The Los Angeles County district attorney says work was already underway on reducing L.A.'s jail population before a zero-bail order was issued.

The structure is a rare example of Art Deco style used for a garage. It will still be used to park cars but also will have amenities for apartment tenants.

Three years after he promised to sell an all-electric Model 3 mass-market sedan for $35,000 before incentives, Elon Musk may finally be coming through.

Behind the scenes at this year's Pebble Beach Concours d'Elegance, the most prestigious car show in the world.

Nearly a month after Fountains of Wayne's Adam Schlesinger died from COVID-19, his girlfriend wrote a heartfelt Instagram caption recounting his final moments.

In 'Upload,' a new Amazon comedy from 'The Office' and 'Parks and Recreation' whiz Greg Daniels, Robbie Amell stars as a man in a (digital) afterlife.

The Times was there as Ryan Murphy's new Netflix series, "Hollywood," filmed its rousing finale, set at the 1948 Oscars ceremony.

Ross Brawn has uncovered the masterplan to get F1 going again in July.

WHITE-TAILED eagles have been spotted in England for the first time in 240 years.

EXCLUSIVE: Wales rugby star George North is about to become a father during the coronavirus.

GRANT SHAPPS announced the Government is introducing a £2 billion travel scheme to encourage Britons to use alternative transport as the UK slowly relaxes lockdown measures.

Zion National Park officials announced this weekend the park will be reopening May 13 "certain areas" of the park. Here's what that means.

A member of Butler's travel party told me saying goodbye to Baldwin was one of the hardest things he has ever done. He spoke for all of Butler Nation.

IndyCar will host its season-opener at Texas Motor Speedway on June 6 as planned, but without fans and in a one-day show.

Simon Property Group plans to reopen on Saturday Indiana malls shuttered during the coronavirus pandemic, according to a leaked internal memo.

Indiana is reopening its economy after its coronavirus closures. Here's what shoppers should know about how malls, stores, salons and gyms will return

You can have a sneak preview at the new Tripadvisor site by browsing this “beta” microsite that TA globally announced today in its newsletter. The user-generated reviews’ giant Tripavisor (part of the Expedia, Inc. family of travel companies), decided to “create a new and easier to use” site. Kristen Nicole from Mashable previously published an article [...]

It comes after reports that garden centres in England and Wales are set to reopen.

Documents obtained from state Treasurer Fiona Ma's office through a records request include an invoice from a BYD subsidiary for 'N95 face masks.'

IndyCar will host its season-opener at Texas Motor Speedway on June 6 as planned, but without fans and in a one-day show.

Some garden centres in the area opened Friday morning with physical distancing measures in place after the provincial government lifted the closures earlier this week.

Japanese researchers at Keio University have unveiled a robotic tail that has been designed to be worn by elderly people who struggle to maintain their balance.

strataconf: A detailed agenda for #StrataRx 2013 is now posted: workshops, sessions, speakers + more http://t.co/RtaRpQroaN #healthdata

This is the first time Google says it has provided this kind of data to the public.

Please visit Search Engine Land for the full article.

The best fresh mint mojitos are made by steeping crushed mint in sugar and rum. So refreshing and minty! This rum cocktail hits the spot on a hot summer day.

Continue reading "Mojito Cocktail" »

The following article, BREAKING: New Docs Prove Obama Knew Details Of Flynn Wiretapping…Newly Surfaced Video Shows Obama Explaining How He Stays Out Of FBI Investigations, was first published on 100PercentFedUp.com.

Barack Obama knew. Documents released yesterday that were used to exonerate President Trump’s new NSA General Flynn, prove that President Barack Obama was aware of the details of Michael Flynn’s intercepted phone calls on December 16 with then-Russian Ambassador Sergey Kislyak. On January 5, 2017, then-Deputy Attorney General, Sally Yates attended an Oval Office meeting […]

Continue reading: BREAKING: New Docs Prove Obama Knew Details Of Flynn Wiretapping…Newly Surfaced Video Shows Obama Explaining How He Stays Out Of FBI Investigations ...

At a time when store front vacancies are growing thanks to COVID-19, a new retail cannabis store in Pillette Village is hoping to open soon.

Numerous zinc ectoenzymes are metalated by zinc and activated in the compartments of the early secretory pathway before reaching their destination. Zn transporter (ZNT) proteins located in these compartments are essential for ectoenzyme activation. We have previously reported that ZNT proteins, specifically ZNT5–ZNT6 heterodimers and ZNT7 homodimers, play critical roles in the activation of zinc ectoenzymes, such as alkaline phosphatases (ALPs), by mobilizing cytosolic zinc into these compartments. However, this process remains incompletely understood. Here, using genetically-engineered chicken DT40 cells, we first determined that Zrt/Irt-like protein (ZIP) transporters that are localized to the compartments of the early secretory pathway play only a minor role in the ALP activation process. These transporters included ZIP7, ZIP9, and ZIP13, performing pivotal functions in maintaining cellular homeostasis by effluxing zinc out of the compartments. Next, using purified ALP proteins, we showed that zinc metalation on ALP produced in DT40 cells lacking ZNT5–ZNT6 heterodimers and ZNT7 homodimers is impaired. Finally, by genetically disrupting both ZNT5 and ZNT7 in human HAP1 cells, we directly demonstrated that the tissue-nonspecific ALP-activating functions of both ZNT complexes are conserved in human cells. Furthermore, using mutant HAP1 cells, we uncovered a previously-unrecognized and unique spatial regulation of ZNT5–ZNT6 heterodimer formation, wherein ZNT5 recruits ZNT6 to the Golgi apparatus to form the heterodimeric complex. These findings fill in major gaps in our understanding of the molecular mechanisms underlying zinc ectoenzyme activation in the compartments of the early secretory pathway.

The value of total retail sales in March, provisionally estimated at $23 billion, fell 42% compared with the same month in 2019, the Census & Statistics Department announced today.

After netting out the effect of price changes over the same period, the volume of total retail sales decreased 43.8% year-on-year.

The value of sales of food, alcoholic drinks and tobacco decreased 21.2%.

This was followed by commodities in department stores (-42.7% in value); other consumer goods, not elsewhere classified (-29.1%); electrical goods and other consumer durable goods, not elsewhere classified (-39.6%); jewellery, watches and clocks, and valuable gifts (-75.2%); medicines and cosmetics (-63.8%); wearing apparel (-67.2%); motor vehicles and parts (-19.8%); fuels (-8%); furniture and fixtures (-14.4%); books, newspapers, stationery and gifts (-48.4%); Chinese drugs and herbs (-51.7%); footwear, allied products and other clothing accessories (-60.6%); and optical shops (-46.6%).

The value of sales of commodities in supermarkets increased 16.1% for the period.

The Government said retail sales continued to plummet in March as the COVID‑19 pandemic and resulting anti-epidemic measures brought inbound tourism to a standstill and seriously disrupted consumption-related activities.

For the first quarter as a whole, the volume of retail sales fell 36.9% year-on-year, the largest decline for a single quarter on record.

Noting that the business environment for retail trade will remain very difficult in the near term amid the deep economic recession and sharp deterioration in the labour market, the Government said it will closely monitor the developments.

Numerous zinc ectoenzymes are metalated by zinc and activated in the compartments of the early secretory pathway before reaching their destination. Zn transporter (ZNT) proteins located in these compartments are essential for ectoenzyme activation. We have previously reported that ZNT proteins, specifically ZNT5–ZNT6 heterodimers and ZNT7 homodimers, play critical roles in the activation of zinc ectoenzymes, such as alkaline phosphatases (ALPs), by mobilizing cytosolic zinc into these compartments. However, this process remains incompletely understood. Here, using genetically-engineered chicken DT40 cells, we first determined that Zrt/Irt-like protein (ZIP) transporters that are localized to the compartments of the early secretory pathway play only a minor role in the ALP activation process. These transporters included ZIP7, ZIP9, and ZIP13, performing pivotal functions in maintaining cellular homeostasis by effluxing zinc out of the compartments. Next, using purified ALP proteins, we showed that zinc metalation on ALP produced in DT40 cells lacking ZNT5–ZNT6 heterodimers and ZNT7 homodimers is impaired. Finally, by genetically disrupting both ZNT5 and ZNT7 in human HAP1 cells, we directly demonstrated that the tissue-nonspecific ALP-activating functions of both ZNT complexes are conserved in human cells. Furthermore, using mutant HAP1 cells, we uncovered a previously-unrecognized and unique spatial regulation of ZNT5–ZNT6 heterodimer formation, wherein ZNT5 recruits ZNT6 to the Golgi apparatus to form the heterodimeric complex. These findings fill in major gaps in our understanding of the molecular mechanisms underlying zinc ectoenzyme activation in the compartments of the early secretory pathway.

Non-residential and residential electricity accounts are benefitting from government relief measures, the Environmental Bureau announced today.

Under the measures, nearly 90% of non-residential electricity bills obtained a 75% subsidy for electricity charges in March, while 40% of residential electricity accounts enjoyed zero electricity charges in the first quarter of the year.

The Government announced about $2.3 billion in provisions last December to provide an electricity charge subsidy to each eligible non-residential electricity account holder to cover 75% of their monthly electricity charges for four months, subject to a monthly cap of $5,000.

The Budget further provided $2.9 billion to extend the subsidy period to eight months.

According to the bills issued by the two power companies in March, 360,000 non-residential bills obtained a 75% subsidy. This is close to 90% of the total eligible non-residential tariff bills.

To balance the impact on people's livelihood of the recent transition to cleaner electricity generating systems in Hong Kong, the bureau implemented the electricity charges relief scheme in January 2019.

A monthly electricity charge relief of $50 has been granted to each eligible residential electricity account for 60 months.

To help the public cope with the challenging economic environment, the Government implemented a new round of one-off electricity charge subsidy schemes in January.

A subsidy of $160 will be credited to each residential electricity account from January to November, while $240 will be credited in December.

From early this year, over 2.7 million households have been benefitting from both the electricity charges relief measures and the electricity charges subsidy. The bills of the two power companies indicated that 40% of residential electricity accounts, representing 1 million households, enjoyed zero electricity charges.

The bureau called on the community to cherish environmental resources, including saving energy and electricity to mitigate climate change and improve air quality.

The SAS Stored Process Server does not create a detailed log file by default. However, you can create a detailed SAS Stored Process Server log file (that will contain information about all of the code that was executed) by using this approach. AUTO

(American Association for the Advancement of Science) High-resolution images and video were taken by the Japanese space agency's Hayabusa2 spacecraft as it briefly landed to collect samples from Ryugu -- a nearby asteroid that orbits mostly between Earth and Mars -- allowing researchers to get an up-close look at its rocky surface, according to a new report.

Director of Retail Studies Mark Cohen offers his view on the changes coming to large retailers, many of which had already seen declining sales and store closures before the pandemic hit.

Numerous zinc ectoenzymes are metalated by zinc and activated in the compartments of the early secretory pathway before reaching their destination. Zn transporter (ZNT) proteins located in these compartments are essential for ectoenzyme activation. We have previously reported that ZNT proteins, specifically ZNT5–ZNT6 heterodimers and ZNT7 homodimers, play critical roles in the activation of zinc ectoenzymes, such as alkaline phosphatases (ALPs), by mobilizing cytosolic zinc into these compartments. However, this process remains incompletely understood. Here, using genetically-engineered chicken DT40 cells, we first determined that Zrt/Irt-like protein (ZIP) transporters that are localized to the compartments of the early secretory pathway play only a minor role in the ALP activation process. These transporters included ZIP7, ZIP9, and ZIP13, performing pivotal functions in maintaining cellular homeostasis by effluxing zinc out of the compartments. Next, using purified ALP proteins, we showed that zinc metalation on ALP produced in DT40 cells lacking ZNT5–ZNT6 heterodimers and ZNT7 homodimers is impaired. Finally, by genetically disrupting both ZNT5 and ZNT7 in human HAP1 cells, we directly demonstrated that the tissue-nonspecific ALP-activating functions of both ZNT complexes are conserved in human cells. Furthermore, using mutant HAP1 cells, we uncovered a previously-unrecognized and unique spatial regulation of ZNT5–ZNT6 heterodimer formation, wherein ZNT5 recruits ZNT6 to the Golgi apparatus to form the heterodimeric complex. These findings fill in major gaps in our understanding of the molecular mechanisms underlying zinc ectoenzyme activation in the compartments of the early secretory pathway.

COVID-19 has completely readjusted how we operate daily. With the proliferation of the ‘work from home’ concept, many persons have become even more stationary as they spend full days on their couches, tapping on their communication devices while...

Brexit. Who knows what’s going to happen in the next few weeks, months, years - the uncertainty is high. In the face of that, you’d hope that the government was doing all it could to plan for any eventuality - let alone for a massive, country altering one like suddenly crashing out without a deal - but Martin McKee, professor of public health at...

The Commission on Dental Accreditation announced April 3 that it directed all CODA-accredited dental programs to submit a report by May 15 on their use of distance learning, enhanced activities and other educational modalities in response to the COVID-19 pandemic.

This recipe features on Foodie Tuesday, a weekly segment on 774 Drive with Raf Epstein, 3.30PM

An activist's lawsuit is an example of how many states, because of outdated software, have trouble answering the public's demand to detail how billions of K-12 dollars are spent.

It was subtle and unexpected move for Schneider, but it was the right one.

"It is timely that the higher education sector examines paths forward to address and indeed engage in the new environment in which it will work in the future. This fellowship explored two approaches to engage students more deeply in their education. The first approach is generally termed 'interdisciplinary studies' where students define their own program of study; the second approach focuses on topic structure where students are given a wide range of choice and in effect can build a topic that suits their interests."--Page iv.

A fun light story by Grammy of camping in the Vales with nighttime noises and shadows scaring all. She knew who was scurrying around the campsite. Would you like to know too? -- Publisher.

Londres : Paris, 1840.

Bruxelles (rue de l'Industrie) : Félix Callewaert père, éditeur, 1875.

Great Britain : CreateSpace, 2017.