learning the Popular UI Framework — The course centers around building a chatbot, which is a nice change from the todos and other overused tutorial examples.

noah kaufman

10 Practical JavaScript Tricks — These kinds of lists are usually pretty run of the mill, but this one actually contains some lesser-known quick tips that you may not have seen before.

zander shirley

Moving TinyMCE to Modern JavaScript — The creators of TinyMCE (a popular WYSIWYG HTML editor) have been refactoring its rather legacy JavaScript (the first version came out 17 years ago!) to modern practices.

Joakim Lindkvist

7 JavaScript Design Patterns Every Developer Should Know — This is sort of like a (very) mini version of Addy Osmani’s 2017 book on JS design patterns (which is referenced at the end of the post).

deven rathore

▶  An Introduction to State Machines Using XStateXState is a neat way to work with state machines in JavaScript, Kyle is a neat teacher, and Egghead is a neat platform for unlocking these videos for us too.

Kyle Shevlin

Ride Down Into JavaScript Dependency Hell

AppSignal sponsor

A Collection of Challenging TypeScript Exercises“The goal: Let everyone play with many different TypeScript features and get an overview of TypeScript capabilities and principles.”

Marat Dulin

A Visual Guide to React Mental Models — Different people learn in different ways but good mental models are always valuable and can be helpful if you need to juggle all of the pieces involved in a framework like React.

Obed Parlapiano

Turning Vue Components Into Reusable npm Packages — Outlines how you can reuse Vue components across your projects by automating your process to bundle, test, document, and publish your components.

Sjoerd de voorhoede

???? Code & Tools

jExcel v4: A Vanilla JS Interactive Table / Spreadsheet Control — 4.0 adds support for tabs/workbooks, updating a remote data source with JSON, formula support in a sheet footer, and more. There are lots of demos and examples on the official homepage.

Paul Hodel

Will It CORS? — A handy online tool/wizard for establishing how your (potential) use case will (or won’t!) operate alongside CORS (Cross-Origin Resource Sharing).

HTTP Toolkit

Get Great Visual Feedback & Bug Reports, Even from Non-Technical Folk — Simply click a page element to pin visual feedback with screenshots & metadata. BugHerd = fast and easy bug tracking.

BugHerd sponsor

utfu: Replace Busted Characters From Legacy Text with UTF-8 — Useful when old content contains characters like “— in place of a single quote, and similar legacy text issues.

Daniel Sieradski

Middy 1.0: A Node Middleware Framework for AWS Lambda — Middy’s aim is to make writing serverless functions (hosted on AWS Lambda) easier by providing a familiar middleware abstraction to Node developers.

Luciano Mammino

useWorker() 3.0: A React Hook for Blocking-Free Background Tasks — Makes it easier to throw tasks off to a Web Worker in React.

Alessio Koci

webpack-blocks: Configure webpack using Functional Feature Blocks

Andy Wermke

JZZ: A MIDI Library for Node and the Browser — Send, receive and play MIDI messages from both Node and the browser on Linux, macOS and Windows.

Sema

MDX 1.6: Use JSX in Markdown Documents — This version introduces initial Vue support.

Compositor and Vercel

???? Upcoming Online Events

  • JavaScript Remote Conf 2020 (May 14-15) — Speakers lined up already include Raymond Camden, Christian Heilmann, and Aleksandra Sikora.
  • ESNEXT CONF 2020 (May 18-22) — From the Pika folks (of Snowpack fame). 12 speakers over 5 days so it's a gradual pace.
  • ForwardJS (May 26-29) — A real world event (ForwardJS Ottawa) that has now become a virtual event.
  • CascadiaJS 2020 (September 1-2) — This upcoming online conference is set to take place in September, and the CFP is open now through May 15.




as

Long-term growth narrative has been set by Sitharaman: BofA's Kaku Nakhate

The government's decision of upholding power purchase agreements as well as the opening up of railways, city gas distribution, and electricity supply to the private sector, are welcome steps




as

Govt has put out a progressive Budget aimed at boosting infra: Sujeet Kumar

It has restored confidence of businesses as well as provided on-ground support that MSMEs need and farmers deserve, Co-founder of Udaan said




as

Podcast: T N Ninan and A K Bhattacharya dissect Budget 2020

Has Finance Minister Nirmala Sitharaman delivered a fiscally prudent and growth-oriented Budget 2020? Business Standard Chairman T N Ninan and Editorial Director A K Bhattacharya discuss




as

New tax structure will leave more cash in the hands of people: Revenue Secy

He said the Budget gives an option to individuals to migrate to a new regime by foregoing their existing exemptions and deductions for a lower tax rate




as

Budget 2020 has not accounted for telcos' AGR dues: DEA secretary

But receipts from firms stand at a whopping Rs 1.33 trillion for FY21




as

Budget disappointing; but fiscal, taxation measures welcome: EAC member

India's GDP growth is expected to slip to a decadal low of 5 per cent this fiscal, pressured by domestic factors like drop in consumption, as well as global issues




as

Discussing Radiation Risks Associated With CT Scans With Patients

Interview with Mark Otto Baerlocher, MD, author of Discussing Radiation Risks Associated With CT Scans With Patients




as

A Physician Management Infrastructure

Interview with Peter J. Pronovost, MD, PhD, author of A Physician Management Infrastructure




as

Association of Unconscious Race and Social Class Bias With Vignette-Based Clinical Assessments by Medical Students

Interview with Julie A. Freischlag, MD, author of Association of Unconscious Race and Social Class Bias With Vignette-Based Clinical Assessments by Medical Students




as

Graduated Driver Licensing and Fatal Crashes Involving 16- to 19-Year-Old Drivers

Interview with Scott V. Masten, PhD, author of Graduated Driver Licensing and Fatal Crashes Involving 16- to 19-Year-Old Drivers




as

Effect of Increasing Doses of Saw Palmetto Extract on Lower Urinary Tract Symptoms: A Randomized Trial

Interview with Kevin T. McVary, MD, author of Effect of Increasing Doses of Saw Palmetto Extract on Lower Urinary Tract Symptoms: A Randomized Trial




as

Regional Variation in the Association Between Advance Directives and End-of-Life Medicare Expenditures

Interview with Lauren Hersch Nicholas, PhD, MPP, author of Regional Variation in the Association Between Advance Directives and End-of-Life Medicare Expenditures




as

Identification of Chronic Obstructive Pulmonary Disease in Lung Cancer Screening Computed Tomographic Scans

Interview with Pim A. de Jong, MD, PhD, author of Identification of Chronic Obstructive Pulmonary Disease in Lung Cancer Screening Computed Tomographic Scans




as

Moderate Alcohol Consumption During Adult Life, Drinking Patterns, and Breast Cancer Risk

Interview with Wendy Y. Chen, MD, MPH, author of Moderate Alcohol Consumption During Adult Life, Drinking Patterns, and Breast Cancer Risk




as

Association Between Physician Billing and Cardiac Stress Testing Patterns Following Coronary Revascularization

Interview with Bimal R. Shah, MD, MB, author of Association Between Physician Billing and Cardiac Stress Testing Patterns Following Coronary Revascularization




as

Effects of the CETP Inhibitor Evacetrapib Administered as Monotherapy or in Combination With Statins on HDL and LDL Cholesterol: A Randomized Controlled Trial

Interview with Steven E. Nissen, MD, author of Effects of the CETP Inhibitor Evacetrapib Administered as Monotherapy or in Combination With Statins on HDL and LDL Cholesterol: A Randomized Controlled Trial




as

Urinary Sodium and Potassium Excretion and Risk of Cardiovascular Events

Interview with Martin J. O'Donnell, MB, PhD, author of Urinary Sodium and Potassium Excretion and Risk of Cardiovascular Events




as

Association Between Valvular Surgery and Mortality Among Patients With Infective Endocarditis Complicated by Heart

Interview with Andrew Wang, MD, author of Association Between Valvular Surgery and Mortality Among Patients With Infective Endocarditis Complicated by Heart Failure




as

Association of Antenatal Corticosteroids With Mortality and Neurodevelopmental Outcomes Among Infants Born at 22 to 25 Weeks' Gestation

Interview with Waldemar A. Carlo, MD, author of Association of Antenatal Corticosteroids With Mortality and Neurodevelopmental Outcomes Among Infants Born at 22 to 25 Weeks' Gestation




as

ADHD Medications and Risk of Serious Cardiovascular Events in Young and Middle-aged Adults

Interview with Laurel A. Habel, PhD, author of ADHD Medications and Risk of Serious Cardiovascular Events in Young and Middle-aged Adults




as

Association Between Marijuana Exposure and Pulmonary Function Over 20 Years

Interview with Stefan Kertesz, MD, author of Association Between Marijuana Exposure and Pulmonary Function Over 20 Years




as

Lansoprazole for Children With Poorly Controlled Asthma: A Randomized Controlled Trial

Interview with Janet T. Holbrook, MPH, PhD, author of Lansoprazole for Children With Poorly Controlled Asthma: A Randomized Controlled Trial




as

Variability in Reexcision Following Breast Conservation Surgery

Interview with Laurence E. McCahill, MD, author of Variability in Reexcision Following Breast Conservation Surgery




as

Association of Age and Sex With Myocardial Infarction Symptom Presentation and In-Hospital Mortality

Interview with John G. Canto, MD, MSPH, author of Association of Age and Sex With Myocardial Infarction Symptom Presentation and In-Hospital Mortality




as

Association of Mental Health Disorders With Prescription Opioids and High-Risk Opioid Use in US Veterans of Iraq and Afghanistan

Interview with Karen H. Seal, MD, MPH, author of Association of Mental Health Disorders With Prescription Opioids and High-Risk Opioid Use in US Veterans of Iraq and Afghanistan




as

Association of Hospital Spending Intensity With Mortality and Readmission Rates in Ontario Hospitals

Interview with Therese A. Stukel, PhD, author of Association of Hospital Spending Intensity With Mortality and Readmission Rates in Ontario Hospitals




as

Utilization of Anesthesia Services During Outpatient Endoscopies and Colonoscopies and Associated Spending in 2003-2009

Interview with Soeren Mattke, MD, DSc, author of Utilization of Anesthesia Services During Outpatient Endoscopies and Colonoscopies and Associated Spending in 2003-2009




as

Out-of-Pocket Medication Costs and Use of Medications and Health Care Services Among Children With Asthma

Interview with Dana P. Goldman, PhD, author of Out-of-Pocket Medication Costs and Use of Medications and Health Care Services Among Children With Asthma




as

Detection of Breast Cancer With Addition of Annual Screening Ultrasound or a Single Screening MRI to Mammography in Women With Elevated Breast Cancer Risk

Interview with Wendie A. Berg, MD, PhD, author of Detection of Breast Cancer With Addition of Annual Screening Ultrasound or a Single Screening MRI to Mammography in Women With Elevated Breast Cancer Risk




as

Association Between Helicopter vs Ground Emergency Medical Services and Survival for Adults With Major Trauma

Interview with Samuel M. Galvagno Jr, DO, PhD, author of Association Between Helicopter vs Ground Emergency Medical Services and Survival for Adults With Major Trauma




as

Association Between Hospital Recognition for Nursing Excellence and Outcomes of Very Low-Birth-Weight Infants

Interview with Eileen T. Lake, PhD, RN, author of Association Between Hospital Recognition for Nursing Excellence and Outcomes of Very Low-Birth-Weight Infants




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Association Between Treatment With Brachytherapy vs Whole-Breast Irradiation and Subsequent Mastectomy, Complications, and Survival Among Older Women With Invasive Breast Cancer

Interview with Benjamin D. Smith, MD, author of Association Between Treatment With Brachytherapy vs Whole-Breast Irradiation and Subsequent Mastectomy, Complications, and Survival Among Older Women With Invasive Breast Cancer




as

Neonatal Abstinence Syndrome and Associated Health Care Expenditures: United States, 2000-2009

Interview with Stephen W. Patrick, MD, MPH, MS, author of Neonatal Abstinence Syndrome and Associated Health Care Expenditures: United States, 2000-2009




as

HIV Development Assistance and Adult Mortality in Africa

Interview with Eran Bendavid, MD, MS, author of HIV Development Assistance and Adult Mortality in Africa




as

Effect of Continuous Positive Airway Pressure on the Incidence of Hypertension and Cardiovascular Events in Nonsleepy Patients With Obstructive Sleep Apnea: A Randomized Controlled Trial

Interview with Ferran Barbé, MD, author of Effect of Continuous Positive Airway Pressure on the Incidence of Hypertension and Cardiovascular Events in Nonsleepy Patients With Obstructive Sleep Apnea: A Randomized Controlled Trial




as

Use of Diagnostic Imaging Studies and Associated Radiation Exposure for Patients Enrolled in Large Integrated Health Care Systems, 1996-2010

Interview with Rebecca Smith-Bindman, MD, author of Use of Diagnostic Imaging Studies and Associated Radiation Exposure for Patients Enrolled in Large Integrated Health Care Systems, 1996-2010




as

Lipid-Related Markers and Cardiovascular Disease Prediction

Interview with Emanuele Di Angelantonio, MD, author of Lipid-Related Markers and Cardiovascular Disease Prediction




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Association Between Vaccination for Herpes Zoster and Risk of Herpes Zoster Infection Among Older Patients With Selected Immune-Mediated Diseases: Herpes Zoster and Immune-Mediated Diseases

Interview with Jeffrey R. Curtis, MD, MS, author of Association Between Vaccination for Herpes Zoster and Risk of Herpes Zoster Infection Among Older Patients With Selected Immune-Mediated Diseases: Herpes Zoster and Immune-Mediated Diseases




as

Association Between Use of Interferon Beta and Progression of Disability in Patients With Relapsing-Remitting Multiple Sclerosis

Interview with Helen Tremlett, PhD, author of Association Between Use of Interferon Beta and Progression of Disability in Patients With Relapsing-Remitting Multiple Sclerosis




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Effect of Biolimus-Eluting Stents With Biodegradable Polymer vs Bare-Metal Stents on Cardiovascular Events Among Patients With Acute Myocardial Infarction: The COMFORTABLE AMI Randomized Trial

Interview with Stephan Windecker, MD, author of Effect of Biolimus-Eluting Stents With Biodegradable Polymer vs Bare-Metal Stents on Cardiovascular Events Among Patients With Acute Myocardial Infarction: The COMFORTABLE AMI Randomized Trial




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Comparison of Physician-, Biomarker-, and Symptom-Based Strategies for Adjustment of Inhaled Corticosteroid Therapy in Adults With Asthma: The BASALT Randomized Controlled Trial

Interview with William J. Calhoun, MD, author of Comparison of Physician-, Biomarker-, and Symptom-Based Strategies for Adjustment of Inhaled Corticosteroid Therapy in Adults With Asthma: The BASALT Randomized Controlled Trial




as

The Attending Physician on the Wards: Finding a New Homeostasis

Special interview by Howard Bauchner, MD, Editor in Chief of JAMA, with Robert M. Wachter, MD, and Abraham Verghese, MD, MACP, authors of The Attending Physician on the Wards: Finding a New Homeostasis




as

Health Benefits of Gastric Bypass Surgery After 6 Years

Interview with Ted D. Adams, PhD, MPH, author of Health Benefits of Gastric Bypass Surgery After 6 Years




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The Next Generation of Obesity Research: No Time to Waste

Interview with Griffin P. Rodgers, MD, author of The Next Generation of Obesity Research: No Time to Waste