Endurance sank beneath the ice during Ernest Shackleton’s legendary Antarctic expedition. More than a hundred years later, researchers document their own saga of how they found the vessel

A debating technique known as the "truth sandwich" is helping archaeologists combat a false narrative about an advanced ancient civilisation forgotten in human history

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Neuropathic pain is a form of chronic pain that develops because of damage to the nervous system. Treatment of neuropathic pain is often incompletely effective, and most available therapeutics have only moderate efficacy and present side effects that limit their use. Opioids are commonly prescribed for the management of neuropathic pain despite equivocal results in clinical studies and significant abuse potential. Thus, neuropathic pain represents an area of critical unmet medical need, and novel classes of therapeutics with improved efficacy and safety profiles are urgently needed. The cannabidiol structural analog and novel antagonist of GPR55, KLS-13019, was screened in rat models of neuropathic pain. Tactile sensitivity associated with chemotherapy exposure was induced in rats with once-daily 1-mg/kg paclitaxel injections for 4 days or 5 mg/kg oxaliplatin every third day for 1 week. Rats were then administered KLS-13019 or comparator drugs on day 7 in an acute dosing paradigm or days 7–10 in a chronic dosing paradigm, and mechanical or cold allodynia was assessed. Allodynia was reversed in a dose-dependent manner in the rats treated with KLS-13019, with the highest dose reverting the response to prepaclitaxel injection baseline levels with both intraperitoneal and oral administration after acute dosing. In the chronic dosing paradigm, four consecutive doses of KLS-13019 completely reversed allodynia for the duration of the phenotype in control animals. Additionally, coadministration of KLS-13019 with paclitaxel prevented the allodynic phenotype from developing. Together, these data suggest that KLS-13019 represents a potential new drug for the treatment of neuropathic pain.

SIGNIFICANCE STATEMENT

Chemotherapy-induced peripheral neuropathy (CIPN) is a common, debilitating side effect of cancer treatment with no known cure. The GPR55 antagonist KLS-13019 represents a novel class of drug for this condition that is a potent, durable inhibitor of allodynia associated with CIPN in rats in both prevention and reversal-dosing paradigms. This novel therapeutic approach addresses a critical area of unmet medical need.

People with sickle cell disease (SCD) often experience chronic pain as well as unpredictable episodes of acute pain, which significantly affects their quality of life and life expectancy. Current treatment strategies for SCD-associated pain primarily rely on opioid analgesics, which have limited efficacy and cause serious adverse effects. Cannabis has emerged as a potential alternative, yet its efficacy remains uncertain. In this study, we investigated the antinociceptive effects of ⁹-tetrahydrocannabinol (THC), cannabis’ intoxicating constituent, in male HbSS mice, which express >99% human sickle hemoglobin, and male HbAA mice, which express normal human hemoglobin A, as a control. Acute THC administration (0.1–3 mg/kg^–1, i.p.) dose-dependently reduced mechanical and cold hypersensitivity in human sickle hemoglobin (HbSS) but not human normal hemoglobin A (HbAA) mice. In the tail-flick assay, THC (1 and 3 mg/kg^–1, i.p.) produced substantial antinociceptive effects in HbSS mice. By contrast, THC (1 mg/kg^–1, i.p.) did not alter anxiety-like behavior (elevated plus maze) or long-term memory (24-hour novel object recognition). Subchronic THC treatment (1 and 3 mg/kg^–1, i.p.) provided sustained relief of mechanical hypersensitivity but led to tolerance in cold hypersensitivity in HbSS mice. Together, the findings identify THC as a possible therapeutic option for the management of chronic pain in SCD. Further research is warranted to elucidate its mechanism of action and possible interaction with other cannabis constituents.

SIGNIFICANCE STATEMENT

The study explores ⁹-tetrahydrocannabinol (THC)’s efficacy in alleviating pain in sickle cell disease (SCD) using a humanized mouse model. Findings indicate that acute THC administration reduces mechanical and cold hypersensitivity in SCD mice without impacting emotional and cognitive dysfunction. Subchronic THC treatment offers sustained relief of mechanical hypersensitivity but leads to cold hypersensitivity tolerance. These results offer insights into THC's potential as an alternative pain management option in SCD, highlighting both its benefits and limitations.

A former aid to Tony Blair has been criticised by the SNP after he said the Government "should do farmers what Thatcher did to the miners".

A type of mathematical problem that was previously impossible to solve can now be successfully analysed with artificial intelligence

Club captain Jordan Henderson, summer signing Naby Keita and centre back Joe Gomez were all absent for the shock midweek Champions League defeat to Red Star Belgrade..

Levels of certain cells, fatty molecules and proteins in the blood are different in people with chronic fatigue syndrome than in those without it, which could help doctors spot the condition sooner

New research into the moments between wakefulness and sleep could bring hope for insomniacs and even make us more creative problem-solvers

Norwegian scientists are working on a project investigating the separate or combined effect and suitability of different methods to reduce the presence of Listeria in salmon and trout. The DeList project is funded by FHF, the Norwegian Seafood Research Fund, and will run until the end of January 2025. Several... Continue Reading

EPICS in IEEE, a service learning program for university students supported by IEEE Educational Activities, offers students opportunities to engage with engineering professionals and mentors, local organizations, and technological innovation to address community-based issues.

The following two environmentally focused projects demonstrate the value of teamwork and direct involvement with project stakeholders. One uses smart biodigesters to better manage waste in Colombia’s rural areas. The other is focused on helping Turkish olive farmers protect their trees from climate change effects by providing them with a warning system that can identify growing problems.

No time to waste in rural Colombia

Proper waste management is critical to a community’s living conditions. In rural La Vega, Colombia, the lack of an effective system has led to contaminated soil and water, an especially concerning issue because the town’s economy relies heavily on agriculture.

The Smart Biodigesters for a Better Environment in Rural Areas project brought students together to devise a solution.

Vivian Estefanía Beltrán, a Ph.D. student at the Universidad del Rosario in Bogotá, addressed the problem by building a low-cost anaerobic digester that uses an instrumentation system to break down microorganisms into biodegradable material. It reduces the amount of solid waste, and the digesters can produce biogas, which can be used to generate electricity.

“Anaerobic digestion is a natural biological process that converts organic matter into two valuable products: biogas and nutrient-rich soil amendments in the form of digestate,” Beltrán says. “As a by-product of our digester’s operation, digestate is organic matter that can’t be transferred into biogas but can be used as a soil amendment for our farmers’ crops, such as coffee.

“While it may sound easy, the process is influenced by a lot of variables. The support we’ve received from EPICS in IEEE is important because it enables us to measure these variables, such as pH levels, temperature of the reactor, and biogas composition [methane and hydrogen sulfide]. The system allows us to make informed decisions that enhance the safety, quality, and efficiency of the process for the benefit of the community.”

The project was a collaborative effort among Universidad del Rosario students, a team of engineering students from Escuela Tecnológica Instituto Técnico Central, Professor Carlos Felipe Vergara, and members of Junta de Acción Comunal (Vereda La Granja), which aims to help residents improve their community.

“It’s been a great experience to see how individuals pursuing different fields of study—from engineering to electronics and computer science—can all work and learn together on a project that will have a direct positive impact on a community.” —Vivian Estefanía Beltrán

Beltrán worked closely with eight undergraduate students and three instructors—Maria Fernanda Gómez, Andrés Pérez Gordillo (the instrumentation group leader), and Carlos Felipe Vergara-Ramirez—as well as IEEE Graduate Student Member Nicolás Castiblanco (the instrumentation group coordinator).

The team constructed and installed their anaerobic digester system in an experimental station in La Vega, a town located roughly 53 kilometers northwest of Bogotá.

“This digester is an important innovation for the residents of La Vega, as it will hopefully offer a productive way to utilize the residual biomass they produce to improve quality of life and boost the economy,” Beltrán says. Soon, she adds, the system will be expanded to incorporate high-tech sensors that automatically monitor biogas production and the digestion process.

“For our students and team members, it’s been a great experience to see how individuals pursuing different fields of study—from engineering to electronics and computer science—can all work and learn together on a project that will have a direct positive impact on a community. It enables all of us to apply our classroom skills to reality,” she says. “The funding we’ve received from EPICS in IEEE has been crucial to designing, proving, and installing the system.”

The project also aims to support the development of a circular economy, which reuses materials to enhance the community’s sustainability and self-sufficiency.

Protecting olive groves in Türkiye

Türkiye is one of the world’s leading producers of olives, but the industry has been challenged in recent years by unprecedented floods, droughts, and other destructive forces of nature resulting from climate change. To help farmers in the western part of the country monitor the health of their olive trees, a team of students from Istanbul Technical University developed an early-warning system to identify irregularities including abnormal growth.

“Almost no olives were produced last year using traditional methods, due to climate conditions and unusual weather patterns,” says Tayfun Akgül, project leader of the Smart Monitoring of Fruit Trees in Western Türkiye initiative.

“Our system will give farmers feedback from each tree so that actions can be taken in advance to improve the yield,” says Akgül, an IEEE senior member and a professor in the university’s electronics and communication engineering department.

“We’re developing deep-learning techniques to detect changes in olive trees and their fruit so that farmers and landowners can take all necessary measures to avoid a low or damaged harvest,” says project coordinator Melike Girgin, a Ph.D. student at the university and an IEEE graduate student member.

Using drones outfitted with 360-degree optical and thermal cameras, the team collects optical, thermal, and hyperspectral imaging data through aerial methods. The information is fed into a cloud-based, open-source database system.

Akgül leads the project and teaches the team skills including signal and image processing and data collection. He says regular communication with community-based stakeholders has been critical to the project’s success.

“There are several farmers in the village who have helped us direct our drone activities to the right locations,” he says. “Their involvement in the project has been instrumental in helping us refine our process for greater effectiveness.

“For students, classroom instruction is straightforward, then they take an exam at the end. But through our EPICS project, students are continuously interacting with farmers in a hands-on, practical way and can see the results of their efforts in real time.”

Looking ahead, the team is excited about expanding the project to encompass other fruits besides olives. The team also intends to apply for a travel grant from IEEE in hopes of presenting its work at a conference.

“We’re so grateful to EPICS in IEEE for this opportunity,” Girgin says. “Our project and some of the technology we required wouldn’t have been possible without the funding we received.”

A purpose-driven partnership

The IEEE Standards Association sponsored both of the proactive environmental projects.

“Technical projects play a crucial role in advancing innovation and ensuring interoperability across various industries,” says Munir Mohammed, IEEE SA senior manager of product development and market engagement. “These projects not only align with our technical standards but also drive technological progress, enhance global collaboration, and ultimately improve the quality of life for communities worldwide.”

For more information on the program or to participate in service-learning projects, visit EPICS in IEEE.

On 7 November, this article was updated from an earlier version.

https://images.google.co.uk/url?q=https://yukselenakademi.com/kurs/detay/emlakcilik-belgesi-seviye-5

1. Church of England head Justin Welby who married Prince Harry and Meghan Markle resigns over pedophile scandal  Hindustan Times
2. Archbishop of Canterbury, Trump critic Justin Welby resigns. What is the sex abuse scandal?  The Times of India
3. Video | UK Church Abuse Scandal: Head Of Church Of England Steps Down  NDTV
4. ‘Church in crisis’: what the papers say about the archbishop of Canterbury’s resignation  The Guardian
5. World News Today Live Updates on November 13, 2024 : Archbishop of Canterbury Justin Welby resigns amid sexual abuse case—Who is he? What's the scandal? All you need to know  Mint

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Researchers at North Carolina State University have developed a robotic prosthetic ankle that can provide stability for lower limb amputees. The ankle uses electromyographic sensors placed on the sites of muscles in the residual limb that then convey the intentions of the wearer with regard to movement. So far, the system has been shown to […]

Mar 7, 2024

Tarek Masoud, who questioned Iriqat’s views of Oct. 7 and how a two-state solution could be achieved during the event, said in an interview later on Thursday that he was “reasonably confident and hopeful” the discussion was an opportunity for learning, and added he appreciated that Iriqat “did not deny the atrocities of Oct. 7.” Understanding the Palestinian perspective is critical for moving toward peace and a two-state solution, Masoud said. Masoud and Iriqat agreed to discuss her controversial social media posts during the dialogue. Iriqat said that she did not intend to justify the violence on Oct. 7, which included kidnappings of children and elderly, beheadings, and massacres of civilians, but meant to place the attack in the context of a decades-long conflict. She was intensely critical of Israel throughout the conversation, saying the “settler-colonial project started 76 years ago.”

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The sweeping epic of the unparalleled love between Harley Quinn and the Joker. Unparalleled because it doesn't really exist. She's co-dependant and he's just using her to inflate his own ego. But, hey, it's still a pretty epic story right up until they realize they're no good for each other and break up leaving the Joker to carry on in his life as a solitary monster, as it should be, and Harley to find love in the most unlikely of places when she meets her new friend Ivy... I'll be honest, I'm not a fan of Harley being with Joker. But this is a great shirt, anyway. Because of the reference. Wrap it around your torso today! $19.95 | URL | Paypal Credit | S - 2XL ')}

A type of mathematical problem that was previously impossible to solve can now be successfully analysed with artificial intelligence

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2nd February 2014 – Colombo, Sri Lanka Agriculture and wetlands should be managed in unison in order to conserve vital ecosystems and support the livelihoods of millions of people, according to a new report published to coincide with World Wetlands Day, today. Download the full media release Download the report

The post Millions affected, billions at stake: Scientists urge ‘wiser’ use of wetlands to tackle poverty and conserve ecosystems first appeared on International Water Management Institute (IWMI).