ia Uzbekistan to make media, songs and films pass 'moral test' By www.thehindu.com Published On :: Wed, 13 Nov 2024 11:45:22 +0530 President Shavkat Mirziyoyev has introduced some reforms since coming to power after the 2016 death of dictator Islam Karimov, but rights groups say the country remains deeply authoritarian Full Article World
ia ‘Anti-war’ comedy play riles Bulgarian nationalists By www.thehindu.com Published On :: Wed, 13 Nov 2024 11:50:04 +0530 Last week’s premiere of Arms and the Man by renowned Irish-born playwright George Bernard Shaw sparked raucous protests by nationalist groups Full Article World
ia Xi leaves China for APEC meeting in Peru: state media By www.thehindu.com Published On :: Wed, 13 Nov 2024 12:55:46 +0530 Chinese leader Xi Jinping travels to Peru for APEC summit amid trade tensions with U.S., inaugurates Chinese-funded port Full Article News
ia COP29: India, other developing countries demand fair climate finance commitments By www.thehindu.com Published On :: Wed, 13 Nov 2024 13:33:21 +0530 India, LMDCs advocate for equitable climate finance at COP29, pushing for transparency, fairness, and flexibility in financial commitments Full Article Environment
ia Iran executes in public a serial rapist convicted in dozens of cases By www.thehindu.com Published On :: Wed, 13 Nov 2024 14:43:02 +0530 Iran’s state media say authorities have executed in public a man convicted of raping dozens of women over two decades Full Article World
ia Lebanon media claims Israeli strike hit apartment south of Beirut By www.thehindu.com Published On :: Wed, 13 Nov 2024 15:10:43 +0530 Israeli warplanes launched a strike at dawn targeting a residential apartment in a building in the Dawhet Full Article World
ia IndiGo, Air India cancel flights to Bali following volcanic eruption By www.thehindu.com Published On :: Wed, 13 Nov 2024 17:23:06 +0530 The Mount Lewotobi Laki Laki volcano located in a remote island in East Nusa Tenggara province erupted earlier this month and has resulted in ash clouds Full Article India
ia Sri Lanka to hold key parliamentary vote on November 14 By www.thehindu.com Published On :: Wed, 13 Nov 2024 20:35:59 +0530 President Anura Kumara Dissanayake’s ruling alliance is looking to secure a majority in Parliament Full Article World
ia Senior Russian naval officer killed in car bombing claimed by Kyiv By www.thehindu.com Published On :: Wed, 13 Nov 2024 21:28:48 +0530 Russia's state Investigative Committee said in a statement that an improvised explosive device had detonated in an act of terrorism, killing a serviceman whom it did not identify Full Article World
ia Indonesia and Australia hold joint military drills after signing a new defense agreement By www.thehindu.com Published On :: Wed, 13 Nov 2024 21:32:15 +0530 The Indonesian and Australian militaries are holding joint combat drills off Indonesia’s main island of Java with about 2,000 troops training in air, maritime, amphibious and land operations Full Article World
ia In vitro identification of oridonin hybrids as potential anti-TNBC agents inducing cell cycle arrest and apoptosis by regulation of p21, γH2AX and cleaved PARP By pubs.rsc.org Published On :: RSC Med. Chem., 2024, 15,3674-3694DOI: 10.1039/D4MD00580E, Research ArticleJinhua Ning, Nini Zhan, Zhanpan Wu, Yuzhe Li, Die Zhang, Yadian Shi, Yingxun Zhou, Chuan-Huizi Chen, Wenbin JinOridonin analogue 11a showed significant antitumor efficacy in vitro via cell cycle arrest and apoptosis by regulation of p21, γH2AX and cleaved PARP accumulation, meanwhile, displayed much more stable than oridonin in human plasma.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ia Stachydrine, a pyrrole alkaloid with promising therapeutic potential against metabolic syndrome and associated organ dysfunction By pubs.rsc.org Published On :: RSC Med. Chem., 2024, 15,3652-3673DOI: 10.1039/D4MD00425F, Review ArticleSemim Akhtar Ahmed, Prasenjit Manna, Jagat Chandra BorahMetabolic syndrome is a multifaceted condition marked by interconnected risk factors, significantly increasing the risk of serious diseases like cardiovascular disease, type 2 diabetes, and stroke.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ia Fexinidazole optimization: enhancing anti-leishmanial profile, metabolic stability and hERG safety By pubs.rsc.org Published On :: RSC Med. Chem., 2024, 15,3837-3852DOI: 10.1039/D4MD00426D, Research ArticleAbdrrahman Shemsu Surur, Chin Fung Chan, Frieda-Marie Bartz, Iris L. K. Wong, Van T. D. Nguyen, Lukas Schulig, Andreas Link, Tak Hang Chan, Larry M. C. Chow, Patrick J. BednarskiStructure-guided optimization of fexinidazole led to analog (S)-51, a promising lead compound with superior activity, improved metabolic stability, and enhanced hERG safetyThe content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ia Evaluating the therapeutic potential of genetically engineered probiotic Zbiotics (ZB183) for non-alcoholic steatohepatitis (NASH) management via modulation of the cGAS-STING pathway By pubs.rsc.org Published On :: RSC Med. Chem., 2024, 15,3817-3836DOI: 10.1039/D4MD00477A, Research ArticleMaha Saad, Walaa Ibrahim, Amany Helmy Hasanin, Aya Magdy Elyamany, Marwa MatboliZBiotics administration in the NASH model downregulated the RNA panel (MAPK3, EDN1, TNF, miR-6888-5p, lncRNA RABGAP1L-DT-206), restored intestinal barrier integrity, reduced hepatic inflammation, and improved lipid profiles and liver enzymes.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ia Correction: computational design, synthesis, and assessment of 3-(4-(4-(1,3,4-oxadiazol-2-yl)-1H-imidazol-2-yl)phenyl)-1,2,4-oxadiazole derivatives as effective epidermal growth factor receptor inhibitors: a prospective strategy for anticancer therapy By pubs.rsc.org Published On :: RSC Med. Chem., 2024, 15,3912-3912DOI: 10.1039/D4MD90040E, Correction Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Nilesh Raghunath Khedkar, Milind Sindkhedkar, Alex JosephThe content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ia Anticancer potential of copper(I) complexes based on isopropyl ester derivatives of bis(pyrazol-1-yl)acetate ligands By pubs.rsc.org Published On :: RSC Med. Chem., 2024, Accepted ManuscriptDOI: 10.1039/D4MD00610K, Research Article Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Maura Pellei, Carlo Santini, Miriam Caviglia, Jo' Del Gobbo, Chiara Battocchio, Carlo Meneghini, Simone Amatori, Chiara Donati, Eleonora Zampieri, Valentina Gandin, Cristina MarzanoIn this paper, the isopropyl ester derivatives LOiPr and L2OiPr of bis(pyrazol-1-yl)acetic acid and bis(3,5-dimethyl-pyrazol-1-yl)acetic acid were used as chelators for the preparation of the new Cu(I) phosphane complexes 1-4....The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ia AIADMK will not form an alliance with BJP in 2026 polls, reiterates Palaniswami By www.thehindu.com Published On :: Wed, 13 Nov 2024 16:30:55 +0530 “During the Lok Sabha election, it was said at the party headquarters and in press bytes that the AIADMK will not have alliance with the BJP in the [2026] Assembly election,” he said Full Article Tamil Nadu
ia Four Swedish companies, including IKEA, looking to set up base in Tamil Nadu: Swedish Ambassador to India By www.thehindu.com Published On :: Wed, 13 Nov 2024 20:56:01 +0530 There are 70 Swedish companies in Tamil Nadu, employing about 25,000 people. But we want to do more, says Jan Thesleff Full Article Tamil Nadu
ia Arvinder Singh Sahney is new chairman of Indian Oil By www.thehindu.com Published On :: Wed, 13 Nov 2024 19:43:29 +0530 Full Article Business
ia Sakhi centre inaugurated at Vizianagaram Collectorate By www.thehindu.com Published On :: Wed, 13 Nov 2024 19:11:36 +0530 Full Article Andhra Pradesh
ia Devotees offer special prayers at Sri Kalyana Venkateswara Swamy temple in Srikakulam By www.thehindu.com Published On :: Wed, 13 Nov 2024 20:19:39 +0530 Full Article Andhra Pradesh
ia RLDA invites bids for commercial land use in Tirupati railway station By www.thehindu.com Published On :: Wed, 13 Nov 2024 20:29:31 +0530 The station is being developed on a massive scale, providing commuting area on the southern side, in view of the crammed locality on the northern side Full Article Andhra Pradesh
ia Andhra Pradesh High Court strikes down PIL seeking to restrain police from taking action on ‘abusive content on social media’ By www.thehindu.com Published On :: Wed, 13 Nov 2024 21:30:39 +0530 Full Article Andhra Pradesh
ia India’s office leasing soars 41% in 2024 amid rent hikes, supply crunch, and GCC growth: Cushman & Wakefield By www.thehindubusinessline.com Published On :: Wed, 13 Nov 2024 09:20:06 +0530 In an interview to businessline, Cushman & Wakefield’s Veera talks about commercial space leasing outlook, trends, and rental and supply trends for the coming months Full Article Real Estate
ia Supreme Court sets pan-India guidelines against ‘bulldozer justice,’ calls demolitions without due process unconstitutional By www.thehindubusinessline.com Published On :: Wed, 13 Nov 2024 11:31:53 +0530 The Apex court maintains that these guidelines do not apply in cases of unauthorized public land construction or where demolition is mandated by a court ruling Full Article News
ia Hyderabad to get regional centre of Indian Institute of Creative Technology By www.thehindu.com Published On :: Wed, 13 Nov 2024 17:34:11 +0530 All activities are going to start quickly. The facility in Hyderabad will be set up in the IMAGE Tower, said Secretary, Union Ministry of Information and Broadcasting Full Article Hyderabad
ia Doctor stabbed at Kalaignar Centenary Super Speciality Hospital in Chennai; one arrested By www.thehindu.com Published On :: Wed, 13 Nov 2024 12:24:15 +0530 The oncologist who was attacked has been identified as Balaji Jagannath. He has been admitted in the ICU, and his condition is said to be critical Full Article Chennai
ia COP29: India, other developing countries demand fair climate finance commitments By www.thehindu.com Published On :: Wed, 13 Nov 2024 13:33:21 +0530 India, LMDCs advocate for equitable climate finance at COP29, pushing for transparency, fairness, and flexibility in financial commitments Full Article World
ia Millions of Nigerians go hungry as floods compound hardship By www.thehindu.com Published On :: Wed, 13 Nov 2024 15:07:00 +0530 Torrential rains and floods in 29 of Nigeria's 36 states this year have destroyed more than 1.5 million hectares of cropland, affecting more than nine million people Full Article Environment
ia 29th Climate Conference (COP) tracker | Day 2 LIVE: Key speeches, UK NDC, and India’s reaction at 5 p.m. on November 13 By www.thehindu.com Published On :: Wed, 13 Nov 2024 17:01:23 +0530 Vibhuti Garg, an Associate and Senior Energy Specialist with over 13 years of experience in the energy sector, will guide us through the implications of these financial negotiations and the potential impacts on global energy transitions and climate commitments at 5 p.m. on November 13 Full Article Environment
ia Uncontrolled diabetes increases risk of hearing loss; doctors call for more awareness, screening By www.thehindu.com Published On :: Wed, 13 Nov 2024 19:04:48 +0530 Hearing loss occurs twice as frequently in patients with uncontrolled diabetes as compared to the non-diabetic population, doctors say, calling for screening to be included in routine diabetes care Full Article Health
ia Doctors believe continual upskilling is crucial for diabetes management: survey By www.thehindu.com Published On :: Wed, 13 Nov 2024 22:00:00 +0530 The survey also found that doctors were interested in using AI tools for early detection and personalised treatment plans to manage diabetes Full Article Health
ia Karnataka Chief Minister Siddaramaiah says no proposal to ease night traffic ban through Bandipur By www.thehindu.com Published On :: Wed, 13 Nov 2024 14:45:12 +0530 Deputy Chief Minister D.K. Shivakumar had stated, in Wayanad in Kerala, that the government would take all possible measures to lift night traffic ban through Bandipur, which had riled wildlife conservationists in Karnataka Full Article Karnataka
ia Karnataka High Court dismisses Union Bank of India’s petition seeking transfer of Valmiki corporation case to CBI By www.thehindu.com Published On :: Wed, 13 Nov 2024 15:28:26 +0530 ‘Banking Regulations Act does not empower banks to seek transfer of probe into criminal cases registered by States to agency of its choice’ Full Article Karnataka
ia ED’s investigation into MUDA case is based on false allegations, says Siddaramaiah By www.thehindu.com Published On :: Wed, 13 Nov 2024 19:12:55 +0530 Full Article Karnataka
ia Only education can empower women: Siddaramaiah By www.thehindu.com Published On :: Wed, 13 Nov 2024 19:33:50 +0530 Full Article Karnataka
ia Pakistan should stop playing cricket with India, says Rashid Latif By www.thehindu.com Published On :: Wed, 13 Nov 2024 15:49:54 +0530 The Pakistan Cricket Board (PCB) has written to ICC asking for written confirmation from the BCCI for India's inability to travel to Pakistan for the tournament Full Article Cricket
ia Why US chess champ Levon Aronian is connecting with the Armenian community in Chennai By www.thehindu.com Published On :: Wed, 13 Nov 2024 15:54:02 +0530 Chess champion Levon Aronian, who competed in Chennai Grand Masters recently, on future Indian chess superstars Full Article Sport
ia Siddhant Banthia sails past Siddharth Vishwakarma in ITF men’s tennis tournament By www.thehindu.com Published On :: Wed, 13 Nov 2024 20:37:44 +0530 Siddhant Banthia broke serve dropping one point, and served out at love in the next game, to gain a stranglehold over the proceedings. He ran up a 5-1 lead in the second set before closing it out without any trouble Full Article Sport
ia India's middle class tightens its belt, squeezed by food inflation By www.thehindu.com Published On :: Wed, 13 Nov 2024 21:50:09 +0530 Slowing urban spending over the past three to four months has not only hurt the earnings of largest consumer goods firms Full Article Economy
ia 667 UK-owned businesses in India generated over ₹5 lakh crores in revenue: report By www.thehindubusinessline.com Published On :: Wed, 13 Nov 2024 09:21:12 +0530 According to the report, fifteen UK companies have achieved triple-digit turnover growth rates, with Vedanta leading as the largest UK company in India by revenue, generating over ₹1,50,100 crores in 2023 Full Article Companies
ia Devotees, martial arts, chants fill Hyderabad streets for Guru Nanak’s birth anniversary By www.thehindu.com Published On :: Wed, 13 Nov 2024 20:30:14 +0530 Full Article Telangana
ia Indian gaming sector urged to embrace diversity beyond performative actions By www.thehindu.com Published On :: Wed, 13 Nov 2024 20:43:04 +0530 ‘Inclusion of female and LGBTQIA+ characters remains limited, underscoring a lack of representation’ Full Article Hyderabad
ia KSRTC invites EoI to ready commercial complex at Ernakulam depot By www.thehindu.com Published On :: Wed, 13 Nov 2024 21:00:29 +0530 Full Article Kerala
ia Jairam Tiger Mahto stands in the way in tough battle for NDA and INDIA blocs in Jharkhand By www.thehindu.com Published On :: Wed, 13 Nov 2024 22:26:16 +0530 Known for raising local issues, the 30-year-old leader hails from Kurmi (Mahtos) community that comprise 22% of the total population, the largest chunk after tribals and plays a decisive role in at least 30 seats Full Article Jharkhand Assembly
ia Watch: Can Trump’s win make it worse for Indian economy? | Business Matters By www.thehindu.com Published On :: Wed, 13 Nov 2024 23:22:29 +0530 Private investment hasn’t really taken off as expected and industry watchers ascribed that to lack of adequate demand. With Trump slated to be next in the White House, how dark do things really look for India? Full Article Videos
ia Tilak’s maiden ton, Abhishek’s 50 fire India to 219/6 against South Africa in 3rd T20I By www.thehindu.com Published On :: Thu, 14 Nov 2024 01:34:36 +0530 Tilak Varma got ample backing from Abhishek Sharma who made a brisk 50 after SA skipper Aiden Markram invited the visitors to bat first. Full Article Cricket
ia Pro Kabaddi League: Gujarat Giants return to winning ways with big win over Bengal Warriorz By www.thehindu.com Published On :: Thu, 14 Nov 2024 06:39:17 +0530 In the second match of the night, Haryana Steelers moved to the top of the table and extended their winning run to four games after defeating the Patna Pirates 37-32 Full Article Sport
ia Tackling diabetes epidemic By www.thehindu.com Published On :: Thu, 14 Nov 2024 07:00:00 +0530 An India free of diabetes-related complications is eminently possible, if lifestyle changes are made Full Article Open Page
ia Year-long action plan to combat diabetes to be launched on World Diabetes Day By www.thehindu.com Published On :: Wed, 13 Nov 2024 22:03:33 +0530 Full Article Kerala