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China publishes draft guideline for bevacizumab copy biologicals

On 7 April 2020, China’s Center for Drug Evaluation (CDE) published draft guidance on clinical trials for the approval of bevacizumab copy biologicals. This guidance is the second specific guideline released by the CDE in April. The agency also released guidance on adalimumab on 1 April 2020 [1].




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COVID-19 LATEST: Valproate reviews must not be delayed, says medicines regulator

All the most important developments in the COVID-19 pandemic for pharmacists and their teams, as they happen.

To read the whole article click on the headline




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FDA and FTC: Coronavirus Products Are Fraudulent, Could Delay Treatment

March 16, 2020 – Amid rising concerns over “Novel Coronavirus Disease 2019” (COVID-19), the Food and Drug Administration and the Federal Trade Commission took action last week against seven companies for selling fraudulent COVID-19 products. The regulators sent Warning Letters to the companies because these products “are unapproved drugs that pose significant risks to patient […]




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FDA delays decision on approval of Bristol Myers' CAR-T

The FDA has delayed its decision on whether to approve Bristol Myers Squibb’s CAR-T cell therapy by three months. Bristol Myers attributed the delay to its submission of additional information upon the request of the FDA.




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Judge grants request to delay start of prison sentence for former Rep. Duncan Hunter

A federal judge found that the uncertainty surrounding the COVID-19 pandemic was good cause for the delay.




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Who to tip and how much for doorstep deliveries during the COVID-19 pandemic

From cash and snacks to a verbal 'thank you,' there are options when it comes to showing your appreciation for delivery drivers.




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Oregon strip club now delivers food — and a dance on the side

Lucky Devil's dancers put on a show in the parking lot when customers order takeout.




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Reply to: An appeal to cost undermines food security risks of delayed mitigation




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High climate sensitivity in CMIP6 model not supported by paleoclimate




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An appeal to cost undermines food security risks of delayed mitigation




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Reply to: An appeal to cost undermines food security risks of delayed mitigation




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High climate sensitivity in CMIP6 model not supported by paleoclimate




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An appeal to cost undermines food security risks of delayed mitigation






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Chromosome-scale assembly of the <i>Kandelia obovata</i> genome




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AAV-mediated cardiac gene transfer of wild-type desmin in mouse models for recessive desminopathies




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Natural polyphenol assisted delivery of single-strand oligonucleotides by cationic polymers




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Microwave ablation of primary breast cancer inhibits metastatic progression in model mice via activation of natural killer cells




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The impact of 2018 ASCO-CAP HER2 testing guidelines on breast cancer HER2 results. An audit of 2132 consecutive cases evaluated by immunohistochemistry and in situ hybridization




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Executable cancer models: successes and challenges




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This physicist-turned-economist is modelling the pandemic’s financial fallout




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Basement membrane remodelling regulates mouse embryogenesis




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Blood pressure control and complex health conditions in older adults: impact of recent hypertension management guidelines




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Gamma-glutamyltransferase, arterial remodeling and prehypertension in a healthy population at low cardiometabolic risk




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Hypertension in rheumatic diseases: prevalence, awareness, treatment, and control rates according to current hypertension guidelines




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Author Correction: A structural model for microtubule minus-end recognition and protection by CAMSAP proteins




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Telomere-based risk models for the early diagnosis of clinically significant prostate cancer




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MHD surrogate model for convection in electromagnetically levitated molten metal droplets processed using the ISS-EML facility

npj Microgravity, Published online: 16 March 2020; doi:10.1038/s41526-020-0099-7

MHD surrogate model for convection in electromagnetically levitated molten metal droplets processed using the ISS-EML facility




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Short-term NAD<sup>+</sup> supplementation prevents hearing loss in mouse models of Cockayne syndrome




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Organotypic human skin culture models constructed with senescent fibroblasts show hallmarks of skin aging




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Tumor-selective delivery of antisense oligomers (antimiRs) against oncogenic microRNAs

miRNA-targeted antimiRs conjugated to a peptide with a low pH–induced transmembrane structure (pHLIP) could help treat solid tumors.




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Tissue-resident ductal macrophages survey the mammary epithelium and facilitate tissue remodelling




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Oncolytic adenovirus encoding LIGHT (TNFSF14) inhibits tumor growth via activating anti-tumor immune responses in 4T1 mouse mammary tumor model in immune competent syngeneic mice




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Author Correction: Quantum wave–particle superposition in a delayed-choice experiment




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Cannabinoid CB<sub>2</sub> receptors mediate the anxiolytic-like effects of monoacylglycerol lipase inhibition in a rat model of predator-induced fear




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Reduction of depression-like behavior in rat model induced by ShRNA targeting norepinephrine transporter in locus coeruleus




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Rodent models of post-traumatic stress disorder: behavioral assessment




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Efficient generation of mouse models with the prime editing system




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Mendelian neurodegenerative disease genes involved in autophagy




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The Folly and Vanity of The Project to Redesign New Delhi, The Wire

Six years ago, the then editor of the Hindustan Times invited me to write a fortnightly column. I agreed, on condition that there would be no censorship. While occasionally some changes to my text were made without my consent, there was no attempt to get me to rewrite my column or change its arguments. Until [...]




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Modeling shield immunity to reduce COVID-19 epidemic spread




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What Policymakers Should Ask Modelers

With decision-makers relying on a growing torrent of forecasts regarding COVID-19 and other important issues, it is more important than ever that they ask questions about how the projections were made. To use predictive tools more effectively, policymakers should ask four questions in particular.




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Factoring Pandemic Risks into Financial Modelling

Today’s economic crisis leaves us with an unsettling and perplexing regret. Why weren’t financial portfolios already adjusted for risks that stem from health events such as pandemics? After all, financial portfolios are adjusted for liquidity risks, market risks, credit risks, and even operational and political risks.




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What Policymakers Should Ask Modelers

With decision-makers relying on a growing torrent of forecasts regarding COVID-19 and other important issues, it is more important than ever that they ask questions about how the projections were made. To use predictive tools more effectively, policymakers should ask four questions in particular.




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Author Correction: <i>Cdkn1a</i> deletion improves stem cell function and lifespan of mice with dysfunctional telomeres without accelerating cancer formation




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Centros de documentación de diarios en el siglo XXI. Panorama después del tsunami

Guallar, Javier and Cornet, Anna Centros de documentación de diarios en el siglo XXI. Panorama después del tsunami. BiD, 2020, n. 44. [Journal article (Unpaginated)]




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Educar para la transparencia y una ciudadanía informada: diseño, aplicación y evaluación del programa IRIS para alumnado de Bachillerato de la Región de Murcia (España)

Campillo-Meseguer, María-José and Galiano-Martínez, Antonio and Gómez-Hernández, José-Antonio and Hidalgo-Pérez, Antonio and López Aniorte, María-del-Carmen and Martínez-Navarro, Emilio and Molina-Molina, José and Mayor-Balsas, José-Manuel and Ros-Media, José Luis and Oliva-Palazón, Elena and Reverte-Martínez, Francisco-Manuel and Baeza-Hernández, María-José . Educar para la transparencia y una ciudadanía informada: diseño, aplicación y evaluación del programa IRIS para alumnado de Bachillerato de la Región de Murcia (España)., 2020 In: Competencias en Información y Políticas para Educación Superior: Estudios Hispano-Brasileños, volumen 1. Universidad Complutense de Madrid, pp. 123-138. [Book chapter]




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Impact of Covid-19 on the media system. Communicative and democratic consequences of news consumption during the outbreak // Impacto del Covid-19 en el sistema de medios. Consecuencias comunicativas y democráticas del consumo de noticias durante el

Casero-Ripollés, Andreu Impact of Covid-19 on the media system. Communicative and democratic consequences of news consumption during the outbreak // Impacto del Covid-19 en el sistema de medios. Consecuencias comunicativas y democráticas del consumo de noticias durante el brote. El profesional de la información, 2020, vol. 29, n. 2. [Journal article (Unpaginated)]




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Comunicación corporativa, relaciones públicas y gestión del riesgo reputacional en tiempos del Covid-19

Xifra, Jordi Comunicación corporativa, relaciones públicas y gestión del riesgo reputacional en tiempos del Covid-19. El profesional de la información, 2020, vol. 29, n. 2. [Journal article (Unpaginated)]