La enseñanza bíblica en profundidad de John MacArthur lleva la verdad transformadora de la Palabra de Dios a millones de personas cada día.

La enseñanza bíblica en profundidad de John MacArthur lleva la verdad transformadora de la Palabra de Dios a millones de personas cada día.

La enseñanza bíblica en profundidad de John MacArthur lleva la verdad transformadora de la Palabra de Dios a millones de personas cada día.

La enseñanza bíblica en profundidad de John MacArthur lleva la verdad transformadora de la Palabra de Dios a millones de personas cada día.

La enseñanza bíblica en profundidad de John MacArthur lleva la verdad transformadora de la Palabra de Dios a millones de personas cada día.

The people meeting in Istanbul's parks are wildly different from each other, but they are now engaging each other in ways they weren't before.

The railroad that bridged German and Italian Switzerland was meant to unify the nation. Up close, the story looked a little different.

The divestment movement aims to combat climate change by stripping investments from fossil fuels and redirecting them toward renewable energy.

At the end of the first week at the 16th Conference of Parties on Biodiversity (COP16), finance emerges as the biggest issue but also shrouded in controversies. On Saturday, as the COP moved closer to its most crucial phase of negotiations, resource mobilization—listed under Target 19 of the Kunming-Montreal Global Biodiversity Framework (KMGBF)—took centerstage, with […]

You have undoubtedly heard people say things like, “God is calling me to the mission field,” or “God led me to attend this college,” or “We feel God wants us to get married.” Perhaps you have even said such things yourself. Christians who use expressions like those often mean they have had an impression or a strong feeling that they interpret as a disclosure of the divine will.

Jennifer Lopez, Ben Affleck tied the knot in Las Vegas on July 16, 2022 Ben Affleck opened up about his exertion over constant questions regarding Jennifer Lopez, as the actor awaits legal verdict on their divorce.As per a close source, "The reason he may always look it when he is out and...

Hugh Jackman divorced Deborra-Lee Furness because of Sutton Foster affairHugh Jackman divorced his wife Deborra-Lee Furness because of his budding romance with longtime friend Sutton Foster.On October 26, gossip blogger Tasha Lustig shared new speculation on her Instagram account...

As the UN’s COP16 biodiversity conference continues, the temptation is to focus on the wild flora and fauna under threat. But there is another, less obvious yet just as critical biodiversity crisis unfolding around the world that also deserves attention. A quarter of livestock breeds – from chickens, ducks and geese to horses, camels and […]

José Aruna, a forest defender from Sud Kivu province in the Democratic Republic of the Congo (DRC), remembers the night in September 2019 when a group of heavily armed men barged into his house in the middle of the night. Aruna and his wife—6 months pregnant at the time—were in bed when he heard sounds […]

It’s often said that we are what we eat. However, our diets are also a reflection on the health of our food systems, the environment and agricultural biodiversity. In the same way that our bodies need a range of nutrients for optimum health, the environment also benefits from systems that produce a variety of foods, […]

In Maldives, youth disengagement and gang violence have emerged as a significant issue, driven by socio-economic factors and limited opportunities for employment and vocational education.

to write a paper on diversity

Gender-lens investing (GLI) represents an opportunity to channel targeted funds to women’s businesses and other gender equality areas.

This study outlines actions Cambodia can take to diversify its economy and shows how cutting business costs, tackling human capital deficits, and reducing vulnerability to external shocks can help drive sustainable, inclusive growth.

This report outlines the cascading environmental, social, and economic impacts of aquatic biodiversity loss in Southeast Asia and recommends ways to develop scalable projects that tackle river pollution and support sustainable development.

The TA is proposed to develop Bhutan's overall power dispatch options and strategies for domestic electricity consumption and international power trade. It will look into strategic views to maximize power export from various potential energy sources of hydropower, solar power, and wind power while meeting growing domestic electricity consumption.

Some lizards dive into streams to escape predators, and a specialised bubble-breathing technique enables them to stay submerged for up to 18 minutes

A pair of ctenophores, or comb jellies, can fuse their bodies together, merging their digestive and nervous systems, without any issues with immune rejection

There are secrets aplenty in a pot of honey – from information about bees' "micro-bee-ota" to DNA from the environment – that can help us fight food fraud and even monitor shifts in climate

Working with a tiny cantilever, physicists managed to violate the second law of thermodynamics, using less energy than expected to change the cantilever’s motion

This claustrophobia-inducing image is taken from photographer Martin Broen's new book Light in the Underworld, a collection of shots from the Yucatán’s cenotes, or sinkholes

Although the COP16 summit in Colombia ended with some important agreements, countries still aren’t moving fast enough to stem biodiversity loss

Title: Nuts Don't Up Risk of Diverticulitis
Category: Health News
Created: 8/27/2008 12:00:00 AM
Last Editorial Review: 8/27/2008 12:00:00 AM

Title: Couples At Risk During 'Divorce Season'
Category: Health News
Created: 8/21/2016 12:00:00 AM
Last Editorial Review: 8/22/2016 12:00:00 AM

Title: Doctors Divided on Safety, Use of Electronic Cigarettes
Category: Health News
Created: 8/26/2016 12:00:00 AM
Last Editorial Review: 8/26/2016 12:00:00 AM

Asgard archaea are of great interest as the progenitors of Eukaryotes, but little is known about the mobile genetic elements (MGEs) that may shape their ongoing evolution. Here, we describe MGEs that replicate in Atabeyarchaeia, a wetland Asgard archaea lineage represented by two complete genomes. We used soil depth–resolved population metagenomic data sets to track 18 MGEs for which genome structures were defined and precise chromosome integration sites could be identified for confident host linkage. Additionally, we identified a complete 20.67 kbp circular plasmid and two family-level groups of viruses linked to Atabeyarchaeia, via CRISPR spacer targeting. Closely related 40 kbp viruses possess a hypervariable genomic region encoding combinations of specific genes for small cysteine-rich proteins structurally similar to restriction-homing endonucleases. One 10.9 kbp integrative conjugative element (ICE) integrates genomically into the Atabeyarchaeum deiterrae-1 chromosome and has a 2.5 kbp circularizable element integrated within it. The 10.9 kbp ICE encodes an expressed Type IIG restriction-modification system with a sequence specificity matching an active methylation motif identified by Pacific Biosciences (PacBio) high-accuracy long-read (HiFi) metagenomic sequencing. Restriction-modification of Atabeyarchaeia differs from that of another coexisting Asgard archaea, Freyarchaeia, which has few identified MGEs but possesses diverse defense mechanisms, including DISARM and Hachiman, not found in Atabeyarchaeia. Overall, defense systems and methylation mechanisms of Asgard archaea likely modulate their interactions with MGEs, and integration/excision and copy number variation of MGEs in turn enable host genetic versatility.

The human major histocompatibility complex (MHC) is a ~4 Mb genomic segment on Chromosome 6 that plays a pivotal role in the immune response. Despite its importance in various traits and diseases, its complex nature makes it challenging to accurately characterize on a routine basis. We present a novel approach allowing targeted sequencing and de novo haplotypic assembly of the MHC region in heterozygous samples, using long-read sequencing technologies. Our approach is validated using two reference samples, two family trios, and an African-American sample. We achieved excellent coverage (96.6%–99.9% with at least 30x depth) and high accuracy (99.89%–99.99%) for the different haplotypes. This methodology offers a reliable and cost-effective method for sequencing and fully characterizing the MHC without the need for whole-genome sequencing, facilitating broader studies on this important genomic segment and having significant implications in immunology, genetics, and medicine.

The 10q11.22 chromosomal region is a duplication-rich interval of the human genome and one of the last to be fully assembled. It carries copy number–variable genes associated with intellectual disability, bipolar disorder, and obesity. In this study, we characterized the structural diversity at this locus by analyzing 64 haploid assemblies produced by the Human Pangenome Reference Consortium. We identified 11 alternative haplotypes that differ in the copy number and/or orientation of large genomic segments, ranging from hundreds of kilobase pairs (kbp) to over one megabase pair (Mbp). We uncovered a 2.4 Mbp size difference between the shortest and longest haplotypes. Breakpoint analysis revealed that genomic instability results from nonallelic homologous recombination between segmental duplication (SD) pairs with varying similarity (94.4%–99.6%). Nonetheless, these pairs generally recombine at positions where their identity is higher (>99.6%). Recurrent inversions occur with different breakpoints within the same inverted SD pair. Inversion polymorphisms shuffle the entire SD arrangement, creating new predispositions to copy-number variations. The SD architecture is associated with a catarrhine-specific subgroup of the AGAP gene family, which likely triggered the accumulation of SDs at this locus over the past 25 million years of human evolution. Our results reveal extensive structural diversity and genomic instability at the 10q11.22 locus, and expand the general understanding of the mutational mechanisms behind SD-mediated rearrangements.

COPD and asthma are two of the most common chronic lung diseases, affecting over 545 million people globally and 34 million in the United States. Annual health care costs related to chronic lung disease are estimated at €380 billion in the European Union, and $24–$50 billion in the United States averaging to $4,000 in out-of-pocket costs per person in the U.S. A full-text literature search was conducted for English publications between January 1, 2005–March 18, 2024. It returned over 5,000 publications that were further narrowed using key search words, resulting in 172 peer-reviewed articles. Using their experience and subject expertise, the authors further narrowed the peer-reviewed articles to 55 that were in their opinion relevant. Also, 38 recently published industry reports and news articles specific to downstream effects of inhaler market changes and the future impact were included. The literature suggests that individuals with chronic lung disease face increased challenges with access to inhaled medication due to rising medication costs, discontinuation of branded medications, introduction of generic medications not covered by insurance, exclusionary preferred drug list tactics that force health care providers into non-medical switching of medication or devices, and ongoing medication shortages. Providers experience ongoing hurdles in prescribing appropriate inhaled medications for individuals with chronic lung disease, including increased time and costs spent on administrative tasks due to inhaler denials, a loss of patient trust, and limits on their ability to prescribe appropriate inhaled medication for individuals with chronic lung disease.

Our knowledge of the roles of individual cytochrome P450 (P450) enzymes in drug metabolism has developed considerably in the past 30 years, and this base has been of considerable use in avoiding serious issues with drug interactions and issues due to variations. Some newer approaches are being considered for "phenotyping" metabolism reactions with new drug candidates. Endogenous biomarkers are being used for noninvasive estimation of levels of individual P450 enzymes. There is also the matter of some remaining "orphan" P450s, which have yet to be assigned reactions. Practical problems that continue in drug development include predicting drug-drug interactions, predicting the effects of polymorphic and other P450 variations, and evaluating interspecies differences in drug metabolism, particularly in the context of "metabolism in safety testing" regulatory issues ["disproportionate (human) metabolites"].

Anorectal malformations (ARMs) constitute a group of congenital defects of the gastrointestinal and urogenital systems. They affect males and females, with an estimated worldwide prevalence of 1 in 5000 live births. These malformations are clinically heterogeneous and can be part of a syndromic presentation (syndromic ARM) or as a nonsyndromic entity (nonsyndromic ARM). Despite the well-recognized heritability of nonsyndromic ARM, the genetic etiology in most patients is unknown. In this study, we describe three siblings with diverse congenital anomalies of the genitourinary system, anemia, delayed milestones, and skeletal anomalies. Genome sequencing identified a novel, paternally inherited heterozygous Caudal type Homeobox 2 (CDX2) variant (c.722A > G (p.Glu241Gly)), that was present in all three affected siblings. The variant identified in this family is absent from population databases and predicted to be damaging by most in silico pathogenicity tools. So far, only two other reports implicate variants in CDX2 with ARMs. Remarkably, the individuals described in these studies had similar clinical phenotypes and genetic alterations in CDX2. CDX2 encodes a transcription factor and is considered the master regulator of gastrointestinal development. This variant maps to the homeobox domain of the encoded protein, which is critical for interaction with DNA targets. Our finding provides a potential molecular diagnosis for this family's condition and supports the role of CDX2 in anorectal anomalies. It also highlights the clinical heterogeneity and variable penetrance of ARM predisposition variants, another well-documented phenomenon. Finally, it underscores the diagnostic utility of genomic profiling of ARMs to identify the genetic etiology of these defects.

Netflix's mega-violent mega-hit series returns December 26.

Chris requires pirate games to be on the ocean. Kelley's over capybaras. Josh is betrayed by his potato peeler's safety guard. Also, everybody hates Wakka.

The post RPG Cast – Episode 737: “India’s Best Divorce Lawyer” appeared first on RPGamer.

ublisher Bethesda Softworks and developer MachineGames have released a gameplay deep dive video for Indiana Jones and the Great Circle that is nearly 15 minutes in length.

"From locations and puzzles to gear and combat, MachineGames Audio Director, Pete Ward, takes us on a whirlwind journey through the world of The Great Circle," reads the description to the video. "Get ready for launch with this look at Indy’s grand adventure."

View the gameplay deep dive below:

Indiana Jones and the Great Circle will launch for the Xbox Series X|S, PC via Steam and Microsoft Store, and Xbox Game Pass on December 9.

A life-long and avid gamer, William D'Angelo was first introduced to VGChartz in 2007. After years of supporting the site, he was brought on in 2010 as a junior analyst, working his way up to lead analyst in 2012 and taking over the hardware estimates in 2017. He has expanded his involvement in the gaming community by producing content on his own YouTube channel and Twitch channel. You can contact the author on Twitter @TrunksWD.

Full Article - https://www.vgchartz.com/article/463033/indiana-jones-and-the-great-circle-gets-gameplay-deep-dive/

Nintendo today hosted a Super Nintendo World Direct livestream that featured Shigeru Miyamoto giving a deep dive look into the Donkey Kong Country-themed land.

The new land will feature a family roller coaster, called Mine-Cart Madness, congas you can hit to a rhythm, letters that can found throughout the land that can be scanned on the new Donkey Kong Power-Up Band, character meet and greets, and new food options.

Donkey Kong Country will open at Universal Studios Japan on December 11, 2024, and will also be a part of Super Nintendo World at Epic Universe in Florida when the theme park opens in May 2025.

View the Direct below:

A life-long and avid gamer, William D'Angelo was first introduced to VGChartz in 2007. After years of supporting the site, he was brought on in 2010 as a junior analyst, working his way up to lead analyst in 2012 and taking over the hardware estimates in 2017. He has expanded his involvement in the gaming community by producing content on his own YouTube channel and Twitch channel. You can contact the author on Twitter @TrunksWD.

Full Article - https://www.vgchartz.com/article/463038/super-nintendo-world-direct-dives-into-the-donkey-kong-country-themed-land/

The dominion of hated Super Earth threatens to expand afresh as Arrowhead CEO Johan Pilestedt toys openly with the prospect of Helldivers 2 cross-over games, beginning with tabletop wargame Trench Crusade and extending to, well, take your pick. Arrowhead's appetite for other licenses appears insatiable. It's the kind of sheer expansionism you'd expect from Earth's loathsome regime, whose "managed democracy" propaganda continues to enthrall thousands of hapless disposable imperialists. Pilestedt even wants to make a Fifth Element game! Milla Jovovich is spinning in her grave. Milla Jovovich isn't dead, you say? Well, that's good news at least.

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Take-Two Interactive have sold their publishing label Private Division to an unnamed party, along with five of Private Division's "live and unreleased titles". The GTA 6 publisher have also finally confirmed that they have shut down OlliOlli World and Rollerdrome devs Roll7 together with Kerbal Space Program 2 creators Intercept Games, months after performing mass layoffs at both studios.

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As our submersible descended, the waters grew darker around us. Looming teeth, some as long as a man’s leg, skirted the edge of our floodlights. The captain was sure this area held caves filled with golden bounty, but to those creatures of the deep it was our flesh and blood that were the true prizes… […]