London : Macmillan, 1891.

Boston : Nathan Hale, 1835.

Edinburgh : Young J. Pentland, 1889.

London : Kegan Paul, Trench, Trubner, 1890.

London : Longmans, Green, 1902.

London : J. & A. Churchill, 1887.

The statewide teacher strike could end today if both chambers of the legislature pass the bill to deliver a 5 percent raise to all school employees.

Boeing CEO Dave Calhoun said the company was aiming to resume production this month, despite the ongoing grounding and coronavirus pandemic.

If you are looking for a well-designed Linux distro that is far from mainstream, loaded with performance features not found elsewhere, check out the 2020 upgrade of the MakuluLinux Core distro. It could change your perspective on what a daily computing driver should offer. Developer Jacque Montague Raymer recently released the 2020 edition of MakuluLinux Core OS.

We’re really, really sorry

Residents can now order up to two bottles of wine, 24 cans of beer or more than a litre of spirits from local restaurants and bars.

Parents-to-be who will have their new child delivered at the Thunder Bay Regional Health Sciences Centre have to follow a different set of guidelines than found at many other hospitals across Ontario.

<span class="topsy_trackback_comment"><span class="topsy_twitter_username"><span class="topsy_trackback_content">"Commonwealth Games will deliver" – ESPN STAR Sports | RSS Feeds ...: Globe and Mail"Commonwealth Games will deliv... http://bit.ly/9hmE8P</span></span>

Taking mom out for Mother's Day brunch is a tradition for many. But with people staying home and restaurants closed except for delivery or pick-up, this year's Mother's Day will be a little bit different. Food columnist Andrew Coppolino looks at options.

Karla Bell was outside an Orangeville hospital waiting to start her nursing shift when she heard a cry for help from a car in the parking lot. She ran up to find a woman in labour in the passenger seat. Natalie Kalata tells us the incredible story of how this baby was born.

As British Columbians maintain physical distancing recommendations during the COVID-19 pandemic, this year’s Easter celebrations will have to change. In Kamloops, B.C., organizations are working to make sure Easter is as fun and social as it can be. 

It’s been a nerve-wracking few years for the traditional auto industry. One Silicon Valley VC firm speculates on its future in an interview with Bloomberg.

OM EAST and a local partner prepare to send copies of the Right Choices Bible to the Nenets tribe on the Yamal Peninsula.

THE Murray window is closing but Tennis Scotland appear to be diving through it just in time. Failing to adequately capitalise on the ongoing successes of Andy and Jamie has been a long-time frustration of the family, with mum Judy vehement in her criticism of the governing bodies for their inertia.

Dandelion Cafe

Baker’s Delight

MY mother was known for her pizza but they were never round, not when we were growing up anyway. She would pull them from the ancient coal-fired cast iron range in the living room on long blackened oblong trays, the dough she had spent the day making puffed and undulating but always thin and super chewy.

Calabash African Restaurant

A SCOTTISH clean energy company has secured a key part in a six-figure contract for a hydrogen fuel project in Northern Ireland.

Temaki

Thyme: Lebanese Street Sajeria

FRANKLY? The restaurant world is going mad. Consider this: I order a home delivery from Yu-ca-taco early on Friday evening. For Saturday night. By text of course.

Neonatal hearing screening occasionally fails because of several perinatal and neonatal factors. However, the effect of mode of delivery on hearing screening has not yet been established.

We show significantly more failures on hearing screening in cesarean delivery infants. Hence, the timing of screening after cesarean delivery should preferably be postponed beyond 48 hours to improve success rate, minimize maternal anxiety, and decrease costs. (Read the full article)

Data suggest that delivery at high-volume, high-technology hospitals reduces neonatal mortality. No study has examined other complications or compared the effects in multiple states by using a study design to control for unmeasured differences in case mix.

The survival benefit to delivering at a high-level NICU between 1995 and 2005 is larger than previously reported and varies between states. The survival benefits affect both extremely and moderately preterm infants. Complication rates were similar between hospital types. (Read the full article)

Excess tissue oxygenation should be avoided during neonatal resuscitation, especially in premature infants. Delivered oxygen concentrations when using a self-inflating bag (SIB) at oxygen flows <1 L/min remain to be established.

Low oxygen concentrations (30%– 40%) can be delivered with a SIB at an oxygen flow <1 L/min. A practical scheme has been developed correlating the oxygen flow rate and the corresponding delivered fraction of oxygen when using a neonatal SIB. (Read the full article)

Preschool language delay is associated with poorer academic performance, more limited employment opportunities, and relationship difficulties. Despite its importance within public health, there has been little progress toward effective population-based prevention and intervention approaches to improve outcomes.

It is feasible to identify low language in 4-year-olds on a population basis and deliver a 1-on-1 intervention. By age 5 years, this resulted in better phonological awareness and letter knowledge. There was weak evidence of better expressive, but not receptive, language. (Read the full article)

Children receive only half of recommended health care; disadvantaged children have higher risk of unmet needs. Practice coaching combined with quality improvement using rapid-cycle feedback has potential to help practices meet quality standards and improve pediatric health care delivery.

The Practice-tailored Facilitation Intervention led to large and sustained improvements in preventive service delivery, including substantial numbers of disadvantaged children, and in multiple simultaneous health care domains. Practice-tailored facilitation holds promise as a method to advance pediatric preventive care delivery. (Read the full article)

Several studies have revealed an association between cesarean section (CS) and childhood type 1 diabetes. Most of these studies lacked important information on indication for CS and induction of labor. It is unknown whether the reported associations are causal.

Using a cohort of 2.6 million children we found an association between elective CS and type 1 diabetes. The sibling analysis suggested the association is not causal. The findings are crucial evidence to advise women on mode of delivery choice. (Read the full article)

Quality improvement (QI) studies generally do not account for concurrent trends of improvement and it is difficult to distinguish the impact of a multihospital collaborative QI project without a contemporary control group.

A multihospital collaborative QI model led to greater declines in hypothermia and invasive ventilation rates in the delivery room compared with an individual NICU QI model and NICUs that did not participate in formal QI activities. (Read the full article)

Maternal gestational weight gain is associated with childhood overweight. It is unknown whether gestational weight gain programs the child’s health or whether gestational weight gain is an indicator of postnatal behavioral factors.

We disentangled these influences by studying the effect of gestational weight gain simultaneously with postdelivery maternal weight change as an indicator for shared family lifestyle on child’s weight development and found that both had an independent effect. (Read the full article)

Probiotics might provide an alternative approach for the control of oral candidiasis. However, studies on the antifungal activity of probiotics in the oral cavity are based on the consumption of yogurt or other dietary products, and there is a necessary to use appropriate biomaterials and specific strains to obtain probiotic formulations targeting local oral administration. In this study, we impregnated gellan gum, a natural biopolymer used as a food-additive, with a probiotic and investigated its antifungal activity against Candida albicans. Lactobacillus paracasei 28.4, a strain recently isolated from the oral cavity of a caries-free individual, was incorporated in several concentrations of gellan gum (0.6% to 1%). All tested concentrations could incorporate L. paracasei cells while maintaining bacterial viability. Probiotic/gellan formulations were stable for 7 days when stored at room temperature or 4°C. Long-term storage of bacteria-impregnated gellan gum was achieved when L. paracasei 28.4 was lyophilized. The probiotic/gellan formulations provided a release of L. paracasei cells over 24 hours that was sufficient to inhibit the growth of C. albicans with effects dependent on the cell concentrations incorporated into gellan gum. The probiotic/gellan formulations also had inhibitory activity against Candida spp. biofilms by reducing the number of Candida spp. cells (p < 0.0001), decreasing the total biomass (p = 0.0003), and impairing hyphae formation (p = 0.0002), compared to the control group which received no treatment. Interestingly, probiotic formulation of 1% w/v gellan gum provided an oral colonization of L. paracasei in mice with approximately 6 log of CFU/mL after 10 days. This formulation inhibited the C. albicans growth (p < 0.0001), prevented the development of candidiasis lesions (p = 0.0013), and suppressed inflammation (p = 0.0006) when compared to the mice not treated in the microscopic analysis of the tongue dorsum. These results indicate that gellan gum is a promising biomaterial and can be used as a carrier system to promote oral colonization for probiotics that prevent oral candidiasis.

Staphylococcus aureus osteomyelitis is a debilitating infection of bone. Treatment of osteomyelitis is impaired by the propensity of invading bacteria to induce pathologic bone remodeling that may limit antibiotic penetration to the infectious focus. The nonsteroidal anti-inflammatory drug diflunisal was previously identified as an osteoprotective adjunctive therapy for osteomyelitis, based on the ability of this compound to inhibit S. aureus quorum sensing and subsequent quorum-dependent toxin production. When delivered locally during experimental osteomyelitis, diflunisal significantly limits bone destruction without affecting bacterial burdens. However, because diflunisal's "quorum-quenching" activity could theoretically increase antibiotic recalcitrance, it is critically important to evaluate this adjunctive therapy in the context of standard of care antibiotics. The objective of this study is to evaluate the efficacy of vancomycin to treat osteomyelitis during local diflunisal treatment. We first determined that systemic vancomycin effectively reduces bacterial burdens in a murine model of osteomyelitis, and identified a dosing regimen that decreases bacterial burdens without eradicating infection. Using this dosing scheme, we found that vancomycin activity is unaffected by the presence of diflunisal in vitro and in vivo. Similarly, locally-delivered diflunisal still potently inhibits osteoblast cytotoxicity in vitro and bone destruction in vivo in the presence of sub-therapeutic vancomycin. However, we also found that the resorbable polyurethane foams used to deliver diflunisal serve as a nidus for infection. Taken together, these data demonstrate that diflunisal does not significantly impact standard of care antibiotic therapy for S. aureus osteomyelitis, but also highlight potential pitfalls encountered with local drug delivery.

True to its name, Home Chef is the homiest of meal services we've tried. The recipes are simple and not too adventurous, but for some home chefs, that's a good thing.

Wolfgang Lindner
May 1, 1999; 103:961-967
ARTICLES

D. Brooks Smith, Chief Judge of the United States Court of Appeals for the Third Circuit, will deliver the Penn State Law in University Park 2020 commencement address on May 16 in Eisenhower Auditorium.

Finance Minister Tito Mboweni is delivering his mini budget, just days after being appointed to the post. What his speech live.

The 26 pound drone and its cargo fell to the ground after somehow managing to sever its own parachute rope. It landed 150 feet away from a group of children.

The trial, which will be open to residents of Christiansburg, Virginia, offers a glimpse into what kinds of services we can expect from Wing's drone-powered delivery system.

A Japanese drone startup said on Tuesday it was partnering with Unilever, the owner of Ben & Jerry's, to explore developing an ice cream drone-delivery service in New York.

Delaware’s Department of Insurance is pleased to announce that it is actively recruiting for a qualified independent contractor to staff and run its new Office of Value-Based Health Care Delivery. The Office will assist the Insurance Commissioner and Delaware’s Primary Care Reform Collaborative in evaluating primary care accessibility and affordability statewide. “Reducing health care costs […]

The biggies have built dark stores, warehousing, last-mile deliveries and launched private labels, but still struggle with low margins.

With increasing interest in Continuous Integration/Continuous Delivery (CI/CD), many SAS Users want to know what can be done for Visual Analytics reports. In this article, I will explain how to use Python and SAS Viya REST APIs to extract a report from a SAS Viya environment and import it into another environment.

Continuous Integration/Continuous Delivery – Using Python and REST APIs for SAS Visual Analytics reports was published on SAS Users.

With increasing interest in Continuous Integration/Continuous Delivery (CI/CD), many SAS Users want to know what can be done for Visual Analytics reports. In this article, I will explain how to use Python and SAS Viya REST APIs to extract a report from a SAS Viya environment and import it into another environment.

Continuous Integration/Continuous Delivery – Using Python and REST APIs for SAS Visual Analytics reports was published on SAS Users.