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TcESTIME: predicting high-temperature hydrogen-based superconductors

Chem. Sci., 2024, Accepted Manuscript
DOI: 10.1039/D4SC04465G, Edge Article
Open Access
Trinidad Novoa, Matías E. di Mauro, Diego Inostroza, Kaoutar El Haloui, Nicolas Sisourat, Yvon Maday, Julia Contreras-García
Superconductivity can be considered among the most exciting discoveries in material science of the XXth century. However, the hard conditions for the synthesis and the difficult characterization, make the statement...
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Gaining the Molecular Design Principles for Efficient Diarylethene Photoacid and Photohydride Generators Based on Photochemical Reaction Mechanism

Chem. Sci., 2024, Accepted Manuscript
DOI: 10.1039/D4SC06202G, Edge Article
Open Access
Yifan Su, Dexin Zheng, Lingfeng Ge, Le Yu, David Lee Phillips, Jiani Ma, Yu Fang
Abstract: Photoacid generators (PAGs) and photohydride generators (PHGs) are specific photolabile protecting groups that release acid and hydride, respectively. Over the past decade, great efforts have been devoted to developing...
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Synthesis of highly condensed phospholes by Lewis acid-assisted dehydrogenative Mallory reaction under visible light irradiation

Chem. Sci., 2024, Accepted Manuscript
DOI: 10.1039/D4SC05657D, Edge Article
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Ikki Kamiyoshi, Yuki Kojima, Shibo Xu, Kosuke Yasui, Yuji Nishii, Koji Hirano
A photo-promoted oxidative cyclization, that is, Mallory reaction of 2,3-diarylbenzophopholes has been developed. With an assistance of Bi(OTf)3 Lewis acid, the reaction proceeds smoothly under visible light irradiation even without...
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$19 mn Loss & Damage funding pledged by Sweden at COP29, bringing total pledged funding to $720 mn




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Providing better healthcare biggest priority: PM Modi ahead of Darbhanga AIIMS inauguration




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Vistara's last flight from Odisha takes off for Delhi ahead of merger with Air India




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Defence Space Agency hosts first ever space exercise 'Antariksha Abhyas - 2024' in Delhi




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Rajnath Singh stresses on adaptive defence to cope with Age of Grey Zone, hybrid warfare




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Union Education Minister Dharmendra Pradhan urges states to support exam reforms for zero-error entrance test




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Akashteer: Transforming India's air defence with cutting-edge technology




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AI and hi-tech technologies will be used in CCTV arrangements: UP DGP Prashant Kumar on Mahakumbh 2025 preparations




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DRDO conducts maiden flight test of Long-Range Land Attack Cruise Missile (LRLACM)




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No gaps in management of biodegradable waste, Kerala tells NGT




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French lower house rejects massively amended 2025 budget

Prime Minister Michel Barnier's minority government now has a largely free hand in submitting a cleaned-up text to the Senate upper house




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China's largest air show takes off with fighter jets, attack drones

China has poured resources into modernising and expanding its aviation capabilities as it faces off against the United States and others around regional flashpoints like Taiwan.




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In vitro identification of oridonin hybrids as potential anti-TNBC agents inducing cell cycle arrest and apoptosis by regulation of p21, γH2AX and cleaved PARP

RSC Med. Chem., 2024, 15,3674-3694
DOI: 10.1039/D4MD00580E, Research Article
Jinhua Ning, Nini Zhan, Zhanpan Wu, Yuzhe Li, Die Zhang, Yadian Shi, Yingxun Zhou, Chuan-Huizi Chen, Wenbin Jin
Oridonin analogue 11a showed significant antitumor efficacy in vitro via cell cycle arrest and apoptosis by regulation of p21, γH2AX and cleaved PARP accumulation, meanwhile, displayed much more stable than oridonin in human plasma.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Preventing SARS-CoV-2 infection using Fv-antibodies targeting the proprotein convertase (PPC) cleavage site

RSC Med. Chem., 2024, 15,3704-3710
DOI: 10.1039/D4MD00552J, Research Article
Jaeyong Jung, Jeong Soo Sung, Soonil Kwon, Hyung Eun Bae, Min-Jung Kang, Joachim Jose, Misu Lee, Jae-Chul Pyun
Fv-antibodies targeting the PPC region of SARS-CoV-2 to prevent infection, screened from an Fv-antibody library (displayed on outer membrane of E. coli cell).
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Design and synthesis of novel multi-target tetrabromophthalimides as CBS and Topo-II inhibitors and DNA intercalators

RSC Med. Chem., 2024, 15,3800-3816
DOI: 10.1039/D4MD00585F, Research Article
Marwa Abdel-Motaal, Dalal Ali Aldakhili, Ayman B. Farag, Ayman Abo Elmaaty, Marwa Sharaky, Nadia A. Mohamed, Saad Shaaban, Abdullah Yahya Abdullah Alzahrani, Ahmed A. Al-Karmalawy
Novel multi-target tetrabromophthalimides as CBS and Topo-II inhibitors and DNA intercalators.
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Prediction of synergistic gemcitabine-based combination treatment through a novel tumor stemness biomarker NANOG in pancreatic cancer

RSC Med. Chem., 2024, 15,3853-3861
DOI: 10.1039/D4MD00165F, Research Article
Jiongjia Cheng, Ting Zhu, Shaoxian Liu, Jiayu Zhou, Xiaofeng Wang, Guangxiang Liu
The synergistic effect observed in gemcitabine-based combination therapies targeting pancreatic cancer stem cells was correlated with the inhibiting effect on the expression of stemness-related gene NANOG.
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Novel PROTAC probes targeting KDM3 degradation to eliminate colorectal cancer stem cells through inhibition of Wnt/β-catenin signaling

RSC Med. Chem., 2024, 15,3746-3758
DOI: 10.1039/D4MD00122B, Research Article
Open Access
Shadid U. Zaman, Piyusha P. Pagare, Hongguang Ma, Rosalie G. Hoyle, Yan Zhang, Jiong Li
We designed and synthesized novel IOX1-based PROTACs, which can selectively degrade KDM3A and KDM3B to eliminate colorectal cancer stem cells through inhibition of Wnt signaling.
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Evaluating the therapeutic potential of genetically engineered probiotic Zbiotics (ZB183) for non-alcoholic steatohepatitis (NASH) management via modulation of the cGAS-STING pathway

RSC Med. Chem., 2024, 15,3817-3836
DOI: 10.1039/D4MD00477A, Research Article
Maha Saad, Walaa Ibrahim, Amany Helmy Hasanin, Aya Magdy Elyamany, Marwa Matboli
ZBiotics administration in the NASH model downregulated the RNA panel (MAPK3, EDN1, TNF, miR-6888-5p, lncRNA RABGAP1L-DT-206), restored intestinal barrier integrity, reduced hepatic inflammation, and improved lipid profiles and liver enzymes.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Southern Railway refuses to share inquiry report of Perumon train tragedy

105 people had died in after several coaches of the Island Express fell into the Ashtamudi Lake in 1988




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Wall Street makes wagers on the likely winners and losers in a second Trump term

Wall Street is already making big bets on what take two for a White House led by Donald Trump will mean for the economy and markets




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U.S. oil industry urges Trump to ditch Biden climate policies




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Argentine monthly inflation falls to three-year low




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Godrej Industries Q2 net profit surges over three fold to ₹288 crore




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Mangaluru Junction - CSMT Superfast Express to get LHB coaches in March 2025

Train No. 12133 Mumbai CSMT-Mangaluru Junction Superfast Express will get an LHB rake from March 1 while its pairing service, Train No. 12134 Mangaluru Junction-Mumbai CSMT Superfast Express, will get an LHB rake from March 2




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Target is to to make 30,000 MT of sand available every day in East Godavari district, says Collector

P. Prasanthi warns boatmen associations of stringent action if they attempt to prevent vehicles transporting sand from the sand reaches




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Andhra Pradesh Budget reflects aspirations of all sections of people, say legislators

It has given impetus to the developmental goals outlined in the NDA’s election manifesto, say MLAs on the first day of discussion




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PAG report points out Andhra Pradesh govt.’s failure to disclose quantum of off-budget borrowings in Budget

Principal amount outstanding in 2019-20 was ₹67,171 crore, and it touched ₹1,54,797 crore in 2023-24, says the PAG report released by the I&PR Department




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Hyderabad to get regional centre of Indian Institute of Creative Technology

All activities are going to start quickly. The facility in Hyderabad will be set up in the IMAGE Tower, said Secretary, Union Ministry of Information and Broadcasting




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Affordable generics will stay relevant amid a premiumisation trend: Bhushan Akshikar

GSK will keep its existing portfolios while entering areas like oncology, said company officials at its centenary celebrations




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Millions of Nigerians go hungry as floods compound hardship

Torrential rains and floods in 29 of Nigeria's 36 states this year have destroyed more than 1.5 million hectares of cropland, affecting more than nine million people




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Doctors believe continual upskilling is crucial for diabetes management: survey

The survey also found that doctors were interested in using AI tools for early detection and personalised treatment plans to manage diabetes




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Synthesis and evaluation of photoaffinity labeling reagents for identifying binding sites of sulfated neurosteroids on NMDA and GABAA receptors

RSC Adv., 2024, 14,36352-36369
DOI: 10.1039/D4RA07074G, Paper
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Mingxing Qian, Yuanjian Xu, Hong-Jin Shu, Zi-Wei Chen, Lei Wang, Charles F. Zorumski, Alex S. Evers, Steven Mennerick, Douglas F. Covey
Photoaffinity labels (PALs) for sulfated steroid binding sites on GABAA and NMDA receptors. The PALs have varying profiles of positive and negative modulatory (PAM and NAM) actions.
The content of this RSS Feed (c) The Royal Society of Chemistry




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PUCL condemns opposition to Dalits’ entry into temple in Mandya village




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After hosting World Cup, Qatar praised by U.N. rights body for labour law reforms but urged to do more

In Qatar, better labour law protections have been passed in recent years relating to a minimum wage, freedom to change employers and combating forced labor and trafficking




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667 UK-owned businesses in India generated over ₹5 lakh crores in revenue: report

According to the report, fifteen UK companies have achieved triple-digit turnover growth rates, with Vedanta leading as the largest UK company in India by revenue, generating over ₹1,50,100 crores in 2023




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Two held on charge of cheating retired engineer of over ₹75 lakh in Kochi

They allegedly promised the victim a windfall through online trading




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Indian gaming sector urged to embrace diversity beyond performative actions

‘Inclusion of female and LGBTQIA+ characters remains limited, underscoring a lack of representation’




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Jairam Tiger Mahto stands in the way in tough battle for NDA and INDIA blocs in Jharkhand

Known for raising local issues, the 30-year-old leader hails from Kurmi (Mahtos) community that comprise 22% of the total population, the largest chunk after tribals and plays a decisive role in at least 30 seats




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Parthiv Patel gets dual responsibility with Gujarat Titans: batting and assistant coach

Parthiv Patel will perform the dual role in the support staff led by head coach Ashish Nehra




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Bharata, his Paduka regency




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Villagers oppose proposal for quarry near Sathanur dam at a public hearing

Tiruvannamalai Collector D. Bhaskara Pandian chaired the hearing organised by the TNPCB on Wednesday. The black granite quarry is proposed to be set up on about 8.46 hectares of government land in Sathanur




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Donald Trump meets Joe Biden in White House; both pledge smooth transition

In a brief meeting, the two leaders assured the nation of a peaceful transition of power on January 20, 2025.




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Rajasthan Assembly bypolls: 65% voter turnout recorded; largely peaceful

Highest voter turnout of 75.27% was recorded in Ramgarh; independent candidate slaps government officer




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Nagamohan Das to head panel to suggest internal reservation among SC communities




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Private college lecturer arrested for sexual assault on job aspirant in Coimbatore




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Irregularities emerge in fund disbursements for Bengal government’s ‘tablet scheme’

So far, at least 10 people from Malda and Uttar Dinajpur districts have been arrested on charges of wrongfully siphoning funds allocated for tablets for the State’s higher secondary students




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Village Administrative Officer arrested in DVAC trap in Tiruppur