go Discovery and optimisation of pyrazolo[1,5-a]pyrimidines as aryl hydrocarbon receptor antagonists By pubs.rsc.org Published On :: RSC Med. Chem., 2024, 15,3477-3484DOI: 10.1039/D4MD00266K, Research ArticleRaitis Bobrovs, Svetlana Terentjeva, Ninni Elise Olafsen, Zilvinas Dambrauskas, Antanas Gulbinas, Toivo Maimets, Indrek Teino, Aigars Jirgensons, Jason Matthews, Kristaps JaudzemsThe aryl hydrocarbon receptor (AHR) is a versatile ligand-dependent transcription factor involved in diverse biological processes, from metabolic adaptations to immune system regulation.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
go Sidechain structure–activity relationships of cyclobutane-based small molecule αvβ3 antagonists By pubs.rsc.org Published On :: RSC Med. Chem., 2024, 15,3616-3624DOI: 10.1039/D4MD00306C, Research Article Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Adam Throup, Manar Saleh Zraikat, Andrew Gordon, Shohreh Jafarinejad Soumehsaraei, Kathrin D. Haase, Laurence H. Patterson, Patricia A. Cooper, Katherine Hanlon, Paul M. Loadman, Mark Sutherland, Steven D. Shnyder, Helen M. SheldrakeCyclobutanes provide a versatile scaffold for the synthesis of small molecule integrin antagonists with good metabolic stability and in vivo tolerability.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
go 3-Thio-3,4,5-Trisubstituted-1,2,4-Triazoles: High Affinity Somatostatin Receptor-4 Agonist Synthesis and Structure-Activity Relationships By pubs.rsc.org Published On :: RSC Med. Chem., 2024, Accepted ManuscriptDOI: 10.1039/D4MD00597J, Research ArticleAlbert Michael Crider, Audrey Hospital, Karin Sandoval, William Neumann, Stephen Kukielski, Lejla Garic, Kristen Ingold, Matthew Dunahoo, Khush Srabony, Rafael Frare, Olivia Slater, Nathan Peel, Maria Kontoyianni, Ken WittSomatostatin receptor-4 (SST4) is a therapeutic target for several conditions, including Alzheimer’s disease, seizures, neuropsychiatric disorders, and pain. Our previous work on 1,2,4-triazole derivatives led to enhanced SST4 binding affinity,...The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
go Govt. urged to extend last date to pay crop insurance premium by farmers By www.thehindu.com Published On :: Thu, 07 Nov 2024 17:45:02 +0530 Full Article Tiruchirapalli
go Bids invited for setting up International Dugong Conservation Centre at Manora By www.thehindu.com Published On :: Thu, 07 Nov 2024 19:03:19 +0530 The proposed centre, to be set up at an estimate of ₹41 crore, is being established to conserve endangered Dugong species and its habitat in the Palk Bay Full Article Tiruchirapalli
go 563: Getting Pulled by the Algorithm, AI Training Data, and SVG Drawing By shoptalkshow.com Published On :: Mon, 01 May 2023 08:51:30 +0000 There's a special guest on the show who takes aim at the billionaires in web dev, do we know better than the algorithm for news, why is AI training data such a secret, Chris and Dave discover JetBrains, monorepo struggles, and SVG drawing tools. Full Article All Episodes AI JetBrains PHP
go 573: Google Reader, Sticky and Overflow, and Figma Thoughts By shoptalkshow.com Published On :: Mon, 10 Jul 2023 08:01:45 +0000 Chris breaks out his banjo, some thoughts on making music vs recording music, what happened to Google Reader and social reading, what black box properties can't Dave or Chris remember, follow up for dev teams communicating with designers, and what's Adobe going to do about Figma? Full Article All Episodes banjo figma google reader music rss
go 599: Fighting the Algorithm With RSS, Blogging, and the IndieWeb By shoptalkshow.com Published On :: Mon, 22 Jan 2024 10:30:04 +0000 Dave and Chris discuss indie web culture, the role of social media in today's society, and the challenges and strategies of freelancing. Additionally, they discuss a range of topics from content moderation, coding and refining tech skills, to emerging startups and the future of web technology. Full Article All Episodes Blogging Freelancing rss salaries
go 615: Dave Goes Windows For Real By shoptalkshow.com Published On :: Mon, 13 May 2024 22:33:10 +0000 Dave's got job news to share, as well as insight into the process of what applying for a job in tech is like in 2024. We also talk about styling, scoping, positioning, and floating UI. Full Article All Episodes applying for a job employment microsoft windows
go 631: Dave’s Second Brain Idea, Notion Thoughts, and Google’s LLM in Chrome By shoptalkshow.com Published On :: Mon, 02 Sep 2024 08:01:07 +0000 Dave's got an idea for a second brain app that's customized to his brain, where we're at with Notion and other notes apps, and accessibility on LLM's in browsers. Full Article All Episodes Chrome LLM notion second brain
go It’s good ‘office times’ for Bengaluru By www.thehindu.com Published On :: Fri, 30 Jan 2015 20:21:59 +0530 The buoyant office market of Bangalore quite makes up for the lukewarm residential segment, according to findings. Full Article Property Plus
go Grey to gold By www.thehindu.com Published On :: Fri, 20 Feb 2015 19:51:11 +0530 Use a three-compartment overhead tank to treat greywater. Full Article Green Living
go Go local is the mantra By www.thehindu.com Published On :: Fri, 06 Mar 2015 14:48:45 +0530 Angela Brady, director, Brady Mallalieu Architects, London, tells Nidhi Adlakha why we need to focus on creating sustainable cities with low carbon footprints Full Article Green Living
go Cargo companies upsize for new business By www.thehindubusinessline.com Published On :: Sun, 20 Oct 2024 19:43:00 +0530 Booming demand for ecommerce delivery spurs freight handlers to open more centres, digitise for efficiency Full Article Logistics
go ‘Our goal is beauty for each,’ says L’Oréal India chief By www.thehindubusinessline.com Published On :: Sat, 26 Oct 2024 13:11:01 +0530 Aseem Kaushik, who leads the global beauty giant in India, says tech is playing a big part in its personalisation journey Full Article Corporate File
go Gold loans: Test by fire By www.thehindubusinessline.com Published On :: Sun, 27 Oct 2024 15:51:06 +0530 Governance, compliance in focus as RBI cautions lenders against lapses Full Article Current Account
go Govt., BJP spar over Chhath planning as festivities begin today By www.thehindu.com Published On :: Tue, 05 Nov 2024 00:56:12 +0530 Full Article Delhi
go Gopal Rai calls meeting over Winter Action Plan progress By www.thehindu.com Published On :: Tue, 05 Nov 2024 01:05:00 +0530 Full Article Delhi
go Several Delhi govt. schemes to tackle toxic air yet to take off By www.thehindu.com Published On :: Tue, 05 Nov 2024 03:07:30 +0530 AAP govt. yet to implement at least 5 programmes it announced over the past two years to curb air pollution; these include using drones to map bad air sources and making PUC mandatory to buy fuel; our plans have been stopped by Centre: AAP Full Article Delhi
go Delhi L-G inspects Gole Market restoration project By www.thehindu.com Published On :: Wed, 06 Nov 2024 01:16:27 +0530 Full Article Delhi
go Delhi govt. to start drive against burning of waste in open today By www.thehindu.com Published On :: Wed, 06 Nov 2024 01:18:55 +0530 Delhi, neighbouring States likely to experience ‘very poor’ quality air over next 10 days, have placed the depts. concerned on high alert: Gopal Rai Full Article Delhi
go Chhath Puja: BJP, Cong. slam Delhi govt. over bad air, water By www.thehindu.com Published On :: Thu, 07 Nov 2024 00:59:21 +0530 Full Article Delhi
go Delhi govt tests drone-based mist spraying to combat pollution By www.thehindu.com Published On :: Fri, 08 Nov 2024 19:39:59 +0530 Pollution levels are elevated at 13 hotspots across Delhi, and this pilot project allows us to test drone-based mist spraying in areas where conventional anti-smog guns can't reach Full Article Delhi
go Delhi govt okays proposal, 10000 Civil Defence Volunteers to return for anti-pollution work: Atishi By www.thehindu.com Published On :: Sat, 09 Nov 2024 16:27:20 +0530 Within two-three days of the registration, the CDVs will be deployed on duties like management of pollution hotspots, preventing dust pollution and garbage burning, she said in a press briefing Full Article Delhi
go Code is a new form of government: Clive Thompson By www.thehindubusinessline.com Published On :: Wed, 10 Jun 2020 16:33:11 +0530 The tech journalist and author of Coders explains how programmers have such a huge impact in our everyday lives Full Article Books
go Dialectics of government deficits By www.thehindubusinessline.com Published On :: Sun, 03 Jan 2021 20:03:22 +0530 The book, espousing modern monetary theory, busts a few conservative myths on government spending Full Article Books
go Dangers of going digital By www.thehindubusinessline.com Published On :: Sun, 15 Aug 2021 20:14:02 +0530 AI, ML collect loads of user data which can be misused Full Article Books
go Start-up Compass: How Iconic Entrepreneurs got it Right By www.thehindubusinessline.com Published On :: Mon, 08 Aug 2022 20:25:04 +0530 A relevant book for those about to embark on their entrepreneurial journey, or can serve as a useful resource for those who like to track the start-up ecosystem Full Article Book Reviews
go Goat doctors in Muzaffarpur turn vegetable entrepreneurs By www.thehindu.com Published On :: Thu, 05 Oct 2023 12:11:12 +0530 Aga Khan Foundation has given women in this Bihar district a new source of income with state-of-the-art agricultural technology Full Article Agriculture
go MSP law cannot be brought in a hurry; farmers should come forward for talks with govt: Arjun Munda By www.thehindu.com Published On :: Tue, 13 Feb 2024 17:35:17 +0530 Union Agriculture Minister Arjun Munda cautioned protesting farmers about some elements usurping their protest for political benefits Full Article Agriculture
go Mango output is set to increase by 14% this year; heat wave unlikely to impact yields By www.thehindu.com Published On :: Wed, 03 Apr 2024 15:05:24 +0530 The total production of mangos could jump to 24 million tonnes in the 2023-24 crop year, as against 21 million tonnes in 2022-23 Full Article Agriculture
go Mangoes in Tamil Nadu hit by excessive heat, but farmers hopeful By www.thehindu.com Published On :: Thu, 02 May 2024 16:17:50 +0530 Farmers in Tamil Nadu are struggling with poor yield, but there is also good news with new varieties being discovered Full Article Society
go 2024 turns out to be the worst-ever season for mango growers in Rayalaseema in five decades By www.thehindu.com Published On :: Wed, 22 May 2024 21:15:51 +0530 With over 80% dip in yield following adverse weather conditions, the prospects of earning profits have faded; the situation has turned adverse, as competitors from Telangana and Tamil Nadu started supplying stocks to the pulp units predominantly located in Chittoor district Full Article Andhra Pradesh
go Farm loan waivers and elections: How do they affect farmers and governments? By www.thehindu.com Published On :: Mon, 27 May 2024 22:42:42 +0530 Promises to waive off farm loans have been issued by most political parties during this Lok Sabha election. Here’s a look at how these waivers are implemented, the effect on farmers and governments and what alternatives exist Full Article Lok Sabha Elections
go Mango growers demand uniform relief of ₹30,000 per acre, fixed prices at tripartite meeting in Krishnagiri By www.thehindu.com Published On :: Fri, 07 Jun 2024 20:46:06 +0530 Full Article Coimbatore
go In Assam, banks suffer from ‘militancy hangover’: experts By www.thehindu.com Published On :: Sat, 06 Jul 2024 18:05:51 +0530 The absence of bank linkage is affecting optimum production by 25 lakh small and marginal farmers in the State, they said Full Article Assam
go Budget 2024: Agriculture, Employment, Infrastructure feature in nine priorities of third NDA government By www.thehindu.com Published On :: Tue, 23 Jul 2024 11:34:00 +0530 Union Budget 2024 unveils nine priorities for this financial year as Finance Minister Nirmala Sitharaman delivers her seventh budget speech in Lok Sabha Full Article Budget
go 90-year-old farmer convicted, sentenced to one-year imprisonment for encroaching 36 guntas of government land in Karnataka By www.thehindu.com Published On :: Mon, 19 Aug 2024 12:44:32 +0530 Small and marginal farmers are worried about being punished for encroachment, demand action against influential people who allegedly encroached on government land Full Article Karnataka
go M.P. Cabinet increases MSP for soya bean; proposal to go for Centre’s nod By www.thehindu.com Published On :: Wed, 11 Sep 2024 01:12:11 +0530 Full Article Madhya Pradesh
go Kohli the run-machine goes past Tendulkar but... By www.rediff.com Published On :: Thu, 02 Nov 2023 21:43:12 +0530 Kohli's knock of 88 (94) was his 10th 50-plus score in the ODI format this year second only to Shubman Gill who leads the charts with twelve 50-plus ODI scores in 2023. Full Article
go 'Stats are going out of the window' By www.rediff.com Published On :: Sat, 27 Apr 2024 00:16:42 +0530 'Very pleasing. Most importantly the win, cricket has turned to baseball isn't it? We're delighted with the two points.' Full Article
go Godrej Industries net down 16% to Rs. 116 crore By www.thehindu.com Published On :: Thu, 26 May 2016 00:00:00 +0530 Full Article Mumbai Capital
go Demand for petrol cars hits Tiago By www.thehindu.com Published On :: Thu, 02 Jun 2016 00:00:00 +0530 Full Article Mumbai Capital
go Delay in handover of units from Goa to Daman leaves investors in limbo By www.thehindu.com Published On :: Mon, 06 Jun 2016 00:00:00 +0530 Full Article Mumbai Capital
go Investment limits for govt. bonds to be auctioned By www.thehindu.com Published On :: Mon, 06 Jun 2016 00:00:00 +0530 Full Article Mumbai Capital
go Delay over handover of industrial estate from Goa to Daman and Diu leaves investors By www.thehindu.com Published On :: Mon, 06 Jun 2016 08:33:16 +0530 Full Article Mumbai Capital
go Why is there an upward rally in gold prices? | Explained By www.thehindu.com Published On :: Thu, 31 Oct 2024 08:30:00 +0530 Why is gold considered a safety cushion by central banks? When does demand for the yellow metal peak in India? Why does the World Gold Council expect an increased demand for gold from rural areas? What factors determine gold prices? Full Article Markets
go Dugong trapped in fishing net rescued, safely released into sea, near Thanjavur district By www.thehindu.com Published On :: Sun, 10 Nov 2024 15:37:18 +0530 Forest Department officials said the fishermen who were involved in rescuing the Dugong would be felicitated and rewarded Full Article Tiruchirapalli
go Indu Makkal Katchi youth wing president Omkar Balaji questioned for remarks on Nakkheeran Gopal By www.thehindu.com Published On :: Sun, 10 Nov 2024 16:08:20 +0530 The Coimbatore police question IMK youth wing leader for threatening to “chop off editor’s tongue”, sparking legal action and protests Full Article Tamil Nadu
go Forest Department free coaching helps tribal youth in Jawadhu Hills to get government jobs By www.thehindu.com Published On :: Sun, 10 Nov 2024 18:37:23 +0530 Full Article Tamil Nadu