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Directed nucleophilic aromatic substitution reaction

Chem. Commun., 2024, Accepted Manuscript
DOI: 10.1039/D4CC04912H, Communication
Yasuyuki Nitta, Takashi Nishikata, Michinori Sumimoto, Yusei Nakashima
In this study, we discovered a directed nucleophilic aromatic substitution reaction, "directed SNAr (dSNAr)", in the reaction of ortho-iodobezamides and amine in the presence of pyridine. The reaction proceeded ortho-specifically...
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Recent Advances in Photochemical Strain-Release Reactions of Bicyclo[1.1.0]butanes

Chem. Commun., 2024, Accepted Manuscript
DOI: 10.1039/D4CC05108D, Highlight
Xiang Zhou, Ye Hu, Yao Huang, Yang Xiong
Bicyclo[1.1.0]butanes (BCBs) are attractive compounds for their beautiful “butterfly” conformations, distinctive properties, and novel reactivities. As soon as the first example had been synthesized, a wide range of strain-release reactions...
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Catalytic asymmetric Michael and Nef-type sequential reaction of nitroolefin with azlactone to construct oxazole-fused succinimide

Chem. Commun., 2024, 60,13384-13387
DOI: 10.1039/D4CC04858J, Communication
Rui Weng, Yuqiao Zhou, Yaqin Zhang, Xiaoming Feng, Xiaohua Liu
A series of oxazole-fused succinimides bearing vicinal quaternary carbon centers were synthesized via catalytic asymmetric Michael addition and Nef-type sequential reactions of nitroolefins with azlactones.
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Employing a PhI(OAc)2-mediated domino reaction to assemble nitrogen-containing heterocyclic derivatives and assessing their anti-inflammatory activity

Chem. Commun., 2024, 60,13352-13355
DOI: 10.1039/D4CC03245D, Communication
Xinyue Li, Yuhua Fang, Yuanyuan Zhao, Shenshen Luo, Yuhui Xue, Tingting Yong, Bin Wang
Metal-free radical cascade synthesis of substituted pyrazole derivatives was initiated by PhI(OAc)2 at 23 °C.
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Ultrafine PtCo alloy nanoparticles integrated into porous N-doped nanosheets for durable oxygen reduction reaction

Chem. Commun., 2024, 60,13432-13435
DOI: 10.1039/D4CC04661G, Communication
Baoliang Chen, Lei Zhao, Zhaozhao Zhu, Pei Xiong, Zhao Li, Jun Song Chen, Lanlan Li, Rui Wu
The PtCo–CoNC–P catalyst, featuring sub-3 nm small-size PtCo alloy nanoparticles integrated into a porous nitrogen-doped nanosheet, exhibits exceptional durability after 30 000 cycles of accelerated durability tests.
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Investigations of the interactions between ZnO nanorods and H2 with 17O NMR spectroscopy

Chem. Commun., 2024, Advance Article
DOI: 10.1039/D4CC05371K, Communication
Benteng Song, Fang Wang, Qin Zhu, Ling-Hai Xie, Luming Peng
Schematic diagram for the interaction of H2 with ZnO nanorods under different conditions.
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Synthesis of substituent-free dioxadiaza[8]circulene to investigate intermolecular interactions and photophysical properties

Chem. Commun., 2024, Advance Article
DOI: 10.1039/D4CC05539J, Communication
Aoi Nakagawa, Wataru Ota, Takumi Ehara, Yusuke Matsuo, Kiyoshi Miyata, Ken Onda, Tohru Sato, Shu Seki, Takayuki Tanaka
Substituent-free dioxadiaza[8]circulene has been synthesized and its dense packing structure and optical properties were analyzed in detail.
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Ceria-based supported metal catalysts for the low-temperature water-gas shift reaction

Chem. Commun., 2024, Accepted Manuscript
DOI: 10.1039/D4CC04072D, Feature Article
Xin-Pu Fu, hui zhao, Chun-Jiang Jia
Water-gas shift (WGS) reaction is a crucial step for the industrial production of hydrogen or upgrading hydrogen generated from fossil or biomass sources by removing the residual CO. However, current...
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Axial oxygen-bridged FeN4O/NC produced by ultrafast joule heating for efficient oxygen reduction reaction

Chem. Commun., 2024, Accepted Manuscript
DOI: 10.1039/D4CC05604C, Communication
Feng Liu, Xinyu Guo, Yan Zhong, Shaqi Fu, Jingsha Li, Chunmei Zhang, Heng Zhang, Fenghui Ye, Shuai Yuan, Chuangang Hu, Chunxian Guo
Herein, we report an atomically dispersed Fe-N-C catalyst with axial oxygen ligands (FeN4O/NC) firstly synthesized by ultrafast joule heating. The formation of oxygen species between FeN4 and graphene, which offers...
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Laccase-catalyzed tyrosine click reaction with 1-methyl-4-arylurazole: rapid labeling on protein surfaces

Chem. Commun., 2024, Advance Article
DOI: 10.1039/D4CC03802A, Communication
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Keita Nakane, Chizu Fujimura, Shogo Miyano, Zhengyi Liu, Tatsuya Niwa, Hafumi Nishi, Tetsuya Kadonosono, Hideki Taguchi, Shusuke Tomoshige, Minoru Ishikawa, Shinichi Sato
Our study shows efficient tyrosine labeling using 1-methyl-4-arylurazole (MAUra) with laccase under mild conditions. This method achieves a high efficiency (kcat/Km = 7.88 × 104 M−1 s−1), selectively targeting exposed tyrosine sites on proteins.
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In silico investigation of the interaction between α-synuclein aggregates and organic supramolecular assemblies

Mol. Syst. Des. Eng., 2024, 9,1155-1166
DOI: 10.1039/D4ME00071D, Paper
Laura Le Bras, Yves L. Dory, Benoît Champagne
An α-synuclein aggregate with the PreNAC and NACore areas, responsible for the aggregation, highlighted.
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DORA-XGB: An improved enzymatic reaction feasibility classifier trained using a novel synthetic data approach

Mol. Syst. Des. Eng., 2024, Accepted Manuscript
DOI: 10.1039/D4ME00118D, Paper
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Yash Chainani, Joseph Ni, Kevin Shebek, Keith Tyo, Linda J. Broadbelt
Retrobiosynthesis tools harness the inherent promiscuities of enzymes for the de novo design of novel biosynthetic pathways to key small molecules. Many existing pathway search algorithms rely on exhaustively enumerating...
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Development of xanthan gum-based solid desiccants for the extraction of water vapors from humid air

Mol. Syst. Des. Eng., 2024, Advance Article
DOI: 10.1039/D4ME00134F, Paper
Hemant Mittal, Ali Al Alili, Saeed M. Alhassan, Naved I. Malek, Md. Didarul Islam
A xanthan gum-acrylamide desiccant with interconnected capillary channels was prepared and showed 1.38 g g−1 water adsorption at 90% RH and 25 °C, retaining 70% capacity over 20 cycles, proving its effectiveness as a salt-free desiccant.
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Exogenous analogues of substance P trigger pseudo-allergic reactions through activation of MRGPRX2

New J. Chem., 2024, Advance Article
DOI: 10.1039/D3NJ04581A, Paper
Yi Shan, Jiayu Lu, Na Li, Xiaoxue Mo, Cheng Wang, Huaizhen He
This article reports that exogenous analogues of the neuropeptide substance P can activate MRGPRX2 to trigger pseudo-allergic reactions.
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A Novel In-Syringe Cloud Point Extraction Method for the Determination of Cadmium and Lead in Human Hair Samples

New J. Chem., 2024, Accepted Manuscript
DOI: 10.1039/D4NJ00335G, Paper
Hesane Zolfaghari, Seyed Mosayeb Daryanavard, Aqil Gholamshahzadeh
The measurement of contaminant elements, especially cadmium and lead, in biological samples typically requires time-consuming sample preparation methods that consume organic solvents that are harmful to humans and the environment....
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Ligand-free ultrasmall palladium nanoparticle catalysis for the Mizoroki–Heck reaction in aqueous micelles

New J. Chem., 2024, 48,7102-7110
DOI: 10.1039/D3NJ05715A, Paper
Xiaojun Luo, Siyuan Wu, Linxi Hou, Xin Ge
A simple and sustainable strategy is proposed to construct a nanoreactor by connecting micelles with in-situ prepared ultrasmall Pd NPs to efficiently catalyze the Mizoroki-Heck reaction.
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Mechanochemical synthesis of biphenyl-derived organic fluorescent materials via solvent-free and ligand-free oxidative homocoupling reactions

New J. Chem., 2024, 48,7356-7361
DOI: 10.1039/D4NJ00886C, Paper
Zefeng Li, Caihang Zhang, Yingxuan Zheng, Ping Deng, Yan Yu
The palladium-catalyzed solvent-free and ligand-free oxidative homocoupling reactions of aryl boronic acids via ball-milling are developed to synthesize a series of biphenyl-derived organic fluorescent materials.
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Nanopolyhedral Zn/Fe-NC derived from bimetallic zeolitic imidazole frameworks as an efficient catalyst for the oxygen reduction reaction in an air-cathode microbial fuel cell

New J. Chem., 2024, 48,7092-7101
DOI: 10.1039/D3NJ05279F, Paper
Qianwu Wang, Jingzhao Lu, Songlin Liu, Boqu Yu, Bolong Liang
The synergistic effect of Zn, N and moderate Fe doping enhances the ORR performance. The maximum power density of the Zn/Fe-NC-0.5 MFC is 1954 ± 20 mW m−2.
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Copper(II) complexes of sterically hindered phenolic Schiff bases: synthesis, characterization, interaction with biomolecules, and antioxidant and antimicrobial activity

New J. Chem., 2024, 48,7134-7147
DOI: 10.1039/D4NJ00430B, Paper
Iveta S. Turomsha, Maxim Y. Gvozdev, Nikolai P. Osipovich, Viktoryia A. Staravoitava, Dmitriy I. Shiman, Natalia V. Loginova
Phenolic Schiff bases and their Cu(II) complexes have been synthesized and characterized by physicochemical methods. The complexes exhibit low cell toxicity and high antioxidant and antibacterial activity, as evidenced by molecular docking studies.
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Construction of NiCo2S4−xPx nanowire arrays for efficient hydrogen evolution reactions in both acidic and alkaline media

New J. Chem., 2024, Advance Article
DOI: 10.1039/D4NJ00361F, Paper
Guanglei Liu, Yutong Feng, Yifan Yang, Yuan Wang, Huixiang Liu, Can Li, Mingxin Ye, Jianfeng Shen
Construction of NiCo2S4−xPx nanowire arrays for improved HER performances in both acidic and alkaline media.
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Oxazoline amino acid bioconjugates: one-pot synthesis and analysis of supramolecular interactions

New J. Chem., 2024, Advance Article
DOI: 10.1039/D4NJ00995A, Paper
Marija Bakija, Berislav Perić, Srećko I. Kirin
Oxazoline amino acid bioconjugates were synthesized; the relative stability of a supramolecular dimer of a tris-derivative was investigated using mean absolute error values (MAE), derived from 1H NMR experiments and DFT calculations.
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1-Butyl-3-methylimidazolium hydrogen sulfate-induced structure modification and reconstruction of nickel foams for oxygen evolution reactions

New J. Chem., 2024, Advance Article
DOI: 10.1039/D3NJ05752F, Paper
Huamei Yang, Ziqin Chen, Kai Luo, Mengjun Yu, Yao Zhang
Surface chemical etching for the in situ growth of metal–organic materials and electrochemical reconstruction are expected to efficiently improve the catalytic performance of oxygen evolution reactions (OERs).
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Electrodeposited Ni-Fe alloy a cost-effective material for harnessing hydrogen via oxygen evolution and urea oxidation reaction

New J. Chem., 2024, Accepted Manuscript
DOI: 10.1039/D4NJ00797B, Paper
Venkatachalam Ananth, Venkatesan Senthilnathan, Murugan Veerapandian, Neelamegam Rajasekaran
Electrochemical energy conversion for hydrogen production is a crucial method to address global energy demand. Here, a cost-effective approach for the preparation of transition metal-based alloy electrode through electrodeposition with...
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Self-Sacrificial templated-directed synthesis of ultrathin 0D/2D FeNi3-NC/NiFeOx Schottky junction as hydrogen evolution reaction electrode for alkaline seawater electrolysis

New J. Chem., 2024, Accepted Manuscript
DOI: 10.1039/D4NJ01321B, Paper
Zili Xu, Yuankang Bao, Xun Xu, Ping Li, Hao Zhang, Deliang Li, Shuwang Duo
Seawater, a plentiful natural resource, is promising for hydrogen production compared to traditional electrocatalytic methods based on high-purity freshwater. This strategy shift addresses the challenge of limited freshwater resources and...
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Interaction of disposable face mask (nano)microplastics with antibiotics: performance and mechanisms

Environ. Sci.: Nano, 2024, Advance Article
DOI: 10.1039/D3EN00775H, Paper
Ting Zhang, Xi Chen, Angrui Jiang, Jingfan Qi, Zhaoyang You, Kinjal J. Shah
The adsorption of ciprofloxacin (CIP), sulfamethoxazole (SMX) and tetracycline (TC) on disposable face mask (nano-)microplastics occurs in the order SMX > CIP > TC, which correlates with the octanol–water partition coefficient of antibiotics.
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Characterization of black carbon and silica nanoparticle interactions with human plasma proteins

Environ. Sci.: Nano, 2024, Advance Article
DOI: 10.1039/D3EN00773A, Communication
Si-si Chen, Hong-juan Chen, Xue-wen Guo, Wei-juan Zheng, Hong-zhen Lian
Black carbon and silica nanoparticles, modeling different sources of PM, differ in protein corona composition and effects on protein structure.
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Fractionation and preconcentration of silver nanoparticles at environmentally relevant concentrations through induced eco-corona formation and spICP-MS characterization

Environ. Sci.: Nano, 2024, 11,1559-1570
DOI: 10.1039/D3EN00933E, Paper
Aline Martins de Andrade, Anerise de Barros, Italo Odone Mazali, Marco Aurélio Zezzi Arruda
The release of nanoparticles (NPs) into environmental matrices has raised concerns regarding the contamination of environmental matrices. An induced eco-corona method was used to preconcentrate silver NPs in environmental waters analysed by spICP-MS.
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Understanding the active sites and associated reaction pathways of metal-free carbocatalysts in persulfate activation and pollutant degradation

Environ. Sci.: Nano, 2024, 11,1368-1393
DOI: 10.1039/D3EN00988B, Critical Review
Huawen Hu, Dongchu Chen, Yaoheng Liang, Wenyi Wang, Yinlei Lin, Xuejun Xu, Xiaowen Wang, Kun Wang, Yuyuan Zhang, Jian Zhen Ou
Environmental remediation based on peroxomonosulfate- and peroxydisulfate-activation-enabled radical/non-radical oxidation has gained growing interest due to the strong oxidation power, long life of reactive oxygen species, and wide pH adaptability.
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Core–shell magnetic zinc-based molecularly imprinted polymer: a robust heterogeneous catalytic nanoreactor toward the CO2 fixation reaction

Environ. Sci.: Nano, 2024, 11,1622-1635
DOI: 10.1039/D3EN00554B, Paper
Tahereh Nasiriani, Neda Adabi Nigjeh, Ahmad Shaabani
This study deals with the synthesis of a core–shell magnetic zinc-based molecularly imprinted polymer (M-Zn-MIP) as a robust heterogeneous catalytic nanoreactor. The catalytic activity of the M-Zn-MIP was explored in the CO2 fixation reaction.
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After Youtuber's arrest, Kerala govt warns stern legal action against misleading social media content

Kerala Police arrested controversial Youtuber 'Thoppi' who had been accused of making allegedly objectionable remarks and creating a traffic block in Malappuram district




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Twitter threatens legal action against “copy cat” Meta for launching Threads

In a letter to Mark Zuckerburg, Alex Spiro, an attorney representing Twitter, accused Meta of unlawfully using Twitter’s trade secrets and other intellectual property by hiring former Twitter employees to create a “copycat” app




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Kerala govt. considering action against IAS officer for creating religion-based WhatsApp group

K. Gopalakrishnan, Director of Industries and Commerce, claimed that his phone was hacked. However, the police could not find any evidence of hacking




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Officials violating service rules will face action, says Revenue Minister

Minister was responding to questions by mediapersons in connection with the recent Facebook posts by IAS officer N. Prasanth against his senior colleague A. Jayathilak




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Private actions in the presence of externalities [electronic resource] : the health impacts of reducing air pollution peaks but not ambient exposure / Susanna B. Berkouwer, Joshua T. Dean

Cambridge, MA. : National Bureau of Economic Research, 2023




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Badlapur case: HC questions Maharashtra govt. on action taken for lapses in probe

A Division Bench of Justices Revati Mohite Dere and Prithviraj Chavan noted that a departmental probe has been set up against the errant Badlapur police officials.




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Why Varun-Samantha Had To Do Action...'

'In the current world of action cinema, where everything is high-tech and glossy, what if we go back in time and take out all the gadgets?'




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Climate action needs a lot more acceleration

As various indicators spike up and weather conditions change, there is a need for concerted effort to mitigate global warming




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Holding building sites accountable for their actions

To combat air pollution New Delhi attempts to rein in construction and demolition waste




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UNGA president calls for global action to ensure success of Pact for the Future




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Baku climate talks: India not attending World Leaders Climate Action Summit




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Telangana CM orders action against traders cheating farmers




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Can we take action?

Bankei’s meditation classes had run into a problem. Somebody was stealing! What could they do?




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Synthesis of 3,5-disubstituted isoxazoles by domino reductive Nef reaction/cyclization of β-nitroenones

Org. Biomol. Chem., 2024, Advance Article
DOI: 10.1039/D4OB00232F, Paper
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Muhammad Ehtisham Ibraheem Khan, Tomas Lighuen Cassini, Marino Petrini, Alessandro Palmieri
β-Nitroenones were converted into 3,5-disubstituted isoxazoles via a domino reaction promoted by tin(II) dichloride. The protocol efficiently works under both microwave and flow conditions.
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Siloxane-containing phosphine (oxide) ligands for enhanced catalytic activity of cobalt complexes for hydrosilylation reactions

Org. Biomol. Chem., 2024, Advance Article
DOI: 10.1039/D4OB00333K, Paper
Peng Liu, Jiajian Peng, Ying Bai, Jiayun Li
A series of siloxane-containing phosphine (oxide) ligands have been designed and synthesized.
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A water mediated multicomponent reaction for the synthesis of novel spirooxindole derivatives and their antifungal activity

Org. Biomol. Chem., 2024, Advance Article
DOI: 10.1039/D4OB00256C, Paper
Min Zhang, Liang Shi, Li Chen, Zhengyu Liu, Ting Zhao, Chunyin Zhu, Liuqing Yang
A total of 27 novel spirooxindoles were synthesized through a water mediated three-component reaction of isatin, 4-aminocoumarin, and 1,3-cyclodicarbonyl compounds. Several compounds showed excellent antifungal activity against Physalospora piricola.
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Diastereoselective synthesis of functionalized spiroindolines via intramolecular ipso-iodocyclization/nucleophile addition cascade reactions of indole-tethered ynones

Org. Biomol. Chem., 2024, Advance Article
DOI: 10.1039/D4OB00112E, Paper
Debojyoti Bag, Sanghapal D. Sawant
Herein, we describe a highly diastereoselective approach for synthesizing polyfunctionalized spiroindolines from indolyl-ynones involving an ipso-iodocyclization/nucleophile addition cascade.
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Use of ionic liquids in amidation reactions for proteolysis targeting chimera synthesis

Org. Biomol. Chem., 2024, Advance Article
DOI: 10.1039/D4OB00304G, Paper
Michela Eleuteri, Jenny Desantis, Gabriele Cruciani, Raimondo Germani, Laura Goracci
Selective degradation of disease-causing proteins using proteolysis targeting chimeras (PROTACs) has gained great attention, thanks to its several advantages over traditional therapeutic modalities.
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Electrochemical and photochemical reaction of isatins: a decade update

Org. Biomol. Chem., 2024, Advance Article
DOI: 10.1039/D4OB00202D, Review Article
Nandini M. Gotgi, J. Saurab Jain, Rita Pal, Debashis Ghosh
This review presents all the recent reports on electro- and photochemical reactions of isatins over the last decade.
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Friedel–Crafts reactions for biomolecular chemistry

Org. Biomol. Chem., 2024, Advance Article
DOI: 10.1039/D4OB00406J, Review Article
Open Access
Jun Ohata
This review demonstrates advances in Friedel–Crafts alkylation and acylation reactions in a variety of biomolecular chemistry fields.
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Stereoselective Synthesis of gem-Dihalopiperidines via Halo-Aza-Prins Cyclization Reaction: Access to Piperidin-4-ones and Pyridines

Org. Biomol. Chem., 2024, Accepted Manuscript
DOI: 10.1039/D4OB00338A, Paper
Anil Kumar Saikia, Surjya Kumar Bora, Subhamoy Biswas, Bipin Kumar Behera
An efficient methodology for the synthesis of 4,4-dihalopiperidine derivatives has been developed from N-(3-halobut-3-en-1-yl)-4-methylbenzenesulfonamide and aldehyde catalyzed by In(OTf)3 in excellent yields. The reaction involves an initial formation of six...
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