mob Bouygues Telecom Entreprises sécurise les flottes mobiles de ses clients avec IBM By www.ibm.com Published On :: mar., 28 mars 2017 08:57:37 GMT aufeminin.com a choisi la solution de Bouygues Telecom Entreprises pour sa simplicité d’utilisation et sa sécurité Full Article Mobile
mob Armed to immobilize By feedproxy.google.com Published On :: Armed to immobilize View Comic! Full Article
mob C&E Spotlight: On-Demand Mobile Fueling—Enforcing Existing Regulations and Evaluating Future Needs By community.nfpa.org Published On :: Wed, 04 Oct 2017 05:28:26 PDT Andrew Klein, Principle with AS Klein Engineering, and Lynne Kilpatrick, Fire Marshal in Sunnyvale, CA led an education session on ‘On-Demand Mobile Fueling; Enforcing Existing Regulations and Evaluating Future Needs” at NFPA Conference & Full Article codes and standards nfpa 30a ce2017 on demand mobile fueling
mob Demobilizing buildings under construction, alteration or demolition during COVID-19 construction shutdown By feedproxy.google.com Published On :: 2020-04-16T20:31:19Z COVID-19 is having an immediate and drastic impact on the construction industry with job sites being abandoned and workers being furloughed. A byproduct of these unprecedented pandemic-related changes has been the demobilization of Full Article fire service ahjs nfpa 241 codes and standards building managers facility managers contractors code officials enforcement installer buildings under construction fire safety plan construction safety covid-19 coronavirus
mob Buzzirk Mobile and Global Verge Compensation Plan - Can You Really Make Some Money? By EzineArticles.com Published On :: Thu, 22 Oct 2009 08:12:59 -0500 A close look at the Buzzirk Mobile and Global Verge Compensation Plan. Also a chance to see if this business can really deliver the goods and make you money. Full Article
mob How to Make a Mobile-Friendly Website: Responsive Design in CSS By www.thesitewizard.com Published On :: Tue, 19 Apr 2016 03:56:06 GMT Find out how you can make your website mobile-ready by simply modifying its Cascading Style Sheets (CSS). Full Article mobile friendly mobile ready responsive design web design CSS webmaster web development
mob [Updated] Free Mobile-Friendly Layout Wizard: now creates 1, 2, 3 column websites By www.thesitewizard.com Published On :: Thu, 25 Jul 2019 06:53:59 GMT For the sake of completeness (and also because a visitor requested it), the Layout Wizard has been updated to support one column websites as well. As a result, it can now create one, two and three column websites (depending on which you prefer). The generated web page is mobile-friendly and completely customizable. There are no advertisements, and nothing you enter into the Wizard is recorded anywhere. And it's free. Full Article CSS HTML website layout website design web design webmaster web development wizards
mob How to Rotate an Image on a Website When Viewed on a Mobile Phone (CSS) By www.thesitewizard.com Published On :: Tue, 17 Mar 2020 05:50:48 GMT In response to a visitor's query, this article deals with how you can turn an image on its side when a web page is viewed on a mobile phone. Full Article CSS HTML web design webmaster web development
mob Geographic Mobility in America: Evidence from Cell Phone Data -- by M. Keith Chen, Devin G. Pope By www.nber.org Published On :: Traveling beyond the immediate surroundings of one’s residence can lead to greater exposure to new ideas and information, jobs, and greater transmission of disease. In this paper, we document the geographic mobility of individuals in the U.S., and how this mobility varies across U.S. cities, regions, and income classes. Using geolocation data for ~1.7 million smartphone users over a 10-month period, we compute different measures of mobility, including the total distance traveled, the median daily distance traveled, the maximum distance traveled from one’s home, and the number of unique haunts visited. We find large differences across cities and income groups. For example, people in New York travel 38% fewer total kilometers and visit 14% fewer block-sized areas than people in Atlanta. And, individuals in the bottom income quartile travel 12% less overall and visit 13% fewer total locations than the top income quartile. Full Article
mob Mobile testing units travel to Utah coronavirus hot spots By www.sltrib.com Published On :: Sat, 09 May 2020 00:04:52 +0000 Full Article
mob Bring on the e-scooters: A Bird executive explains how New York City can smartly and safely welcome the micromobility devices By www.nydailynews.com Published On :: Thu, 07 May 2020 20:08:58 +0000 Electric scooters are coming to New York and, with a little planning and preparation, they can safely thrive here. To understand how, it helps to start with some context. Full Article
mob Hoodlums in the ’hood: Where mobsters lived in South Florida By www.nydailynews.com Published On :: Wed, 04 Mar 2020 15:43:38 +0000 Some of the most infamous mobsters lived in South Florida neighborhoods we call home today, from Miami to Hollywood to Boca Raton. Full Article
mob Pistol-whipping Russian mobster explodes at prosecutor at Brooklyn sentencing: ‘I can’t listen to these lies!’ By www.nydailynews.com Published On :: Thu, 20 Feb 2020 23:24:49 +0000 Aleksey Tsvetkov, 40, blew up while an Assistant U.S. Attorney recited his criminal history during his sentencing hearing in Brooklyn Federal Court on racketeering charges.. Full Article
mob Legendary mobster Sonny Franzese dead at 103 By www.nydailynews.com Published On :: Mon, 24 Feb 2020 19:23:16 +0000 The renowned tough guy did his prison time without ever turning on his mob associates following a 1967 conviction that was widely considered both inside and outside organized crime as a set-up. Full Article
mob SEE IT: 15-year-old girl ‘traumatized’ after being beaten and robbed by teen mob in Brooklyn By www.nydailynews.com Published On :: Fri, 06 Mar 2020 13:49:47 +0000 The teen victim was chased to the corner of Utica Ave. and Sterling Place around 4:10 p.m. Thursday before being knocked to the ground. Video then shows a horde of teens descending upon her. Full Article
mob 3 Reasons Why A Mobile-Friendly Website Design Is Essential By feedproxy.google.com Published On :: Wed, 06 May 2015 13:17:27 +0000 Online advertisers, logged off organizations, mentors, and creators are listening to all the more habitually about the need to guarantee that you have a mobile-friendly site plan. Basically, this implies that your site should naturally and powerfully conform to whichever gadget is being utilized to view the site, whether this is a cell phone, a tablet, or a desktop PC. Alterably conforming implies that the peruser does not need to make conformities physically; its done naturally. A variable influencing this ... The post 3 Reasons Why A Mobile-Friendly Website Design Is Essential appeared first on RSS Feed Converter. Full Article eBusiness Tips mobile design responsive website design webmaster tips
mob Mobile Marketing: How to Convert the Mobile Visitor By feedproxy.google.com Published On :: Fri, 15 May 2015 17:51:27 +0000 Digital marketing is having a moment — and it’s a mobile one. For months, digital marketers have been readying their sites for mobile traffic page by page and #Mobilegeddon has come to define the current zeitgeist. According to SMX Speaker and WordStream Content Marketing Specialist Margot da Cunha, this has been a long time coming. “Everyone’s been preaching the importance of having a robust mobile marketing strategy for the past seven years or so, and although we all know this, ... The post Mobile Marketing: How to Convert the Mobile Visitor appeared first on RSS Feed Converter. Full Article eBusiness Tips online marketing targeted audience tips targeted visitor
mob RepeatServer.com gets a mobile-friendly overhaul By www.repeatserver.com Published On :: Tue, 17 Apr 2018 22:56:22 GMT RepeatServer.com now allows you to update your RSS feeds, etc, from your smart phones and tablets Full Article
mob USC's Isaiah Mobley finding his stride after rough start to college career By www.latimes.com Published On :: Tue, 18 Feb 2020 22:11:22 -0500 Isaiah Mobley has learned to deal with adversity since arriving at USC as one of the top college basketball recruits in the nation. Full Article
mob John 'Sonny' Franzese, powerful mob boss who hung out with Frank Sinatra, dies at 103 By www.latimes.com Published On :: Tue, 25 Feb 2020 13:54:53 -0500 Alleged to be a prolific killer, Franzese was finally released from prison when he was 100 Full Article
mob PUBG Mobile update 0.18.0 download issues ahead of Season 13 Pass release By feedproxy.google.com Published On :: Sat, 09 May 2020 05:25:00 +0100 TENCENT has confirmed that issues with the latest PUBG Mobile update process are being looked into this weekend, ahead of the Season 13 Royale Pass release. Full Article
mob PUBG Mobile update 0.18.0 download issues ahead of Season 13 Pass release By feedproxy.google.com Published On :: Sat, 09 May 2020 05:25:00 +0100 TENCENT has confirmed that issues with the latest PUBG Mobile update process are being looked into this weekend, ahead of the Season 13 Royale Pass release. Full Article
mob Rap videos, virtual running club, bookmobile: Teachers go above and beyond amid pandemic By rssfeeds.indystar.com Published On :: Mon, 04 May 2020 11:19:56 +0000 Join IndyStar and #ThankATeacher during Teacher Appreciation Week. These are some educators that are making the best of a bad situation. Full Article
mob Orange Extends Services with Interactive TV and Mobile Apps By www.tvover.net Published On :: Thu, 18 Oct 2012 20:25:16 GMT Orange Slovensko the leading telco operator on the market uses the nangu.TV Media Platform for IPTV and OTT delivery. "With the growing demand for interactive television and more viewing possibilities, Orange sought a proven solution to bring to the market," says Product Manager at Orange, Martin Hainzl. Orange offers their customers TV with value added features, which gives them more options and comfort than classic live TV. The VoD selection stores 50 movie titles, accessible on multiple screens: TV, PC, Smartphone or tablet. The TV Archive allows playback of content up to 7 days in the past. Customers can utilize the time shift feature to browse content already aired and watch it at their leisure with pause, play and star t over commands. They have flexibility in watching television on the go with the newly released applications for both iOS and Android devices. The nangu.TV solution allows operators to stay ahead of competition by giving cutomers the chance to be in control of how they watch TV. Full Article Interactive TV;Mobile TV
mob From Concept to Design: How Developers Create Today’s Most Popular Mobile Games By spyrestudios.com Published On :: Thu, 16 Apr 2020 08:00:00 PDT In the past five years, mobile games have exploded in popularity. With the advent of Apple’s App Store, mobile app developers have jumped on the opportunity to create mobile games from scratch on the most popular devices in the world. What Makes a Mobile Game Go Viral? Why is it that some mobile games become […] The post From Concept to Design: How Developers Create Today’s Most Popular Mobile Games appeared first on SpyreStudios. Full Article Apps Development development games mobile apps
mob oscon: Mobile UX Design & Development for Apps - learn to craft an app that’s functional and fun to use http://t.co/L8kTLaxbYH #oscon #tutorial By twitter.com Published On :: Thu, 23 May 2013 16:11:21 +0000 oscon: Mobile UX Design & Development for Apps - learn to craft an app that’s functional and fun to use http://t.co/L8kTLaxbYH #oscon #tutorial Full Article
mob AT#409 - Travel to Mobile, Alabama By usa.amateurtraveler.com Published On :: Sat, 01 Mar 2014 13:30:00 +0000 Hear about travel to Mobile, Alabama as the Amateur Traveler talks to Carla Rountree from theinconsistentnomad.com about her home state. There are beautiful beaches. It is an area that was founded in the early 1700s so there is lots of culture, lots of history and it is even the area where Mardi Gras actually started in the USA. Full Article
mob Leaders need to mobilize change-ready workforces By feedproxy.google.com Published On :: Mon, 23 Mar 2020 09:58:00 +0000 Rita J. King, co-director and EVP for business development at Science House, recently conducted a series of interviews with business leaders, exploring the challenges and hurdles companies face in evolving business landscapes. In this interview, King chats with Jen Bruno, SVP of culture and human capital at LPL Financial, about mobilizing a change-ready workforce, leadership […] Full Article Future of the Firm Big Systemic Thinking
mob Article: Mobile Apps, Influencer Marketing Top Fraud Targets for 2018 By www.emarketer.com Published On :: Wed, 03 Jan 2018 04:01:00 GMT Michael Tiffany, co-founder and president of ad verification and fraud prevention firm White Ops, discusses the next evolution of fraudulent practices for 2018. Full Article
mob Why We Need a Transatlantic Charter for Data Security and Mobility By feedproxy.google.com Published On :: Tue, 27 Jun 2017 09:59:17 +0000 28 June 2017 Dr Christopher Smart @csmart Former Associate Fellow, US and the Americas Programme Setting common guidelines for data flows is crucial both to protect the goods and services that already depend on big data and to support the next generation of productivity gains and business opportunities. 2017-06-23-TsystemsData.jpg Data centre for T-Systems, a subsidiary of Deutsche Telekom. Photo by: Thomas Trutschel/Photothek/Getty Images While trade and tax remain at the heart of the difficult economic conversations between Europe and the US, a new issue has emerged as a potential source of even greater friction: data.Growth in the traditional global trade in goods and services has levelled off, but cross-border data flows continue to expand rapidly and the challenges of developing policies that protect privacy, security and innovation are already tremendous. For example, data analytics are driving dramatic productivity gains in industry, particularly for large and complex installations whose safety and efficiency will increasingly depend on flows of those data across jurisdictions. Meanwhile, ‘fintech’ (financial technology) start-ups and large banks alike are testing new modes of accumulating, analysing and deploying customer data to provide less expensive services and manage the risk profile of their businesses.The rules that govern the collection, transmission and storage of data are perhaps one of the more surprising controversies in the transatlantic relationship. Similar liberal democracies with similar geostrategic interests might be expected to approach the handling of personal, corporate and government data in more or less the same way. And yet the US and its key European partners have struck different balances in the trade-offs between national security and citizens’ rights, between freedom of expression and personal privacy, and between free enterprise and market regulation.While the US debate on the use of data has often been framed around the trade-off between national security and personal privacy, Europeans often face an even more complex set of concerns that include worries that their digital and technology firms lag behind dominant US competitors. The political and regulatory uncertainty helps neither side, and leaves transatlantic companies struggling to comply with uncertain and conflicting rules in different jurisdictions.This makes more determined efforts by US and European policymakers to agree basic principles that will guide the usage and protection of personal and commercial data all the more important. While common regulations or even greater alignment among regulators seem out of reach, a ‘Transatlantic Charter for Data Security and Mobility’ would provide a set of principles for more specific rules amid political landscapes and technological developments that are evolving rapidly. It could also provide the basis for firms, whether in manufacturing or financial services or health care, to draft their own voluntary standards on how they protect data even as they develop new algorithms that improve productivity, safety and customer satisfaction.Embarrassing leaks, careful denials and endless lawsuits will continue to shape the awkward efforts of policymakers to find common ground around issues like cyberespionage, defence of common networks and the sharing of personal data with law enforcement. Cyberattacks with the aim of disrupting government operations or influencing election campaigns will add still further pressures. These will all serve as a noisy backdrop to a related but separate debate over how commercial firms should exploit the opportunities of global networks and ‘big data’ analytics while protecting national interests and privacy.Yet, setting common guidelines for commercial data transmission and storage remains crucial both to protect the goods and services that already depend on sophisticated data-gathering and analysis, and to support the next generation of productivity gains and business opportunities.Global firms yearn for clarity and predictability as they organize themselves to make the most of the data revolution. Neither is likely to become a reality soon. The EU’s new General Data Protection Regulation will take effect in 2018, but its implementation will inevitably be coloured by the fact that American firms currently dominate the information technology business. Last year’s ‘Privacy Shield’ agreement between the US and the EU renews the permission for firms with transatlantic business interests to transfer data, subject to compliance with basic standards of protection, but the agreement remains vulnerable to European court challenges. Britain’s decision to leave the EU adds a further complication, as it establishes its own set of data protection rules that may not easily align with either European or US requirements. Meanwhile, the World Trade Organization continues to debate new rules for digital trade, even as markets like China, Russia and Brazil make up their own.If this ‘Transatlantic Charter for Data Security and Mobility’ were adopted bilaterally, say as part of the annual reviews of the US–EU Privacy Shield agreement, it could form the basis for broader cooperation on these issues, helping to drive progress in the G7 and G20 and ultimately perhaps in trade agreements under the WTO. It would hardly secure complete alignment on these questions, but it could help establish the framework for a debate that all too often lurches to extremes and risks damaging a fundamental alliance for global stability – along with a fundamental driver of 21st-century economic progress.To comment on this article, please contact Chatham House Feedback Full Article
mob Supporting the US Economy by Improving the Mobility of High-skilled Labour Across the Atlantic By feedproxy.google.com Published On :: Wed, 20 Sep 2017 10:33:17 +0000 27 September 2017 US policymakers should give special consideration to a more open immigration policy for highly skilled professionals from the EU. This would ultimately benefit the US economy. Read online Download PDF Marianne Schneider-Petsinger Senior Research Fellow, US and the Americas Programme @mpetsinger 2017-09-25-labour-mobility-us-economy.jpg Businessman on bicycle passing skyline of La Defense business district in Paris, France. Photo: Getty Images. SummaryThe United States and the European Union are deeply integrated economically in terms of movement of goods, services and capital across the Atlantic, but this is not matched by the mobility of labour. Freer movement of high-skilled workers across the Atlantic has a potentially critical role to play in maintaining and strengthening the bilateral economic relationship.Both the US and EU seek to attract high-skilled labour through the use of temporary visa programmes. Various routes are available for highly skilled workers from the EU to temporarily work in the US (for instance, through the H-1B visa for foreign nationals in ‘specialty occupations’, as well as other visa categories for treaty traders and investors, intra-company transferees, and international students seeking work authorization in the US before or after graduation). The main ways for highly skilled workers from the US to temporarily work in EU member states are through EU-wide schemes that apply in 25 out of the 28 member states (for holders of EU Blue Cards or intra-company transferees); or via member states’ parallel national schemes.The experiences of US and EU employers and workers under the US H-1B programme and the EU’s Blue Card scheme differ greatly. The EU Blue Card scheme avoids many of the drawbacks of the H-1B visa. It does not have an annual cap on the number of visas issued. It also grants greater autonomy to the worker by not requiring the employer to sponsor long-term residence, by providing greater flexibility to switch employment, and by having a longer grace period for visa-holders to find new employment after dismissal.The US visa system hampers America’s economic growth. Restrictive policies such as an annual limit on the number of H-1B visas issued, and the associated uncertainty for employees and employers, hinder the ability of US companies to expand and innovate. The complex and costly visa application process is a particular burden for small and medium-sized enterprises. Problems around the timely availability of visas frustrate investors both from the US and from abroad (including from the EU). European firms face difficulties in acquiring visas for intra-company transferees, and not all EU member states have access to the treaty trader and treaty investor visa categories. At times, this impedes foreign direct investment and restricts US job creation. In addition, current policies hinder the economy’s retention of EU and other graduates of US universities. This is of particular concern given that skilled graduates have a critical role to play in addressing the US’s growing shortage of workers in the science, technology, engineering and mathematics (STEM) fields.Given the comparability of US and EU wages and labour markets, US concerns about foreign workers ‘stealing’ their jobs or depressing wages generally do not apply to EU citizens. On the contrary, a more open immigration policy for high-skilled workers – in particular for EU citizens – would benefit the US economy.Efforts to reform visa systems for high-skilled labour are under way in both the US and EU. In order to facilitate the movement of highly skilled workers across the Atlantic, this research paper recommends (1) creating a special visa for highly skilled EU citizens to work temporarily in the US; (2) extending the availability of treaty trader and investor visas to all EU member states; and (3) increasing efforts to eliminate fraud and abuse in the H-1B system. These measures could potentially help to create more investment, jobs and economic growth in the US. Department/project International Security Programme, US and the Americas Programme Full Article
mob Up in smoke? Global tobacco advocacy and local mobilization in Africa By feedproxy.google.com Published On :: Wed, 04 Sep 2019 14:05:11 +0000 4 September 2019 , Volume 95, Number 5 Amy S. Patterson and Elizabeth Gill Read online Even though most African states have signed and ratified the Framework Convention on Tobacco Control (FCTC), a global treaty to limit tobacco use, African states have been slow to pass and implement tobacco control policies like regulations on sales, smoke-free environments and taxes. This article examines how the ineffectiveness of local tobacco-control advocacy contributes to this suboptimal outcome. It asserts that the disconnect between the global tobacco-control advocacy network and local advocates shapes this ineffectiveness. With funding and direction predominately from the Bloomberg Initiative, local advocates emulate the funders' goal of achieving quick, measurable policy results. Their reliance on the network drives African advocates to strive to pass legislation, even in difficult political climates, and to remake their agendas when funders change their priorities. They also emulate the network's focus on evidence-based arguments that stress epidemiological data and biomedical interventions, even when this issue frame does not resonate with policy-makers. Financial dependence can draw local advocates into expectations about patronage politics, undermine their ability to make principled arguments, and lead them to downplay the ways that their home country's socioeconomic and cultural contexts affect tobacco use and control. Based on key informant interviews with African advocates, media analysis and the case-studies of Ghana and Tanzania, the article broadens the study of philanthropy in global health, it adds an African perspective to the literature on global health advocacy, and it deepens knowledge on power dynamics between external funders and local actors in the realms of health and development. Full Article
mob Putting the auto in automobile By www.ams.org Published On :: Wed, 22 Aug 2012 10:48:09 -0400 It may be hard to accept but it.s likely that we.d all be much safer in autonomous vehicles driven by computers, not humans. Annually more than 30,000 Americans die in car crashes, almost all due to human error. Autonomous vehicles will communicate position and speed to each other and avoid potential collisions-without the possibility of dozing off or road rage. There are still many legal (and insurance) issues to resolve, but researchers who are revving up the development of autonomous vehicles are relying on geometry for recognizing and tracking objects, probability to assess risk, and logic to prove that systems will perform as required. The advent of autonomous vehicles will bring in new systems to manage traffic as well, for example, at automated intersections. Cars will communicate to intersection-managing computers and secure reservations to pass through. In a matter of milliseconds, the computers will use trigonometry and differential equations to simulate vehicles. paths through the intersection and grant entry as long as there is no conflict with other vehicles. paths. Waiting won.t be completely eliminated but will be substantially reduced, as will the fuel--and patience--currently wasted. Although the intersection at the left might look wild, experiments indicate that because vehicles would follow precise paths, such intersections will be much safer and more efficient than the ones we drive through now. Full Article
mob CBD Joint Press Release: Mobilizing society to support biodiversity: As Countdown 2010 initiative closes, local coordinated actions show way to solving the global biodiversity crisis. By www.cbd.int Published On :: Wed, 20 Oct 2010 00:00:00 GMT Full Article
mob CBD Communiqué: World Association of Zoos and Aquariums mobilized for the United Nations Decade on Biodiversity By www.cbd.int Published On :: Fri, 14 Oct 2011 00:00:00 GMT Full Article
mob CBD News: Parties to the Convention on Biological Diversity (CBD) wrapped up a weeklong meeting on implementation with recommendations on, among others, resource mobilization, technical and scientific cooperation, poverty eradication and sustainable devel By www.cbd.int Published On :: Fri, 20 Jun 2014 00:00:00 GMT Full Article
mob CBD News: To support the mobilisation and alignment of technical and financial resources for priority capacity-building needs, IPBES is developing a prototype Matchmaking Facility. This Facility aims to promote and facilitate dialogue and cooperation amon By us8.campaign-archive1.com Published On :: Mon, 20 Jul 2015 00:00:00 GMT Full Article
mob CBD News: On 12 April, Sir David Attenborough joins the head of the UN's Convention on Biological Diversity and a panel from government, business and civil society to discuss how to mobilise global action to tackle what is said to be the greatest thre By www.cbd.int Published On :: Wed, 11 Apr 2018 00:00:00 GMT Full Article
mob CBD News: The film highlights the importance of nature in tackling climate change, calling for the need to protect, restore and fund nature and mobilizing attention to scale nature-based solutions. By www.youtube.com Published On :: Fri, 20 Sep 2019 00:00:00 GMT Full Article
mob Mobile web optimisation tips By www.techworld.com Published On :: Tue, 13 Aug 2019 10:05:00 GMT Full Article
mob Evaluation and Evolution of Diabetes Mobile Applications: Key Factors for Health Care Professionals Seeking to Guide Patients By spectrum.diabetesjournals.org Published On :: 2013-11-01 Ryan A. RistauNov 1, 2013; 26:211-215From Research to Practice Full Article
mob Going Mobile With Diabetes Support: A Randomized Study of a Text Message-Based Personalized Behavioral Intervention for Type 2 Diabetes Self-Care By spectrum.diabetesjournals.org Published On :: 2015-05-01 Korey CapozzaMay 1, 2015; 28:83-91Feature Articles Full Article
mob MoBay residents flock COVID ‘giveaway truck’ By jamaica-star.com Published On :: Fri, 08 May 2020 05:02:14 -0500 Despite being placed under strict restrictions and COVID-19 curfew measures, shoppers, commuters, motorists, and vendors in Montego Bay got a feel of Christmas on Wednesday, when they were showered with items as part of the COVID-19 giveaway by an... Full Article
mob MaxQuant software for ion mobility enhanced shotgun proteomics By feedproxy.google.com Published On :: 2020-03-10 Nikita PrianichnikovMar 10, 2020; 0:TIR119.001720v1-mcp.TIR119.001720Technological Innovation and Resources Full Article
mob Mobilizing Multinational Military Operations in Africa: Quick Fixes or Sustainable Solutions? By feedproxy.google.com Published On :: Wed, 16 Oct 2019 09:55:01 +0000 Research Event 25 October 2019 - 9:30am to 11:15am Chatham House | 10 St James's Square | London | SW1Y 4LE Event participants Professor Tony Chafer, University of PortsmouthProfessor Gordon Cumming, Cardiff UniversityDr Roel van der Velde, Cardiff UniversityAhmed Soliman, Research Fellow, Horn of Africa, Chatham HouseDr Elisa Lopez Lucia, Université Libre de Bruxelles; University of PortsmouthChair: Janet Adama Mohammed, West Africa Programme Director, Conciliation Resources Peacekeeping missions which have sought to address evolving forms of conflict and instability on the African continent – led by the United Nations, African Union and European Union – have frequently been overstretched.Across regions including the Sahel, the Horn and West Africa, the issues of violent extremism and criminality – often set against a backdrop of collapsing or severely weakened central states – have led to the mobilisation of a diverse set of new collective responses.These include notable African-led efforts such as AMISOM in Somalia or more recently the G5 Sahel, where France have played a pivotal role in initiating new and more ad hoc approaches to coalition-building.As existing multinational missions in Africa continue to evolve on the ground and while new collective opportunities increasingly present themselves, it is critical for policymakers to understand how far such efforts reflect meaningful long-term solutions to the challenges of conflict and insecurity.At this roundtable event, participants will reflect on how such missions become mobilised and legitimised, the extent to which they can be defined as ‘new’, and whether they represent a truly sustainable means to tackle the issue of conflict in Africa.This roundtable is held in partnership with Cardiff University and the University of Portsmouth and is supported by the Leverhulme Trust. Department/project Africa Programme, West Africa, African Peace and Security, Horn of Africa Fergus Kell Projects Assistant, Africa Programme + 44 (0) 20 7314 3671 Email Full Article
mob Central & Eastern Europe and Africa Engagement: Labour Mobility and Policy in East Africa By feedproxy.google.com Published On :: Wed, 08 Jan 2020 12:35:01 +0000 Research Event 15 January 2020 - 10:00am to 12:30pm Nairobi, Kenya Strengthened links between the states of sub-Saharan Africa (SSA) and Central and Eastern Europe (CEE) are emerging marked by growth in diplomatic representation, trade and economic ties and supporting networks.Against this backdrop, labour migration within and from the CEE and East Africa sub-regions are a key policy area with significant potential for shared learning and cooperation. For both regions, migration trends in recent years have evolved as a result of a diverse range of interactions among public, private and civil society actors and at local, national, regional and international levels. Unpacking such interactions and their political and geographical specificities is essential to effective engagement and cooperation within and between the regions on issues of labour migration and their management.This roundtable brainstorming workshop will provide a platform for stakeholders based in East Africa to discuss the way in which different actors and agencies in the region influence and shape labour migration processes and policy responses.This event is supported by the Robert Bosch Stiftung. Event attributes Chatham House Rule Department/project Africa Programme, Foreign Relations and Africa’s Agency in the International System, Inclusive Economic Growth, Governance and Technology Fergus Kell Projects Assistant, Africa Programme + 44 (0) 20 7314 3671 Email Full Article
mob MaxQuant software for ion mobility enhanced shotgun proteomics [Technological Innovation and Resources] By feedproxy.google.com Published On :: 2020-03-10T07:35:19-07:00 Ion mobility can add a dimension to LC-MS based shotgun proteomics which has the potential to boost proteome coverage, quantification accuracy and dynamic range. Required for this is suitable software that extracts the information contained in the four-dimensional (4D) data space spanned by m/z, retention time, ion mobility and signal intensity. Here we describe the ion mobility enhanced MaxQuant software, which utilizes the added data dimension. It offers an end to end computational workflow for the identification and quantification of peptides and proteins in LC-IMS-MS/MS shotgun proteomics data. We apply it to trapped ion mobility spectrometry (TIMS) coupled to a quadrupole time-of-flight (QTOF) analyzer. A highly parallelizable 4D feature detection algorithm extracts peaks which are assembled to isotope patterns. Masses are recalibrated with a non-linear m/z, retention time, ion mobility and signal intensity dependent model, based on peptides from the sample. A new matching between runs (MBR) algorithm that utilizes collisional cross section (CCS) values of MS1 features in the matching process significantly gains specificity from the extra dimension. Prerequisite for using CCS values in MBR is a relative alignment of the ion mobility values between the runs. The missing value problem in protein quantification over many samples is greatly reduced by CCS aware MBR.MS1 level label-free quantification is also implemented which proves to be highly precise and accurate on a benchmark dataset with known ground truth. MaxQuant for LC-IMS-MS/MS is part of the basic MaxQuant release and can be downloaded from http://maxquant.org. Full Article
mob Adipose Triglyceride Lipase is a Key Lipase for the Mobilization of Lipid Droplets in Human Beta Cells and Critical for the Maintenance of Syntaxin1a Level in Beta Cells By diabetes.diabetesjournals.org Published On :: 2020-03-31T14:12:19-07:00 Lipid droplets (LDs) are frequently increased when excessive lipid accumulation leads to cellular dysfunction. Distinct from mouse beta cells, LDs are prominent in human beta cells, however, the regulation of LD mobilization (lipolysis) in human beta cells remains unclear. We found that glucose increases lipolysis in non-diabetic human islets, but not in type 2 diabetic (T2D) islets, indicating dysregulation of lipolysis in T2D islets. Silencing adipose triglyceride lipase (ATGL) in human pseudoislets (shATGL) increased triglycerides, and the number and size of LDs indicating that ATGL is the principal lipase in human beta cells. In shATGL pseudoislets, biphasic glucose-stimulated insulin secretion (GSIS) and insulin secretion to IBMX and KCl were all reduced without altering oxygen consumption rate compared with scramble control. Like human islets, INS1 cells showed visible LDs, glucose responsive lipolysis, and impairment of GSIS after ATGL silencing. ATGL deficient INS1 cells and human pseudoislets showed reduced Stx1a, a key SNARE component. Proteasomal degradation of Stx1a was accelerated likely through reduced palmitoylation in ATGL deficient INS1 cells. Therefore, ATGL is responsible for LD mobilization in human beta cells and supports insulin secretion by stabilizing Stx1a. The dysregulated lipolysis may contribute to LD accumulation and beta cell dysfunction in T2D islets. Full Article
mob Adipose Triglyceride Lipase is a Key Lipase for the Mobilization of Lipid Droplets in Human Beta Cells and Critical for the Maintenance of Syntaxin1a Level in Beta Cells By diabetes.diabetesjournals.org Published On :: 2020-04-20T08:51:08-07:00 Lipid droplets (LDs) are frequently increased when excessive lipid accumulation leads to cellular dysfunction. Distinct from mouse beta cells, LDs are prominent in human beta cells, however, the regulation of LD mobilization (lipolysis) in human beta cells remains unclear. We found that glucose increases lipolysis in non-diabetic human islets, but not in type 2 diabetic (T2D) islets, indicating dysregulation of lipolysis in T2D islets. Silencing adipose triglyceride lipase (ATGL) in human pseudoislets (shATGL) increased triglycerides, and the number and size of LDs indicating that ATGL is the principal lipase in human beta cells. In shATGL pseudoislets, biphasic glucose-stimulated insulin secretion (GSIS) and insulin secretion to IBMX and KCl were all reduced without altering oxygen consumption rate compared with scramble control. Like human islets, INS1 cells showed visible LDs, glucose responsive lipolysis, and impairment of GSIS after ATGL silencing. ATGL deficient INS1 cells and human pseudoislets showed reduced Stx1a, a key SNARE component. Proteasomal degradation of Stx1a was accelerated likely through reduced palmitoylation in ATGL deficient INS1 cells. Therefore, ATGL is responsible for LD mobilization in human beta cells and supports insulin secretion by stabilizing Stx1a. The dysregulated lipolysis may contribute to LD accumulation and beta cell dysfunction in T2D islets. Full Article
mob Pharmacologic PPAR-{gamma} Activation Reprograms Bone Marrow Macrophages and Partially Rescues HSPC Mobilization in Human and Murine Diabetes By diabetes.diabetesjournals.org Published On :: 2020-04-28T07:09:24-07:00 Mobilization of hematopoietic stem/progenitor cells (HSPCs) from the bone marrow (BM) is impaired in diabetes. Excess oncostatin M (OSM) produced by M1 macrophages in the diabetic BM signals through p66Shc to induce Cxcl12 in stromal cells and retain HSPCs. BM adipocytes are another source of CXCL12 that blunts mobilization. We tested a strategy of pharmacologic macrophage reprogramming to rescue HSPC mobilization. In vitro, PPAR- activation with pioglitazone switched macrophages from M1 to M2, reduced Osm expression, and prevented transcellular induction of Cxcl12. In diabetic mice, pioglitazone treatment downregulated Osm, p66Shc and Cxcl12 in the hematopoietic BM, restored the effects of granulocyte-colony stimulation factor (G-CSF), and partially rescued HSPC mobilization, but it increased BM adipocytes. Osm deletion recapitulated the effects of pioglitazone on adipogenesis, which was p66Shc-independent, and double knockout of Osm and p66Shc completely rescued HSPC mobilization. In the absence of OSM, BM adipocytes produced less CXCL12, being arguably devoid of HSPC-retaining activity, whereas pioglitazone failed to downregulate Cxcl12 in BM adipocytes. In diabetic patients under pioglitazone therapy, HSPC mobilization after G-CSF was partially rescued. In summary, pioglitazone reprogrammed BM macrophages and suppressed OSM signaling, but sustained Cxcl12 expression by BM adipocytes could limit full recovery of HSPC mobilization. Full Article