Disclosed is a spectrofluorimetrically detectable luminescent composition consisting essentially of at least one energy transfer acceptor lanthanide(III) complex having an emission spectrum maximum in the range from 300 to 2000 nanometers and a luminescence-enhancing amount of at least one energy transfer donor selected from the group consisting of a fluorophore, a lumiphore, an organic compound, a salt of an organic ion, a metal ion, a metal ion complex, or a combination thereof. Such energy transfer donor enhances the luminescence of at least one energy transfer acceptor lanthanide(III) complex, with the conditions that the emission spectrum of any energy transfer donor differs from that of its energy transfer acceptor lanthanide(III) complex; and such energy transfer donor can be dissolved to form a unitary solution in a solvent having an evaporation rate at least as great as that of water.

A reagent for conjugation to a biomolecule, wherein the reagent is a single molecule with at least three functional parts and has schematic structure (I): a) wherein a trifunctional cross-linking moiety is coupled to b) an affinity ligand via a linker 1, said affinity ligand being capable of binding with another molecule having affinity for said ligand, to c) an effector agent, optionally via a linker 2, said effector agent exerting its effect on cells, tissues and/or humorous molecules in vivo or ex vivo, and to d) a biomolecule reactive moiety, optionally via a linker 3, said moiety being capable of forming a bond between the reagent and the biomolecule.

This invention relates to bis-azo colorants for use as bluing agents, laundry care compositions comprising bis-azo colorants that may serve as bluing agents, processes for making such bluing agents and laundry care compositions and methods of using the same. The bluing agents are generally comprised of at least two components: at least one chromophore component and at least one polymeric component. These bluing agents are advantageous in providing a whitening effect to fabrics, while not building up over time and causing undesirable blue discoloration to the treated fabrics.

Disclosed herein is a GO-Gd-DTPA (gadolinium-diethylenetriamine pentaacetic-graphene oxide) complex, which is formed by an ester bond of graphene oxide (GO) and gadopentetic acid (Gd-DTPA). Since the GO-Gd-DTPA can stably exist in the body because it has high stability in water, it is expected that it can be effectively used as an MRI contrast agent.

An organic compound has the following chemical structure: wherein R is different from R*; R and R* are independently hydrogen, halogen, nitro or methoxyl; and R1 is a C1-C6 alkyl or a phenyl group. A quaternary data storage device includes a bottom electrode, a top electrode, and the organic film layer sandwiched between the bottom electrode and the top electrode.

The present disclosure relates to an azoquinone compound represented by formula (1) below. In formula (1), R1 to R4 are identical or different and each represents a hydrogen atom, a C1 to C6 alkyl group or a C6 to C12 aryl group, and Ar represents a C6 to C12 aryl group.

A storage rack arrangement (10) for the storage of nuclear fuel elements in a storage pool includes at least two storage racks (1.1-1.3) which each contain a plurality of vertical channels (9) arranged next to one another for the reception of the fuel elements, with positioning elements (6) being provided at the storage racks at the bottom. The storage racks are connected to one another at the top and the storage rack arrangement (10) additionally includes one or more base plates (2.1-2.3) which are provided with positioning members (8) which fit with the positioning elements (6) of the storage racks (1.1-1.3) and which, together with the positioning elements, position the storage racks with respect to the base plate or base plates (2.1-2.3) to prevent a displacement of the storage racks on the base plate or plates.

The present disclosure relates to a Co-029 inhibitor for inhibiting the migration of cancer cells which express Co-029. The disclosure relates to a Co-029 inhibitor for the treatment of cancer and/or the prevention of cancer metastasis and pharmaceutical compositions comprising said inhibitor and provides Co-029 antibodies. The disclosure provides a method for predicting the response of a patient afflicted with or susceptible to be afflicted with cancer to a medical treatment with a Co-029 inhibitor, a method for diagnosing a cancer in a patient and a method for predicting the survival in a cancer patient.

Sponsored-content may be placed based on images in video content. A first image in a frame of a video content item is identified. The first image is matched with a second stored image. A sponsored-content item to be presented is selected based on an association between the second stored image and the sponsored-content item.

A method for virtual channel management is provided. The method includes the following steps. In response to a command, a control unit of a network-based multimedia reproduction system determines whether the command is associated with virtual channel switching. When the command is associated with virtual channel switching, the control unit checks whether a channel value corresponding to the command exists in an application virtual channel table. When the channel value exists in the application virtual channel table, the control unit determines an application corresponding to the channel number from the application virtual channel table, and executes the application. According to a first operation parameter set corresponding to the application, the control unit sets the executed application to retrieve digital contents through a network unit of the network-based multimedia reproduction system.

An optical film has a cellulose acylate film base material containing cellulose acylate and a plurality of sugar ester compounds having different ester substitution degrees in which an average ester substitution degree of the plurality of sugar ester compounds is from 60 to 94%, and an antistatic hardcoat layer formed from a coating composition containing at least an organic antistatic agent and a curable compound having a (meth)acryloyl group in a molecule of the curable compound.

The present invention is directed to the use of the peptide compound Ac-Arg-Phe-Met-Trp-Met-Arg-NH2 as a therapeutic agent for the prophylaxis and/or treatment of cancer, autoimmune diseases, fibrotic diseases, inflammatory diseases, neurodegenerative diseases, infectious diseases, lung diseases, heart and vascular diseases and metabolic diseases. Moreover the present invention relates to pharmaceutical compositions preferably in form of a lyophilisate or liquid buffer solution or artificial mother milk formulation or mother milk substitute containing the peptide Ac-Arg-Phe-Met-Trp-Met-Arg-NH2 optionally together with at least one pharmaceutically acceptable carrier, cryoprotectant, lyoprotectant, excipient and/or diluent.

The present invention is directed to the use of the peptide compound Pyr-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2 as a therapeutic agent for the prophylaxis and/or treatment of cancer, autoimmune diseases, fibrotic diseases, inflammatory diseases, neurodegenerative diseases, infectious diseases, lung diseases, heart and vascular diseases and metabolic diseases. Moreover the present invention relates to pharmaceutical compositions preferably in form of a lyophilizate or liquid buffer solution or artificial mother milk formulation or mother milk substitute containing the peptide Pyr-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2 optionally together with at least one pharmaceutically acceptable carrier, cryoprotectant, lyoprotectant, excipient and/or diluent.

Mono-pegylated arginase conjugate and method producing thereof. The mono-pegylated arginase is homogeneous in molecular weight and shows therapeutic effect for treating cancers and viral infections. The method of producing such arginase conjugate has a main step of genetically modifying the gene encoding an arginase so that the PEG moiety can attach to the enzyme at a predetermined, specific intended site. This is achieved by removing the PEG attaching amino acid residues at undesirable sites while keeping (or adding, if necessary) the one at the desirable site of the enzyme. Two exemplary mono-pegylated arginase conjugates so produced are human arginase I (HAI) where a polyethylene glycol (PEG) moiety is site-specific covalently bonded to Cys45 of the enzyme and Bacillus caldovelox arginase (BCA) where a polyethylene glycol (PEG) moiety is site-specific covalently bonded to Cys161 of the enzyme.

The present invention relates to treating a tissue in a mammal from the effects of reperfusion using flagellin.

Disclosed is a drug effective in the treatment of fibromyalgia. Basically, the disclosed therapeutic agent was created on the basis of experiments showing improvement in symptoms when etanercept was administered to patients suffering from fibromyalgia. Etanercept is known as a therapeutic agent for rheumatoid arthritis, and the JFIQ score of patients not suffering from fibromyalgia improved considerably in the preferred embodiment. In other words, a therapeutic agent for fibromyalgia is disclosed that contains etanercept as an active ingredient in an effective amount.

A method of treating a disease or condition in which up-regulating GAGs is therapeutically beneficial is disclosed, in particular osteoarthritis and skin diseases. The method comprises locally administering to a subject a therapeutically effective amount of an agent capable of down-regulating activity or expression of a component of the renin-angiotensin system.

The present invention provides variable mass labeling reagents, a set of the variable mass labeling reagents, and a multiplexed set of variable mass labeling reagents.

A data storage and retrieval system includes a head carriage unit adapted for rotational motion and having multiple heads disposed at a working surface. The system also includes a tape drive unit configured to move a tape media past the working surface of the head carriage unit, the tape media having a width approximately equal to a width of the working surface. As the head carriage unit rotates and the tape moves past the working surface, a first head is configured to write a data track to the tape and a second head is configured to thereafter read the data track, where data read by the second head is for use in verifying data integrity and performing error correction.

In one embodiment an enclosure for a high-density storage system, comprises a backplane to which a plurality of data storage devices may be coupled, a front panel opposite the backplane and defining a first airflow channel adjacent a front side of the data storage devices, a back panel opposite the front panel and comprising a second airflow channel adjacent the backplane, a floor panel and a top panel, a first side panel comprising an array of air flow inlets, a second side panel comprising at least one air flow outlet, and a fan assembly to expel air from the at least one air outlet.

A forage harvester has an engine which is drivingly connected to a chopper cylinder via first drive belt, and to a first end of a drive shaft of a discharge accelerator. A second end of the drive shaft of the discharge accelerator is drivingly connected to a kernel processor via a second drive belt, is arranged, in the direction of harvested material flow, between the chopper cylinder and the discharge accelerator. The discharge accelerator comprises support disks which extend radially, and paddles. The support disks are attached to a hollow shaft enclosing the drive shaft, and, a sensor is arranged between the drive shaft and the discharge accelerator for the determination of the force transmitted by the drive shaft to the discharge accelerator.

A granular material stirring apparatus for breaking up clumps of a granular material in an interior of a storage bin comprises a base assembly for resting on a floor of the bin, an agitation rotor rotatably mounted on the base assembly, and a rotation device connected to the rotatable agitation rotor to cause the agitation rotor to rotate with respect to the base assembly. The agitation rotor may include a central member rotatable about a substantially horizontal axis and a plurality of stirrer members extending substantially radially outwardly from the central member to rotate about the substantially horizontal axis.

A method for filling sausages with a paste-like substance by means of a filling machine and to a filling machine for performing this method, including a sensor unit capable of determining at least one parameter that varies differently for different paste-like substances as a function of time. Depending on the at least one determined parameter, a controller determines whether a measure to be implemented on one or more wearing parts is necessary, the wearing parts wearing out at different times depending on the different paste-like substances.

The present invention relates to a loading station for a storage frame. In the loading station, the storage frame serves for temporarily holding and transporting rod-like elements, in particular smoking rods, on which sausage-shaped products, like sausages, are stored, and comprises two side parts, wherein each side part has two supports being substantially parallel to each other and wherein the side parts are connected with each other by at least one cross beam, and horizontally arranged trays for accommodating rod-like elements. The loading station comprises at least one position defining device for defining a predetermined position of the storage frame. Moreover, at least one locking device is provided for releasably locking of the storage frame in its predetermined position.

A power storage device cell is configured to include a capacitor positive electrode, a lithium positive electrode, and a common negative electrode in which electrode layers are formed on a collector foil in which penetration holes are formed, and such that the capacitor positive electrode and the lithium positive electrode are directly connected; each of the electrode layers of the common negative electrode is formed of a carbon-based material in which graphite particles and hard carbon particles are mixed, and the proportion of the hard carbon particles in the carbon-based material is from 5% by weight to 70% by weight.

An energy storage composite particle is provided, which includes a carbon film, a conductive carbon component, an energy storage grain, and a conductive carbon fiber. The carbon film surrounds a space. The conductive carbon component and the energy storage grain are disposed in the space. The conductive carbon fiber is electrically connected to the conductive carbon component, the energy storage grain, and the carbon film, and the conductive carbon fiber extends from the inside of the space to the outside of the space. The energy storage composite particle has a high gravimetric capacity, a high coulomb efficiency, and a long cycle life. Furthermore, a battery negative electrode material and a battery using the energy storage composite particle are also provided.

When a continuous short circuit occurs between both terminals of a battery pack, fault, destruction and rupture of the battery can occur. Further, when a momentary short circuit occurs, a user may continue to use, without knowing thermal and electrical damage to the batteries, and reliability for the batteries is impaired, To overcome the problem, in a battery pack configured by connecting a plurality of storage batteries in series, at least one first storage battery is included which has a low capacity compared to second storage batteries during high-rate discharge, and the first storage battery undergoes polarity inversion during external short circuit, thereby preventing the other batteries from becoming damaged. There are also included a detector that detects voltage of the first storage battery, and a fault signal generator that generates an output fault signal when a voltage detected by the detector inverses.

An information storage device having a first part such as an insert on which information is provided and a second part comprising a holder for the first part, whereby the first part may be stored in the second part. The edges of the first and second parts may be provided with lips for mating together to provide interlocking parts whereby the first part may be pulled outwardly to expose the information thereon but is prevented from being completely separated from the holder.

A business form is provided which is particularly useful in shipping products where certain preprinted information can be provided and then individualized information is printed before the form is applied to a substrate. The form includes a face ply which has a pattern of adhesive applied to at least a portion of the inner face, and a release liner which includes a pattern of adhesive which exposes a portion of the release liner to direct adhesive contact to the face ply without intervening release coating to permanently adhere a part of the release liner to the face ply. The release liner has a surrounding protective border provided with release coating on the release face thereof and which is removed prior to application to the substrate, and a slip which remains with the form as applied to the substrate. The face ply includes lines of perforation defining a central portion. At least a part of the central portion is directly adhered by the adhesive to the slip without intervening release coating between the adhesive and the slip or the central portion. Individualized indicia, such as an address, may be printed on a label area of the top face of the central portion, while other individualized indicia, such as the content of a package, may be printed on the back face of the slip. Masking indicia is preferably provided on one of the inner face of the top ply or the release face of the release liner to inhibit viewing of the content indicia until the slip is removed from the package.

A printer, as an image forming apparatus, reverses the front and back sides of tab sheets that became no longer necessary and discharges when a reverse discharge is specified.

The invention provides the user a first insertion page position setting part that allows a user to designate insertion page positions that respectively indicate pages at which first tab sheets are to be inserted, and a second insertion page position setting part that allows the user to designate insertion page positions that respectively indicate pages at which second tab sheets are to be inserted, when a request for initiating the setting concerning the tab sheets is received. Further, the tab positions in the second tab sheets, which correspond to the insertion page positions designated in said second insertion page position setting part, are set up in accordance with the tab positions in the first tab sheets, which correspond to the insertion page positions designated in said first insertion page position setting part.

In contrast to slot-type gaming machines with their preset paylines designating predetermined array positions, the paylines of this novel wagering game are unknown until the indicia in the array have been selected. The indicia are selected from a variety of indicium types, each having a different number of members for identifying adjacent indicia. The randomly selected indicia determine the paylines, if any, in the array. Conditions may be imposed that limit the size and geometry of the paylines in this wagering game.

A method for controlling within a printer driver the insertion of tab sheets into a print job. According to one embodiment, sheets of multiple levels are insertable. The printer driver provides at least input fields for entry and display of parameters for the definition of at least one tab sheet, and an interactive area for visualizing the hierarchical structure and the order of the at least one defined tab sheet corresponding to the level of the tab sheet in the print job. Depending on changes of a tab sheet defined by entered parameters, the visualization of the hierarchical structure and the order of the at least one defined tab sheet in the print job is updated in the interactive area.

A system and method are disclosed for providing location-based wagering. In one embodiment, wagerable data associated with a location of a first user is identified. The wagerable data may be any type of data on which a wager may be based. Then, a wager recommendation is generated based on the wagerable data and returned to the first user. The first user defines a wager, and the wager is published to one or more second users located in proximity to the first user. Each of the one or more second users is enabled to accept the wager if desired. In addition, one or more winners and one or more losers of the wager may be identified and payout may then be effected.

A method is described for producing a character, pattern, symbol and/or image (8) on a substrate (2) by way of pigment particles (1) which are arranged thereon and lose their color effect under the action of a laser (23), wherein different pigment particles (1) with at least three different color effects are arranged on and/or in the substrate (2). The invention is distinguished by the following method steps: (a) production of a color chart (14), in which the individual color effect of individual pigment particles (1) or individual clusters of pigment particles is contained as a function of their spatial coordinate on and/or in the substrate (2); (b) spatially resolved irradiation, which changes the color effect of only individual pigment particles (1) or individual clusters of pigment particles, by way of a laser (23) at a single frequency on the basis of the color chart (14) in order to produce a resulting color effect. Furthermore, the present invention relates to substrates, in particular security documents, produced using a method of this type, and devices for carrying out methods of this type.

A magnetic storage medium is formed of magnetic nanoparticles that are encapsulated within nanotubes (e.g., carbon nanotubes).

A novel information storage device is disclosed and claimed. The information storage device includes a device housing with a generally rectangular bay to accommodate a disk drive. The generally rectangular bay includes a base portion and a plurality of side portions. The information storage device further includes a damping insert sheet disposed between the disk drive and the base portion. The damping insert sheet has a plurality of elastomeric cushions, for example with a cushion thickness in the range 0.5 mm to 10 mm, and a spanning sheet, for example having a sheet thickness in the range 0.02 mm to 0.35 mm. Each of the plurality of elastomeric cushions is attached to the spanning sheet. Each of the plurality of elastomeric cushions contacts and is compressed between the generally rectangular bay and the disk drive.

Various embodiments concern a DSA suspension of a disk drive. The DSA suspension comprises a support configured to attach to the disk drive, the support comprising a proximal portion, a distal portion, and a linkage portion therebetween. The DSA head suspension system further comprises at least one motor mounted on the support, each motor positioned between the proximal portion and the distal portion. The DSA suspension further comprises a damper attached to some or all of the proximal portion, the motor(s), the distal portion, and the linkage portion. The damper can be a single layer or multilayered. The damper can comprise viscoelastic material. The damper can be adhesive. The damper may only be attached to the support and the motors and not to other components of the DSA suspension.

Various embodiments concern a dual stage actuation suspension that comprises a loadbeam having a load point projection. The suspension further comprises a gimbal assembly having a point of contact that is in contact with the load point projection such that the gimbal assembly can gimbal about the load point projection. The gimbal assembly is cantilevered from the loadbeam and has an axis of rotation aligned with the load point projection and the point of contact. The suspension further comprises a pair of motors mounted on the gimbal assembly and positioned proximal of the point of contact. The pair of motors is mounted between a tongue and a pair of spring arms to rotate the tongue about the point of contact and the load point projection. The loadbeam further comprises a void into which the pair of motors extends.

Methods for providing magnetic storage elements with high magneto-resistance using Heusler alloys are provided. One such method includes depositing a substrate including NiFe, depositing a seed layer on the substrate, depositing a buffer layer on the seed layer, and growing, epitaxially, an upper layer on the buffer layer, the upper layer including a Heusler alloy.

A disk drive is disclosed comprising a disk, and a slider comprising a head, where the head comprises a write component electrically insulated from the slider. A bias voltage is applied to the write component, and a current flowing between the write component and the disk is measured, wherein the current is indicative of a fly height of the head.

The present subject matter is directed to a bearing assembly for a wind turbine. The bearing assembly includes an outer race, an inner race rotatable relative to the outer race, a plurality of rolling elements positioned between the inner and outer races, and a cage assembly configured to maintain separation between neighboring rolling elements. The cage assembly includes a plurality of cage elements and a plurality of spacers. Each of the cage elements are separated by at least one of the spacers. Further, each of the cage elements extends around at least a portion of the plurality of rolling elements. Moreover, at least one of the spacers contact one or more of the rolling elements.

A roller bearing cage has a cage element adapted for retaining the generally cylindrically shaped rollers and allowing the rollers to be rollable therein. The cage element includes a main portion having a plurality of pockets, an outward flange portion extending outwardly in a radial direction and an inward flange portion extending outwardly in the radial direction. The outward flange portion is formed on a side edge of the main portion and the inward flange is formed on an opposite side edge portion thereof. The main portion defines the smallest diameter of the bearing cage and is less than the roller pitch diameter.

A two piece rolling element cage for a bearing assembly comprising a first and second cage, with axial projections extending from a cage body, oriented toward each other and inserted between rolling elements, on opposite axial ends of the rolling elements.

A cage for a roller bearing includes a first annular portion and a second annular portion opposite the first annular portion and a plurality of pillars interconnecting the first annular portion and the second annular portion. Adjacent pairs of the pillars each define a pocket for holding rollers. Each of the pockets is configured to receive at least one roller. One or more radially outward facing concave roller support surface is formed in one or more of the pillars at a position proximate a radially outer edge of the pillar. The concave roller support surface is configured to radially outwardly support a portion of one of the rollers.

There is provided a resin cage of a tapered roller bearing. The cage includes a small diameter annular portion, a large diameter annular portion, and a plurality of bar portions arranged at intervals in a circumferential direction to connect the annular portions. The bar portion has a pair of circumferentially-directed side surfaces, each having a roller guide surface, and an inner-side inner peripheral surface, a circumferential width of which is smaller on a side of the large diameter annular portion than on a side of the small diameter annular portion, and has a roller retaining region in which a radially outer side pocket width and a radially inner side pocket width between the opposed circumferentially-directed side surfaces of the adjacent bar portions are smaller than a diameter of the roller.

A cage, which is annular, and is used in a thrust roller bearing, includes a plurality of cage segments arranged in a circumferential direction. Each of the cage segments includes an arc portion; and a bar portion that extends radially inward from the arc portion and that maintains a circumferential interval between rollers adjacent to each other. A groove portion extending along an axial direction is formed at each of end faces of the arc portions, the end faces facing each other in the circumferential direction. In the cage, elastic bodies are inserted into the groove portions and urge the arc portions in the circumferential direction, each of the elastic bodies is disposed between the end faces facing each other, and the cage segments are connected to each other by the elastic bodies.

Administering message acknowledgements in a parallel computer that includes compute nodes, with each compute node including a processor and a messaging accelerator, includes: storing in a list, by a processor of a compute node, a message descriptor describing a message and an acknowledgement request descriptor describing a request for an acknowledgement of receipt of the message; processing, by a messaging accelerator of the compute node, the list, including transmitting, to a target compute node, the message described by the message descriptor and transmitting, to the target compute node, the request described by the acknowledgement request descriptor; receiving, by the messaging accelerator from the target compute node, an acknowledgement of receipt of the message, including notifying the processor of receipt of the acknowledgement; and removing, by the processor from the list, the message descriptor and the acknowledgment request descriptor.

The techniques described herein implement an operating system that can reliably process time sensitive information in non real-time manner. Thus, the operating system described herein is capable of processing an instance of time sensitive input during a time period after the instance of time sensitive input is received (e.g., at a future point in time). To accomplish this, the techniques timestamp each instance of time sensitive input when it is received at a device. The techniques then store the timestamped instance of time sensitive input in a temporary queue, and make the timestamped instance available to the operating system at a time period after the time period when it is received, as indicated by the timestamp. Additional techniques described herein prioritize the activation of a driver configured to receive the time sensitive information during a boot sequence or a reboot sequence.

A status management device is presented, the device including multiple first application units for monitoring status information indicating a status of a management target, multiple second application units for outputting first acquisition request information of the status information with identification information of the management target, a search unit for outputting a storage location corresponding to the identification information when the first acquisition request information is received from the second application unit, a request unit for outputting second acquisition request information of the status information to the first application unit corresponding to the outputted storage location, and a transmission unit for outputting the status information supplied from the first application unit in response to the second acquisition request information to the second application unit which corresponds to a request source of the first acquisition request information.