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Providing better healthcare biggest priority: PM Modi ahead of Darbhanga AIIMS inauguration




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Chandigarh's air quality continues to be worse than Punjab, Haryana




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There will be census in country but not based on caste: Union Minister Shobha Karandlaje




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AI and hi-tech technologies will be used in CCTV arrangements: UP DGP Prashant Kumar on Mahakumbh 2025 preparations




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All cases related to loan fraud at Perumbavoor Urban Cooperative Society to be handed over to Crime Branch

Police say 29 cases have been registered. Probe by district joint registrar of Cooperative department finds 26 persons, mostly members of previous director boards, accountable for irregularities to the tune of ₹33.33 crore




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Uzbekistan to make media, songs and films pass 'moral test'

President Shavkat Mirziyoyev has introduced some reforms since coming to power after the 2016 death of dictator Islam Karimov, but rights groups say the country remains deeply authoritarian




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Fifth storm in a month bears down on the Philippines

The local government also reported knee-high floods across Santiago, a city of 1,50,000 people along an upper bank of the Cagayan river




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Cold War-era H-6 bomber enhances China’s ability to strike U.S. bases

The H-6 long-range bomber was used in China’s October war games around Taiwan; it flew close to the U.S. mainland for first time in June




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Lebanon media claims Israeli strike hit apartment south of Beirut

Israeli warplanes launched a strike at dawn targeting a residential apartment in a building in the Dawhet




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Sri Lanka to hold key parliamentary vote on November 14

President Anura Kumara Dissanayake’s ruling alliance is looking to secure a majority in Parliament




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Pyridinyl 4-(2-oxoalkylimidazolidin-1-yl)benzenesulfonates and their hydrochloride salts as novel water soluble antimitotic prodrugs bioactivated by cytochrome P450 1A1 in breast cancer cells

RSC Med. Chem., 2024, 15,3728-3745
DOI: 10.1039/D4MD00476K, Research Article
Vincent Ouellette, Chahrazed Bouzriba, Atziri Corin Chavez Alvarez, Quentin Bruxelles, Geneviève Hamel-Côté, Sébastien Fortin
New water soluble antimitotic CYP1A1-activated prodrugs named PYRAIB-SOs and their hydrochlorides targeting breast cancers.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Novel PROTAC probes targeting KDM3 degradation to eliminate colorectal cancer stem cells through inhibition of Wnt/β-catenin signaling

RSC Med. Chem., 2024, 15,3746-3758
DOI: 10.1039/D4MD00122B, Research Article
Open Access
Shadid U. Zaman, Piyusha P. Pagare, Hongguang Ma, Rosalie G. Hoyle, Yan Zhang, Jiong Li
We designed and synthesized novel IOX1-based PROTACs, which can selectively degrade KDM3A and KDM3B to eliminate colorectal cancer stem cells through inhibition of Wnt signaling.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Design and synthesis of novel 8-(azaindolyl)-benzoazepinones as potent and selective ROCK inhibitors

RSC Med. Chem., 2024, 15,3862-3879
DOI: 10.1039/D4MD00313F, Research Article
Daniele Pala, David Clark, Christine Edwards, Elisa Pasqua, Laura Tigli, Barbara Pioselli, Piotr Malysa, Fabrizio Facchinetti, Fabio Rancati, Alessandro Accetta
This study reports a novel, potent and selective series of ROCK inhibitors based on 8-(azaindolyl)-benzoazepinones identified through a core-hopping strategy.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Supreme Court stays order for CBI probe into sexual assault of minor in Chennai

Calls for a list of five to seven direct recruit IPS officers, including three women, who hail from other States but are now serving in Tamil Nadu cadre




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T.N. govt. to take a call on verifying criminal antecedents before appointing schoolteachers

It also assures Madras High Court of putting in place an effective complaint redressal mechanism in the interest of school students




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DUSU election results to be announced on November 21

The counting of votes for both the central panel and college representatives will begin at 8:30 a.m. on November 21 at the DU Conference Centre




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SKDRDP provides desks and benches worth ₹2.75 crore to 507 government primary schools in four districts of Karnataka

Rajya Sabha MP Veerendra Heggade urges parents to get their wards admitted to government schools as they now have better facilities




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Water supply from Pampa Reservoir to be paused this rabi

IAB makes decision to allow reservoir gate repairs and aqueduct construction works; water to affected lands to be supplied from the Eastern Godavari Delta, Pithapuram Branch Canal and Yeleru Reservoir instead




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IMD forecasts onset of winter in Telangana by November-end




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Over 2,300 kilograms of drugs incinerated by Cyberabad police

The wide range of drugs were seized from 155 cases registered under the NDPS Act




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Metro Rail services to be extended to Medchal and other parts of northern Hyderabad under Phase-III: Telangana CM




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Doctor stabbed at Kalaignar Centenary Super Speciality Hospital in Chennai; one arrested

The oncologist who was attacked has been identified as Balaji Jagannath. He has been admitted in the ICU, and his condition is said to be critical




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29th Climate Conference (COP) tracker | Day 2 LIVE: Key speeches, UK NDC, and India’s reaction at 5 p.m. on November 13

Vibhuti Garg, an Associate and Senior Energy Specialist with over 13 years of experience in the energy sector, will guide us through the implications of these financial negotiations and the potential impacts on global energy transitions and climate commitments at 5 p.m. on November 13




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Uncontrolled diabetes increases risk of hearing loss; doctors call for more awareness, screening

Hearing loss occurs twice as frequently in patients with uncontrolled diabetes as compared to the non-diabetic population, doctors say, calling for screening to be included in routine diabetes care




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Doctors believe continual upskilling is crucial for diabetes management: survey

The survey also found that doctors were interested in using AI tools for early detection and personalised treatment plans to manage diabetes




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Synthesis and evaluation of photoaffinity labeling reagents for identifying binding sites of sulfated neurosteroids on NMDA and GABAA receptors

RSC Adv., 2024, 14,36352-36369
DOI: 10.1039/D4RA07074G, Paper
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Mingxing Qian, Yuanjian Xu, Hong-Jin Shu, Zi-Wei Chen, Lei Wang, Charles F. Zorumski, Alex S. Evers, Steven Mennerick, Douglas F. Covey
Photoaffinity labels (PALs) for sulfated steroid binding sites on GABAA and NMDA receptors. The PALs have varying profiles of positive and negative modulatory (PAM and NAM) actions.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Satish Jarkiholi supporter to lead Belagavi DCC bank

Before the election, the three Jarkiholi brothers — Satish (Congress MLA), Ramesh (BJP MLA), and Balachandra (BJP MLA) — met in a private hotel in Belagavi to discuss the names of candidates




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Illegal export of iron ore from Belekeri port: Karnataka High Court suspends sentence and grants bail to MLA Satish Sail and five other convicts




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Marakumbi atrocity case: 99 persons granted bail by High Court Dharwad Bench




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Kannada has survived because of native speakers from North Karnataka: Horatti




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Comeback man Shami hogs the spotlight as MP takes honours on opening day against Bengal




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India's middle class tightens its belt, squeezed by food inflation

Slowing urban spending over the past three to four months has not only hurt the earnings of largest consumer goods firms




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SoftBank swings to profit of $7.7 billion for September quarter on back of strong listings

Vision Funds (SVF1 and SVF2) sold investments totalling $1.85 billion for the six-month period ended September 30




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Indian gaming sector urged to embrace diversity beyond performative actions

‘Inclusion of female and LGBTQIA+ characters remains limited, underscoring a lack of representation’




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Yet another incident of doctor being attacked 




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On the Draw — November 13, 2024




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News from the world of Education: November 13, 2024

Information on new courses, entrance exams, admissions, scholarships, research studies, and other events from educational institutions




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80% of non-executive directors believe existing practices, structures are inadequate to oversee AI: Gartner




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On the Draw — November 14, 2024




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Letters to The Editor — November 14, 2024




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Pro Kabaddi League: Gujarat Giants return to winning ways with big win over Bengal Warriorz

In the second match of the night, Haryana Steelers moved to the top of the table and extended their winning run to four games after defeating the Patna Pirates 37-32




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Tackling diabetes epidemic

An India free of diabetes-related complications is eminently possible, if lifestyle changes are made




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Year-long action plan to combat diabetes to be launched on World Diabetes Day




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Don’t follow self-healing methods to control diabetes, says diabetologists




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Inaugural U.S.-India Indian Ocean Dialogue to be held on November 14

The two sides will discuss measures to promote security and prosperity throughout the Indo-Pacific region.




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Irregularities emerge in fund disbursements for Bengal government’s ‘tablet scheme’

So far, at least 10 people from Malda and Uttar Dinajpur districts have been arrested on charges of wrongfully siphoning funds allocated for tablets for the State’s higher secondary students




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Metrowater to start replacing portion of reverse osmosis membranes in Nemmeli desalination plant by December




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CMC organises exhibition and poster competition on diabetes




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Tambaram Corporation begins population survey and area mapping for improved coverage of UPHCs




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Kozhikode Corporation to rehabilitate traders evicted from shop rooms below CH Flyover

Around 40% of evicted traders find alternative locations; Deputy Mayor urges others to wait for funds to be allocated, while traders offer to build shops themselves