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Pinkbike Poll: How Often Do You Drive to Your Local Trails?



Are you lucky enough to have trails in your backyard, or do you need to drive to ride?
( Photos: 1, Comments: 239 )




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Anthony Davis to help Staples Center employees, local restaurants and hospital workers

Lakers star Anthony Davis announces a partnership with world's largest cold food storage company to help Staples Center employees find jobs during the coronavirus pandemic.




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All state and local beaches in Orange County must temporarily close, Gov. Gavin Newsom says

The news comes after a memo saying California's governor would go further, closing all state and local beaches and parks, a plan he appeared to abandon.




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Staff news: Shelby Grad to oversee local coverage; Kim Murphy to head national/foreign

A memo to the newsroom from Times Editor Davan Maharaj and Managing Editor Marc Duvoisin: Today we announce a reorganization involving three of our most important news departments.




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Sen. Elizabeth Warren applauds NYC Council bills requiring pay hikes for local workers

Elizabeth Warren touted her own “universal workers’ bill of rights" and said of New Yorkers, "I’m glad to see people who are picking up this idea at the state level."




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Grand Canyon National Park closes on advice of local health officials

The park had been criticized for allowing visitors to access roads and South Rim view points during the coronavirus pandemic.




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Response to statement from Secretary of State for Housing, Communities and Local Government

London Fire Brigade welcomes the announcement on building safety made by the Secretary of State.




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Your local farm in a box: How farmers are coping with the crisis

These are unprecedented times for farmers, accustomed to selling produce to restaurants. Many have shifted to CSA boxes and other methods to cope




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Letters to the Editor: A pandemic is the worst time for local newspapers to die

We need local reporting now more than ever, but things don't look good after the folding of three community newspapers in Southern California.




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Letters to the Editor: Rich people riding out the pandemic in country homes put locals at risk

A resident of Sedona, Ariz., did not appreciate an L.A. Times story on wealthy out-of-towners fleeing to their second homes.




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May the Fourth be with you: St. George enthusiast talks Star Wars, local 501st Legion

A local 501st Legion member discusses his introduction to the Star Wars universe, what it takes to be a trooping member of the worldwide organization.

       




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Local saddlemaker discusses the iconic western saddle and what it takes to build it right

Saddlemaker Steve Hafen talks about what it takes to build a saddle to last generations, and how family and hard work are key components in his life.

       




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Local outdoor enthusiasts step up, keep land clean amid non-local influx

Members of Trail Hero and other local outdoor enthusiasts step up to keep Sand Hollow State Park clean after a wave of non-locals ended in vandalism.

       




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Dallara transforms local IndyCar shop for fight against COVID-19

As Dallara's Stefano DePonti saw his parent company begin to manufacture parts for ventilators back in Italy, he knew the IndyCar shop needed to step in to help fight COVID-19.

      




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Where locals land on new basketball prospect rankings for 2019 and 2020

A look at where locals land on new national lists

      




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Several locals in new national football recruiting rankings

In-state names sprinkled through new rankings for 2020, '21 and '22

       




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Locals all over new national basketball recruiting rankings

In-state players well-represented in national recruiting rankings

       




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'There's no playbook': What local governments can legally limit during coronavirus

The most important decisions during a public health emergency are more likely to be made by Indiana's governor and local officials than the president.

       




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Letter from Editor Katrice Hardy: Thank you for supporting local journalism

The pandemic has impacted us in many ways, but despite these challenges, our commitment to our community and you is stronger than ever.

       




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Local musician Tim Brickley entertains socially distant neighbors with impromptu show

Tucked into his porch, musician Tim Brickley sang classics for a tiny group of neighbors and passersby as relief from home isolation.

      




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Joan Jett added to lineup of local Warped Tour date

Rock and Roll Hall of Famer Joan Jett will make a special appearance at the Indiana stop of the Vans Warped Tour.

       




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Joan Jett added to lineup of local Warped Tour date

Rock and Roll Hall of Famer Joan Jett will make a special appearance at the Indiana stop of the Vans Warped Tour.

      




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Sen. Braun: Empower local communities, businesses to safely reopen economy

We should not use the blanket approach that government took in shutting down the economy to reopen it.

       




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Letter from Editor Katrice Hardy: Thank you for supporting local journalism

The pandemic has impacted us in many ways, but despite these challenges, our commitment to our community and you is stronger than ever.

       




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Gatineau Park reopens to local users during COVID-19 pandemic

For the first time in six weeks, Gatineau Park is open to the public during the COVID-19 pandemic.




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Google surfacing more local COVID news content to satisfy massive search demand

Local news publishers have struggled to monetize spike in consumer interest.

Please visit Search Engine Land for the full article.




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A script that detects anomalies at a local level

This script alerts advertisers when regional differences related to the coronavirus have an impact on your PPC campaigns.

Please visit Search Engine Land for the full article.




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Channel24.co.za | SABC granted a local TV content quota reprieve due to Covid-19

South Africa's broadcasting regulator has approved an application from the SABC for its annual local TV content quotas to be waived because of the Covid-19 coronavirus pandemic.




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Selling in Europe – How to Localize Your eCommerce Business for Local Markets

As a digital company, your business is not bound by conventional borders and has the freedom and opportunity to reach customers anywhere in the world. And just as you look outward for new markets, customers are also looking beyond their physical borders for their goods and services. As a study by KPMG shows, online buyers […]




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Local health unit credits public with slowing COVID spread, encourages cottagers to stay home

While infection rates remain steady across the region, the Simcoe Muskoka District Health Unit is reporting more than half of all 360 cases have now recovered.




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The FKH domain in FOXP3 mRNA frequently contains mutations in hepatocellular carcinoma that influence the subcellular localization and functions of FOXP3 [Molecular Bases of Disease]

The transcription factor forkhead box P3 (FOXP3) is a biomarker for regulatory T cells and can also be expressed in cancer cells, but its function in cancer appears to be divergent. The role of hepatocyte-expressed FOXP3 in hepatocellular carcinoma (HCC) is unknown. Here, we collected tumor samples and clinical information from 115 HCC patients and used five human cancer cell lines. We examined FOXP3 mRNA sequences for mutations, used a luciferase assay to assess promoter activities of FOXP3's target genes, and employed mouse tumor models to confirm in vitro results. We detected mutations in the FKH domain of FOXP3 mRNAs in 33% of the HCC tumor tissues, but in none of the adjacent nontumor tissues. None of the mutations occurred at high frequency, indicating that they occurred randomly. Notably, the mutations were not detected in the corresponding regions of FOXP3 genomic DNA, and many of them resulted in amino acid substitutions in the FKH region, altering FOXP3's subcellular localization. FOXP3 delocalization from the nucleus to the cytoplasm caused loss of transcriptional regulation of its target genes, inactivated its tumor-inhibitory capability, and changed cellular responses to histone deacetylase (HDAC) inhibitors. More complex FKH mutations appeared to be associated with worse prognosis in HCC patients. We conclude that mutations in the FKH domain of FOXP3 mRNA frequently occur in HCC and that these mutations are caused by errors in transcription and are not derived from genomic DNA mutations. Our results suggest that transcriptional mutagenesis of FOXP3 plays a role in HCC.




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Local Pathways Towards De-escalation of Libya's Conflict

Invitation Only Research Event

28 January 2020 - 3:00pm to 4:30pm

Chatham House | 10 St James's Square | London | SW1Y 4LE

Event participants

Usama Otman Essed, Libya Center for Strategic & Future Studies
Chair: Tim Eaton, Middle East and North Africa Programme, Chatham House

A shaky truce remains broadly in place among rival Libyan forces fighting for control of Tripoli. However, a durable ceasefire to bring an end to the current bout of conflict, which was initiated by Khalifa Haftar’s Libyan Arab Armed Forces’ (LAAF) offensive on the capital in April 2019, has not been reached. In recent weeks attention has focused on talks hosted in Moscow and Berlin, with the former aimed at agreeing a ceasefire and the latter seeking to reach agreement among international actors to bring an end to external military support for Libyan warring actors, and to craft a way forward for future intra-Libyan talks. Yet, there has been little emphasis on Libyan actors – beyond Haftar and prime minister Fayez al-Serraj – in this process.
 
This roundtable will bring together experts and policymakers to discuss means of de-escalating the conflict and seeking a lasting resolution through the development of interconnected intra-Libyan social and security negotiation tracks. Mr Usama Otman Essed of the Libya Center for Strategic and Future Studies (LCSFS) will present his research group’s ideas on these issues and discuss their ongoing efforts to promote dialogue among social and security actors.

Attendance at this event is by invitation only. 

Event attributes

Chatham House Rule

Reni Zhelyazkova

Programme Coordinator, Middle East and North Africa Programme
+44 (0)20 7314 3624




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Building Global Partnerships for Stronger Local Economies

Members Event

11 February 2015 - 6:00pm to 7:00pm

Chatham House, London

Event participants

Scott Walker, Governor, Wisconsin, United States
Chair: Justin Webb, Presenter, Today Programme, BBC Radio 4 

Drawing on his experience as governor of Wisconsin, Scott Walker will outline the importance of forging strong global partnerships to fuel business growth and build prosperous local economies. Governor Walker will consider how mutually beneficial partnerships can be developed within the global community and the impact of these on local communities.

LIVE STREAM: This event will be live streamed. The live stream will be made available at 18:00 GMT on Wednesday 11 February.

ASK A QUESTION: Send questions for the speaker by email to questions@chathamhouse.org or using #CHEvents on Twitter. A selection will be put to him during the event.

Event attributes

Livestream

Members Events Team




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Up in smoke? Global tobacco advocacy and local mobilization in Africa

4 September 2019 , Volume 95, Number 5

Amy S. Patterson and Elizabeth Gill

Even though most African states have signed and ratified the Framework Convention on Tobacco Control (FCTC), a global treaty to limit tobacco use, African states have been slow to pass and implement tobacco control policies like regulations on sales, smoke-free environments and taxes. This article examines how the ineffectiveness of local tobacco-control advocacy contributes to this suboptimal outcome. It asserts that the disconnect between the global tobacco-control advocacy network and local advocates shapes this ineffectiveness. With funding and direction predominately from the Bloomberg Initiative, local advocates emulate the funders' goal of achieving quick, measurable policy results. Their reliance on the network drives African advocates to strive to pass legislation, even in difficult political climates, and to remake their agendas when funders change their priorities. They also emulate the network's focus on evidence-based arguments that stress epidemiological data and biomedical interventions, even when this issue frame does not resonate with policy-makers. Financial dependence can draw local advocates into expectations about patronage politics, undermine their ability to make principled arguments, and lead them to downplay the ways that their home country's socioeconomic and cultural contexts affect tobacco use and control. Based on key informant interviews with African advocates, media analysis and the case-studies of Ghana and Tanzania, the article broadens the study of philanthropy in global health, it adds an African perspective to the literature on global health advocacy, and it deepens knowledge on power dynamics between external funders and local actors in the realms of health and development.




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Syria Showcases the Failure to Engage Locals in Development

20 August 2015

Kholoud Mansour

Former Academy Associate
The problems of the international humanitarian response in the war-torn country are part of a broader difficulty in connecting development with local sustainability.

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UN Deputy Special Envoy to Syria Ramzy Ezzeldin Ramzy, UNDP Representative in Syria Yacoub al-Helo and the commissioner general of UNRWA, Pierre Krahenbuhl, answer questions during an interview on 14 April 2015 in Damascus. Photo by Getty Images.

The international community’s response to the Syria crisis has been unsatisfactory on many fronts, and humanitarian aid and development is no exception. While there has been renewed emphasis by development organizations on the importance of engaging local actors − notably highlighted in the new Sustainable Development Goals − the reality is this has been woefully lacking in practice. And Syria is simply one example of many where the failure of UN agencies and other humanitarian actors to partner with local actors has hampered the response to humanitarian crises.

Double standards

The problem is that international agencies usually have high and unfair expectations from Syrian individuals and organizations, requiring them to speak the ‘language’ of development, meet international standards, and demonstrate a wide range of expertise. However, these demands are not reciprocated by international organizations and experts being expected to have the same depth of knowledge of the local context in which they are operating. In addition, while Syrian actors are expected to be neutral, impartial and politically unaffiliated, foreign aid appears to be driven − explicitly and unashamedly − by the political objectives of the donor countries.

There is a double standard at work. In many cases, international ‘experts’ on Syria have little local knowledge, but there are no channels to measure or question their level of expertise. At the same time, including local Syrians in decision-making is seen as a threat to predetermined objectives, rather than as an asset.

Syrians could add an indispensable source of knowledge and context to international agencies, as well as add local credibility. But too often they are brought on board to be part of the humanitarian and development picture or to get their simple feedback for evaluation and needs assessment reports to satisfy donors’ requirements, rather than employed as an integral component of designing and implementing projects. Though some of this is down to a pretext of lack of capacity, it raises the question of whether there is an international political willingness and genuine organizational courage to involve Syrians at programming, decision and policy making-levels.

The importance of local

The Syrian example is not isolated. While there is now a debate to encourage engaging local actors, this does not happen in practice. The Local to Global Protection Initiative study reported that local and national humanitarian actors received only 0.2% of the overall direct global humanitarian response in 2013.

Moreover, the international humanitarian and development systems are designed, together with foreign aid policy, to be self-contained and to exclude local actors. This allows donor governments to use the systems as political tools for leveraging control. It is equally difficult for both outsiders as well as insiders to understand how the system really functions. The UN-led coordination structure is one example of the heavy international architecture that remains unable to reform itself, learn from its previous mistakes, or to engage with local actors.

And that engagement matters. The Independent Research Forum emphasized in its brief in February 2014 how engaging local researchers and implementing bottom-up participatory learning can make countries better prepared to achieve the post-2015 Sustainable Development Goals. Those goals, as well as the upcoming World Humanitarian Summit, highlight the importance of including local actors in the humanitarian and development responses.

Moving forward

Fortunately, such initiatives are creating a momentum within the development community to make radical changes through bottom-up approaches that put sustainability into practice. But if the Sustainable Development Goals want to affect real change, there will have to be a significant drive to move from rhetoric and ‘intentions’ to reality and actions. Currently it seems that the international community prefers to simply maintain the current status quo. It only takes a brief reflection on how many Syrians are included in every project or programme and how many Syrians are in positions to contribute at the policy and decision-making levels to realise the scale of the impetus required to change this system. To make that change might provide an opportunity for Syrians to restore some of the ownership to the outcomes and decisions of their conflict.

To comment on this article, please contact Chatham House Feedback




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Adipocyte death defines macrophage localization and function in adipose tissue of obese mice and humans

Saverio Cinti
Nov 1, 2005; 46:2347-2355
Research Articles




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A kinesin adapter directly mediates dendritic mRNA localization during neural development in mice [Neurobiology]

Motor protein-based active transport is essential for mRNA localization and local translation in animal cells, yet how mRNA granules interact with motor proteins remains poorly understood. Using an unbiased yeast two–hybrid screen for interactions between murine RNA-binding proteins (RBPs) and motor proteins, here we identified protein interaction with APP tail-1 (PAT1) as a potential direct adapter between zipcode-binding protein 1 (ZBP1, a β-actin RBP) and the kinesin-I motor complex. The amino acid sequence of mouse PAT1 is similar to that of the kinesin light chain (KLC), and we found that PAT1 binds to KLC directly. Studying PAT1 in mouse primary hippocampal neuronal cultures from both sexes and using structured illumination microscopic imaging of these neurons, we observed that brain-derived neurotrophic factor (BDNF) enhances co-localization of dendritic ZBP1 and PAT1 within granules that also contain kinesin-I. PAT1 is essential for BDNF-stimulated neuronal growth cone development and dendritic protrusion formation, and we noted that ZBP1 and PAT1 co-locate along with β-actin mRNA in actively transported granules in living neurons. Acute disruption of the PAT1–ZBP1 interaction in neurons with PAT1 siRNA or a dominant-negative ZBP1 construct diminished localization of β-actin mRNA but not of Ca2+/calmodulin-dependent protein kinase IIα (CaMKIIα) mRNA in dendrites. The aberrant β-actin mRNA localization resulted in abnormal dendritic protrusions and growth cone dynamics. These results suggest a critical role for PAT1 in BDNF-induced β-actin mRNA transport during postnatal development and reveal a new molecular mechanism for mRNA localization in vertebrates.




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Privileging Local Food is Flawed Solution to Reduce Emissions

23 April 2020

Christophe Bellmann

Associate Fellow, Hoffmann Centre for Sustainable Resource Economy
The COVID-19 pandemic has brought food security and food imports to the forefront again. Some fear that the crisis could quickly strain global food supply chains as countries adopt new trade restrictions to avoid domestic food shortages.

2020-04-23-Trade-Food-Apples

Apples being picked before going into cold storage so they can be bought up until Christmas. Photo by Suzanne Kreiter/The Boston Globe via Getty Images.

The pressure of the coronavirus pandemic is adding to a widely held misconception that trade in food products is bad for the environment due to the associated ‘food miles’ – the carbon footprint of agricultural products transported over long distances.

This concept, developed by large retailers a decade ago, is often invoked as a rationale for restricting trade and choosing locally-produced food over imports. Consuming local food may seem sensible at first glance as it reduces the carbon footprint of goods and generates local employment. 

However, this assumption ignores the emissions produced during the production, processing or storage stages which often dwarf transport emissions. Other avenues to address the climate change impact of trade are more promising.

Demystifying food emissions

In the US, for example, food items travel more than 8,000 km on average before reaching the consumer. Yet transport only accounts for 11 per cent of total emissions with 83 per cent – mostly nitrous oxide (N2O) and methane (CH4) emissions – occurring at the production stage.

US Department of Agriculture data on energy use in the American food system echoes this finding, showing that processing, packaging, and selling of food represent ten times the energy used to transport food.

In practice, it may be preferable from an environmental perspective to consume lamb, onion or dairy products transported by sea because the lower emissions generated at the production stage offset those resulting from transport. Similarly, growing tomatoes under heated greenhouses in Sweden is often more emissions-intensive than importing open-grown ones from Southern Europe.

Seasonality also matters. British apples placed in storage for ten months leads to twice the level of emissions as that of South American apples sea-freighted to the UK. And the type of transport is also important as, overall, maritime transport generates 25 to 250 times less emissions than trucks, and air freight generates on average five times more emissions than road transport.

Therefore, air-freighted Kenyan beans have a much larger carbon footprint than those produced in the UK, but crossing Europe by truck to import Italian wine might generate more emissions than transatlantic shipments.

Finally, one should take into account the last leg of transport. A consumer driving more than 10 km to purchase 1 kg of fresh produce will generate proportionately more greenhouse gas (GHG) emissions than air-freighting 1 kg of produce from Kenya.

Shifting consumption towards local foods may reduce GHG emissions in sectors with relatively low emissions intensities but, when non-carbon dioxide emissions are taken into account, this is more often the exception than the rule.

Under these circumstances, preventing trade is an inefficient and expensive way of reducing GHG emissions. Bureau et al. for example, calculate that a global tariff maintaining the volume of trade at current levels until 2030 may reduce global carbon dioxide emissions by 3.5 per cent. However, this would be roughly seven times less than the full implementation of the Paris Agreement and cost equivalent to the current GDP of Brazil or 1.8 per cent of world GDP.

By preventing an efficient use of resources, such restrictions would also undermine the role of trade in offsetting possible climate-induced production shortfalls in some parts of the world and allowing people to access food when they can’t produce it themselves.

Reducing the climate footprint of trade

This is not to say that nothing should be done to tackle transport emissions. The OECD estimates that international trade-related freight accounted for over 5 per cent of total global fuel emissions with shipping representing roughly half of it, trucks 40 per cent, air 6 per cent and rail 2 per cent. With the projected tripling of freight transport by 2050, emissions from shipping are expected to rise between 50 and 250 per cent.

Furthermore, because of their international nature, these emissions are not covered by the Paris Agreement. Instead the two UN agencies regulating these sectors – the International Civil Aviation Organization and the International Maritime Organization – are responsible for reducing these emissions and, so far, significant progress has proven elusive.

Regional or bilateral free trade agreements to further stimulate trade could address this problem by exploiting comparative advantages. Impact assessments of those agreements often point towards increases in GHG emissions due to a boost in trade flows. In the future, such agreements could incorporate – or develop in parallel – initiatives to ensure carbon neutrality by connecting carbon markets among contracting parties or by taxing international maritime and air transport emissions.

Such initiatives could be combined with providing additional preferences in the form of enhanced market access to low-carbon food and healthier food. The EU, as one of the chief proponents of bilateral and regional trade agreements and a leader in promoting a transition to a low-carbon economy could champion such an approach.

This article is part of a series from the Chatham House Global Trade Policy Forum, designed to promote research and policy recommendations on the future of global trade. It is adapted from the research paper, Delivering Sustainable Food and Land Use Systems: The Role of International Trade, authored by Christophe Bellmann, Bernice Lee and Jonathan Hepburn.




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CBD News: Statement from Mr. Ahmed Djoghlaf, Executive Secretary of the Convention on Biological Diversity on the occasion of the High Level Roundtable on Local and Regional Authorities, IUCN World Conservation Congress, Barcelona, 7 October 2008.




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CBD News: Statement by Ahmed Djoghlaf, Executive Secretary of the Convention on Biological Diversity, on the occasion of the Indigenous and Local Community, Business and Biodiversity Consultation, UN Headquarters, New York, 12 May 2009.




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CBD News: Inviting Parties, other Governments, other relevant organizations, and indigenous and local communities, to the peer review of the draft report of scientific synthesis on the impacts of ocean fertilization on marine biodiversity.




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CBD Press Release: The Role of Indigenous and Local Communities in Protecting Life on Earth.




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CBD News: Statement by Mr. Ahmed Djoghlaf on the occasion of Latin American and Caribbean Indigenous and Local Community Capacity-building Workshop on the Convention on Biological Diversity, Including Issues Relevant to Article 8(j), TK and ABS: Mesoameri




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CBD News: Statement by Mr. Ahmed Djoghlaf, Executive Secretary of the Convention on Biological Diversity, on the occasion of the Inaugural Meeting of the Local Action for Biodiversity (LAB) Advisory Committee, 24 March 2010, Rio De Janeiro, Brazil.




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CBD News: Message from Ahmed Djoghlaf, CBD Executive Secretary, on the occasion of the International Symposium for Local and Regional Policy Makers on the Value of Nature for Local Development, Curitiba, 9-10 September 2010.




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CBD Joint Press Release: Mobilizing society to support biodiversity: As Countdown 2010 initiative closes, local coordinated actions show way to solving the global biodiversity crisis.




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CBD Press Release: Faced with "Empty Forests", experts urge better regulation of bushmeat trade - International gathering identifies innovative solutions for resolving the bushmeat crisis, for the benefit of indigenous peoples and local communi




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CBD Communiqué: City of Edmonton a model of local government support for the CBD




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CBD Press Release: Indigenous and local communities meet with governments to discuss traditional knowledge and the implementation of the global Strategic Plan for Biodiversity 2011-2020




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CBD News: Statement by Mr. Braulio Ferreira de Souza Dias, CBD Executive Secretary, on the occasion of the Third Meeting on the Implementation of the Plan of Action on Sub-National Governments, Cities and Other Local Authorities for Biodiversity, Nagoya,