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Rationally modified SNX-class Hsp90 inhibitors disrupt extracellular fibronectin assembly without intracellular Hsp90 activity

RSC Med. Chem., 2024, 15,3609-3615
DOI: 10.1039/D4MD00501E, Research Article
Open Access
Gciniwe S. Mathenjwa, Abir Chakraborty, Abantika Chakraborty, Ronel Muller, Mathew P. Akerman, Moira L. Bode, Adrienne L. Edkins, Clinton G. L. Veale
Rationally modified Hsp90 inhibitors which retained of on-target activity but showed no engagement of intracellular Hsp90, or stimulation of the heat shock response, were found to significantly alter the extracellular fibronectin network.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Exploring apoptotic induction of malabaricone A in triple-negative breast cancer cells: an acylphenol phyto-entity isolated from the fruit rind of Myristica malabarica Lam.

RSC Med. Chem., 2024, 15,3558-3575
DOI: 10.1039/D4MD00391H, Research Article
Pothiyil S. Vimalkumar, Neethu Sivadas, Vishnu Priya Murali, Daisy R. Sherin, Madhukrishnan Murali, Anuja Gracy Joseph, Kokkuvayil Vasu Radhakrishnan, Kaustabh Kumar Maiti
Malabaricone A isolated from Myristica malabarica induces apoptosis in triple-negative breast cancer cells through intrinsic and extrinsic pathways, which is validated through in vitro and in silico studies and resembles a potent phyto-entity.
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meso-Substituted AB3-type phenothiazinyl porphyrins and their indium and zinc complexes photosensitising properties, cytotoxicity and phototoxicity on ovarian cancer cells

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00601A, Research Article
Open Access
Brém Balázs, Bianca Stoean (Vasile), Éva Molnár, Eva Fischer-Fodor, Ovidiu Bălăcescu, Raluca Borlan, Monica Focsan, Adriana Grozav, Patriciu Achimaş-Cadariu, Emese Gál, Luiza Gaina
New meso-substituted AB3-type phenothiazinyl porphyrins and ferrocenylvinyl phenothiazinyl porphyrin were synthesised by Suzuki–Miyaura and Mizoroki–Heck cross-coupling reactions, respectively.
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Discovery of N-substituted-2-oxoindolin benzoylhydrazines as c-MET/SMO modulators in EGFRi-resistant non-small cell lung cancer

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00553H, Research Article
Stefano Tomassi, Benito Natale, Michele Roggia, Luisa Amato, Caterina De Rosa, Carminia Maria Della Corte, Emma Baglini, Giorgio Amendola, Anna Messere, Salvatore Di Maro, Elisabetta Barresi, Federico Da Settimo, Maria Letizia Trincavelli, Fortunato Ciardiello, Sabrina Taliani, Floriana Morgillo, Sandro Cosconati
Non-small cell lung cancer (NSCLC), the leading cause of cancer-related mortality worldwide, poses a formidable challenge due to its heterogeneity and the emergence of resistance to targeted therapies.
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Centre announces 3 AI Centres of Excellence focused on healthcare, agri and sustainable cities

The Centres of Excellence will be led by top educational institutions, in consortium with industry partners and startups, Union Education Minister Dharmendra Pradhan said




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Panchayat, aided schools in Tiruchi district bag awards for excellence in teaching, better enrolment

The schools are assessed based on including basic infrastructure, quality of education and teaching practices, technology-enabled teaching, development of the school, and activities done by students




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Carboxymethyl cellulose-stabilized calcium phosphate particles for injectable hydrogel-based bone tissue engineering

Soft Matter, 2024, Advance Article
DOI: 10.1039/D4SM00670D, Paper
Piyaporn Srisura, Yuwaporn Pinyakit, Umphan Ngoensawat, Pongsakorn Yuntasiri, Khoiria Nur Atika Putri, Theerapat Chanamuangkon, Waranyoo Phoolcharoen, Varol Intasanta, Voravee P. Hoven
Carboxymethyl cellulose-stabilized calcium phosphate particles well-dispersed in aqueous solution can be integrated into an injectable hydrogel made of methacrylated hyaluronic acid which is a promising material for bone regeneration applications.
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The cellular Potts model on disordered lattices

Soft Matter, 2024, 20,8337-8352
DOI: 10.1039/D4SM00445K, Paper
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Hossein Nemati, J. de Graaf
Extending the cellular Potts model to disordered Voronoi lattices reduces artifacts observed on regular lattices. An order–disorder transition is observed as a function of surface tension on the disordered lattice and the regular lattices.
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Chemo-mechanical model of cell polarization initiated by structural polarity

Soft Matter, 2024, 20,8407-8419
DOI: 10.1039/D4SM00800F, Paper
Hexiang Wang, Zhimeng Jia, Yuqiang Fang
We establish a multiscale model of a cell to explore the chemomechanical mechanisms of cell polarization initiated by structural polarity. The two-dimensional vertex model is built by coupling the cytoskeletal reorganization and the Cdc42 activation.
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Cell shape and orientation control galvanotactic accuracy

Soft Matter, 2024, Advance Article
DOI: 10.1039/D4SM00952E, Paper
Ifunanya Nwogbaga, Brian A. Camley
We study the physical factors that control the accuracy with which elongated cells can sense the direction of an electric field, exploring whether cells are more accurate sensors when oriented parallel to the field or perpendicular to it.
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Src kinase slows collective rotation of confined epithelial cell monolayers

Soft Matter, 2024, Accepted Manuscript
DOI: 10.1039/D4SM00827H, Paper
Nastassia Pricoupenko, Flavia Marsigliesi, Philippe Marcq, Carles Blanch-Mercader, Isabelle A Bonnet
Collective cell migration is key during development, wound healing and metastasis and relies on coordinated cell behaviors at the group level. Src kinase is a key signalling protein for physiological...
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Liquid crystalline collagen assemblies as substrates for directed alignment of human Schwann cells

Soft Matter, 2024, Advance Article
DOI: 10.1039/D4SM00534A, Paper
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Homa Ghaiedi, Luis Carlos Pinzon Herrera, Saja Alshafeay, Leonard Harris, Jorge Almodovar, Karthik Nayani
Collagen is a key component of the extracellular matrix (ECM) and well-oriented domains of collagen are important for mimicking the local cell environment in vitro. Here, we demonstrate macroscopic alignment on collagen in 2-D substrates and 3-D hydrogels.
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Co-assembly of Cellulose Nanocrystals and Gold Nanorods: Insights from Molecular Dynamics Modelling

Soft Matter, 2024, Accepted Manuscript
DOI: 10.1039/D4SM00871E, Paper
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Jiaxin Hou, William W Sampson, Ahu Gumrah Dumanli
A coarse-grained molecular dynamics model is developed to explore the co-assembly of cellulose nanocrystals (CNCs) and gold nanorods (AuNRs) under sedimentation conditions with varying vol- umetric concentration and particle-size ratios....
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Biomimetic mineralization of positively charged silica nanoparticles templated by thermoresponsive protein micelles: applications to electrostatic assembly of hierarchical and composite superstructures

Soft Matter, 2024, Advance Article
DOI: 10.1039/D4SM00907J, Paper
Nada Y. Naser, William C. Wixson, Helen Larson, Brandi M. Cossairt, Lilo D. Pozzo, François Baneyx
Exploiting the ability of a solid-binding elastin-like peptide to micellize, we mineralize monodisperse silica nanoparticles whose positive surface charge enables one-step electrostatic assembly of various mono- and bi-material superstructures.
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Scale-dependent sharpening of interfacial fluctuations in shape-based models of dense cellular sheets

Soft Matter, 2024, Accepted Manuscript
DOI: 10.1039/D4SM00804A, Paper
Haicen Yue, Charles Packard, Daniel Sussman
The properties of tissue interfaces – between separate populations of cells, or between a group of cells and its environment – has attracted intense theoretical, computational, and experimental study. Recent...
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Bevel Up - Drugs, Users and Outreach Nursing / directed by: Nettie Wild ; produced by: Fiona Gold, Juanita Maginley, Betsy Carson, Nettie Wild, Svend-Erik Eriksen, Rina Fraticelli ; production agencies: National Film Board of Canada (Montreal), British Co

Montreal : National Film Board of Canada, 2016




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Jamia Millia Islamia appoints JNU professor Mazhar Asif as new Vice-Chancellor

Mr. Asif is currently a professor at Jawaharlal Nehru University's (JNU) School of Languages




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ISRO, IIT-M sign MoU to set up centre of excellence in fluid and thermal sciences

The institute gets ₹1.84 crore seed money to set up the centre of excellence




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Former vice-chancellor of Bangalore University Professor M.S. Thimmappa passes away

He suffered a brain injury a month ago due to a fall in the bedroom, for which he had been undergoing treatment




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Remove NEHU Vice Chancellor, others: Apex northeast students’ body to Dharmendra Pradhan

A lockdown by two students’ organisation has paralysed the Central university in Meghalaya for a week now




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Career options in stem cell research

The field of stem cell research offers lucrative career options for people looking for something different in the field of medical science.




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A comparative study on the thermal runaway process mechanism of a pouch cell based on Li-rich layered oxide cathodes with different activation degrees

RSC Adv., 2024, 14,35074-35080
DOI: 10.1039/D4RA06355D, Paper
Open Access
Wei Quan, Jinghao Liu, Jinhong Luo, Hangfan Dong, Zhimin Ren, Guohua Li, Xiaopeng Qi, Zilong Su, Jiantao Wang
Li-rich layered oxide (LLO) is regarded as one of the most promising candidates for the next-generation batteries.
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Probing intrinsic defects of aluminium-doped CuO thin films for solar cell applications

RSC Adv., 2024, 14,35184-35197
DOI: 10.1039/D4RA06413E, Paper
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Adithya Prakash, Vikash Mishra, Mahesha M. G.
Defect-engineered Al-doped CuO thin films deposited via chemical spray pyrolysis find application in solar cell absorbers.
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Macroporous chitosan/alginate hydrogels crosslinked with genipin accumulate and retain glioblastoma cancer cells

RSC Adv., 2024, 14,35286-35304
DOI: 10.1039/D4RA06197G, Paper
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Lauriane Parès, Sahar Naasri, Lisa Delattre, Hélène Therriault, Benoît Liberelle, Gregory De Crescenzo, Marc-Antoine Lauzon, Nathalie Faucheux, Benoit Paquette, Nick Virgilio
This work demonstrates how macroporous hydrogels can be prepared with porous polylactide molds, and homogeneous solutions of sodium alginate and chitosan crosslinked with genipin, in order to accumulate glioblastoma cancer cells.
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In vitro bioactivity, mechanical, and cell interaction of sodium chloride-added calcium sulfate–hydroxyapatite composite bone cements

RSC Adv., 2024, 14,35460-35474
DOI: 10.1039/D4RA06034B, Paper
Open Access
Pharatree Jaita, Chamnan Randorn, Anucha Watcharapasorn, Parkpoom Jarupoom
In this research, sodium chloride-added calcium sulfate–hydroxyapatite composite bone cements (0.70CaS–0.30HAP)/xNaCl were studied.
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Physicochemical properties and mechanism of action of a new copper(II) pyrazine-based complex with high anticancer activity and selectivity towards cancer cells

RSC Adv., 2024, 14,36295-36307
DOI: 10.1039/D4RA06874B, Paper
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
B. Rogalewicz, T. Sierański, M. Szczesio, A. Olczak, K. Gobis, C. Orlewska, I. Korona-Głowniak, A. Korga-Plewko, M. Iwan, M. Michalczuk, J. Kubik, G. Adamczuk, M. Korga, N. Rutkowska, T. Boruta, K. Gas, M. Sawicki, E. Poleszak, W. Maniukiewicz, M. Świątkowski, A. Czylkowska
The presented work underlines the importance of coordination compounds in the development of new anticancer agents that are safer and more efficient.
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Vice President Harris is in ‘excellent health,’ physician says

Her most recent physical exam in April was “unremarkable,” Simmons added




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Quantitative determination and subcellular mapping of Pt-based drugs in single breast tumour cells via laser ablation-ICP-mass spectrometry

Dalton Trans., 2024, Advance Article
DOI: 10.1039/D4DT02467B, Paper
Open Access
Legna Colina-Vegas, Thibaut Van Acker, Wilmer Villarreal, Olivier De Wever, Alzir Azevedo Batista, Joaquim Araújo Nóbrega, Frank Vanhaecke
This study utilizes LA-ICP-MS to reveal the distribution and determine the concentration of Pt in MDA-MB-231 cells, providing insight into the mechanism and efficacy of Pt-based chemotherapeutic drugs.
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Effect of mono- and dinuclear thiosemicarbazone platinacycles in the proliferation of a colorectal carcinoma cell line

Dalton Trans., 2024, 53,17803-17818
DOI: 10.1039/D4DT01490A, Paper
Open Access
Francisco Reigosa-Chamorro, Sandra Cordeiro, M. Teresa Pereira, Beatriz Filipe, Pedro V. Baptista, Alexandra R. Fernandes, José M. Vila
The study of the antiproliferative activity of thiosemicarbazone platinacycles puts forward their high selectivity and low IC50 values.
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Of coruscating celluloid

The cameras back then captured raw, real, and unadulterated images




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Medical malpractice destroys profession’s nobility, says BLDE Vice-Chancellor




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Siege Courageous, Kalamitsi, Galahad, King Of War and Chotipari excell




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Effect of extracellular organic matter (EOM) accumulation on algal proliferation and disinfection by-product precursors during cyclic cultivation

Environ. Sci.: Water Res. Technol., 2024, 10,3024-3034
DOI: 10.1039/D4EW00207E, Paper
Open Access
Jr-Lin Lin, Fahrudin Sidik
Algal blooms, driven by nutrient enrichment from nitrogen and phosphorus, pose significant challenges to water treatment processes, particularly due to the accumulation of extracellular organic matter (EOM).
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Concurrent boron removal from reverse osmosis concentrate and energy production using a microbial desalination cell-Donnan dialysis hybrid system

Environ. Sci.: Water Res. Technol., 2024, Advance Article
DOI: 10.1039/D4EW00621F, Paper
A. Yagmur Goren, H. Eser Okten
The removal of boron from aqueous solutions offers an important opportunity to improve the management of sustainable resources.
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Environmental application of dicarboxylated hairy cellulose crosslinked with calcium for removal and confining of Pb(II)

Environ. Sci.: Water Res. Technol., 2024, Accepted Manuscript
DOI: 10.1039/D4EW00720D, Paper
Tanese Montesinos-Vázquez, C. A. Galan-Vidal, Susana Rojas-Lima, Jose A. Rodriguez, Ma. Elena Páez-Hernández
Cellulose can be oxidised with periodate to obtain hairy cellulose, which, thanks to the aldehyde groups, facilitates chemical modification with different functional groups, such as carboxylates, which enhance interaction with...
The content of this RSS Feed (c) The Royal Society of Chemistry




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Solar cell manufacturing to outstrip global demand by 2024: report

The sector experienced huge growth in 2023 with solar cell, wafers and modules capacity nearly doubling in comparison with the previous year, says World Solar Market Report 2024




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Leadership void at DUK and KTU: Administrative challenges persist amid Vice-Chancellor vacancies




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Sanjeev Sanyal accepted Chancellorship of Gokhale Institute of Politics and Economics

He will succeed Bibek Debroy, the Chairman of the Economic Advisory Council to the Prime Minister of India




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State can regulate madrasa education to ensure standards of excellence: SC 

The Supreme Court on Tuesday partially upheld the constitutional validity of the Uttar Pradesh Madrasa Education Board Act of 2004 while confirming that States can regulate madrasa education to ensure standards of excellence.




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Revealing degradation mechanisms in 3D/2D perovskite solar cells under photothermal accelerated ageing

Energy Environ. Sci., 2024, 17,8313-8324
DOI: 10.1039/D4EE03869J, Paper
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Zijian Peng, Andrej Vincze, Fabian Streller, Vincent M. Le Corre, Kaicheng Zhang, Chaohui Li, Jingjing Tian, Chao Liu, Junsheng Luo, Yicheng Zhao, Andreas Späth, Rainer Fink, Thomas Heumüller, Andres Osvet, Ning Li, Martin Stolterfoht, Larry Lüer, Christoph J. Brabec
Three-dimensional/two-dimensional (3D/2D) heterojunctions in perovskite solar cells exhibit excellent optoelectronic properties and enhanced stability under mild ageing conditions.
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Heterojunction lithiation engineering and diffusion-induced defect passivation for highly efficient Sb2(S,Se)3 solar cells

Energy Environ. Sci., 2024, 17,8402-8412
DOI: 10.1039/D4EE03135K, Paper
Cong Liu, Anweng Gong, Chen Zuo, Tao Liu, Xiaoyang Liang, Donglou Ren, Kai Shen, Jianzha Zheng, Qifan Xue, Zhiqiang Li, Ruud E. I. Schropp, Bingsuo Zou, Yaohua Mai
A heterojunction lithiation strategy has been developed to achieve a certified efficiency of 10.50%, which is the record efficiency for all of the Sb-based solar cells.
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Synergistic enhancement of charge extraction and heat dissipation in inverted perovskite solar cells via n-doped top interlayers

Energy Environ. Sci., 2024, 17,8304-8312
DOI: 10.1039/D4EE02836H, Paper
Sangmi Park, Sang Young Jeong, Jaehoon Kim, Heunjeong Lee, Hye Seung Kim, Young Wook Noh, Ye In Kim, Shinuk Cho, Joon Sang Kang, Han Young Woo, Myoung Hoon Song
n-Doping the fullerene-based interlayer in perovskite solar cells enhances heat dissipation and charge extraction by improving thermal/electrical conductivity, and energy level alignment, which boosts photovoltaic performance and stability.
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Efficient 1.77 eV-bandgap perovskite and all-perovskite tandem solar cells enabled by long-alkyl phosphonic acid

Energy Environ. Sci., 2024, 17,8219-8227
DOI: 10.1039/D4EE02483D, Paper
Hongling Guan, Shiqiang Fu, Guojun Zeng, Weiqing Chen, Chen Wang, Hongsen Cui, Dexin Pu, Peng Jia, Weiwei Meng, Guojia Fang, Weijun Ke
Incorporating dodecylphosphonic acid additives into 1.77 eV-bandgap perovskites enabled single-junction solar cells to achieve a PCE of 20.2%. Tandem cells further reached impressive PCEs of 27.41% (two-terminal) and 28.65% (four-terminal).
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Well-regulated structure-featuring giant-molecule acceptors enable long-term stability and high-performance binary organic solar cells

Energy Environ. Sci., 2024, Advance Article
DOI: 10.1039/D4EE03754E, Paper
Jingyu Shi, Pengfei Ding, Jintao Zhu, Zhenyu Chen, Shuangjiao Gao, Xueliang Yu, Xiaochun Liao, Quan Liu, Ziyi Ge
Through systematically selecting the numbers and positions of selenium atom of giant-molecule acceptors, the device based on PM6:GMA-SSeS yields the highest PCE of 19.37% with high VOC of 0.917 V and exhibits extended t80% lifetimes of 5600 h.
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From generation to collection – impact of deposition temperature on charge carrier dynamics of high-performance vacuum-processed organic solar cells

Energy Environ. Sci., 2024, Advance Article
DOI: 10.1039/D4EE03623A, Paper
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Richard Adam Pacalaj, Yifan Dong, Ivan Ramirez, Roderick C. I. MacKenzie, Seyed Mehrdad Hosseini, Eva Bittrich, Julian Eliah Heger, Pascal Kaienburg, Subhrangsu Mukherjee, Jiaying Wu, Moritz Riede, Harald Ade, Peter Müller-Buschbaum, Martin Pfeiffer, James Robert Durrant
Substrate heating during co-evaporation of bulk heterojunction organic solar cells aids phase separation and improves performance. While recombination remains unaffected, hole transport improves due to more crystalline donor domains.
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Stabilizing doped Spiro-OMeTAD by organic molten salt for efficient and stable perovskite solar cells

Energy Environ. Sci., 2024, Accepted Manuscript
DOI: 10.1039/D4EE04310C, Paper
Tengfei Pan, Zhiwei Li, Biyun Ren, Wan Yang, Xueqin Ran, Yajing Li, Yutian Xu, Yue Wang, Deli Li, Yingdong Xia, Xingyu Gao, Lingfeng Chao, Yonghua Chen
Bis(trifluoromethane)sulfonimide (LiTFSI) and 4-tert-butylpyridine (TBP) have been currently suggested to be irreplaceable in classic doped 2,2',7,7'-tetrakis (N,N-di-p-methoxyphenylamine)-9,9'-spirobifluorene (Spiro-OMeTAD) for high-performance perovskite solar cells (PSCs). However, the stability of Spiro-OMeTAD was...
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Stress regulation via surface micro-etching and reconstruction for enhancing triple-cation perovskite solar cells with an efficiency of 25.54%

Energy Environ. Sci., 2024, Advance Article
DOI: 10.1039/D4EE04248D, Paper
Yang Ding, Erming Feng, Siyuan Lu, Jianhui Chang, Caoyu Long, Sichao Tong, Hengyue Li, Junliang Yang
A surface micro-etching and reconstruction strategy is developed to regulate the stresses in a perovskite film, achieving a benign transition from tensile stress to compressive stress.
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N-type Ag2S modified CZTSSe solar cell with lowest Voc,def

Energy Environ. Sci., 2024, Advance Article
DOI: 10.1039/D4EE03244F, Paper
Jin Yang, Junjie Fu, Weiwei Dong, Shu Ren, Xin Zhang, Jingyi Su, Chaoliang Zhao, Meng Wei, Dandan Zhao, Yange Zhang, Sixin Wu, Zhi Zheng
The Sn, Zn-doped Ag2S plays a triple role in CZTSSe devices: p–n conversion, front-interface bandgap grading, and defect passivation. This strategy achieved an efficiency of 14.25%, with the Voc of 0.584 V and the lowest Voc,def of 0.228 V.
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Flexible spacer-block multi-component copolymerized donors enable resilient organic solar cells with over 40% crack-onset strain

Energy Environ. Sci., 2024, Advance Article
DOI: 10.1039/D4EE04208E, Paper
Congqi Lin, Zhenyu Chen, Ruixiang Peng, Wei Song, Jiangwei Gao, Xueliang Yu, Tingting Feng, Yongqi Bai, Ziyi Ge
A series of novel block donors were synthesized, achieving excellent PCE of 19.57% in rigid OSCs and 18.03% in f-OSCs, along with an outstanding crack-onset strain value of 40.29%.
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Data-driven discovery of electrode materials for protonic ceramic cells

Energy Environ. Sci., 2024, Advance Article
DOI: 10.1039/D4EE03762F, Paper
Open Access
Xueyu Hu, Yucun Zhou, Zheyu Luo, Haoyu Li, Nai Shi, Zhijun Liu, Weilin Zhang, Weining Wang, Yong Ding, Meilin Liu
A schematic representation of a four-stage data-driven material screening methodology, progressing from uncovering unexplored chemical spaces through high-throughput calculations to validating findings in protonic ceramic cells.
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