Disclosed herein are compounds of formula I: X-(L-Z)p-L-R[L-(Z-L)p-Y]q (I) wherein L is a perfluoropolyether; R is q can be an integer equal to or greater than 1; p can independently be integers from 0 to 7; X and Y can independently be chosen from: —OH, —CH2CH2OH, CH2CH2OCH2CH2OH, —CH2CH(OH)CH2OH, —C6H5, —CH2C6H5, —CH2CH(OH)CH3, F, —CF3, —CF2CF3, piperonyl, triazine, benzotriazole, and derivatives thereof; and Z, if present, can independently be chosen from: —C6H4—, —CH2C6H4CH2—, —CH2CH(OH)CH2—, —CH2CH(OH)CH2CH(OH)CH2—, —CH(OH)CH(OH)CH2—, —CH(CH2OH)—, or —CH(C6H5)—.

Lubrication additives of the current invention require formation of emulsions in base lubricants, created with an aqueous salt solution plus a single-phase compound such that partitioning within the resulting emulsion provides thermodynamically targeted compounds for boundary layer organization thus establishing anti-friction and/or anti-wear. The single-phase compound is termed “boundary layer organizer”, abbreviated BLO. These emulsion-contained compounds energetically favor association with tribologic surfaces in accord with the Second Law of Thermodynamics, and will organize boundary layers on those surfaces in ways specific to the chemistry of the salt and BLO additives. In this way friction modifications may be provided by BLOs targeted to boundary layers via emulsions within lubricating fluids, wherein those lubricating fluids may be water-based or oil-based.

A water-soluble metalworking oil agent is provided by blending the following components A, B, C and D: (A) at least one of a condensed fatty acid obtained by dehydration-condensing a ricinoleic acid, and a condensed fatty acid obtained by dehydration-condensing a monovalent carboxylic acid with an alcoholic hydroxyl group of a condensed fatty acid obtained by dehydration-condensing a ricinoleic acid;(B) an ester compound provided by a dehydration condensate of a monovalent or multivalent alcohol and a monovalent carboxylic acid;(C) an amine compound; and(D) water. A blend ratio of the component A is 10 mass % or more of a total amount of the oil agent and a blend ratio of the component B is 5 mass % or more of the total amount of the oil agent.

A tool stocker includes main stockers for holding a plurality of tools detachably mounted on a main spindle for machining a workpiece, an auxiliary stocker for holding and transferring tools to and from the main stockers, and a tool transfer mechanism for transferring tools between the main stockers and the auxiliary stocker. The auxiliary stocker includes a plurality of tool pods for removably supporting the tools therein, a rail in sliding engagement with outer surfaces of the tool pods, a chain for moving the tool pods in sliding engagement with the rail, and a motor for actuating the chain. The rail has a recess defined therein in alignment with the tool transfer mechanism, such that the tools transferred by the tool transfer mechanism pass through the recess.

Device for managing the electrodes for electrical discharge machining EDM machine tools comprises at least one magazine (1) that has a series of individual housings (33) designed to accept and hold exchangeable elements (5) consisting of electrodes (6, 22) mounted on an electrode holder (11a, 11b), and a changer device (2) equipped with a gripper (2) intended to move the exchangeable elements (5) from the individual housings (33) towards the machine and vice versa. A first adapter piece (21) is associated with each of the exchangeable elements (5). This adapter piece (21) surrounds the electrode holder (11a, 11b) and is gripped around its periphery by the gripper (9) of the changer (2) so as to guarantee that the exchangeable element (5) is held precisely. The device further comprises a second adapter piece (32) associated with each of the individual housings (33) of the magazine (1) that are likely to be used.

A network component comprising at least one processor coupled to a memory and configured to exchange security information using a plurality of attributes in a management entity (ME) in an optical network unit (ONU) via an ONU management control interface (OMCI) channel, wherein the attributes provide security features for the ONU and an optical line terminal (OLT). Also included is an apparatus comprising an ONU configured to couple to an OLT and comprising an OMCI ME, wherein the OMCI ME comprises a plurality of attributes that support a plurality of security features for transmissions between the ONU and the OLT, and wherein the attributes are communicated via an OMCI channel between the ONU and the OLT and provide the security features for the ONU and the OLT.

A repeater includes a reception part configured to receive an optical signal transmitted by wavelength division multiplexing from a preceding repeater in a path from a source to a destination; a determination part configured to determine the channel allocation of the signal received by the reception part by determining a bit rate and a modulation technique with respect to each of channels in the received signal; and a detection part configured to detect a prohibited channel not to be included in the optical signal to be transmitted from the repeater, based on the channel allocation and a predetermined criterion.

An apparatus for sampling and storing biological fluids from a human or animal subject is provided. In one embodiment of the present disclosure, the apparatus includes a main body, lancet carrier or hub, lancet, lancet trigger, capillary tube, and sample compartments for collecting and storing dried blood and other bodily fluids. The lancet hub supports a lancet and provides for moving the lancet longitudinally between a first retracted position and a second extended position. The device includes a capillary tube having an internal diameter sized to draw and retain fluid from a contacted source using capillary action. The main body of the apparatus further includes a sample compartment for holding sampling and storage materials. In at least one embodiment of the present disclosure, the sample compartment can be accessed by lifting sample compartment lid. Also included is a new “fan” or “daisy” shaped collection material format for use in collecting and preserving samples.

The present invention is for extremely pure solutions of chlorine dioxide, methods for making such solutions and to compositions and methods for storing, shipping and using such solutions. Generally, the chlorine dioxide solutions of the invention are aqueous solutions containing about 2500 ppm or less of total impurities. The chlorine dioxide solution can be prepare by passing dilute highly pure chlorine gas through a bed of substantially solid sodium chlorite and contacting the resulting chlorine dioxide gas with a liquid.

A 3D image sensor includes a depth pixel that includes; a photo detector generating photo-charge, first and second floating diffusion regions, a first transfer transistor transferring photo-charge to the first floating diffusion region during a first transfer period in response to a first transfer gate signal, a second transfer transistor transferring photo-charge to the second floating diffusion region during a second transfer period in response to a second transfer gate signal, and an overflow transistor that discharges surplus photo-charge in response to a drive gate signal. Control logic unit controlling operation of the depth pixel includes a first logic element providing the first transfer gate signal, a second logic element providing the second transfer gate signal, and another logic element providing the drive gate signal to the overflow transistor when the first transfer period overlaps, at least in part, the second transfer period.

The range image sensor is a range image sensor which is provided on a semiconductor substrate with an imaging region composed of a plurality of two-dimensionally arranged units (pixel P), thereby obtaining a range image on the basis of charge quantities QL, QR output from the units. One of the units is provided with a charge generating region (region outside a transfer electrode 5) where charges are generated in response to incident light, at least two semiconductor regions 3 which are arranged spatially apart to collect charges from the charge generating region, and a transfer electrode 5 which is installed at each periphery of the semiconductor region 3, given a charge transfer signal different in phase, and surrounding the semiconductor region 3.

An estimation device is configured to estimate a feature value of a specific component contained in a sample and includes: a spectral estimation parameter storage module; a calibration parameter storage module; a multiband image acquirer; an optical spectrum operator configured to compute an optical spectrum from a multiband image using a spectral estimation parameter; and a calibration processor configured to compute the feature value from the optical spectrum using a calibration parameter.

A dispersion managed interferometric fiber optic gyroscope comprising: a coupler coupled to the broadband light source via a first input fiber; an IOC comprising: a beamsplitter that directs the input signal to a first output and a second output; a combiner configured to combine a first return signal from the first output and a second return signal from the second output into a combined return signal; an integrated optical circuit input coupled to the coupler via a second input fiber; a fiber optic gyroscope sensing coil coupled to a first pigtail fiber and second pigtail fiber, the sensing coil comprising sensing fibers, wherein at least one dispersion slope of at least one of the first input fiber, second input fiber, first pigtail fiber, second pigtail fiber, and the sensing fibers is selected such that the signals at the IOC input has a second order coherence substantially equal to two.

A reflection type optical sensor that detect a surface condition of a moving body and that is used for an image generation apparatus which forms images on a recording media includes a light-emitting device which has a plurality of light emitter systems including at least two light-emitting members and a light-emitting optical system having a plurality of light-emitting lenses corresponding to a plurality of the light emitter systems and guiding light emitted from the light emitter systems to the moving body and a light-receiving device which has a light receiver system including at least two light-receiving members and a light-receiving optical system having light-receiving lenses corresponding to the at least two light-receiving members and guiding light reflected by the moving body to the light receiver system. The image generation apparatus has further a surface condition judging device in addition to the reflection type optical sensor.

A scrapbooking page alignment device for temporarily aligning at least two adjacent scrapbook pages having retention receivers extending from their respective spine edges, the device comprising (i) a base; and (ii) two or more spaced retention posts extending from said base; where said retention posts are dimensioned to temporarily receive the retention receivers of the two adjacent scrapbook pages.

A switching circuit (400) comprising an inductive component (406) including at least one winding; and a switch (404) is configured to transfer power from a voltage source (402) to the inductive component (406) in accordance with a switch control signal (412). The switching circuit (400) also comprises a controller (408) configured to integrate the voltage across the inductive component (406) in order to generate a signal representative of magnetic flux in the inductive component (406); and use the signal representative of the magnetic flux in the inductive component to account for a peak magnetization current value in order to control the switch (404).

An additional electric power receiving method replacing conventional grounding with a negative voltage source includes the step of transmitting electromagnetic wave or current from a power supply source to a rectifier, wherein a grounding end of the rectifier is in electrical communication with the negative voltage source, and the negative voltage source is selected from a negative potential intrinsic of an organism. A device applicable to the electric power receiving method includes a rectifier having an input end and two output ends, wherein the input end is in electrical communication with a power supply source, and rectified direct current is transmitted from the output ends. With the method and device, not only an increase in additional electric power obtained is achieved, but conversion efficiency and stability of current and electromagnetic wave is enhanced.

A power supply can provide brown-out protection and overheat protection. The power supply includes a rectifier, a transformer, and a power management device. The rectifier is used for receiving an alternating current voltage. The alternating current voltage has a voltage cycle. The transformer coupled to the rectifier has an inductor coupled to a switch for supplying an output voltage. The power management device is used for controlling the switch to make the inductor save power or release power. The power management device has a multi-functional pin coupled to the rectifier for receiving a detection voltage corresponding to a positive half cycle of the alternating current voltage. The multi-functional pin is also coupled to a thermistor for receiving an overheat protection signal.

A power converter and a method for balancing voltages across input capacitors are disclosed in the present application. The power converter includes: two DC input terminals; a first input capacitor and a second input capacitor; a first bridge arm and a second bridge arm connected in series with one another; and an output circuit configured to generate a signal required by the power converter based on the signals at a midpoint of the first bridge arm and a midpoint of the second bridge arm. The power converter further includes: a first voltage balancing unit and a second balancing unit configured to reduce a voltage difference between the first input capacitor and the second input capacitor. The power converter provided by the present application solves the problem of imbalance in the voltages across the first input voltage and the second input voltage.

A voltage regulator coupled to an unregulated DC input voltage source by an input terminal, and to a load by an output terminal is disclosed. The voltage regulator converts an input voltage at the input terminal to an output voltage at the output terminal. The voltage regulator includes one or more slaves, and each slave includes a switching circuit which serves as a power switch for alternately coupling and decoupling the input terminal to an intermediate node. The voltage regulator also includes a filter coupled to the slaves, the filter including one or more inductor banks each of which having a predetermined number of inductors.

The invention discloses a voltage source converter and a voltage source converter system. The voltage source converter comprises: a multi-level voltage source converter, being adapted to output a multiple levels of a first voltage at one of two first output terminals through a multiple of first conducting paths; a first energy store; and a first switching element, being arranged to directly connected with the first output terminal, and being adapted to switch the first energy store in or out of the first conducting path so as to combine a level of the voltage of the first energy store with the level of the first voltage as a second voltage output at a second output terminal. By having the topology as above, the voltage class of each of the power semiconductors can be kept lower with the number of the power semiconductors unchanged. Besides, VDRM is lowed as compared to conventional topology. This renders the reduction of the cost and the increase of the liability.

A Low Forward Voltage Rectifier (LFVR) circuit includes a bipolar transistor, a parallel diode, and a capacitive current splitting network. The LFVR circuit, when it is performing a rectifying function, conducts the forward current from a first node to a second node provided that the voltage from the first node to the second node is adequately positive. The capacitive current splitting network causes a portion of the forward current to be a base current of the bipolar transistor, thereby biasing the transistor so that the forward current experiences a low forward voltage drop across the transistor. The LFVR circuit sees use in as a rectifier in many different types of switching power converters, including in flyback, Cuk, SEPIC, boost, buck-boost, PFC, half-bridge resonant, and full-bridge resonant converters. Due to the low forward voltage drop across the LFVR, converter efficiency is improved.

A high voltage full wave rectifier and doubler circuit having complementary serially connected low voltage MOSFET stacks to provide high voltage capability. The state of the MOSFETs in the MOSFET stacks is controlled by means of resistors coupled between the circuit's outputs and a time varying input signal. The resistance values of the resistors are selected to maintain operation of the stacked MOSFETs below their breakdown voltages.

System and method for regulating a power converter. A system for regulating a power converter includes a controller, a first switch, and a second switch. The controller is configured to generate a first switching signal and a second switching signal. The first switch is configured to receive the first switching signal, the first switch being coupled to an auxiliary winding of the power converter further including a primary winding and a secondary winding. The second switch is configured to receive the second switching signal and coupled to the primary winding of the power converter. The controller is further configured to, change, at a first time, the second switching signal to open the second switch, maintain, from the first time to a second time, the first switching signal to keep the first switch open, and change, at the second time, the first switching signal to close the first switch.

An aspect of the present invention relates to glass for a magnetic recording medium substrate, which includes essential components in the form of SiO2, Li2O, Na2O, and one or more alkaline earth metal oxides selected from the group consisting of MgO, CaO, SrO, and BaO, wherein a molar ratio of a content of MgO to a combined content of MgO, CaO, SrO, and BaO (MgO/(MgO+CaO+SrO+BaO)) is equal to or greater than 0.80, and which has a Young's modulus of equal to or greater than 80 GPa, and a glass transition temperature of equal to or greater than 620° C.

A data storage device is disclosed comprising a head actuated over a disk, wherein the head comprises a laser configured to heat the disk while writing data to the disk. A temperature is measured, and a first input power is generated based on a first function of the measured temperature, wherein the first function compensates for a temperature dependent output power of the laser. A second input power is generated based on a second function of the measured temperature, wherein the second function compensates for a temperature dependent coercivity of the disk. The first input power is combined with the second input power to generate a write power applied to the laser while writing data to the disk.

A machine readable information storage medium, a reproducing method and apparatus which reproduces data from the storage medium, and a recording method and apparatus for recording data on the storage medium. The information storage medium includes a control area which stores within a data structure information usable by the recording or reproducing apparatus to record or reproduce the data on or from the storage medium. The information stored within the data structure includes a version corresponding to a specification.

A compression dressing and method of use is provided. The dressing is self-adherent, washable and reusable and provides a selected and generally constant pressure to the surface of an animal.

A bandage includes a reservoir filled with a perfluorochemical fluid, saturated with oxygen. Oxygen passes through a permeable membrane to the skin or wound to promote healing, and carbon dioxide travels from the skin or wound to the reservoir.

A junctional and truncal tourniquet and a hip-girdling pelvic sling device for maintaining a desired amount of tension surrounding a person's hips and pelvis to securely support and stabilize a pelvis that has been fractured and for securing a pressure applying device to a person so that blood vessel-occluding pressure can be applied. Areas of mating types of fastener material such as mating hook-bearing fastener material and loop pile fastener material are arranged on the device to enable a strap to be secured at various effective lengths to provide a wide range of adjustability. The device may include inflatable bladders, stays, and a chin support and may be wrapped around a patient's neck as a cervical support collar, or around the torso to occlude blood vessels proximal to an injury on a limb.

The invention relates to dietary fiber for human and animal nutrition and more particularly to roughage consisting of a fiber formulation containing lignocellulose. Said formulation contains a fraction of a fibrous substance that is fermentable in the digestive tract and a fraction of a fibrous substance that is poorly or non-fermentable in the digestive tract.

A method for preparing lignin graft copolymer comprising: reacting lignocellulosic materials with an acrylic compound by bulk condensation under nitrogen atmosphere in the presence of a non-oxidizing strong organic acid as catalyst; separating the reaction mixture to obtain a solid phase mainly containing lignocellulosic materials and a liquid phase containing lignin graft copolymer and unreacted acrylic compound; and removing solvent from the liquid phase to obtain the lignin graft copolymer.

Disclosed are soil additives capable of hydrophilizing soil particles and/or increase available water capacity in soil. The soil additive are capable of increasing the available water content/capacity (AWC) in soils, the additive in one embodiment comprising a polymer composition having a hydrophilic portion and a hydrophobic portion, wherein the hydrophobic portion of the copolymer binds with the soil particle surface and the hydrophilic portion of the copolymer can bind with water. This results in the prevention, arrest or decelerated loss of water from the targeted area, for example the plant root zone, which allows for improved water usage efficiency by plants, grasses, vegetation, etc.

A polyester resin is a polycondensate obtained by reacting a divalent alcohol, a divalent carboxylic acid, and a mono- or divalent rosin by the use of a zinc compound as a reaction catalyst.

The present invention relates to an image-based, patient-specific medical spinal surgery technique and to a spinal prosthesis used in the surgery, and particularly, to an image-based, patient-specific medical spinal surgery technique and to a spinal prosthesis which are intended to solve a problem of damage to a spine caused by installing a spinal prosthesis used in spinal surgery, by introducing an image of a patient to manufacture an insertable spinal prosthesis that is customized for a shape of a spine of an individual patient in a polymer-based material.

Fluoroaryl Grignard reagents are produced from a hydrocarbyl Grignard reagent and fluoroaromatic compounds via separate additions of different fluoroaromatic compounds, such that the conversion of hydrocarbyl Grignard reagent to the desired fluoroaryl Grignard reagent is essentially complete, and thus the reaction product is free or essentially free of agents that may negatively affect subsequent reactions. The fluoroaryl Grignard reagents may be further reacted with boron trihalides in order to obtain tris(fluoroaryl)boranes or tetrakis(fluoroaryl)borates.

The present invention relates to a rapid, sensitive, simple, and cost-effective spectrophotometric method of detecting and quantifying mycolic acid in a mycolic acid-fuschin dye complex with absorbance maxima ranging between 490-500 nm in the presence of various test compounds, for screening mycolic acid biosynthesis inhibitors useful as anti-microbial agents and a diagnostic kit thereof comprising basic fuschin dye in the concentration ranging between 0.1-1.0 gm/100 ml, phenol and 95% ethanol in the ratio ranging between 1:4 to 2:1 (v/v), and phenol and distilled water in the ratio ranging between 1:14 to 1:25.

A universal linker structure is provided, in which a functional group and activating leaving group are placed on a tether, allowing the placement of an electrophile at the end of any nucleic acid sequence. The electrophile on the tether can react with a second nucleic acid carrying a nucleophile when the two nucleic acids are hybridized near one another, resulting in release of the leaving group, and creation of a functional change. The linker can be designed to destabilize the ligation product without slowing the rate of reaction. This lowers product inhibition, and the target DNA or RNA can become a catalyst for isothermally generating multiple signals for detection. This enhanced signal is demonstrated in solution experiments and in solid supported assays. The universal linkers of the present invention are simple and inexpensive to prepare, and can be appended to any polynucleotide in automated steps on a standard DNA synthesizer.

There is provided a novel, useful dehydroxyfluorination agent containing sulfuryl fluoride (SO2F2) and an organic base that is free from a free hydroxyl group in the molecule. According to the present dehydroxyfluorination agent, it is not necessary to use perfluoroalkanesulfonyl fluoride, which is not preferable in large-scale use, and it is possible to advantageously produce optically-active fluoro derivatives, which are important intermediates of medicines, agricultural chemicals and optical materials, for example, 4-fluoroproline derivatives, 2'-deoxy-2'-fluorouridine derivatives, optically-active α-fluorocarboxylate derivatives, and monofluoromethyl derivatives, even in large scale.

The invention relates to a safety device (1) for detecting electrode breakage in an electric arc furnace, wherein an electrode (6) is secured on an electrode support arm (4), and wherein a conduit is filled with a medium under a constant pressure and a pressure drop is produced at an electrode breakage, which is detected as an alarm signal. Here, the conduit (7a-d,3) is integrated in a protective component that is arranged beneath the electrode support arm (4) thereon, wherein in case of an electrode breakage, the conduit (7a-d,3) is damaged by a produce electric arc and the pressure drop takes place.

A low temperature melting furnace using an external cooling passage includes a wall including a plurality of metal sectors, each metal sector including a cooling passage formed along a longitudinal direction thereof, and an extension tube provided outwardly from the wall and connected to the cooling passage.

An electromagnetic induction melting furnace to control an average nominal diameter of the TiB2 cluster of the Al—Ti—B alloy includes a main body containing the melted alloy; and a multi-layer coil disposed on the main body, wherein a frequency of the alternative current of each coil of the multi-layer coil is different, and the alloy is heated by inducing a magnetic field generated by the alternative currents. The selection of the frequency and the changeable magnetic field may reduce the cohesion force between the TiB2 grains of the Al—Ti—B alloy to control the average nominal diameter of the TiB2 cluster.

An electromagnetic induction melting furnace to control an average nominal diameter of the TiC cluster of the Al—Ti—C alloy includes a main body containing the melted alloy; and a multi-layer coil disposed on the main body, wherein a frequency of the alternative current of each coil of the multi-layer coil is different, and the alloy is heated by inducing a magnetic field generated by the alternative currents. The selection of the frequency and the changeable magnetic field may reduce the cohesion force between the TiC grains of the Al—Ti—C alloy to control the average nominal diameter of the TiC cluster.

A coupling for connecting a rotating tube cleaning shaft to a tube cleaning machine where high pressure fluid is pumped through the coupling, where the coupling is sealed to contain the high pressure fluid, and where a machine driven rotary flexible shaft passes through the coupling.

A network device receives notification configuration information that includes a time interval criteria and a selected geographical area for providing power outage notifications. The network device receives, during a particular time interval, a loss-of-power alarm from a network interface device (NID) associated with a customer premises. The loss-of-power alarm includes a particular NID identifier. The network device retrieves, from a database, customer configuration information that associates the particular NID identifier with a particular address and identifies a power outage in a particular region associated with the particular address. The identifying is based on receiving the loss-of-power alarm and determining if other loss-of-power alarms have been received from other NIDs in the same region and within the particular time interval.

A method models a defect management routine. Both the modeling and a handling are executed within a manufacturing execution system. During an engineering phase: modeling the production process and creating a library of possible defect types which may occur; assigning the defect types to at least one defect group; creating a library of defect specifications; creating a library of defect type specification details; creating at least one runtime defect criteria that is used to link the defect type to a certain production volume; and creating a runtime defect measurement routine that monitors a corrective measure. During a runtime production phase evaluating the product produced; identifying the respective defect type out of the library of defect types; and using the identified defect type to determine a corrective measure, a runtime defect criteria identifying the resource causing the defect type, a production volume, and to run the respective runtime defect management routine.

Systems, methods, and other embodiments associated with swarm management are described. One example system comprises a communication component configured to establish a communication link with at least one element, where the at least one element is part of a swarm. The example system also comprises a management component configured to manage performance of a task list by the swarm through the communication link.

A system for locating goods stored in a storage area includes a computer, radio frequency transceivers and modular hangers. Ordered goods are placed in storage units that each have addresses at a central filling center. The filled storage units are shipped to local storage areas where they are coupled to hook units to form modular hangers and stored on rails. The identifications of the goods and the electronic addresses for corresponding hangers are stored on a local computer database. When a user wants to pick up goods stored in the containers, the user inputs the identification or order information for the goods and the computer will cause the radio frequency transmitter to emit a data packet that includes a search address and illumination data. The hangers compare the search address to the electronic address. If there is a match, the hanger is illuminated so the ordered goods can be found.

An information processing apparatus for performing recognition processing by a recognizer for a position and orientation of a work subject to undergo work by a working unit of a robot arm. The information processing apparatus including an obtaining unit adapted to obtain, for each of a plurality of positions and orientations of the work subject, a position and an orientation of the working unit in which the working unit can perform the work, and a restriction unit adapted to restrict a position and an orientation of the work subject used in the recognition processing by the recognizer to a position and an orientation of the work subject corresponding to the position and the orientation of the working unit that have been obtained by the obtaining unit.

The invention relates to compounds and methods for targeting radionuclide-based imaging agents to cells having receptors for a vitamin, or vitamin receptor binding derivative or analog thereof, by using such a vitamin as the targeting ligand for the imaging agent. The vitamin-based compounds can be used to target radionuclides to cells, such as a variety of tumor cell types, for use in diagnostic imaging of the targeted cells.