On 20 March 2019 the Competition and Markets Authority (‘CMA’)  imposed a fine  of £25,000  on the guitar supplier Fender Musical Instruments Europe Limited (‘Fender Europe’) for failure to comply with a ...

On 3 June 2019, the Competition and Markets Authority (“CMA”) published a report1 by economic consultancy firm Lear, commissioned by the CMA, on merger control in digital markets (“Report”). On the...

  On 21 January 2020, the Court of Appeal (‘CoA’) upheld the Competition Appeal Tribunal (‘CAT’) judgment, finding that Ping Europe Ltd (‘Ping’) breached competition law by prohibiting its retailers from sell...

On 4 March 2020, the Competition and Markets Authority (“CMA”) fined four pharmaceutical companies for breaching competition law through market sharing and the exchange of competitively sensitive information relating to the supply of nor...

On 7 February 2020 the Competition and Markets Authority (“CMA”) launched a review into the IVF sector. The review stems from concerns that IVF clinics may not be compliant with UK consumer law on the basis that they are not aware of the...

(MENAFN - IANS) Thiruvananthapuram, May 9 (IANS) Fourteen-day home quarantine for all Keralites returning from other states would be compulsory, s... ......

1. ICMR teams up with Bharat Biotech to develop Covid-19 vaccine  Hindustan Times
2. Bharat Biotech to lead monoclonal antibodies project for Covid-19 therapy  The Financial Express
3. Bharat Biotech leads CSIR project to develop antibodies against Covid-19  Times of India
4. Bharat Biotech to lead project on monoclonal antibodies therapy for COVID-19  The New Indian Express
5. Indian scientists to develop medicine against COVID-19  Deccan Herald
6. View Full coverage on Google News

PESHAWAR: CM Mahmood Khan has directed the officials concerned to finalise all arrangements for a formal groundbreaking of Rashakai Economic Zone.He was chairing a meeting held here on Friday to review progress on Rashakai and Hattar Economic Zones projects, said an official handout. Besides...

In a series of in-depth articles we look at the global backlash China may face as a result of its response to the pandemic. 1. Who is winning the China-US race to run the world amid the pandemic? Coronavirus crisis has brought potential to redraw the map of global power and influence, but there is ‘deep-seated mistrust’ of Beijing. 2. Has pandemic shifted balance of military force in the Indo-Pacific? Taiwan Strait and South China Sea are settings for China and the US to assert influence…

In a series of in-depth articles, we look at the early lessons learned from the coronavirus pandemic. 1. Wanted: world leaders to answer the coronavirus pandemic alarm The international community has sleepwalked into an emergency that it could have prepared for years ago, analysts say. 2. One virus caused Covid-19; scientists say thousands more are in waiting In the second part of our series on lessons learned from the pandemic, we look at the need to identify new viruses and the risks of…

A series exploring the different experiences of recovered Covid-19 patients around the world. 1. Life as a coronavirus patient in Wuhan during its darkest hour A teacher’s story in the first of a series exploring the experiences of Covid-19 survivors from around the world. 2. Musician recounts horror from Covid-19 bar cluster Mark Anthony Balcueva struggled to breathe and had to be put on a cocktail of drugs, with only the thought of his daughter back in the Philippines keeping him alive. …

1. Pandemic drives rethink of Hong Kong’s hospital needs More isolation beds and more land to hold them among key concerns going forward, Hospital Authority chief tells the Post. 2. Inadequate links between public, private hospitals ‘Non-urgent’ cases postponed as overburdened public hospitals focus on Covid-19 patients. 3. Musician recounts horror from Covid-19 bar cluster Mark Anthony Balcueva struggled to breathe and had to be put on a cocktail of drugs, with only the thought of his…

ISLAMABAD: Former Chairman Senate Mian Raza Rabbani Friday questioned the formation of the National Council for Minorities through notification and termed it violation of the judgement of the...

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LAHORE: Chief Minister Sardar Usman Buzdar chaired a meeting at his office here Friday which reviewed anti-coronavirus steps and future roadmap of phase-wise easing of lockdown. It expressed concern over increase in the number of coronavirus cases in Lahore and decided to devise a separate policy...

SST Announces Qualification of Smartbit™ OTP NVM Technology for ON Semiconductor’s 110 nm CMOS Process

SST and UMC Announce Qualification of Embedded SuperFlash® Technology on 40 nm CMOS Process

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PUNE: The anti-encroachment squad of the Pimpri Chinchwad Municipal Corporation (PCMC) on Monday demolished an unauthorized construction in Akurdi. Shirish Poreddy, spokesperson of the PCMC’s engineering department, said the razed construction had ground plus three floors and covered a total area of 4,500 sq ft. Executive engineer Ramdas Tambe supervised the drive. The PCMC has demolished a total of 27 unauthorized constructions within the municipal limits in the past one month. The other 26 razed constructions covered a total area of 18,000 sq ft. Out of that 19 structures were built in March 2012, while the remaining are older constructions. “The civic body has been conducting the demolition drive against […]

Title: ECMO: Technology That Might Help COVID Patients When Ventilators Can't
Category: Health News
Created: 5/1/2020 12:00:00 AM
Last Editorial Review: 5/1/2020 12:00:00 AM

Background:

In 2015, Vyvanse (lisdexamfetamine) became the first Food and Drug Administration (FDA)-approved treatment for binge-eating disorder (BED), a condition first recognized by the DSM–V in 2013. Because pharmaceutical companies use continuing medical education (CME) to help sell drugs, we explored possible bias in CME modules on BED.

Methods:

We utilized a qualitative thematic analysis research approach to identify and classify patterns in CME activities focusing on BED.

Results:

We identified 27 online CME activities on BED in 2015. All were funded by Shire, which manufactures lisdexamfetamine. Seven of 16 presenters disclosed financial ties with Shire. Twenty-nine slides recurred in at least 2 CME modules, and 12 slides were repeated in 5 or more modules. Diagnosis-related themes included: BED is a real, treatable disease; BED is highly prevalent but often missed; BED can occur in anyone; BED results in poor quality of life; many patients with BED are obese; and BED makes losing weight difficult. Treatment-related themes included: lisdexamfetamine is highly effective; topiramate is limited by substantial adverse effects; and other therapeutic options for BED are inferior to lisdexamfetamine because they do not cause weight loss. Although amphetamines can cause addiction, myocardial infarction, stroke, and death, no module mentioned these serious adverse effects.

Conclusions:

It seems that CME is being used to promote lisdexamfetamine for weight loss (a contraindicated use) and to highlight benefits of lisdexamfetamine while underplaying the risks.

Purpose:

Multiple myeloma (MM) patients with disease refractory to all available drugs have a poor outcome, indicating the need for new agents with novel mechanisms of action.

Experimental Design:

We evaluated the anti-MM activity of the fully human BCMAxCD3 bispecific antibody JNJ-7957 in cell lines and bone marrow (BM) samples. The impact of several tumor- and host-related factors on sensitivity to JNJ-7957 therapy was also evaluated.

Results:

We show that JNJ-7957 has potent activity against 4 MM cell lines, against tumor cells in 48 of 49 BM samples obtained from MM patients, and in 5 of 6 BM samples obtained from primary plasma cell leukemia patients. JNJ-7957 activity was significantly enhanced in patients with prior daratumumab treatment, which was partially due to enhanced killing capacity of daratumumab-exposed effector cells. BCMA expression did not affect activity of JNJ-7957. High T-cell frequencies and high effector:target ratios were associated with improved JNJ-7957–mediated lysis of MM cells. The PD-1/PD-L1 axis had a modest negative impact on JNJ-7957 activity against tumor cells from daratumumab-naïve MM patients. Soluble BCMA impaired the ability of JNJ-7957 to kill MM cells, although higher concentrations were able to overcome this negative effect.

Conclusions:

JNJ-7957 effectively kills MM cells ex vivo, including those from heavily pretreated MM patients, whereby several components of the immunosuppressive BM microenvironment had only modest effects on its killing capacity. Our findings support the ongoing trial with JNJ-7957 as single agent and provide the preclinical rationale for evaluating JNJ-7957 in combination with daratumumab in MM.

Cần bán nhanh shophouse block B chung cư Citi Home, Phường Cát Lái, Quận 2, TP HCM. Mã căn: B0 - 05, tầng trệt + lửng, block B thuộc dự án chung cư Citi Home, Phường Cát Lái, Quận 2, Tp HCM. Diện tích: Tổng 86.5m2. Được thiết kế vừa kinh doanh, vừa ở với diện tích tầng trệt 54,9m2, tầng lửng 31,6m2. Chung cư block B Citihome và các Block citihome bên cạnh với 17 tầng đã phủ đầy...

Hệ thống ngân hàng TP.HCM phối hợp cùng công ty CP Tập đoàn ĐN - ĐN Group trân trọng thông báo tới các Tổ chức/Cá nhân quan tâm về việc mua tài sản thế chấp của khách hàng. Thông tin chi tiết như sau:1. Thông tin tài sản: - 6 lô góc và 30 nền đất thổ cư đường số 7, phường Tân Tạo...

Hệ thống ngân hàng TP. HCM trân trọng thông báo đến quý khách hàng. Phát mãi 39 nền đất và 10 nền đất xây biệt thự Bình Tân liền kề bến xe Miền Tây Aeon Bình Tân TP. HCM.Quý khách đăng ký để nhận thông tin và thời gian phát mãi tại phòng phát mãi tài sản (0901 679 578) chi nhánh ...

Theo tôi được biết thì ở Tp.HCM có chia làm 3 khu vực với quy định về diện tích tối thiểu cấp sổ hồng khác nhau. Theo đó thì các quận huyện như Hóc Môn, Củ Chi, Quận 12 phải có diện tích trên 80m2 đối với đất đã có nhà. Tuy nhiên khi tìm mua nhà thì có nơi cam kết có sổ hồng cho nhà đất tại Hóc Môn với diện tích chỉ 60m2. Theo người bán thì đây là nhà trong khu quy hoạch dân cư nhà phố nên được phép tách như vậy. Xin hỏi việc này có đúng không? Văn bản nào quy định điều này? Xin cám ơn luật sư!