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Complementary and Integrative Medicine: Emerging Therapies for Diabetes, Part 1: Preface

Cynthia Payne
Aug 1, 2001; 14:
Preface




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Secrecy, spies and the global South: intelligence studies beyond the 'Five Eyes' alliance

6 November 2019 , Volume 95, Number 6

Zakia Shiraz and Richard J. Aldrich

The study of secrecy and spies remain subjects dominated by Anglo-American experiences. In recent years there has been some effort to refocus the lens of research upon ‘intelligence elsewhere’, including the global South. This is partly because of intense interest in the Arab Spring and ‘managed democracy’, placing a wider range of secret services under the spotlight. However, the approach to research is still dominated by concepts and methods derived from studying the English-speaking states of the ‘Five Eyes’ alliance and their European outriders. This article calls for a re-examination of research strategies for Intelligence Studies and for those theorizing surveillance, suggesting that both fields have much to learn from area studies and development studies, especially in the realm of research practice and ethics. If the growing number of academics specializing in intelligence genuinely wish to move forward and examine the global South they will need to rethink their tool-kit and learn from other disciplines. We suggest there is a rich tradition to draw upon.




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Guidance Document: Validation of a High-Performance Liquid Chromatography-Tandem Mass Spectrometry Immunopeptidomics Assay for the Identification of HLA Class I Ligands Suitable for Pharmaceutical Therapies [Commentary]

For more than two decades naturally presented, human leukocyte antigen (HLA)-restricted peptides (immunopeptidome) have been eluted and sequenced using liquid chromatography-tandem mass spectrometry (LC-MS/MS). Since, identified disease-associated HLA ligands have been characterized and evaluated as potential active substances. Treatments based on HLA-presented peptides have shown promising results in clinical application as personalized T cell-based immunotherapy. Peptide vaccination cocktails are produced as investigational medicinal products under GMP conditions. To support clinical trials based on HLA-presented tumor-associated antigens, in this study the sensitive LC-MS/MS HLA class I antigen identification pipeline was fully validated for our technical equipment according to the current US Food and Drug Administration (FDA) and European Medicines Agency (EMA) guidelines.

The immunopeptidomes of JY cells with or without spiked-in, isotope labeled peptides, of peripheral blood mononuclear cells of healthy volunteers as well as a chronic lymphocytic leukemia and a bladder cancer sample were reliably identified using a data-dependent acquisition method. As the LC-MS/MS pipeline is used for identification purposes, the validation parameters include accuracy, precision, specificity, limit of detection and robustness.




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Secrets and Spies: UK Intelligence Accountability After Iraq and Snowden

20 January 2020

How can democratic governments hold intelligence and security agencies to account when what they do is largely secret? Jamie Gaskarth explores how intelligence professionals view accountability in the context of 21st century politics. 

Jamie Gaskarth

Senior Lecturer, University of Birmingham

Using the UK as a case study, this book provides the first systematic exploration of how accountability is understood inside the secret world. It is based on new interviews with current and former UK intelligence practitioners, as well as extensive research into the performance and scrutiny of the UK intelligence machinery.

The result is the first detailed analysis of how intelligence professionals view their role, what they feel keeps them honest, and how far external overseers impact on their work.

The UK gathers material that helps inform global decisions on such issues as nuclear proliferation, terrorism, transnational crime, and breaches of international humanitarian law. On the flip side, the UK was a major contributor to the intelligence failures leading to the Iraq war in 2003, and its agencies were complicit in the widely discredited U.S. practices of torture and 'rendition' of terrorism suspects. UK agencies have come under greater scrutiny since those actions, but it is clear that problems remain.

Secrets and Spies is the result of a British Academy funded project (SG151249) on intelligence accountability.

Open society is increasingly defended by secret means. For this reason, oversight has never been more important. This book offers a new exploration of the widening world of accountability for UK intelligence, encompassing informal as well as informal mechanisms. It substantiates its claims well, drawing on an impressive range of interviews with senior figures. This excellent book offers both new information and fresh interpretations. It will have a major impact.

Richard Aldrich, Professor of International Security, University of Warwick, UK

Gaskarth’s novel approach, interpreting interviews with senior figures from the intelligence world, brings fresh insight on a significant yet contested topic. He offers an impressively holistic account of intelligence accountability—both formal and informal—and, most interestingly of all, of how those involved understand it. This is essential reading for those wanting to know what accountability means and how it is enacted.

Rory Cormac, Professor of International Relations, University of Nottingham

About the author

Jamie Gaskarth is senior lecturer at the University of Birmingham, where he teaches strategy and decision-making. His research looks at the ethical dilemmas of leadership and accountability in intelligence, foreign policy, and defence. He is author/editor or co-editor of six books and served on the Academic Advisory panel for the 2015 UK National Security Strategy and Strategic Defence and Security Review.

Available now: Buying options

Insights: Critical Thinking on International Affairs

Department/project




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Secrets and Spies: UK Intelligence Accountability After Iraq and Snowden

20 January 2020

How can democratic governments hold intelligence and security agencies to account when what they do is largely secret? Jamie Gaskarth explores how intelligence professionals view accountability in the context of 21st century politics. 

Jamie Gaskarth

Senior Lecturer, University of Birmingham

Using the UK as a case study, this book provides the first systematic exploration of how accountability is understood inside the secret world. It is based on new interviews with current and former UK intelligence practitioners, as well as extensive research into the performance and scrutiny of the UK intelligence machinery.

The result is the first detailed analysis of how intelligence professionals view their role, what they feel keeps them honest, and how far external overseers impact on their work.

The UK gathers material that helps inform global decisions on such issues as nuclear proliferation, terrorism, transnational crime, and breaches of international humanitarian law. On the flip side, the UK was a major contributor to the intelligence failures leading to the Iraq war in 2003, and its agencies were complicit in the widely discredited U.S. practices of torture and 'rendition' of terrorism suspects. UK agencies have come under greater scrutiny since those actions, but it is clear that problems remain.

Secrets and Spies is the result of a British Academy funded project (SG151249) on intelligence accountability.

Open society is increasingly defended by secret means. For this reason, oversight has never been more important. This book offers a new exploration of the widening world of accountability for UK intelligence, encompassing informal as well as informal mechanisms. It substantiates its claims well, drawing on an impressive range of interviews with senior figures. This excellent book offers both new information and fresh interpretations. It will have a major impact.

Richard Aldrich, Professor of International Security, University of Warwick, UK

Gaskarth’s novel approach, interpreting interviews with senior figures from the intelligence world, brings fresh insight on a significant yet contested topic. He offers an impressively holistic account of intelligence accountability—both formal and informal—and, most interestingly of all, of how those involved understand it. This is essential reading for those wanting to know what accountability means and how it is enacted.

Rory Cormac, Professor of International Relations, University of Nottingham

About the author

Jamie Gaskarth is senior lecturer at the University of Birmingham, where he teaches strategy and decision-making. His research looks at the ethical dilemmas of leadership and accountability in intelligence, foreign policy, and defence. He is author/editor or co-editor of six books and served on the Academic Advisory panel for the 2015 UK National Security Strategy and Strategic Defence and Security Review.

Available now: Buying options

Insights: Critical Thinking on International Affairs

Department/project




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Virtual Roundtable: Re-integration or Dis-integration: What Does the Future Hold for Occupied Donbas?

Invitation Only Research Event

28 April 2020 - 4:00pm to 5:30pm

Event participants

Paul D’anieri, Professor of Public Policy and Political Science, University of California, Riverside
Vlad Mykhnenko, Associate Professor of Sustainable Urban Development, St Peter’s College, University of Oxford
Chair: Orysia Lutsevych, Research Fellow and Manager, Ukraine Forum, Chatham House

The armed conflict in Donbas has now entered its seventh year. President Zelenskyy, who came to power in May 2019, promised to end the war with Russia and bring peace to Ukraine.

Since assuming office, Zelenskyy has managed to revive the Normandy Format talks, complete military disengagement at three points along the line of contact and negotiate the release of over a hundred Ukrainians held as prisoners of war in Russia. However, ceasefire violations continue to occur frequently.

Looking at the origins of the armed conflict in Donbas and the region’s economic role in Ukraine’s economy, this event discusses the prospects for conflict resolution. Do the recent events signify an opportunity for peace? Does Zelenskyy have a viable plan for re-integrating Donbas or will the region be cut off from mainland Ukraine for the foreseeable future?

The speakers assess the strategy and track record of the Ukrainian government and its Western allies in bringing parts of the occupied Donbas under Kyiv’s control. They also review possible policy implications of the COVID-19 pandemic for the conflict.

Anna Morgan

Administrator, Ukraine Forum
+44 (0)20 7389 3274




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Virtual Roundtable: Re-integration or Dis-integration: What Does the Future Hold for Occupied Donbas?

Invitation Only Research Event

28 April 2020 - 4:00pm to 5:30pm

Event participants

Paul D’anieri, Professor of Public Policy and Political Science, University of California, Riverside
Vlad Mykhnenko, Associate Professor of Sustainable Urban Development, St Peter’s College, University of Oxford
Chair: Orysia Lutsevych, Research Fellow and Manager, Ukraine Forum, Chatham House

The armed conflict in Donbas has now entered its seventh year. President Zelenskyy, who came to power in May 2019, promised to end the war with Russia and bring peace to Ukraine.

Since assuming office, Zelenskyy has managed to revive the Normandy Format talks, complete military disengagement at three points along the line of contact and negotiate the release of over a hundred Ukrainians held as prisoners of war in Russia. However, ceasefire violations continue to occur frequently.

Looking at the origins of the armed conflict in Donbas and the region’s economic role in Ukraine’s economy, this event discusses the prospects for conflict resolution. Do the recent events signify an opportunity for peace? Does Zelenskyy have a viable plan for re-integrating Donbas or will the region be cut off from mainland Ukraine for the foreseeable future?

The speakers assess the strategy and track record of the Ukrainian government and its Western allies in bringing parts of the occupied Donbas under Kyiv’s control. They also review possible policy implications of the COVID-19 pandemic for the conflict.

Anna Morgan

Administrator, Ukraine Forum
+44 (0)20 7389 3274




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Why do the Scottish do fewer knee arthroscopies?

The “correct” rates of discretional interventions are difficult to define. However, David Hamilton and Colin Howie point out that discrepancies in usage of knee arthroscopy within the UK suggest the organisation of the care pathway may be an important determinant Read their full analysis: http://www.bmj.com/content/351/bmj.h4720




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Secrets and Spies: UK Intelligence Accountability

Members Event

5 March 2020 - 6:00pm to 7:00pm

Chatham House | 10 St James's Square | London | SW1Y 4LE

Event participants

Abigail Watson, Research Manager, Oxford Research Group
Dr Jamie Gaskarth, Reader in Foreign Policy and International Relations, University of Birmingham; Author, Secrets and Spies: UK Intelligence Accountability After Iraq and Snowden
Jo Hare, Ethics Counsellor
Dr Claudia Hillebrand, Senior Lecturer in International Relations, Cardiff University
Chair: Professor Sir David Omand GCB, Visiting Professor, King's College London; Security and Intelligence Coordinator, Cabinet Office, UK (2002-05); Director, GCHQ (1996-97)

As an important global actor, the UK gathers intelligence material that helps inform decisions on issues such as nuclear proliferation, terrorism, transnational crime and breaches of international humanitarian law. On the flip side, the UK was a major contributor to intelligence failures leading up to the Iraq war in 2003.

Using the UK as a case study and drawing on new research and interviews conducted by Dr Jamie Gaskarth, the panel will reflect on UK intelligence accountability in the context of 21st century politics. How can democratic governments hold intelligence and security agencies to account when what they do is largely secret? Should intelligence organizations create ethics committees allowing the public more input into intelligence decisions? And what has been the impact of technological and social changes, including the rise of artificial intelligence and social media, on the UK intelligence machinery?

This event will be followed by a drinks reception.

Secrets and Spies: UK Intelligence Accountability After Iraq and Snowden is part of the Chatham House Insights book series published jointly with the Brookings Institution Press. Secrets and Spies was the result of a project funded by the British Academy (SG151249). 


COVID-19
This event is proceeding as scheduled, as are other Chatham House events, in accordance with the advice from the UK Government, Foreign and Commonwealth Office and Public Health England. However, we are closely monitoring the spread of COVID-19 and will send updates to attendees as the situation warrants. 
In the meantime, in line with the official advice for returning travellers or visitors to the UK from specified countries and areas (see guidance here), we ask that:

  • If you have travelled from Category 1 countries/areas, you refrain from attending the event even if asymptomatic (i.e. even if you are showing no symptoms);
  • If you have travelled from Category 2 countries/areas, you refrain from attending the event should you develop symptoms.

If you fall under one of these affected categories and have any questions, please call +44 (0)207 314 3638 or email lbedford@chathamhouse.org.
 

This event is open to Chatham House Corporate Members only. Not a member? Find out more.

For further information on the different types of Chatham House events, visit Our Events Explained.

 

Members Events Team




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Dr. Loree Bolin is ADA’s 2020 Humanitarian Award recipient

Dr. Loree Bolin’s humanitarian work has drawn accolades from the dental community in her home state of Washington, and now Dr. Bolin is being recognized nationally by being named the recipient of the ADA’s 2020 Humanitarian Award, bestowed by the ADA Board of Trustees.




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Harvard dental student recipient of health literacy essay contest

An essay on community water fluoridation yielded a Harvard University dental student a first-place win in the annual American Dental Association’s Health Literacy in Dentistry essay contest.




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Risk of Major Adverse Cardiovascular Events, Severe Hypoglycemia, and All-Cause Mortality for Widely Used Antihyperglycemic Dual and Triple Therapies for Type 2 Diabetes Management: A Cohort Study of All Danish Users

OBJECTIVE

The vast number of antihyperglycemic medications and growing amount of evidence make clinical decision making difficult. The aim of this study was to investigate the safety of antihyperglycemic dual and triple therapies for type 2 diabetes management with respect to major adverse cardiovascular events, severe hypoglycemia, and all-cause mortality in a real-life clinical setting.

RESEARCH DESIGN AND METHODS

Cox regression models were constructed to analyze 20 years of data from the Danish National Patient Registry with respect to effect of the antihyperglycemic therapies on the three end points.

RESULTS

A total of 66,807 people with type 2 diabetes were treated with metformin (MET) including a combination of second- and third-line therapies. People on MET plus sulfonylurea (SU) had the highest risk of all end points, except for severe hypoglycemia, for which people on MET plus basal insulin (BASAL) had a higher risk. The lowest risk of major adverse cardiovascular events was seen for people on a regimen including a glucagon-like peptide 1 (GLP-1) receptor agonist. People treated with MET, GLP-1, and BASAL had a lower risk of all three end points than people treated with MET and BASAL, especially for severe hypoglycemia. The lowest risk of all three end points was, in general, seen for people treated with MET, sodium–glucose cotransporter 2 inhibitor, and GLP-1.

CONCLUSIONS

Findings from this study do not support SU as the second-line treatment choice for patients with type 2 diabetes. Moreover, the results indicate that adding a GLP-1 for people treated with MET and BASAL could be considered, especially if those people suffer from severe hypoglycemia.




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A Profile of Current DACA Recipients by Education, Industry, and Occupation

An average of 915 DACA recipients every day will lose their work authorization and protection from deportation once the phaseout of the program moves into full force in spring 2018, MPI estimates. This fact sheet also offers U.S. and state estimates of the school enrollment and educational attainment, workforce participation, and industries and occupations of employment for the nearly 690,000 current DACA holders.




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Sketch for a Self-Analysis, by Pierre Bourdieu

Pierre Bourdieu, a philosopher by education, and an anthropologist and sociologist by choice, is one of the most esteemed names in twentieth-century French thought. With his election in 1981 to the chair of sociology at the College de France, he joined the distinguished ranks of the most respected French social scientists, Raymond Aron and Claude Levi-Strauss. Prolific writer, Bourdieu has published more than 30 books and 340 articles over the period 1958 to 1995. The Social Science Citation Index ranking from high to low in 1989 for leading French thinkers was the following: Foucault, Bourdieu, Levi-Strauss, Derrida, Althusser, Sartre, Poulantzas, Touraine, Lacan, Baudrillard, and Aron.

Although his subject was mainly Algerian and French society,  Bourdieu’s approach is useful in analyzing power in many more illuminating ways than offered by Foucault. While Foucault sees power as "ubiquitous" and beyond agency or structure, Bourdieu sees power as economically, culturally, socially and symbolically created, and constantly re-legitimized through an interplay of agency and structure. The main way this comes about is through what he calls "habitus" or socialized norms or tendencies that unconsciously guide behavior, choices and thinking. In Bourdieu’s stipulation, habitus is "the way society becomes deposited in persons in the form of lasting dispositions, or trained capacities and structured propensities to think, feel and act in determinant ways, which then guide them."
In his Sketch for a Self-Analysis, written shortly before his death in January 2002, Bourdieu offers a "self-socioanalysis," in only 113 pages, and provides a compelling narrative of his life and career, and insights from his lifelong preoccupation with sociology, including intimate insights into the ideas of Foucault, Sartre, Althusser and de Beauvoir, among others, as well as his reflections on his own formative years at boarding school and his moral outrage at the colonial war in Algeria. Please join us as at Brooklyn Book Talk, as we explore some of the most stimulating thoughts of one of the greatest sociologists of the twentieth-century.




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Khachapuri - Georgian cheese pie

This recipe was featured on Foodie Tuesday, a weekly segment with Raf Epstein on Drive, 774 ABC Melbourne, 3:30 PM, courtesy of Alice in Frames. www.aliceinframes.com




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Coorong Angus Beef Pie with Red Wine, Fennel and Green Olives

This recipe featured on Foodie Tuesday, a weekly segment with Raf Epstein on Drive, 774 ABC Melbourne, 3.30PM, courtesy of Maggie Beer. Maggie's new book is "Autumn Harvest".




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Easter ricotta, spinach, egg and dill pie

This is a simplified version of a traditional Italian spinach and ricotta pie, commonly eaten on Good Friday.





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Lemon Meringue Pie

For the pastry casing: 200g plain flour 100g butter 50g sugar zest of half a lemon 1g vanilla seed 1/2 egg (beat egg, then halve it - should be about 25g) For the curd: 450ml water 180g sugar 75g cornflour 3ea lemons 45g butter 4 eggs For the Italian meringue: 4 x egg whites 270g caster sugar 1 x drop lemon juice 100ml water




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Teenagers Who Believe They Are Particularly Intelligent Tend To Be More Narcissistic And Happier With Life

By Emily Reynolds. But self-assessed intelligence was not actually related to objective measures of intelligence




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'Chris Spielman: A Football Life'

Former NFL linebacker talks about growing up with the game of football.




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Whit : Piecing Together the life and Death of South Australian Police Inspector Geoff Whitford.




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Utilisation of carp biomass : final report / Dr Janet Howieson, Andrew Tilley, Ewan Colquhoun, Elise O'Keefe, Steven Nash, Declan McDonald, Tony Evans, Gerry Gillespie, David Hardwick, Dr Sarah Beavis, Charles Francina, Daniel McCorey, Luke Wheat.




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Never run out : we all have a roll to play! / Lou Papier.

"A light-hearted take on the Australian toilet paper shortage. With a lot of worry and fear in the world today (2020), it is important to be informed and make good decisions based on the facts at hand. Panic buying caused supply shortages for some products. In Australia, one of the bizarre products to fall to panic buying was toilet roll. This little book, produced as a light-hearted response, offers a reminder that there is always an alternative. Contained in this book are sixteen "sheets". It may be single ply, but we are sure you will agree the 70lb paper has plenty of bulk" -- from the introduction.




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Jim Johnson mineralogy letters : copies of correspondence between James Eric (Jim) Johnson and Michael P. (Mick) Vort-Ronald, 1967-1977. / edited and illustrated by Michael P. Vort-Ronald.




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Colours of Impressionism : masterpieces from the Musée d'Orsay / [curators: Marine Kisiel, Paul Perrin].

Musée d'Orsay -- Exhibitions.




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The bastard brigade : the true story of the renegade scientists and spies who sabotaged the Nazi atomic bomb / Sam Kean.

Manhattan Project (U.S.) -- History.




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Catch and kill : lies, spies, and a conspiracy to protect predators / Ronan Farrow.

Weinstein, Harvey, 1952-




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Des paralysies pneumoniques / par Pierre Boulloche.

Paris : G. Steinheil, 1892.




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Des stations médicales dans les maladies des enfants; climatothérapie, hydrothérapie, eaux minérales, bains de mer / par Le Dr E. Perier.

Paris : Rueff, 1896.




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Diagnose und Therapie der Krankheiten des Menschen : mit Zugrundelegung der Lehren und Recepturen der ersten medicinisch-chirurgischen Autoritäten, und Anführung von 1500 Receptformeln im metrischen Gewichte, nebst einem Anhange über Balneo

Wien : M. Perles, 1878.




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Die Aetiologie der alteren und modernen Ophthalmologie in ihrer besonderen Bedeutung fur die Therapie / von Wilhelm Manz.

Freiburg : H.M. Poppen, 1886.




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Die allgemeine chirurgische Pathologie und Therapie : in einundfünfzig Vorlesungen : ein Handbuch für Studirende und Aerzte / von Theodor Billroth und Alex. v. Winiwarter.

Berlin : G. Reimer, 1893.




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Die allgemeine chirurgische Pathologie und Therapie : in fünfzig Vorlesungen : ein Handbuch für Studirende und Aerzte / von Theodor Billroth.

Berlin : G. Reimer, 1863.




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Die allgemeine chirurgische Pathologie und Therapie : in fünfzig Vorlesungen : ein Handbuch für Studirende und Aerzte / von Theodor Billroth.

Berlin : G. Reimer, 1876.




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Die Anwendung der Galvanokaustik im Innern des Kehlkopfes und Schlundkopfes : nebst einer kurzen Anleitung zur Laryngoskopie und Rhinoskopie / von Rudolph Voltolini.

Wien : W. Braumuller, 1867.




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Die Elektrotherapie und deren besondere Verwerthung in Nerven- und Muskelkrankheiten : ein Handbuch fur praktische Arzte / von Moriz Rosenthal.

Wien : Wilhelm Braumuller, 1873.




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Die Entstehung der Gefahr im Krankheitsverlaufe : mit besonderer Berücksichtigung der Diagnose der Gefahr, ihrer Prophylaxe und Therapie / von L.M. Politzer.

Wien : W. Braumuller, 1878.




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Die Erkrankungen der weiblichen Harnröhre und Blase : mit besonderer Berucksichtigung der Endoskopie und Cystoskopie dargestellt / von Gustav Kolischer.

Leipzig : F. Deuticke, 1898.




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Die Fötuslunge im gebornen Kinde für Pathologie, Therapie und gerichtliche Arzneiwissenschaft / geschildert von Eduard Jorg.

London : Black, Young & Young, 1835.




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Die Influenza : ihre Geschichte, Epidemiologie, Aetiologie Symptomatologie und Therapie, sowie ihre Complicationen und Nachkrankheiten / von A. Ripperger.

Munchen : J.F. Lehmann, 1892.




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Die Inhalations-Therapie in Krankheiten der Respirations-Organe : mit besonderer Berücksichtigung der durch das Laryngoscop ermittelten Krankheiten des Kehlkopfs / von Georg Lewin.

Berlin : A. Hirschwald, 1865.




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Die Krankheiten der Nase, ihrer Nebenhöhlen und des Rachens : mit Einschluss der Rhinoskopie und der localtherapeutischen Technik : für Studirende und Ärzte / von L. Rethi.

Wien : A. Holder, 1892.




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Die Krankheiten des Kehlkopfes und der Luftrohre : mit Einschluss der Laryngoskopie und local-therapeutischen Technik fuer praktische Aerzte und Studirende / von Philipp Schech.

Leipzig : Franz Deuticke, 1897.




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Die Pathologie und Therapie der Gehirn-Krankheiten : für Aerzte und Studirende / bearbeitet von Rud. Leubuscher.

Berlin : A. Hirschwald, 1854.




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Die Pathologie und therapie der hereditären Syphilis : nach ihrem gegenwärtigen Standpunkte / dargestellt von Ludwig Fürth.

Wien : Urban & Schwarzenberg, 1879.




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Die Pathologie und Therapie der Leukamie / klinisch bearbeitet von Friedrich Mosler.

Berlin : A. Hirschwald, 1872.




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Die Pathologie und Therapie der Nieren-Krankheiten : klinisch bearbeitet / von Siegmund Rosenstein.

Berlin : A. Hirschwald, 1870.




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Die Pathologie und Therapie der Nierenkrankheiten : klinisch bearbeitet / von Siegmund Rosenstein.

Berlin : A. Hirschwald, 1886.




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Die physiologische Diagnostik als Basis fur rationelle Therapie / systematisch bearbeitet von Josef Neisser.

Berlin : A. Hirschwald, 1879.