Early recognition of longus colli calcific tendinitis can prevent unnecessary interventions including antibiotics and surgical procedures.

OBJECTIVES:

To test the hypotheses that minority children with long-bone fractures are less likely to (1) receive analgesics, (2) receive opioid analgesics, and (3) achieve pain reduction.

A 16-year-old girl presented to her primary care physician with a one-month history of decreased appetite and abdominal pain. She had normal bowel movements and no vomiting, but her periumbilical pain limited her ability to finish most meals. She had gradual weight loss over the previous 2 years, and during the previous 4 years, she intermittently received counseling for depression after the loss of her mother. Her initial physical examination and laboratory evaluation were unremarkable. She was referred to a nutritionist, adolescent medicine, and pediatric gastroenterology. Her presentation evolved over time, which ultimately led to a definitive diagnosis.

Although pain is a prevalent nonmotor symptom in Parkinson’s disease (PD), it is undertreated, in part because of our limited understanding of the underlying mechanisms. Considering that the basal ganglia are implicated in pain sensation, and that their synaptic outputs are controlled by the subthalamic nucleus (STN), we hypothesized that...

Chronic pain is a highly prevalent disease with poorly understood pathophysiology. In particular, the brain mechanisms mediating the transition from acute to chronic pain remain largely unknown. Here, we identify a subcortical signature of back pain. Specifically, subacute back pain patients who are at risk for developing chronic pain exhibit...

The presence of large palaeo-landslides can hinder the construction of railway lines if they cause an alteration of the natural balance of the slope, significantly increasing the cost of the project. During the construction works in a section of the Madrid–Asturias high-speed railway line (Spain), a large-scale hillside instability affected 460 m of the section. The ground movement began 10 months after the start of the excavations and remained active throughout the observation period (2008–2010). Data provided by fieldwork, boreholes and instrumental monitoring have allowed the investigation of the geological units involved, together with the geometry and the kinematics of the mass movement. This landslide involves a Paleozoic basement with an estimated volume of 4 400 000 m³. It shows low displacement rates (<45 mm a^–1) and was accommodated on a single surface of rupture, which reaches more than 60 m depth. The kinematics is favoured by structural and lithological conditions, there being a strong rheological contrast in the lower part of the mobilized ground. This movement is linked to a large palaeo-landslide that was partially reactivated when excavations undermined the lower slopes of the hillside. Technical solutions for the stabilization have already caused an additional cost of 17% over the initial budget.

Metastatic breast cancer is prevalent worldwide, and one of the most common sites of metastasis is long bones. Of patients with disease, the major symptom is pain, yet current medications fail to adequately result in analgesic efficacy and present major undesirable adverse effects. In our study, we investigate the potential of a novel monoacylglycerol lipase (MAGL) inhibitor, MJN110, in a murine model of cancer-induced bone pain. Literature has previously demonstrated that MAGL inhibitors function to increase the endogenous concentrations of 2-arachydonylglycerol, which then activates CB1 and CB2 receptors to inhibit inflammation and pain. We demonstrate that administration of MJN110 significantly and dose dependently alleviates spontaneous pain behavior during acute administration compared with vehicle control. In addition, MJN110 maintains its efficacy in a chronic-dosing paradigm over the course of 7 days without signs of receptor sensitization. In vitro analysis of MJN110 demonstrated a dose-dependent and significant decrease in cell viability and proliferation of 66.1 breast adenocarcinoma cells to a greater extent than KML29, an alternate MAGL inhibitor, or the CB2 agonist JWH015. Chronic administration of the compound did not appear to affect tumor burden, as evidenced by radiograph or histologic analysis. Together, these data support the application for MJN110 as a novel therapeutic for cancer-induced bone pain.

Researchers investigated pain perception in patients with diabetic foot ulcers (DFUs) by analyzing pre- and postoperative physical function (PF), pain interference (PI), and depression domains of the Patient-Reported Outcome Measurement Information System (PROMIS). They hypothesized that 1) because of painful diabetic peripheral neuropathy (DPN), a majority of patients with DFUs would have high PROMIS PI scores unchanged by operative intervention, and 2) the initially assessed PI, PF, and depression levels would be correlated with final outcomes. Seventy-five percent of patients with DFUs reported pain, most likely because of painful DPN. Those who reported high PI and low PF were likely to report depression. PF, PI, and depression levels were unchanged after operative intervention or healing of DFUs.

Paint your home blue before selling it, as the color brings a sense of peace, softness. Many people love blue and it may help you sell home more quickly.

Black paint usually absorbs heat, but a new two-layer polymer paint reflects infrared light and keeps objects 16°C cooler, which could help make buildings more energy efficient

FRENCHIC, the British paint brand with eco-friendly formulas for breathing new life into furniture, homes and garden decor, has seen sales surge 500 percent recently as lockdown sends DIYers into overdrive.

We’re joined by a new staffer (Peter) this week for a HUGE cast! We set off a KEMCO alert with massively overpriced DLC, we’re accidentally...

… Trains for 1st Time inside Davis Cup Venue VALENCIA, Spain – World No … the Spanish national team’s Davis Cup quarterfinals against Germany. Nadal, who ….

… a big upset in his Davis Cup debut on Friday, defeating Spaniard ….

Read our live coronavirus updates HERE

Follow our live coronavirus updates HERE Coronavirus: The symptoms

Follow our live coronavirus updates here Coronavirus: the symptoms

Follow our live coronavirus updates HERE Coronavirus: The symptoms

Spain's prime minister has revealed his government's plans to start winding down the country's coronavirus lockdown in the second half of May.

CCTV footage has captured the moment a valuable Vincent van Gogh painting was stolen in an overnight raid from a Dutch museum that had closed due to coronavirus.

Dominic Raab has warned that a "second spike" in UK coronavirus cases would trigger a second lockdown which would "prolong the economic pain we are all going through".

Specially decorated postboxes have been created by the Royal Mail as a way of thanking NHS workers for their efforts during the coronavirus crisis.

Postboxes have been painted blue to thank NHS workers for their efforts during the crisis.

Spain's strict coronavirus lockdown has sent the unemployment rate to a near four-year high.

The country's Ministry of Health also recorded just 721 new confirmed cases on Friday, bringing total infections to 223,578.

The beat against Congress has always been that its members are out of touch with average Americans. The result is a wide and deep imprint on the same Congress charged with helping a traumatized nation. “Everyone by now knows someone that had it," said Sen. Amy Klobuchar, D-Minn., whose husband, John Bessler, recovered from a frightening coronavirus infection that sent him to the hospital.

Tomorrow marks 75 since the nation celebrated VE day - the end of fighting against Nazi Germany in Europe.

Karen Cumming is finding a way to deal with delayed hip surgery

We can expect psychological difficulties to follow as we come out of lockdown. But we have an opportunity to remake our relationship with our bodies, and the social body we belong to. By Susie Orbach

When lockdown started, I was confused by bodies on television. Why weren’t they socially distancing? Didn’t they know not to be so close? The injunction to be separate was unfamiliar and irregular, and for me, self-isolating alone, following this government directive was peculiar. It made watching dramas and programmes produced under normal filming conditions feel jarring.

Seven weeks in, the disjuncture has passed. I, like all of us, am accommodating to multiple corporeal realities: bodies alone, bodies distant, bodies in the park to be avoided, bodies of disobedient youths hanging out in groups, bodies in lines outside shops, bodies and voices flattened on screens and above all, bodies of dead health workers and carers. Black bodies, brown bodies. Working-class bodies. Bodies not normally praised, now being celebrated.

Coronavirus: The symptoms

How to look after your body physically while WFH

Spanish Prime Minister Pedro Sanchez hopes LaLiga will return "soon" and says that it will be up to federations and clubs to decide when.

Former Southampton and Everton boss and current Netherlands coach Ronald Koeman has been admitted to hospital in Amsterdam with heart problems.

Glenda McCulloch paints contemporary Indigenous art. After advertising her paintings on Instagram, she found the demand for her art is much stronger than she first expected.

The acclaimed Australian artist is painting black squares on a gallery wall with his eyes closed to protest against the values that led us to climate crisis.

A Sydney mechanic who rescued a seven-year-old girl being raped by convicted sex offender Anthony Sampieri tells a court he still has nightmares about the "feeling of a scalpel being dragged across the back of my neck".

SUNCARE favourite Banana Boat has been slammed by beachgoers after they were left with horrific sunburn. The manufacturer says the product is fine.

A virtual sports internship program at USC will help students this summer who had their original summer internship displaced by COVID-19.

An international team of researchers including the University of Adelaide, has completed the first large-scale study of DNA belonging to ancient humans of the central Andes in South America and found early genetic differences between groups of nearby regions, and surprising genetic continuity over thousands of years.