A third pipeline break in Grand Canyon National Park has closed a one-mile section of the North Kaibab Trail between Roaring Springs and Cottonwood Campground. https://www.nps.gov/grca/learn/news/news_release_31may2012.htm

The staff on the North Rim of Grand Canyon National Park will begin to shut down most visitor services and facilities on Monday, October 15; but the North Rim will remain open to visitors through November 25 or until snow closes Highway 67 leading into the park. https://www.nps.gov/grca/learn/news/2012-09-49_nr-soft-closure.htm

Grand Canyon National Park has begun improvements to Cape Royal Road on the North Rim. Beginning September 3, 2013 Cape Royal Road from Roosevelt Point to Cape Royal Point, at approximately mile 11.5, will be closed for repaving. https://www.nps.gov/grca/learn/news/road-improvements-to-temporarily-close-portion-of-cape-royal-road-on-the-north-rim-of-grand-canyon-national-park.htm

Cape Royal Road at Grand Canyon National Park Closed. All Other Roads Including Point Imperial Road Remain Open https://www.nps.gov/grca/learn/news/update-cape-royal-road-at-grand-canyon-national-park-closed.htm

The North Rim of Grand Canyon National Park is now closed to vehicle traffic for the season. Arizona State Route 67, leading to the North Rim closed on December 2, 2013. State Route 67 and all services on the North Rim are expected to re-open for the 2014 season on May 15, 2014. https://www.nps.gov/grca/learn/news/2013-north-rim-closed-for-season.htm

The trail between the El Tovar Hotel and the train depot will close for repairs July 1. https://www.nps.gov/grca/learn/news/el-tovar-walkway-detour.htm

The Arizona Department of Transportation has closed State Route 67 between Jacob Lake and the North Rim of Grand Canyon National Park. The North Rim is now closed to vehicle traffic for the winter. https://www.nps.gov/grca/learn/news/north-rim-winter-closure.htm

Due to rodent activity and the potential exposure risk to hantavirus, the National Park Service has temporarily closed Cave of the Domes. https://www.nps.gov/grca/learn/news/cave-of-the-domes-closure.htm

Firefighters conducted an aerial reconnaissance flight this afternoon and estimate the Fuller Fire is approximately 1,324 acres. https://www.nps.gov/grca/learn/news/point-imperial-rd-closure.htm

On Monday, March 27, Grand Canyon National Park will begin daily closures of the North Kaibab Trail at Redwall Bridge to remove debris from a storm-caused rockslide. During this time, rim-to-rim travel will be restricted. https://www.nps.gov/grca/learn/news/north-kaibab-ribbons-falls-temporary-closures.htm

Due to an unanticipated rockslide the National Park Service (NPS) will close the Colorado River Trail between Pipe Creek and the Silver Bridge for trail repair starting Monday, April 3. https://www.nps.gov/grca/learn/news/repairs-close-river-trail.htm

After nearly 100 years since its opening, Grand Canyon Pioneer Cemetery will close to new burials due to lack of space. Although the cemetery is closed to new plots, some burials may continue for individuals with a spouse or immediate family already interred in the cemetery. https://www.nps.gov/grca/learn/news/2017-06-26-historic-pioneer-cemetery-has-closed.htm

Grand Canyon National Park has closed the yurt located at CC Hill on the North Rim effective September 21, 2017 for safety concerns. https://www.nps.gov/grca/learn/news/20171003-grand-canyon-nr-yurt-permanently-closed.htm

The Kaibab Suspension Bridge, also called the Black Bridge, will close to foot traffic while trail crews replace wood decking and tread boards. https://www.nps.gov/grca/learn/news/repairs-close-black-bridge.htm

Effective August 21, 2018 Kolb Studio will be closed and a detour will be in place while work is being completed along the Rim Trail. This project will be completed on August 23, 2018. https://www.nps.gov/grca/learn/news/rim-trail-detour-historic-kolb-studio-temporarily-closed-august-21-23-2018.htm

The National Park Service (NPS) received a letter today from the Health and Human Services Director and Chief Health Officer for Coconino County recommending the full closure of Grand Canyon National Park. https://www.nps.gov/grca/learn/news/grand-canyon-national-park-closed-04-01-2020.htm

Using just CSS to produce a click action multi-level menu with persist.

An update to the previous version of the click action multi-level menu with persist.

A click action dropline menu with persist and accessibility.

A vertical concertina menu with a click to open and close action and animation.

Using just CSS to produce a multi-level menu with a click to open/close action instead of the normal hover suitable for the iPad.

It has not yet been confirmed when the fast-food branch will open

Privately owned forests provide many public benefits, including clean water and air, wildlife habitat, and recreational opportunities. By 2030, 44.2 million acres of rural private forest land across the conterminous United States are projected to experience substantial increases in residential development. As housing density increases, the public benefits provided by private forests can be permanently altered. We examine factors behind projected patterns of residential development and conversion of private forest land by 2030 in northwestern Washington, southern Maine, and northwestern Georgia. Some key factors affecting the extent of future residential housing include (1) population growth from migration into an area; (2) historical settlement patterns, topography, and land ownership; and (3) land use planning and zoning.

Scientists have had little information about how prescribed fire and cattle grazing—common practices in many Western ponderosa pine forests—affect plant abundance and reproduction in the forest understory. Pacific Northwest Research Station scientists began to explore how these practices affect vegetation in a five-year study of postfire vegetation in eastern Oregon ponderosa pine forests where cattle have been routinely pastured from late June or early July through early to mid August. For this area of eastern Oregon, they found that excluding cattle grazing during peak growing season increased native plant cover and grass flowering capability in ungrazed areas compared to grazed areas. Because vegetation was measured prior to releasing cattle on the land, the study's results tend to reflect lasting grazing impacts rather than simple consumption.

The price by which RICKI LEE and AARON ISHMAEL's LOUD MEDIA (SARATOGA RADIO LLC) is purchasing AC simulcast WNYV/WHITEHALL, NY and WVNR-A and the construction permit for W242DF/POULTNEY, … more

More than 150 meals being rustled up

IOWA CITY — Once upon a time, there was a house in a city that loved literature. It was a quaint, two-story home in the heart of the historic district with brick stairs, pale yellow siding, a...

An Eastern Iowa furniture manufacturer will permanently close two plants, laying off about 370 employees as it drops two lines of business. Flexsteel Industries will close a factory in Dubuque with...

In response to the coronavirus, Americans were told by their federal and state governments to shut down their businesses, stop going to church, work, school or out to eat, travel only when necessary and hunker down at home. Originally, Americans were led to believe this was for a two- or three-week period, in order to flatten the curve and not overwhelm our health care system.

At seven weeks and counting, with staggering economic loss that will leave families and thousands of small businesses and farmers with profound devastation, the question must be asked, are we trying to flatten the curve or flatten our country?

The initial models that pointed to staggering loss of life from the coronavirus have proved wildly inaccurate. As of May 2, the CDC placed the number of deaths in the U.S. from the virus at 66,746. While all loss of life is deeply regrettable, these numbers cannot be considered in a vacuum. For perspective, deaths from pneumonia in the U.S. during the same period were 64,382, with average yearly deaths from influenza in the same range.

The original goal of closing much of the U.S. economy and staying at home was to flatten the curve of new coronavirus cases so that our hospital systems would not be overwhelmed. Hospitals built by the Army Corps of Engineers to handle the increased volume have mostly been taken down. Except for a few spots in the U.S. the health care system was not overwhelmed. As the medical models of casualties from the coronavirus continue to be adjusted down, it is clear the curve has been flattened, so why do we continue to stay closed and worsen the economic devastation that tunnel vision has thus far kept many of our leaders from acknowledging?

Many health experts say 80 percent of Americans will get the coronavirus and experience only mild symptoms. The curve has been flattened. Our health care system is not overwhelmed. Why is our economy, for the most part, still closed?

A University of Washington study recently revised the projected number of deaths from the coronavirus in Iowa from 1,367 to a much lower estimate of 365. While all loss of life is horrific, we must also consider the devastation being done to our economy, our families and our way of life by actions taken to combat the coronavirus.

It must be noted that 578 Iowans died from the flu and pneumonia in 2017, a greater number than are likely to pass away from the coronavirus. We also know that many who die from the virus are elderly with underlying health conditions, increasing the likelihood that any serious illness could result in their death. Are draconian government restrictions in response to the coronavirus still needed and economically sustainable? The data shows that the answers to both questions is no. We are no longer flattening the curve; we are flattening our state and nation.

We have seen the medical data. What has been less visible in news conferences and in the overall reporting of the coronavirus and our response to it, are the economic and human costs of what we are doing:

• 30 million Americans are out of work and the number grows daily.

• Dairy farmers are pouring out milk they have no market for.

• Pork producers are euthanizing hogs they have no market for.

• According to a study by Iowa State University, the losses to Iowa Agriculture are at a staggering $6.7 billion and growing, with the largest losses in pork production and ethanol.

• In Iowa, the economic loss for corn is estimated to be $788 million, $213 million for soybean and $34 million for cattle.

• The Iowa Restaurant Association estimates that between 10 & 25% of Iowa’s restaurants will not reopen.

• Iowa’s public universities are predicting a $187 million loss.

• Iowa is spending $200 million or more per month on unemployment claims, with over 171,000 Iowans unemployed.

• 29 percent of the U.S. economy is frozen as a result of government action, with U.S. economic output down 29 percent.

• U.S. unemployment could soon hit 47 million.

• Losses to U.S. tourism are predicted to top $910 billion.

• Retirement plans for millions of Americans are being decimated, with recent reports projecting the average 401(k) loss at 19 percent.

• Drug and alcohol addiction and relapse are increasing.

• Testing for chronic diseases such as high blood pressure, diabetes and heart disease are being delayed, which could lead to increasing health problems and life-threatening illnesses in the future.

• Economic damage to rural hospitals could lead to hospital closures and less access to health care in some areas.

• Warnings of a possible meat shortage in the U.S. have been issued by executives of Farmland and Tyson, with reports that the food supply chain is under stress. Several grocery store chains are now limiting meat purchases and some national restaurant chains are no longer offering certain meat products on their menus. Higher meat prices are almost certain in the months to come.

• Huge U.S. debt increases unlike anything seen since World War II, to the tune of over $3 trillion and counting, are adding to the already monstrous $22 trillion in U.S. debt. This does not bode well for our children or future economic stability.

The list of consequences goes on and on, and behind each of the statistics is a family struggling to survive, a father and mother fearful of how they will care for their children, a small-business owner seeing their dreams and hard work destroyed overnight by draconian government mandates, a restaurant owner deciding never to reopen, a dairy farmer throwing in the towel and a business owner postponing indefinitely plans for expanding.

Behind these numbers is an economy greatly impacted by the government response to the coronavirus, with implications for our economic well-being profound and long lasting. Expansion projects delayed, business closures, layoffs and contraction for many businesses will likely keep unemployment numbers high and depress economic expansion for an unknown amount of time.

Let us be clear, it grows worse every day we remain closed.

Steve Holt represents District 18 in the Iowa House.

IOWA CITY — Once upon a time, there was a house in a city that loved literature.

It was a quaint, two-story home in the heart of the historic district with brick stairs, pale yellow siding, a hipped red roof and a rich history: Its original owner was Emma J. Harvat, who in 1922 became the nation’s first female mayor for a city of more than 10,000.

Nearly a century later, in 2014, Andrea Wilson was working in advertising in Florida and pined for a more “altruistic purpose” for her life. So she planned a return to Iowa, where she grew up in Columbus Junction.

But this time Wilson would live in Iowa City, known for — among other things — pioneering academic creative writing pursuits at the University of Iowa’s famed Writers’ Workshop.

Wilson wanted to write and found the idea of the historic Harvat house so charming she bought it “sight unseen” from down in Miami, aiming to run it as a bed-and-breakfast. But when she arrived, Wilson discovered a need in her new community she aimed to fill. It had a surprising dearth of literary resources for those outside the university.

“There wasn’t any place for the public to take a class or meet other writers or really be part of a writing community where people could just express their humanity through words,” she said. “It became my passion project — to try to create that for this community. I thought if anywhere should have a place like that, it would be America’s only UNESCO City of Literature at the time.”

So in March 2015, Wilson debuted Iowa City’s first community-based literary center for writers — or those aspiring. She had hoped to open a communal writing space closer to downtown but didn’t have the funding. So she gave her home a third identity: the Iowa Writers’ House.

She continued to live there and maintain her bed-and-breakfast business, which funded the writing endeavor and kept its cozy corridors bustling with interesting characters.

Famed visiting writers included Leslie Jamison, American novelist and essayist with works on the New York Times bestseller list; Hope Edelman, whose six non-fiction books have published in 17 countries and translated in 11 languages; Alison Bechdel, an American cartoonist and MacArthur fellow; and Piedad Bonnett Velez, Colombian poet, playwright and novelist of international acclaim.

And over the years, the Iowa Writers’ House connected, served and motivated thousands with its workshops, seminars, readings and summer camps. It offered editing services, founded a Bicultural Iowa Writers’ Fellowship, and — among other things — inspired a growing network of friends and creatives to value their own stories and the stories of others.

“I said yes to everything anyone ever asked of me,” Wilson said. “We gave tours. I received visiting scholars. We hosted dinners for visiting poets and writers for the university. And a lot of that was all volunteer. We never had a steady funding stream like most literary centers do.”

So when the coronavirus in March reached Iowa City, later shuttering storefronts, canceling events, curtailing travel plans and crippling the economy, the Iowa Writers’ House momentum stopped, too.

“Once COVID hit, because all of our programming is live and people come to the house, we had to cancel it,” Wilson said.

She dropped most of the organization’s spring season. She lost all her projected bed-and-breakfast business. And in a message posted to the Iowa Writers’ House website last month, Wilson announced her hard but unavoidable news.

“As the situation pushes on, and with no programming in the foreseeable future, we must make drastic changes,” she wrote. “Organizations must weather the storm or adapt, and in the case of this little organization with a big heart, evolution is the only option.”

And so after five years of intimate conversations, communal meals, singing, laughing, crying and lots and lots of writing and reading — all done in the shadow of Harvat — the organization is leaving the historic space and “taking a break to assess our mission and consider our best options for the future.”

Wilson said she plans to focus on her own writing. And the Bicultural Iowa Writers’ Fellowship program will continue — allowing for the release later this year of a third volume of “We the Interwoven: An Anthology of Bicultural Iowa,” including six new authors with multilingual stories of living in Iowa.

News of the goodbye — at least for now — has been met with an outpouring of support and testimonials of the impact the Iowa Writers’ House has had,

“I grew up without a writing community, and it was a very lonely experience,” Erin Casey wrote to Wilson after learning of its pause.

Casey — on the Iowa Writers’ House team and director of The Writers’ Rooms, an offshoot of the house — said her involvement in the project shaped not only her career but her personal growth.

“You, and the Iowa Writers’ House, helped me become a stronger person who felt deserving of companionship, respect, and love,” she wrote. “Watching the house grow, the workshops fill, and the stories come in about how much the IWH touched people’s lives added to the joy. I finally found a place to call home.”

Casey said that while the future is unknown, its legacy is not.

“The IWH will live on in the hearts of the people you touched,” she wrote. “Writers have found friends, support, guidance …”

Although the project isn’t getting a fairy-tale ending, Wilson said the story isn’t over.

“The organization is leaving the space. I’m leaving the space. We’re going on an organizational break so we can determine what a sustainable future might be,” she said. “But it’s really the end of a chapter. And we don’t know what the next chapter will be.”

Comments: (319) 339-3158; vanessa.miller@thegazette.com

An Eastern Iowa furniture manufacturer will permanently close two plants, laying off about 370 employees as it drops two lines of business.

Flexsteel Industries will close a factory in Dubuque with 200 employees that manufactures products for the recreational vehicle industry.

The publicly traded company also will close a plant in Starkville, Miss., that produces products for the RV and hospitality industries and employs about 170 people.

In a news release, Flexsteel said its decision to stop manufacturing RV and hospitality furniture was due to rapidly declining customer demand and changing market conditions resulting from the ongoing COVID-19 pandemic.

Flexsteel said the two markets already had entered a cyclical decline before the effects of the pandemic occurred.

“It has become clear that what was thought to be a short-term hit to these two already challenged businesses will now extend well into the future and will likely not return to pre-pandemic levels for some time,” said Jerry Dittmer, Flexsteel president and CEO. “This pandemic has been unforgiving to many companies, including ours. We find ourselves making these hard decisions as we attempt to navigate these uncharted business conditions.”

The Dubuque and Starkville plants temporarily were shut down in late March due to sudden drops in demand as many of Flexsteel’s customers shut down in the wake of the pandemic.

Dittmer said the company will be working with its work force, customers and suppliers to determine a feasible ramp-down plan. While it is anticipated that both facilities could close as early as June, the date may fluctuate sooner or later based on business conditions.

Dittmer said the company will increase its focus on home furnishings, e-commerce and workspace solutions.

We’re a big step closer to a Canon EOS R5 release announcement now, as Nokishita Tweets that it has passed its Bluetooth certification. The belief is that the EOS R5 was originally scheduled to ship in July, and Canon Rumors reports that they’ve been told that’ll still happen. With lockdowns still in effect in much […]

The post The Canon EOS R5 release gets closer as it passes Bluetooth certification appeared first on DIY Photography.

The Baumslag Solitar group $BS(2,3)$, is a so-called non-Hopfian group, meaning that it has an epimorphism $phi$ onto itself, that is not injective. In particular this is equivalent to saying that $BS(2,3)$ has a quotient that is isomorphic to itself. As a consequence the Cayley graph of $BS(2,3)$ has a quotient that is isomorphic to itself up to change of generators. We describe this quotient on the graph-level and take a closer look at the most common epimorphism $phi$. We show its kernel is a free group of infinite rank with an explicit set of generators.

Several problems of artificial intelligence, such as predictive learning, formal concept analysis or inductive logic programming, can be viewed as a special case of half-space separation in abstract closure systems over finite ground sets. For the typical scenario that the closure system is given via a closure operator, we show that the half-space separation problem is NP-complete. As a first approach to overcome this negative result, we relax the problem to maximal closed set separation, give a greedy algorithm solving this problem with a linear number of closure operator calls, and show that this bound is sharp. For a second direction, we consider Kakutani closure systems and prove that they are algorithmically characterized by the greedy algorithm. As a first special case of the general problem setting, we consider Kakutani closure systems over graphs, generalize a fundamental characterization result based on the Pasch axiom to graph structured partitioning of finite sets, and give a sufficient condition for this kind of closures systems in terms of graph minors. For a second case, we then focus on closure systems over finite lattices, give an improved adaptation of the greedy algorithm for this special case, and present two applications concerning formal concept and subsumption lattices. We also report some experimental results to demonstrate the practical usefulness of our algorithm.

As this issue goes to press we are all staying home to battle the coronavirus.…

Non-ionic water-soluble cellulose ethers modified with 3-azido-2-hydroxypropyl groups bound via an ether link are provided having a molar degree of substitution MSAHP in the range from 0.001 to 0.50. Exemplary cellulose ethers are alkyl celluloses, including methyl, hydroxyalkyl (e.g. hydroxyethyl or hydroxypropyl) or alkylhydroxyalkyl cellulose (e.g. methylhydroxyethyl). Reaction products with alkyne compounds are also provided, resulting in a terminal alkyne group. The reaction of azide with the alkyne proceeds as a 1,3-dipolar cycloaddition reaction, advantageously with Cu(I) or ruthenium catalysts. A multiplicity of cellulose ethers can be obtained from the conversion reaction. Variations in the macroscopic properties can be achieved by controlled modification, ranging from increased or reduced viscosity. The reaction, taking place within a few seconds, requires only minimal catalyst. Gel formation is reversible by adjustment of the pH such that a monophasic system (high-viscous fluid) arises again from a biphasic system (gel+low-viscous water phase).

A production method of a cationized cellulose or a cationized hydroxyalkylcellulose, including step 1 for adding a cationizing agent to cellulose and mechanically decrystallizing the cellulose and step 2 for adding a basic compound to the mixture obtained in step 1 and mechanically decrystallizing the cellulose, or a production method of a cationized cellulose or a cationized hydroxyalkylcellulose, including a step 3 for adding a basic compound to cellulose and mechanically decrystallizing the cellulose and step 4 for adding a cationizing agent to the mixture obtained in step 3 and mechanically decrystallizing the cellulose. The cellulose and the cationizing agent are allowed to react with each other in step 2 or step 4.

Flame retardant cellulose is prepared comprising cellulose fibers and an organophosphate compound bonded to the cellulose fibers. Accordingly, the bonded phosphate-functional group provides the cellulose fibers with pendant phosphate ester functionality. Numerous phosphate derivatives can be envisaged that will accomplish the intended task.

This invention provides cellulose ester interpolymers, and methods of oxidizing cellulose interpolymers and cellulose ester interpolymers. The invention also provides routes to access carboxylated cellulose ester derivatives with high acid numbers wherein the carboxyl group is attached directly to the cellulose backbone by a carbon-carbon bond. Through functionalization of an intermediate aldehyde, the corresponding cationic or zwitterionic cellulose ester derivatives can also be accessed. The interpolymers of the present invention have a number of end-use applications, for example, as binder resins in various types of coating compositions and as drug delivery agents.

This invention provides cellulose ester interpolymers, and methods of oxidizing cellulose interpolymers and cellulose ester interpolymers. The invention also provides routes to access carboxylated cellulose ester derivatives with high acid numbers wherein the carboxyl group is attached directly to the cellulose backbone by a carbon-carbon bond. Through functionalization of an intermediate aldehyde, the corresponding cationic or zwitterionic cellulose ester derivatives can also be accessed. The interpolymers of the present invention have a number of end-use applications, for example, as binder resins in various types of coating compositions and as drug delivery agents.

This invention provides cellulose ester interpolymers, and methods of oxidizing cellulose interpolymers and cellulose ester interpolymers. The invention also provides routes to access carboxylated cellulose ester derivatives with high acid numbers wherein the carboxyl group is attached directly to the cellulose backbone by a carbon-carbon bond. Through functionalization of an intermediate aldehyde, the corresponding cationic or zwitterionic cellulose ester derivatives can also be accessed. The interpolymers of the present invention have a number of end-use applications, for example, as binder resins in various types of coating compositions and as drug delivery agents.

A coating agent containing a hydroxyalkyl cellulose in which a content of hydroxyalkoxy groups within the hydroxyalkyl cellulose is within a range of 40 to 50% by mass, preferably a coating agent containing a hydroxyalkyl cellulose in which the content of hydroxyalkoxy groups is within a range of 40 to 50% by mass and also a viscosity of 2% aqueous solution at 20° C. is within a range of 3.0 to 5.9 mPa·s; and a solid preparation coated with the coating agent.

Compounds which are trehalose-6-phosphate or trehalose-6-phosphonate precursors of formula (I) or agriculturally acceptable salts thereof are provided: (I) The compounds are useful in increasing starch production in plants.

A method for computer-aided closed and/or open-loop control of a technical system is provided. A first value of an output quantity is predicted on a data-based model at a current point in time. A second value of the output quantity is determined from an analytical model. The state of the technical system at the current point is assigned a confidence score in the correctness of prediction of the data-based model. A third value of the output quantity is determined from the first and second value as a function of the confidence score for controlling the technical system. A suitable value for the output quantity can be derived from the analytical model even for regions of the technical system in which the quality of prediction of the data-based model is low because of a small set of training data. The technical systems can be turbines, such as gas turbines.

The present invention provides a closed-loop system for treating neurological disorders, such as epilepsy. In one embodiment the system comprises an input assembly that is adapted to receive one or more signals from a patient that are indicative of a patient's neurological state. The input assembly processes the one or more signals to generate one or more control input signals. An output assembly receives the one or more control input signals from the input assembly and generate a neuromodulation signal that is a function of the patient's neurological state. An electrode array is configured to deliver the neuromodulation signal to a patient's peripheral nerve, such as the vagus nerve.

An enclosed polishing apparatus include a housing, a fixing seat, a guiding mechanism, and a chain-driven polishing mechanism. The housing includes a bottom housing and a top housing connected to the bottom housing. The fixing seat is securely placed in the bottom housing. The guiding mechanism is placed in the top housing above the fixing seat. The polishing mechanism is movably mounted on the guiding mechanism above the fixing seat. The polishing mechanism is driven and guided by the guiding mechanism to follow a desired polishing contour on a workpiece.

A MEMS sensor includes at least one closed nodal anchor along a predetermined closed nodal path on at least one surface of a resonant mass. The resonant mass may be configured to resonate substantially in an in-plane contour mode. Drive and/or sense electrodes may be disposed within a cavity formed at least in part by the resonant mass, the closed nodal anchor, and a substrate.

A centrifuge to which sample tubes can be introduced while the centrifuge is in motion. The centrifuge comprises a carousel having an upper portion and a lower portion. The upper portion of the carousel has a plurality of positions for sample tubes for a centrifugation operation, a plurality of drive mechanisms attached to the upper portion of the carousel, a movable element mounted upon each drive mechanism, the movable element capable of traversing the length of the drive mechanism when the drive mechanism is actuated, a sample tube-holding assembly comprising a sample tube holder and a bearing attached to each movable element, and at least one balancing element capable of contributing to a force vector that cancels an imbalance vector generated by rotation of the centrifuge.

The present disclosure relates to an improved device and methods for adapting to a laser diffraction apparatus used for measuring particle size distribution and density of the plume of a powder composition emitted from a dry powder inhaler.

A ring binder mechanism for retaining loose-leaf pages securely holds closed ring members together to prevent inadvertent loss of pages retained by the mechanism. The mechanism comprises a housing supporting two hinge plates for pivoting motion to open and close paired ring members mounted on the plates. Free ends of the paired ring members have interlocking configurations that securely join together when the ring members close. The configurations prevent misalignment of the closed ring members in all directions transverse to longitudinal centerlines of the ring members. The mechanism also includes locking elements that interact with the hinge plates to block their pivoting motion when the ring members are closed. This holds the free ends of the closed paired ring members together so that the interlocking configurations of the ring members remain interengaged.