tri Bacterial CagA protein compromises tumor suppressor mechanisms in gastric epithelial cells By www.jci.org Published On :: Approximately half of the world’s population is infected with the stomach pathogen Helicobacter pylori. Infection with H. pylori is the main risk factor for distal gastric cancer. Bacterial virulence factors, such as the oncoprotein CagA, augment cancer risk. Yet despite high infection rates, only a fraction of H. pylori–infected individuals develop gastric cancer. This raises the question of defining the specific host and bacterial factors responsible for gastric tumorigenesis. To investigate the tumorigenic determinants, we analyzed gastric tissues from human subjects and animals infected with H. pylori bacteria harboring different CagA status. For laboratory studies, well-defined H. pylori strain B128 and its cancerogenic derivative strain 7.13, as well as various bacterial isogenic mutants were employed. We found that H. pylori compromises key tumor suppressor mechanisms: the host stress and apoptotic responses. Our studies showed that CagA induces phosphorylation of XIAP E3 ubiquitin ligase, which enhances ubiquitination and proteasomal degradation of the host proapoptotic factor Siva1. This process is mediated by the PI3K/Akt pathway. Inhibition of Siva1 by H. pylori increases survival of human cells with damaged DNA. It occurs in a strain-specific manner and is associated with the ability to induce gastric tumor. Full Article
tri Dysfunctional polycomb transcriptional repression contributes to lamin A/C–dependent muscular dystrophy By www.jci.org Published On :: Lamin A is a component of the inner nuclear membrane that, together with epigenetic factors, organizes the genome in higher order structures required for transcriptional control. Mutations in the lamin A/C gene cause several diseases belonging to the class of laminopathies, including muscular dystrophies. Nevertheless, molecular mechanisms involved in the pathogenesis of lamin A–dependent dystrophies are still largely unknown. The polycomb group (PcG) of proteins are epigenetic repressors and lamin A interactors, primarily involved in the maintenance of cell identity. Using a murine model of Emery-Dreifuss muscular dystrophy (EDMD), we show here that lamin A loss deregulated PcG positioning in muscle satellite stem cells, leading to derepression of non–muscle-specific genes and p16INK4a, a senescence driver encoded in the Cdkn2a locus. This aberrant transcriptional program caused impairment in self-renewal, loss of cell identity, and premature exhaustion of the quiescent satellite cell pool. Genetic ablation of the Cdkn2a locus restored muscle stem cell properties in lamin A/C–null dystrophic mice. Our findings establish a direct link between lamin A and PcG epigenetic silencing and indicate that lamin A–dependent muscular dystrophy can be ascribed to intrinsic epigenetic dysfunctions of muscle stem cells. Full Article
tri 'Ego Stripping', by Fleuriel (H.B. Woodrose) By erowid.org Published On :: Sat, 02 May 2020 07:10:01 GMT Erowid Exp108047 Full Article Erowid : Experience :
tri Berlin Connecticut needs candidates from a third political party to stop the strict partisan voting on the Town Council By www.cpa-connecticut.com Published On :: Sun, 05 Jul 2015 17:21:15 +0000 Berlin needs an independent candidate on its Town Council to counter and prevent the dominance of a major political party from unilaterally imposing its agenda and will on the citizens of Berlin. Our Town Council has been voting along strict party lines on key issues even though members pledged to reach across the aisle. It has dismissed or circumvented the results of referendums, reducing them to mere dog-and-pony shows. Berlin has more unaffiliated voters than those of the two major parties. Let's petition, nominate, and place on the ballot an independent candidate to represent these citizens and prevent the control of our Town by the dominant party on the Town Council. If interested, please contact us: berlinctpropertyownersassn@gmail.com. Continue reading → Full Article Accountants CPA Hartford Articles Berlin Connecticut Berlin Connecticut needs candidates from a third political party to stop the strict partisan voting on the Town Council Berlin Town Council democracy Democratic Party independent candidates independent party partisan politics Republican party special interests voting along strict party line
tri Did companies and countries buy access to the State Department by donating to the Clinton Foundation? By www.cpa-connecticut.com Published On :: Thu, 18 Aug 2016 05:21:01 +0000 Pulitzer Prize-winning reporter James Grimaldi of The Wall Street Journal, who has covered the Clinton Foundation for years, looks at the relationship between the Clinton Foundation and the State Department during Hillary Clinton’s time as secretary of state, and what it would be if she became president. Newly released State Department emails include exchanges between top members of the Clinton Foundation and Clinton’s top State Department advisers, including Huma Abedin and Cheryl Mills. The FBI reportedly wanted to investigate the Clinton Foundation earlier this year, but U.S. Attorney General Loretta Lynch pushed back. Continue reading → Full Article Accountants CPA Hartford Articles Ambassador Jeffrey Feltman appearance of a conflict of interest Bill Clinton billionaire Nigerian-Lebanese developer Gilbert Chagoury Boeing buying access to State Department by making donations to Clinton Foundation Canada Cheryl Mills China Conflict of Interest Did Companies & Countries Buy State Dept. Access by Donating to Clinton Foundation? Did companies and countries buy access to the State Department by donating to the Clinton Foundation? Douglas Band Elizabeth Trudeau General Electric Hillary Clinton how donations to the Clinton Foundation won access to State Department diplomatic officials Huma Abedin James Grimaldi Keystone XL Pipeline Lebanon Loretta Lynch Microsoft North Korea Pulitzer Prize winning reporter Quid pro quo relationship between the State Department under Clinton and the Clinton Foundation Robert Wolf Saudi Arabia The Clinton Foundation UBS Wall Street Journal Walmart WikiLeaks
tri Does Joe Aresimowicz put his constituents in the 30th Connecticut House District first or public employee unions first? By www.cpa-connecticut.com Published On :: Mon, 11 Jun 2018 12:59:22 +0000 Connecticut General Assembly Majority Leader Joe Aresimowicz speaking at the 2014 CEUI Convention. Joe Aresimowicz, in speaking to a governmental employee union group in 2014, assured governmental union employees that he would be looking out for them: "You guys have one of your own that sits in the caucus room of the General Assembly. You cannot replicate that." "I will never allow an anti-collective bargaining bill to be called to the House floor. I'm the majority leader. I can make that guarantee." "Please, stand together, stand as brothers and sisters, and be a family. And make sure we are looking out for our own." Continue reading → Full Article Accountants CPA Hartford Articles 2014 CEUI Convention AFSCME Berlin Connecticut CEUI Collective Bargaining Connecticut General Assembly Majority Leader Connecticut General Assembly Majority Leader Joe Aresimowicz speaking at the 2014 CEUI Convention Connecticut House District 30 State Representative Does Joe Aresimowicz put his constituents in the 30th Connecticut House District first or public employee unions first? General Assembly Joe Aresimowicz public employee unions Southington Connecticut Speaker of Connecticut House of Representatives Joe Aresimowicz speaking at the 2014 CEUI Convention transcript of speech
tri IBM and Citizen-Scientists Poised to Contribute Equivalent of up to $200 Million for Climate & Environmental Research By www.ibm.com Published On :: Mon, 10 Jul 2017 11:01:42 GMT As climate change accelerates, IBM is galvanizing the global science community with a massive infusion of computing resources, weather data, and cloud services to help researchers examine the effects of climate change, and explore strategies to mitigate its effects. IBM pledges to help direct the equivalent of up to $200 million for up to five climate-related projects judged to offer the greatest potential impact, and will then broadly share the experiments' results. Full Article Smarter Planet
tri The Coronavirus Journal: Alternative Distribution Will Help Us Survive By www.comicsbeat.com Published On :: Fri, 08 May 2020 20:45:06 +0000 DC made a good choice in moving away from Diamond. The post The Coronavirus Journal: Alternative Distribution Will Help Us Survive appeared first on The Beat. Full Article DC The Retailer's View Top News comics distribution comics retailing COVID-19 DC Comics lunar distribution
tri IBM and SAP to Offer New Co-Created Industry Solution for Retail and Consumer Packaged Goods Industries By www.ibm.com Published On :: Thu, 24 Aug 2017 01:01:20 GMT IBM and SAP SE have teamed up to provide a co-innovated solution for the retail and consumer packaged goods industries to help both increase profitability and improve the consumer experience. Full Article Retail
tri Electrical Power Use of the CR-10 3d Printer By cockeyed.com Published On :: Tuesday, February 13, 2018 11:15:00 GMT 3D printers can be loud and hot, but they don't actually use a ton of electricity. Full Article
tri Mayo Clinic’s clinical trial matching project sees higher enrollment in breast cancer trials through use of artificial intelligence By www.ibm.com Published On :: Thu, 08 Mar 2018 01:11:05 GMT Mayo Clinic and IBM Watson Health today unveiled results from early use of the Watson for Clinical Trial Matching, an IBM cognitive computing system. Use of this system in the Mayo Clinic oncology practice has been associated with more patients enrolled in Mayo’s breast cancer clinical trials. Full Article IBM Watson
tri IBM Study: 61 Percent of Surveyed CMOs and Sales Leaders Say Cognitive Computing Will Be a Disruptive Force in Their Industries—But Are They Ready for the Disruption? By www.ibm.com Published On :: Tue, 08 Aug 2017 12:33:45 GMT While marketing and sales professionals increasingly find themselves drowning in data, a new IBM study finds that nearly two thirds—64 percent--of surveyed CMOs and sales leaders believe their industries will be ready to adopt cognitive technologies in the next three years. However despite this stated readiness, the study finds that only 24 percent of those surveyed believe they have strategy in place to implement these technologies today. Full Article Education
tri IBM contribuye a la reinvención de la fuerza de trabajo en América Latina, beneficiando a más de 370.000 estudiantes con acceso a conocimiento en IA, Cloud y Blockchain By www.ibm.com Published On :: jue, 11 oct 2018 11:16:39 GMT IBM (NYSE: IBM) anunció hoy que está trabajando con más de 300 universidades y más de 400 instituciones educativas en toda Latinoamérica para respaldar la inminente necesidad de desarrollar habilidades asociadas a los requerimientos de la transformación digital, ya que el 60% de los ejecutivos se esfuerza hoy por mantener las habilidades de la fuerza laboral actualizadas y relevantes frente al rápido avance tecnológico. Full Article All Topics
tri Innovative partnership between Unitec, Concentrix and IBM meets commitment to build local skilled and experienced workforce for the digital economy By www.ibm.com Published On :: Tue, 19 Aug 2014 01:42:58 GMT Unitec today announced that the number of people employed in two Delivery Centres at its Mount Albert campus now exceeds 500, and continue to drive benefits for Unitec students and the Auckland economy. Full Article Education
tri Millennials prefieren las tecnologías biométricas de seguridad a las contraseñas By www.ibm.com Published On :: lun, 29 ene 2018 09:19:30 GMT El 67% de los usuarios en todo el mundo se siente actualmente cómodo utilizando tecnologías biométricas (lectura de huella dactilar, escaneado de retina y reconocimiento facial o de voz) para acceder a sus aplicaciones, según el estudio IBM Security Future of Identity elaborado por IBM. Full Article Security
tri Ecodex incrementa servicios de certificación tributaria para empresas con soluciones inteligentes de IBM By www.ibm.com Published On :: jue, 04 dic 2014 04:35:50 GMT La empresa se afianza como líder de Proveedores Autorizados de Certificación (PAC) y logra procesar grandes volúmenes de transacciones de manera sencilla Full Article Software
tri El Tecnológico de Monterrey e IBM redefinen profesiones e industrias con Big Data By www.ibm.com Published On :: lun, 14 sep 2015 05:48:58 GMT Estamos en un punto de inflexión en el que los datos resuelven problemas y dan resultados rápidos en formas nunca antes vistas. México requiere estar listo para esta nueva era en la que los negocios e instituciones están en constante evolución. Para lograrlo, los servicios y las tecnologías de información, y sobre todo el talento detrás de estos, son clave. Full Article Analytics
tri Grupo Cleber obtiene una visión inteligente de su negocio automotriz con analítica de IBM By www.ibm.com Published On :: lun, 30 nov 2015 04:53:57 GMT IBM y Grupo Cleber anunciaron hoy que el importante conglomerado automotriz con sede en Monterrey obtuvo una visión integral y regional de su negocio con soluciones de analítica de IBM. Full Article Analytics
tri District Health Board IT initiative to reduce risk of outages By www.ibm.com Published On :: Wed, 04 Mar 2015 01:30:59 GMT IBM and Health Benefits Limited announce agreement to introduce National Infrastructure Platform to District Health Boards, based on IBM Cloud. Full Article Cloud Computing
tri IBM’s Corporate Services Corps Heading to Six Emerging Countries to Spark Socio-Economic Growth By www.ibm.com Published On :: Mon, 12 May 2008 04:03:30 GMT One hundred IBM (NYSE: IBM) employees from 33 countries – including six from Australia and New Zealand – have been selected to participate in the company's new Corporate Service Corps program. The program is part of the Global Citizen's Portfolio initiative announced by CEO Sam Palmisano to develop leadership skills, while addressing socio-economic challenges in emerging markets. Full Article Travel & Transportation
tri Successful blockchain trial for bank guarantees By www.ibm.com Published On :: Wed, 11 Oct 2017 05:28:32 GMT ANZ and Westpac have teamed with IBM (NYSE:IBM) and shopping centre operator Scentre Group and have now successfully digitised the bank guarantee process used for commercial property leasing. Full Article Banking and Financial Services
tri Peter MacCallum Cancer Centre publishes results from study using IBM Watson for Clinical Trial Matching By www.ibm.com Published On :: Thu, 28 Nov 2019 05:11:09 GMT A Peter MacCallum Cancer Centre study has demonstrated the potential for artificial intelligence to help reduce the time for clinicians to match lung cancer patients to relevant clinical trials. Full Article IBM Watson
tri IBM Announces Natural Resources Solution Centre for Mining, LNG & Petroleum Industries By www.ibm.com Published On :: Mon, 07 Jun 2010 11:13:16 GMT IBM (NYSE: IBM) today announced it will establish a Natural Resources Solution Centre (NRSC) in Perth to help mining, LNG and petroleum companies accelerate the development and adoption of innovative technologies and business strategies. Full Article Energy & Utilities
tri IBM Australia signs volume distributor agreement with Synnex By www.ibm.com Published On :: Tue, 28 Jun 2011 01:15:10 GMT IBM (NYSE:IBM) today announced it has selected Synnex, one of Australia’s largest IT distribution companies, as a new IBM System and Technology Group (STG) distributor. The strategic agreement enables IBM to capture a larger share of the lucrative small and medium business IT marketplace with its IBM Express volume hardware products. Full Article Business partners
tri IBM Appoints Katrina Troughton as Managing Director of IBM Australia and New Zealand By www.ibm.com Published On :: Fri, 26 Jul 2019 03:39:30 GMT IBM Appoints Katrina Troughton as Managing Director of IBM Australia and New Zealand Full Article Corporate
tri tricknewstyle By ameblo.jp Published On :: Sat, 14 Sep 2019 19:33:39 +0900 2019.9.14うす塁斗オナカスイタ昨日は新宿文化センターでプレビュー公演でしたありがとうございました!始まったねcircusカーテンコールでスタンディングオベーションも頂くことができて感謝です。そして富山公演から!まず地方をまわってからの東京、大和頑張ります。まだネタバレになるから言えませんがあれをやったりこれもやったりラストが、、、、とか色々とお楽しみに、、目を凝らして観てね 気づくことや気づかないこと気づいて欲しいことや気づいてもらえることアクションもダンスも汗かくほどやってます。それは毎回ですが。あと憶測とか目で見たものが全てじゃないからねdopeなものほどカッコいいとか玄人好みのものとか牛すじ煮込みのカレーとキュウリとか大根のぬか漬けカレーの方が見栄えとか魅力あるように見える事も多いかもしれないけど、ぬか漬けだって手間暇がかなりかかる大変な事だよね、牛すじ煮込みのカレーは圧力鍋使って30分以内にできてる事もあるしね、美味しくて好きだけどぬか漬け永遠に食えるけど一般的に腹筋バ続きをみる『著作権保護のため、記事の一部のみ表示されております。』 Full Article
tri 247B, Notes 1: Restriction theory By terrytao.wordpress.com Published On :: Mon, 30 Mar 2020 01:49:14 +0000 This set of notes focuses on the restriction problem in Fourier analysis. Introduced by Elias Stein in the 1970s, the restriction problem is a key model problem for understanding more general oscillatory integral operators, and which has turned out to be connected to many questions in geometric measure theory, harmonic analysis, combinatorics, number theory, and […] Full Article 247B - Classical Fourier Analysis math.CA Kakeya conjecture multilinear analysis multilinear Kakeya conjecture restriction theorems
tri Triggers, FlashForward, and Me By sfwriter.com Published On :: Sat, 15 Apr 2017 19:34:00 +0000 A piece I finished five years ago today, on April 15, 2012, for the blog of Gollancz, my UK publisher: Triggers, FlashForward, and Me by Robert J. Sawyer Thanks to the good people at Gollancz, I was recently interviewed in SFX, the world’s top-selling English-language magazine devoted to science fiction. I spoke in that interview […] Full Article Anniversaries FlashForward Triggers
tri “The Most Physically Grueling of Them All”: Mark Hamill on Star Wars: The Empire Strikes Back By www.starwars.com Published On :: Mon, 04 May 2020 12:30:19 +0000 The actor behind Luke Skywalker takes StarWars.com on a journey through filming the Star Wars sequel in time for the 40th anniversary of its release. Full Article Behind the Scenes Interviews Luke Skywalker (Star Wars) Mark Hamill mark hamill interview Star Wars: The Empire Strikes Back ThisWeek
tri Academy Award Winner Taika Waititi to Direct and Co-Write new Star Wars Feature Film for Theatrical Release; Oscar Nominee Krysty Wilson-Cairns to Co-Write Screenplay with Waititi By www.starwars.com Published On :: Mon, 04 May 2020 16:00:34 +0000 Emmy Nominee Leslye Headland to write, produce, and serve as showrunner for new untitled Star Wars series for Disney+. Full Article Disney+ Films Lucasfilm Star Wars Films ThisWeek
tri Empire at 40 | 40 Great Quotes from Star Wars: The Empire Strikes Back By www.starwars.com Published On :: Tue, 05 May 2020 13:00:48 +0000 These lines are impressive. Most impressive. Full Article Characters + Histories Films Star Wars Episode V: The Empire Strikes Back (1980) | Movies | 4e50811e5f140eff9f3e8e30 star wars quotes
tri Board Game Review - Triora: City of Witches By www.thatswhatjennisaid.com Published On :: Wed, 28 Aug 2019 07:09:00 +0000 There are some games in my collection that I get excited about when they arrive at my house but it takes me months to get them to the table. Typically in these cases the artwork is lovely, the theme is interesting, and the mechanics look promising but there is something standing in the way of playing the game right away. For Triora: City of Witches (designed by Michael C. Alves), what stood in the way is the game’s rulebook. It absolutely flummoxed me. Even with the errata notes released a few months ago, it’s hard to make sense of the rules. It made a mess of things. And look what’s it’s done to my review – I usually like to start with a nice overview of a game’s theme, cover the components and artwork, and then dive into the gameplay. But the rulebook is so awful in this case, I’m forced to lead with that. The publisher needs a skilled editor to rewrite the rulebook entirely. It’s laden with spelling errors and unclear language. So that’s the bad news; the rulebook is subpar. The good news is the game itself is quite interesting. In Triora: City of Witches, players take on the role of witches and their familiars who have traveled to the city to face off against the nobility and the inquisitor, both of whom have been persecuting local women they suspect are witches. To win the game, a player must have the highest total victory points (referred to as doom points and sometimes ruin points in the rulebook) at the conclusion of the game. The end of the game happens at the end of the round in which one of two conditions are met: [1] three of the four main locations in the city are destroyed,or[2] a witch is captured by the inquisitor after they have already accumulated the maximum inquisition points. Note that a witch captured this way is out of the game and ineligible for victory, as all of their doom/ruin points are forfeited. Gameplay centers on making and using potions toward strategic ends. Players can create potions both by simply moving their witch meeple to a new location (grants 1 cauldron automatically, which can be used to make one type of potion from the requisite herbs held by the player) and by visiting a location with their witch or familiar that grants a cauldron as part of the action of that location. Note that there is an entire subroutine for generating the requisite herbs on a player’s board; once used to make a potion, herbs shift to a seed state and then must pass through planting and harvesting phases before they transform into usable herbs once more. Potions are consumed when visiting locations on the board that require a potion to complete an action at a location (either as an upfront cost to initiate the action or as an input to the action such as when changing potions into silver or taking control of villagers). Certain locations on the board are defined targets for destruction; when players move their witch or familiar to these locations (there are 4 of them), as part of the location’s action, they place one of their wooden player tokens on the location. When the required number of tokens have been placed, the location is destroyed. I’ve mentioned players moving their witch or their familiar on their turns. A player gets two turns per round; one turn to move their witch and the other to move their familiar. It is up to the player to determine which to move first. There is more freedom in moving witches (familiars cannot be moved to a location where a witch or another familiar is currently located) and moving a witch grants extra benefits (the automatic cauldron as mentioned above but also there is a witch’s bonus at each location that is granted only when a witch is moved to the location). However, there is also more risk in moving a witch and so it must be done with great attention to detail. This is because in addition to the witches and their familiars, there is also an Inquisitor meeple moving around the board (up to 2 spaces per round; it moves after all players have finishes their witch and familiar movements for the round). If the Inquisitor lands on a location where a witch is standing, the controlling player of the witch receives a penalty, which can include the immediate loss of the game if they have sufficiently high inquisition points already (inquisition points are assigned when completing certain actions as well as each time the Inquisitor catches your witch). In fact, in all of the games I played, the ending was triggered because a player didn’t carefully consider the Inquisitor’s upcoming movement when moving their witch on their turn and thus they found themselves caught by the Inquisitor and disqualified from winning. And these were smart opponents with several years of experience playing strategy games. So remember to be mindful of the Inquisitor’s current location and movement possibilities before you pick up your witch to move her. In addition to the Inquisitor, there is a meeple representing the spirit of Morgana, the great witch who drew the witches and familiars to Triora. If Morgana catches up to a player’s witch on the board, the player is granted doom points or shovels (used in the seed to herb subroutine) if they are willing to accept some inquisition points as the cost for these benefits.There is a moderate amount of analysis paralysis inherent in the game, but it’s not extreme. What will cause slowdowns during gameplay is trying to determine consensus on the rules as questions arise that the rulebook fails to address. For example:1 . For the two player setup, the rulebook notes that two extra familiars should be placed on the board; these will move around the board each round and serve to occupy spaces and simulate the limitations on familiar movement that players would normally encounter during a three or four player game. Once they are initially placed (instructions say each player should place one familiar), are players limited to controlling the extra familiar they placed or can they select either of the extra familiars to move? The rulebook just states that before or after a player moves their own familiar they should move one of the extra familiars. We had much debate on this; I thought you should be able to move either familiar but my husband thought it made more sense that you should only be able to move the one you initially placed otherwise you could just move the one your opponent placed each turn to get it out of your way. 2. Do players alternate with other players their turns in which they place their witch and their familiar or does play pass from one player to another only after a player does both their turns?3. When and how often do villager bonuses trigger? The rulebook states that they grant a bonus to the player in the final round, which implies the end of the game. But the bonus list includes “produce 1 shovel”, which would do no good in the final round so that doesn’t make sense. We think it should have read in each round, but we can’t be sure. Also, it’s a high price to play for a villager if you get its bonus only once per game as most villagers cost 3 potions. 4. More villager confusion: the rulebook notes that villagers may be used for actions in the Swamp House. But the only action available in the swamp house is to corrupt and acquire more villagers. It’s not clear how a player would use a villager to corrupt and acquire another villager. And the rulebook also states that villagers may be used for the action in the City location. But the City is the other location where you corrupt and acquire villagers. Based on this, we think the rulebook was trying to convey that these 2 locations are where you get villagers, not where you use them as is actually written. 5. If a player is not at max inquisition points but the result of the Inquisitor catching their witch would take them over 32 points, does that also trigger the end of the game? Once players get the rules sorted out (they will likely will need to decide on house rules for the questions above or request feedback from the publisher), they can dive in and enjoy the mechanics of the game. The artwork is lovely and the components are pretty well made (components include plastic coated cards, wooden meeples, wooden and cardboard tokens, cardboard player boards, and the large central board hosting all the locations). I’m really indecisive on the final rating I should award Triora: City of Witches. A perfect rating (oui! oui! oui!) is out of the question because there are some minor problems with the game independent of the rulebook. For example, a round begins with nightfall and the movement of the Inquisitor and Morgana come after that during the day phase but on the top of the main board the Inquisitor’s movement is the very first item shown on the left, followed by Morgana’s movement; nightfall is shown at the end of the line. Why does the sequence of phases on the board not match the actual sequence of play? Is it possible that in earlier drafts of the game nightfall marked the end of the round instead of the beginning and the board was designed based on those drafts? If the rulebook wasn’t a disaster the game could absolutely be worthy a oui! oui! rating. So how heavily should the rulebook factor in here? It’s entirely possible that the problems with the rulebook aren’t the result of shoddy work but simply language translation issues (the game originated in Brazil; I am assuming the English rulebook is a translation). That makes me feel bad about dropping my rating down a notch. But with an oversaturated board game market (I heard last week that approximately 3000 new games are published yearly), I can’t in good faith recommend folks invest in a game that is such a headache to sort out how to play. So Triora: City of Witches gets a oui! from me for now. I’m going to hold onto the game and may play it occasionally and I’m happy to take another look at the game as a courtesy to the publisher should they fix their rulebook and ask me to re-evaluate. Bonus side story: when posting pictures of the game to Instagram, I found out the village baker in Triora and other folks interested in the city track the #triora hashtag. This came to my attention because these individuals began to send me private messages on IG. They had heard a game was being made about their village but they didn’t know the details. They wanted to know the locations in the village depicted on the board (to see if they corresponded to actual locations). They wanted to know how one wins the game (imagine how awkward it was to explain that one of the goals of the game is to destroy the city). They wanted to see pictures of the game. It was a very entertaining series of conversations and now I’ve actually made a new friend from overseas after having chatted with him at length about the game and the village and its historical events regarding witchcraft. -------------------------------------------------Publisher: Meeple BR JogosPlayers: 2-4Actual Playing Time (vs the guideline on the box): varies widely depending on whether the game ends via Inquisitor or destruction; 10-60 minutes. Game type: worker placement, area controlRating:Jenni’s rating scale:OUI: I would play this game again; this game is ok. I probably would not buy this game myself but I would play it with those who own it and if someone gave it to me I would keep it.OUI OUI: I would play this game again; this game is good. I would buy this game.OUI OUI OUI: I LOVE THIS GAME. I MUST HAVE THIS GAME.NON: I would not play this game again. I would return this game or give it away if it was given to me. Full Article Arcano Games area control games board game reviews Meeple BR Jogos worker placement games
tri NEWS: October Con Trio 2015! By starfightercomic.com Published On :: Mon, 21 Sep 2015 15:55:00 GMT I will be traveling quite a bit from this weekend until the end of October for conventions!Event Yaoi's Yaoi Yuri Con - I will be a guest of honor at this convention in Lyon, France! I don't get to travel abroad for conventions very often so I am really looking forward to meeting European fans! :)NYCC - I will have a table in the Artist Alley! (Table T12)Nijicon - I will be a guest here! (I'll have a panel!)So, I have three cons this month (IT JUST SORTA HAPPENED), one of which is overseas, so the Starfighter updates will have to wait until I get back! That sucks, I know, but I will be meeting with friends and fans at conventions, so it's all for a good cause! :) I will be back shortly after I return to wrap up Encke and Keeler!I hope to do you all proud! Thank you so much as always for your support! -Hamlet Full Article
tri Vláda schválila odklad sociálního pojištění pro firmy na tři měsíce By www.idnes.cz Published On :: Thu, 07 May 2020 15:21:00 GMT Firmy si budou moci odložit platby za sociální pojištění za tři měsíce. Odvody za květen, červen a červenec smí uhradit až do 20. října, rozhodla vláda. Odložená částka se však bude úročit. Full Article Ekonomika - Domácí
tri U.S. Financial System “Monitor” Failed to Flash Warning as Fed Pumped $6 Trillion Emergency Liquidity into Wall Street By wallstreetonparade.com Published On :: Fri, 08 May 2020 12:49:24 +0000 U.S. Financial System “Monitor” Failed to Flash Warning as Fed Pumped $6 Trillion Emergency Liquidity into Wall Street By Pam Martens and Russ Martens: May 8, 2020 ~ The Office of Financial Research (OFR) was created under the Dodd-Frank financial reform legislation of 2010 to keep the Financial Stability Oversight Council (F-SOC) informed on emerging threats that have the potential to implode the financial system — as occurred in 2008 in the worst financial crash since the Great Depression. The Trump administration has gutted both its funding and staff. One of the early warning systems of an impending financial crisis that OFR was supposed to have created is the heat map above. Green means low risk; yellow tones mean moderate risk; while red tones flash a warning of a serious problem. On September 17, 2019, liquidity was so strained on Wall Street that the Federal Reserve had to step in and began providing hundreds of billions of dollars per week in repo loans. By January 27, 2020 (before … Continue reading → - Full Article Uncategorized
tri Cuddle Cobra by Trivena By skin-horse.com Published On :: Sun, 26 Apr 2020 04:01:00 +0000 Shaenon: Oh my gosh, look at this! Trivena writes, “Looking for something to do during isolation, I raided my craft stash and found some snakeskin print left over from another project. As a big fan of hugs, which are difficult[…]↓ Read the rest of this entry... Full Article
tri KVÍZ: Zatím ještě dotace, za dva roky pokuty. Víte, jak ušetřit výměnou kotle? By www.idnes.cz Published On :: Sat, 25 Apr 2020 22:00:00 GMT Od 1. září 2022 nebude možné provozovat kotle na tuhá paliva, které nevyhovují přísnějším emisním normám. Včasnou výměnou kotle můžete ušetřit. Nejenže snížíte náklady za topení, ale stihnete navíc využít státní dotaci na jeho pořízení. Víte, jak na to? Otestujte své znalosti. Full Article Finance - Finanční rádce
tri Odklad splátek nebo refinancování. Jak dnes ušetřit na hypotéce By www.idnes.cz Published On :: Mon, 04 May 2020 22:00:00 GMT Splácíte hypotéku, u níž se blíží zlomové datum fixace? Jak na to, když chcete brzy půjčku doplatit nebo ji refinancovat? A lze před doplacením využít odkladu splátek? Full Article Finance - Hypotéky a půjčky
tri Začínali podnikat v bytě, dnes má rodinná firma tři tisíce zaměstnanců By www.idnes.cz Published On :: Fri, 08 May 2020 22:00:00 GMT Česká rodinná firma SSI Group vznikla v době, kdy jsme ještě neznali mobilní telefony a podnikatelské prostředí 90. let bylo poměrně divoké. Přesto se ji Václavu Vodrážkovi společně se synem Janem a dalšími členy rodiny dařilo každý rok posouvat o něco dál. Letos tak na trhu významná bezpečnostní agentura oslaví 30 let svého působení na trhu. Full Article Finance - Práce a podnikání
tri Entries from May 2019 By radar.spacebar.org Published On :: Fri, 31 May 2019 23:48:50 -0400 Well, nothing major to report this month, except at least we have some content: The conference I first showed my Reverse Emulation project at in 2018 (Deconstruct) finally posted the video of my talk, which was called "Improper Hierarchy." The talk is of course similar to the living room CRT video I put on youtube, but it might be interesting even if you've already seen that (watching it a year later, there are at least some funny ad-libbed parts IMO!). The video production is very high quality (in general the conference was very well run and the speaker experience in particular I heartily endorse) but also quite serious-seeming, so I like how it comes across as some bizarro-world TED talk. This month I've made some progress on another video, which maybe I can wrap up this weekend. Nothing too grandeur, though. Sometimes hard to keep that under control! Also: I played through Minit, which was a really excellent and creative little game (can finish it in an evening) that I super recommend. I just started The Messenger which definitely has some charms and surprises; I need to finish it before I can decide between "good" and "great" but I think I can at least recommend it if you like exploration-style platformers. Full Article
tri Triton DeepView 24-Seat Submarine By uncrate.com Published On :: Fri, 08 May 2020 15:30:00 -0500 Full Article Transportation
tri 00s movies - trivia 10 By fun-movie-trivia.blogspot.com Published On :: Sun, 16 Sep 2012 01:34:00 +0000 Full Article 00s Movies Action Bollywood Crime
tri 80s movies - trivia 9 By fun-movie-trivia.blogspot.com Published On :: Mon, 08 Jul 2013 12:12:00 +0000 Full Article 80s Movies Adventure Comedy Sci-Fi
tri Registration open for USGL Lover Triad Convocation By oto-usa.org Published On :: Wed, 18 Dec 2019 18:41:57 +0000 A convocation of the Lover Triad of United States Grand Lodge will be held in Cleveland, Ohio, August 14-16 2020. Registration for the convocation is now open. See this site for more information. Full Article Events
tri Histogram: You have to know the past to understand the present by Tomas Petricek By lambda-the-ultimate.org Published On :: Sun, 15 Sep 2019 01:26:13 +0000 Histogram: You have to know the past to understand the present by Tomas Petricek, University of Kent Programs are created through a variety of interactions. A programmer might write some code, run it interactively to check whether it works, use copy and paste, apply a refactoring or choose an item from an auto-complete list. Programming research often forgets about these and represents programs as the resulting text. Consequently, thinking about such interactions is often out of scope. This essay shifts focus from programs to a more interesting question of programming. We represent programs as lists of interactions such as triggering an auto-complete and choosing an option, declaring a value, introducing a variable or evaluating a piece of code. We explore a number of consequences of this way of thinking about programs. First, if we create functions by writing concrete code using a sample input and applying a refactoring, we do not lose the sample input and can use it later for debugging. Second, if we treat executing code interactively as an interaction and store the results, we can later use this information to give more precise suggestions in auto-complete. Third, by moving away from a textual representation, we can display the same program as text, but also in a view inspired by spreadsheets. Fourth, we can let programmers create programs by directly interacting with live previews as those interactions can be recorded and as a part of program history. We discuss the key ideas through examples in a simple programming environment for data exploration. Our focus in this essay is more on principles than on providing fine tuned user experience. We keep our environment more explicit, especially when this reveals what is happening behind the scenes. We aim to show that seeing programs as lists of interactions is a powerful change of perspective that can help us build better programming systems with novel features that make programming easier and more accessible. The data exploration environment in this interactive essay may not yet be that, but it gives a glimpse of the future. Full Article LtU Forum
tri Civic Tech: We tried to get a copy of the Sidewalk Toronto agreement By torontoist.com Published On :: Thu, 12 Apr 2018 14:18:03 +0000 Why all the secrecy? If you follow the news in Toronto or if you’re interested in technology, you’ve probably heard of Sidewalk Toronto by now. It’s a joint project of Sidewalk Labs, a sister company of Google, and Waterfront Toronto. This is the tech giant’s first foray into urban development and infrastructure, with Toronto hosting the pilot project. In […] The post Civic Tech: We tried to get a copy of the Sidewalk Toronto agreement appeared first on Torontoist. Full Article cityscape
tri Zombie Strippers Porn Star Dancing By feedproxy.google.com Published On :: Sat, 22 Jan 2011 15:24:00 EST Zombie Strippers has got to be hands down one of the cheesiet, oddest, zombie movies movies I have ever seen Full Article
tri Offline seo tricks By feedproxy.google.com Published On :: Sat, 22 Jan 2011 15:43:00 EST Using social networks, building backlines, and article writing are just a few free SEO tools you can use to get traffic to your website or blog. But you don’t always need to be in front of your computer all day to boost traffic and get your site noticed. There are lots of ways to get noticed using offline SEO tactics. I’ve tried to include as many free or as inexpensive ideas as possible, some of them will be on the more expensive side and will probably be out of your budget for. But as your site grows and your revenue (if your making money from your site) goes up there worth considering. Full Article
tri 14 Black Hat SEO Tricks To Avoid By feedproxy.google.com Published On :: Tue, 14 Jun 2011 05:19:00 EST Black hat SEO, if you’re not familiar with it, it’s a general term that covers everything that’s considered unethical or “cheating” to get your site ranked in the number one spots in the search engines. In the short term many of these tricks do work at getting your site the number 1 spot, in the long term however your site will be penalized, pushed down in search engine rankings, or your domain may be completely abandoned by them. And if your website is about trying to make money, or is part of a business this can have a serious impact. So how do you know what’s considered black hat seo if you’re brand new to the whole website or blogging game? Here is a list of 14 black hat seo tricks to avoid............. Full Article
tri Grey Hat SEO Tricks By feedproxy.google.com Published On :: Wed, 15 Jun 2011 03:58:00 EST What is grey hat seo? The term grey hat is used to categorize all the seo tricks out there that fall somewhere in-between white hat which is ethical, and black hat or non ethical. Using gray hat seo is all about the risk versus the reward of trying to rank well in the search engines to get traffic. Abusing them can have a negative effect on your website, but don’t carry the harsh penalties that black hat seo tricks would......... It’s also important to understand that many grey hat seo tricks wind up becoming black hat from over abuse. Tricks such as cloaking where you present two versions of your website, one for your visitors, the other for the search engines that are stuffed with keywords that they want to rank for. Or paid links where you pay the site owner of a higher rank site for a link are now considered full blown black hat tricks. Full Article