A molecular dynamics study of 72 flavonoids indicates certain flavonoids inhibit the main protease of SARS-CoV-2, which is responsible for COVID-19 disease.

Ramu Gorai utilizes both local American and Indian talent in his movies to address a variety of social issues.

EMMY® Nominee Rachel Brosnahan Partnered with GBK & Covenant House for a Meet & Greet Auction Where All the Proceeds Went to the Charity

Ambient Edge is one of Kingman's best-rated HVAC services companies

Getting Rid of Mineral Deposits on Shower Heads/Faucets

Dr Miner has been endorsed by Marquis Who's Who as a leader in the astrophysics field

Spanish learning program is "Small Business Trends" weekly spotlight company

The awards will be presented at the Jan. 27 Awards Luncheon at the 2020 NTSA Summit, Jan. 26-28, 2020, at the Gaylord Rockies Resort and Convention Center in Denver, CO

JoAllyn Archambault is the Director of American Indian Programs at the Smithsonian, where she is the preeminent curator of- and authority on American Indian culture, including its study, preservation, appreciation and celebration.

Famed Conservator Tapped For Work Attributed To Whistler

In partnership with Brand Apiary & Hollywood Swag Bag

The heirs of Nazi victim and Jewish Berlin banker Paul von Mendelssohn-Bartholdy announce that the National Gallery of Art in Washington, DC has transferred ownership to them of Pablo Picasso's Blue Period pastel entitled "Head of a Woman"

Herbiar presents its natural Advanced Lash High Definition Waterproof Mascara black, composed of high-quality natural ingredients which are carefully selected after extensive research and consideration.

EMMY™ Nominee Rachel Brosnahan Partnered with GBK & Covenant House for a Meet & Greet Auction Where All the Proceeds Went to the Charity

Fort Lauderdale Foreclosure Defense Attorneys look to ease the government employees affected by the current shutdown by helping them with their foreclosure and housing needs, and deferring payment for such services until they return to work.

In partnership with Brand Apiary & Hollywood Swag Bag

In partnership with Brand Apiary & Hollywood Swag Bag

The latest data analyzed by The Block Research shows that bitcoin miners made 8% more revenue in April as compared to March, thanks to a gradual recovery in bitcoin’s price.The post Bitcoin miners made $412.5 million in revenue during April, new data indicates appeared first on The Block.

Digitally determined businesses are those that have the bigger picture in mind and plan a roadmap towards advanced changes with a view of the entire business.

Nitin Gadkari, the minister for MSME and road transport and highways, also called upon the retailers to start exploring option of home delivery.

The amount towards upfront payment to the coal-bearing states i.e. Chhattisgarh, West Bengal, Madhya Pradesh and Odisha was sanctioned, an official said.

Abondoned Mine Closure Plan Public Scoping https://www.nps.gov/grca/learn/news/abandoned-mine-lands-closure-plan-project-scoping.htm

The National Park Service has released an Abandoned Mine Lands (AML) Closure Plan and Environmental Assessment for projects to correct health and safety hazards associated with abandoned mines in four national park system sites in Arizona. https://www.nps.gov/grca/learn/news/2010-02-12_mines_ea.htm

Abandoned Mine Lands Project https://www.nps.gov/grca/learn/news/abandoned-mine-lands-safety-projects-begin-in-grand-canyon-national-park.htm

The Irish people are repaying a debt of gratitude to Native Americans suffering from COVID-19, 170 years after a tribe helped Ireland during the Great Famine.

The post Irish People Are Repaying Debt of Gratitude to Suffering Native Americans 170 Years After Potato Famine appeared first on Good News Network.

Reports suggest that Cheryl is pushing for Girls Aloud to get back together after The Greatest Dancer was axed by the BBC

COLORADO-based THE LUMINEERS are presenting TODAY (5/8) COLORADO GIVES BACK, a live stream benefit concert from 1-4p MT for the COLORADO RESTAURANT WORKERS and NATIONAL MUSIC COMMUNITY. The … more

Hip Hop artist EMINEM reportedly confronted and detained an intruder in his DETROIT-area home in early APRIL. The alleged intruder, MATTHEW DAVID HUGHES, had set off a security alarm when he … more

The San Francisco Examiner is a longtime daily newspaper distributed in and around San Francisco, California, and has been published continuously since the late 19th century.

Today, the U.S. Environmental Protection Agency (EPA) announced a final rule that threatens to undermine the Mercury and Air Toxics Standards. The American Lung Association, Allergy & Asthma Network, Alliance of Nurses for Healthy Environments, American...

If you missed my conversation with my dear friend photographer + entrepreneur Jasmine Star, we were LIVE on CreativeLive TV. CreativeLiveTV is a brand-new, free, 24/7 variety show, live-streamed from the very casual living rooms, studios, and kitchen tables of our worldwide community of legendary creators.  Worth checking out over at http://creativelive.com/tv. In this episode, we’re coming to you from our living rooms to chat about not just survive in these strange times, but to thrive. In particular, finding, participating, and growing your online community. Enjoy! FOLLOW JASMINE: instagram | twitter | website Listen to the Podcast Subscribe   Watch the Episode This podcast is brought to you by CreativeLive. CreativeLive is the world’s largest hub for online creative education in photo/video, art/design, music/audio, craft/maker, money/life and the ability to make a living in any of those disciplines. They are high quality, highly curated classes taught by the world’s top experts — Pulitzer, Oscar, Grammy Award winners, New York Times best selling authors and the best entrepreneurs of our times.

The post Surviving + Thriving with Jasmine Star appeared first on Chase Jarvis Photography.

MineRL 2019 competition challenged participants to train sample-efficient agents to play Minecraft, by using a dataset of human gameplay and a limit number of steps the environment. We approached this task with behavioural cloning by predicting what actions human players would take, and reached fifth place in the final ranking. Despite being a simple algorithm, we observed the performance of such an approach can vary significantly, based on when the training is stopped. In this paper, we detail our submission to the competition, run further experiments to study how performance varied over training and study how different engineering decisions affected these results.

[IMAGE-1] I honestly don't know how people like Bryan Stevenson keep up the fight. Just Mercy is the true origin story of a literal social justice warrior, a Harvard-educated lawyer who, in the late 1980s, launched the Equal Justice Initiative in Montgomery, Alabama, to take on the neediest, most desperate cases.…

Disclosed herein is a method for producing an alcohol and an amine from an amide under an atmosphere of hydrogen with the use of, as a catalyst, a ruthenium complex that is easily prepared, easy to handle, and relatively cheaply obtained. Specifically, the method is a method for producing an alcohol and/or an amine from an amide compound under an atmosphere of hydrogen with the use of as a catalyst, a ruthenium carbonyl complex represented by the following general formula (1): RuXY(CO)(L) (1) wherein X and Y may be the same or different from each other and each represents an anionic ligand and L represents a tridentate aminodiphosphine ligand containing two phosphino groups and a —NH— group.

Provided is a method for stably and economically producing xylylenediamine with a high yield and long catalyst service life by hydrogenating dicyanobenzene that is obtained by ammoxidating xylene. By bringing an aqueous basic solution into contact with a dicyanobenzene-absorbed liquid, which is obtained by bringing an ammoxidation reaction gas into contact with an organic solvent, under specified temperature conditions, and subjecting a base and a carboxylic acid in the dicyanobenzene-absorbed liquid to a neutralization reaction so as to form an aqueous phase that contains a water-soluble salt, and then subjecting an organic phase and the aqueous phase to liquid-liquid separation so as to remove the aqueous phase, it is possible to remove the carboxylic acid contained in the dicyanobenzene-absorbed liquid with high selectivity while inhibiting loss of the dicyanobenzene. By subjecting the raw material dicyanobenzene, which is obtained by separating low boiling point compounds from the post liquid-liquid separation organic phase by distillation under reduced pressure, to hydrogenation, xylylenediamine is produced with a high yield and the service life of the hydrogenation catalyst is extended.

A process for reductive amination of aliphatic cyanoaldehydes to aliphatic diamines comprising (1) providing a mixture of 1,3-cyanocyclohexane carboxaldehyde and/or 1,4-cyanocyclohexane carboxaldehyde; (2) contacting said mixture with a metal carbonate based solid bed or a weak base anion exchange resin bed at a temperature from 15 to 40 ° C. for a period of at least 1 minute; (3) thereby treating said mixture, wherein said treated mixture has a pH in the range of 6 to 9; (4) feeding said treated mixture, hydrogen, and ammonia into a continuous reductive amination reactor system; (6) contacting said treated mixture, hydrogen, and ammonia with each other in the presence of one or more heterogeneous metal based catalyst systems at a temperature from 80 ° C. to 160 ° C. and a pressure from 700 to 3500 psig; (7) thereby producing one or more cycloaliphatic diamines is provided.

A process for preparing alkylated p-phenylenediamine having the steps of reacting aniline and nitrobenzene in presence of a complex base catalyst to obtain 4-aminodiphenylamine intermediates, hydrogenating the 4-aminodiphenylamine intermediates to 4-aminodiphenylamine in presence of a hydrogenation catalyst, and reductively alkylating the 4-aminodiphenylamine to alkylated p-phenylenediamine.

Disclosed is a process for preparing an aryloxyalkylene amine compound via an aminoethylation reaction comprising: a) reacting an aromatic hydroxyl compound in the presence of a basic catalyst with a 2-oxazolidinone compound of the formula II to form an intermediate reaction product; wherein R3 is selected from the group consisting of hydrogen or lower alkyl having 1 to 6 carbon atoms, R4 is selected from the group consisting of hydrogen, straight or branched chain alkyl having from one to six carbon atoms, phenyl, alkaryl, or arylalkyl; and b) reacting the intermediate product of step a) with a polyalkylene polyamine.

A process for conversion of aliphatic bicyclic amines to aliphatic diamines including contacting one or more bicyclic amines selected from the group consisting of 3-azabicyclo[3.3.1]nonane and azabicyclo[3.3.1]non-2-ene with ammonia and hydrogen, and alcohols in the presence of heterogeneous metal based catalyst systems, a metal selected from the group consisting of Co, Ni, Ru, Fe, Cu, Re, Pd, and their oxides at a temperature from 140° C. to 200° C. and a pressure from 1540 to 1735 psig for at least one hour reactor systems; forming a product mixture comprising aliphatic diamine(s), bicyclic amine(s), ammonia, hydrogen, and alcohol(s); removing said product mixture from the reactor system; removing at least some of the ammonia, hydrogen, water, alcohols, bicyclic amines from said product mixture; thereby separating the aliphatic diamines from said product mixture.

An improved process for making ethoxylated amine compounds such as ethanolamines. The improvement comprises the addition of an acid to the amine compound prior to the addition of ethylene oxide to a reactor wherein the ethoxylated amine compound is prepared. The improvement reduces the concentration of undesirable glycol ether and/or vinyl ether ethoxylate byproducts which may contribute to undesirable properties, such as color and foaming, of the ethoxylated amine compounds.

The invention relates to a method for preparing ring-halogenated N,N-dialkylbenzylamines and intermediates obtainable therefrom for preparing agrochemicals and pharmaceutically active ingredients.

The disclosed embodiments describe a method, an apparatus, an application specific integrated circuit, and a server that provides a fast and efficient look up for data analysis. The apparatus and server may be configured to obtain data segments from a plurality of input devices. The data segments may be individual unique subsets of the entire data set obtained by a plurality input devices. A hash function may be applied to an aggregated set of the data segments. A result of the hash function may be stored in a data structure. A codebook may be generated from the hash function results.

The invention relates to the use of a composition of A) at least one quaternary ammonia compound comprising at least one organic radical bonded to the ammonia nitrogen atom and optionally comprising heteroatoms and having 1 to 36 carbon atoms, and B) at least one amine alkoxylate ester of formula (1) or a salt thereof, where A, B are, independently of each other, a C2- through C5-alkylene radical R1, a C8- through C24-alkyl radical or alkenyl radical R2, R3, R4 independent of each other, H, or a C8- through C24-acyl radical, with the stipulation that at least one of the radicals R2, R3 or R4 stands for a C8- through C24-acyl radical, and x, y, z, independently of each other, stand for a whole number from 0 through 50, with the stipulation that x+y+z is a whole number from 1 through 100, in quantities of 10 through 5000 g/tonne of ore as a collector in silicate floation.

Disclosed embodiments provide pyrimidinediamine compounds useful for inhibiting kinase activity, including the activity of polo-like kinase 1 (PLK1). Also disclosed are pharmaceutical compositions comprising these compounds and methods of treating diseases associated with kinase activity, in particular enhanced PLK1 catalytic activity, such as diseases associated with abnormal cell proliferation, including neoplastic disorders.

The present invention provides 2,4-pyrimidinediamine compounds that inhibit the IgE and/or IgG receptor signaling cascades that lead to the release of chemical mediators, intermediates and methods of synthesizing the compounds and methods of using the compounds in a variety of contexts, including in the treatment and prevention of diseases characterized by, caused by or associated with the release of chemical mediators via degranulation and other processes effected by activation of the IgE and/or IgG receptor signaling cascades.

A system, method and computer program product for avoiding a processing flaw in a computer processor triggered by a predetermined sequence of hardware events. The system may include a detecting unit and a power-on reset unit. The detecting unit detects that the predetermined sequence of hardware events is going to occur at the computer processor. The power-on reset unit initializes the computer processor to a state stored in computer memory in response to detecting the sequence of hardware events.

An independently functioning or centrally controlled wall light switch is configured to operate in normal mode and a Jewish holiday mode wherein the state of the light is fixed, regardless of the user's physical manipulation of the light switch. The control system automatically activates holiday mode by combining a geographically determined Jewish religious clock executed by software and hardware that utilizes the current time, date and geographical location of the apparatus in accordance with the Jewish definition of time and laws for calculating numerous religiously significant shifting daily points in time. The control system further incorporates several energy saving and preference modes by utilizing a particular day's calculated religious points in time in conjunction with holiday behavior patterns common to most Jewish families to provide the user with a greatly simplified means of programming an automatically adjusting on/off light timer and dimming overlay functionality during holiday mode.

Process for producing silica-comprising dispersions comprising a polyetherol or a polyether amine, which comprises the steps of (i) admixing an aqueous silica sol (K) having an average particle diameter of from 1 to 150 nm and a silica content, calculated as SiO2, of from 1 to 60% by weight and a pH of from 1 to 6 with at least one polyetherol (b1) and/or polyether amine (b2) based on ethylene oxide and/or propylene oxide and having an average OH or amine functionality of from 2 to 6 and a number average molecular weight of from 62 to 6000 g/mol,(ii) distilling off at least part of the water,(iii) admixing the dispersion with at least one compound (S) having at least one at least monoalkoxylated silyl group and at least one alkyl, cycloalkyl or aryl substituent, where this substituent may have groups which are reactive toward an alcohol, an amine or an isocyanate in an amount of from 0.1 to 20 μmol of (S) per m2 of surface area of (K), where steps (i) and (iii) can be carried out simultaneously or in succession in any order, (iv) optionally adjusting the pH of the silica-comprising dispersions obtained to a value of from 7 to 12 by adding a basic compound, where step (iv) can also be carried out between steps (ii) and (iii).

Processes are disclosed for the conversion of a carbohydrate source to hexamethylenediamine (HMDA) and to intermediates useful for the production of hexamethylenediamine and other industrial chemicals. HMDA is produced by direct reduction of a furfural substrate to 1,6-hexanediol in the presence of hydrogen and a heterogeneous reduction catalyst comprising Pt or by indirect reduction of a furfural substrate to 1,6-hexanediol wherein 1,2,6-hexanetriol is produced by reduction of the furfural substrate in the presence of hydrogen and a catalyst comprising Pt and 1,2,6-hexanediol is then converted by hydrogenation in the presence of a catalyst comprising Pt to 1,6 hexanediol, each process then proceeding to the production of HMDA by known routes, such as amination of the 1,6 hexanediol. Catalysts useful for the direct and indirect production of 1,6-hexanediol are also disclosed.