The Sports Ministry had banned spectators in stadiums for any events, including cricket matches, in one of its earliest advisories on the pandemic before all sporting events were brought to a halt altogether.

A pandemic-forced lockdown may not be the ideal way to get families together, but it's not something that's under human control. What's in your control is to stay safe at home, hug your mom and say 'Happy Mother's Day'.

Former Union minister G K Vasan, who quit the Congress recently, unveiled a tri-colour flag for his yet-to-be named party on Wednesday.

महाराष्ट्र राज्य सड़क परिवहन निगम ने ग्रीन ज़ोन इलाकों में अंतर-जिला बस संचालन शुरू कर दिया है। दरअसल, केंद्रीय परिवहन एवं राजमार्ग मंत्री नितिन गडकरी ने हाल ही में कहा था कि लॉकडाउन के कारण बंद पड़े बस सेवाओं को कोविड-19

New Delhi, May 10: The Delhi Congress has forwarded two lists of nearly 9,500 migrant workers to Chief Minister Arvind Kejriwal saying that they want to return back to their native states and the party is ready to pay for their

Due to the COVID-19 pandemic, India is currently facing a nationwide lockdown till May 17. This crisis has affected almost all businesses across the nation. Public transport has been shut down to follow social distancing norms.

Mahindra's Pascal Wehrlein took a lights-to-flag victory in the third round of Formula E's 'Race at Home Challenge' on Saturday to end BMW i Andretti driver Maximilian Guenther's run of success in the esports series.

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Top sports news: A grey-bearded MS Dhoni enjoys playtime with Ziva, T2...

Esports: Wehrlein ends Guenther's run of virtual Formula E success

A division bench of the Kerala High Court will hold a special sitting on Sunday to consider issues pertaining to the transport of Keralites from acros

The transmembrane intracellular lectin ER–Golgi intermediate compartment protein 53 (ERGIC-53) and the soluble EF-hand multiple coagulation factor deficiency protein 2 (MCFD2) form a complex that functions as a cargo receptor, trafficking various glycoproteins between the endoplasmic reticulum (ER) and the Golgi apparatus. It has been demonstrated that the carbohydrate-recognition domain (CRD) of ERGIC-53 (ERGIC-53CRD) interacts with N-linked glycans on cargo glycoproteins, whereas MCFD2 recognizes polypeptide segments of cargo glycoproteins. Crystal structures of ERGIC-53CRD complexed with MCFD2 and mannosyl oligosaccharides have revealed protein–protein and protein–sugar binding modes. In contrast, the polypeptide-recognition mechanism of MCFD2 remains largely unknown. Here, a 1.60 Å resolution crystal structure of the ERGIC-53CRD–MCFD2 complex is reported, along with three other crystal forms. Comparison of these structures with those previously reported reveal that MCFD2, but not ERGIC-53–CRD, exhibits significant conformational plasticity that may be relevant to its accommodation of various polypeptide ligands.

This article reports conformational polymorphisms of the EF-hand protein MCFD2 which is involved in glycoprotein transport..

The outer membrane of Gram-negative bacteria is highly impermeable to hydrophilic molecules of larger than 600 Da, protecting these bacteria from toxins present in the environment. In order to transport nutrients across this impermeable membrane, Gram-negative bacteria utilize a diverse family of outer-membrane proteins called TonB-dependent transporters. The majority of the members of this family transport iron-containing substrates. However, it is becoming increasingly clear that TonB-dependent transporters target chemically diverse substrates. In this work, the structure and phylogenetic distribution of the TonB-dependent transporter YncD are investigated. It is shown that while YncD is present in some enteropathogens, including Escherichia coli and Salmonella spp., it is also widespread in Gammaproteobacteria and Betaproteobacteria of environmental origin. The structure of YncD was determined, showing that despite a distant evolutionary relationship, it shares structural features with the ferric citrate transporter FecA, including a compact positively charged substrate-binding site. Despite these shared features, it is shown that YncD does not contribute to the growth of E. coli in pure culture under iron-limiting conditions or with ferric citrate as an iron source. Previous studies of transcriptional regulation in E. coli show that YncD is not induced under iron-limiting conditions and is unresponsive to the ferric uptake regulator (Fur). These observations, combined with the data presented here, suggest that YncD is not responsible for the transport of an iron-containing substrate.

Yung-An Huang, Chih-Hsuan Hsu, Ho-Chieh Chiu, Pei-Yu Hsi, Chris T. Ho, Wei-Lun Lo, and Eric Hwang

Microtubule (MT) is the most abundant cytoskeleton in neurons and controls multiple facets of their development. While the MT-organizing center (MTOC) in mitotic cells is typically located at the centrosome, MTOC in neurons switches to non-centrosomal sites. A handful of cellular components have been shown to promote non-centrosomal MT (ncMT) formation in neurons, yet the regulation mechanism remains unknown. Here we demonstrate that the small GTPase Ran is a key regulator of ncMTs in neurons. Using an optogenetic tool that enables light-induced local production of RanGTP, we demonstrate that RanGTP promotes ncMT plus-end growth along the neurite. Additionally, we discovered that actin waves drive the anterograde transport of RanGTP. Pharmacological disruption of actin waves abolishes the enrichment of RanGTP and reduces growing ncMT plus-ends at the neurite tip. These observations identify a novel regulation mechanism of ncMTs and pinpoint an indirect connection between the actin and MT cytoskeletons in neurons.

Juan Martin D'Ambrosio, Veronique Albanese, Nicolas-Frederic Lipp, Lucile Fleuriot, Delphine Debayle, Guillaume Drin, and Alenka Copic

Osh6 and Osh7 are lipid transfer proteins (LTPs) that move phosphatidylserine (PS) from the endoplasmic reticulum (ER) to the plasma membrane (PM). High PS level at the PM is key for many cellular functions. Intriguingly, Osh6/7 localize to ER-PM contact sites, although they lack membrane-targeting motifs, in contrast to multidomain LTPs that both bridge membranes and convey lipids. We show that Osh6 localization to contact sites depends on its interaction with the cytosolic tail of the ER-PM tether Ist2, a homologue of TMEM16 proteins. We identify a motif in the Ist2 tail, conserved in yeasts, as the Osh6-binding region, and we map an Ist2-binding surface on Osh6. Mutations in the Ist2 tail phenocopy osh6 osh7 deletion: they decrease cellular PS levels, and block PS transport to the PM. Our study unveils an unexpected partnership between a TMEM16-like protein and a soluble LTP, which together mediate lipid transport at contact sites.

The generalized Darwin–Hamilton equations [Wuttke (2014). Acta Cryst. A70, 429–440] describe multiple Bragg reflection from a thick, ideally imperfect crystal. These equations are simplified by making full use of energy conservation, and it is demonstrated that the conventional two-ray Darwin–Hamilton equations are obtained as a first-order approximation. Then an efficient numeric solution method is presented, based on a transfer matrix for discretized directional distribution functions and on spectral collocation in the depth coordinate. Example solutions illustrate the orientational spread of multiply reflected rays and the distortion of rocking curves, especially if the detector only covers a finite solid angle.

To describe multiple Bragg reflection from a thick, ideally imperfect crystal, the transport equations are reformulated in three-dimensional phase space and solved by spectral collocation in the depth coordinate. Example solutions illustrate the orientational spread of multiply reflected rays and the distortion of rocking curves, especially for finite detectors.

Vaishnavi Ananthanarayanan
Apr 17, 2020; 133:jcs245928-jcs245928
Meeting Report

While every mode of transportation in the U.S. will be affected as the climate changes, potentially the greatest impact on transportation systems will be flooding of roads, railways, transit systems, and airport runways in coastal areas because of rising sea levels and surges brought on by more intense storms, says a new report from the National Research Council.

Young athletes in the U.S. face a culture of resistance to reporting when they might have a concussion and to complying with treatment plans.

With the sharp and largely unexpected increase in the long-distance movement of domestically produced crude oil, ethanol, and natural gas since 2005, a number of concerns have arisen about the safe transport of these hazardous materials, particularly in relation to railroad track defects, rural communities’ emergency response preparedness, and the older tank car designs that will continue to be used in multi-car unit trains, says a new report from the National Academies of Sciences, Engineering, and Medicine.

Current federal safety regulations for small distribution systems used for propane and other liquefied petroleum gases (LPGs) should be improved for clarity, efficiency, enforceability, and applicability to risk, says a new reportfrom the National Academies of Sciences, Engineering, and Medicine.

Victoria A. Arroyo, executive director of the Georgetown Climate Center, and Leslie S. Richards, secretary of transportation for the Pennsylvania Department of Transportation (PennDOT), have been appointed as chair and vice chair, respectively, to the 2019 Transportation Research Board (TRB) Executive Committee, which provides oversight of TRB activities.

A new report from the National Academies of Sciences, Engineering, and Medicine presents a research roadmap to address gaps and uncertainties in estimating the impacts of proposed changes in truck size and weight limits -- the regulations that set the maximum weights, lengths, and numbers of trailers allowed for trucks on U.S. highways.

More than 13,000 people – including industry leaders, policymakers, administrators, and researchers from government, industry, and academia – are expected to gather for the Transportation Research Board’s 98th Annual Meeting.

Nearly 14,000 people – including industry leaders, policymakers, administrators, and researchers from government, industry, and academia – are expected to gather for the Transportation Research Board’s 99th Annual Meeting, taking place at the Walter E. Washington Convention Center in Washington, D.C., from Jan. 12-16, 2020.

Autonomous vehicles (AV) took center stage at the Chair’s Luncheon of the Transportation Research Board’s annual meeting today.

A new study of attitudes towards transport and mobility has identified five groups of travellers. The groups differ significantly in their choice of transport, distance travelled and the impact their transport choices have on the environment in terms of greenhouse gas (GHG) emissions.

People living close to road, rail and aircraft noise are likely to experience negative health effects. Long-term noise exposure may lead to problems with their heart and circulatory (cardiovascular) system and night-time noise is particularly disruptive of sleep patterns, which in turn may lead to cardiovascular health problems, a review of research into the effects of noise on cardiovascular diseases has found.

A new study of attitudes towards transport and mobility has identified five groups of travellers. The groups differ significantly in their choice of transport, distance travelled and the impact their transport choices have on the environment in terms of greenhouse gas (GHG) emissions.

The environmental benefits of cleaner, more efficient transport may be offset by increasing distances travelled by passengers and goods, according to a new report by the European Environmental Agency (EEA). The report suggests that technology needs to go hand-in-hand with a policy package that improves, avoids and shifts transport emissions.

New research has explored public expectations of public transport. Surveys of Spanish citizens revealed that existing bus users have different expectations of transport quality compared to non- or “potential” users. The results may help to inform future public transport policy and campaigns which encourage more people to use public transport.

A recent assessment of fuels used in public transport in Kaunas, Lithuania, has found that buses powered with locally-produced biogas and trolleybuses powered with electricity generated from natural gas cause the least environmental damage for the city.

A new UK study suggests that there are associations between obesity, physical activity, and levels of CO2 emissions from transport. These associations seem mostly to reflect the fact that obese people tend to travel longer distances by motorised forms of travel. They may also partly reflect less ‘active travel’ by bicycle or walking by obese people.

A new report indicates that some progress has been made towards meeting key sustainable transport targets, but challenges remain. Improvements in passenger vehicle efficiency has led to reductions in emissions, however, reductions in oil consumption are not sufficient to meet targets, with more policy initiatives and continued monitoring needed to ensure that sustainability goals are achieved.

A new method of assessing the sustainability of noise reduction devices (NRDs) used in transport infrastructure, such as noise barriers or absorptive claddings, is presented in a recent study. The new set of specially designed sustainability criteria allows NRDs to be easily and accurately evaluated, its developers suggest.

A ‘feebate’ can be an effective policy option to aid the transition to a more environmentally-friendly transport system, a UK study suggests. This combination of fees and rebates can increase the take-up of low-carbon cars, the researchers argue, which leads to reduced life cycle greenhouse gas (GHG) emissions.

The transition to a low-carbon transport system needs a coherent national policy framework that supports all its aspects, according to a review of transport and innovation policy in Finland. Its findings suggest that policy makers need to identify and remove contradictory policies that present barriers to achieving a greener transport system.

Climate change will have major consequences for transport networks, especially those located on coastlines. This study assessed the impact of projected sea-level rise on a vulnerable stretch of railway line on the coast of South West England. The authors say their semi-empirical modelling method could provide guidance to policymakers worldwide.