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How mobile data can help rationalise bus routes




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Good, but not enough: On the extended coverage of the Ayushman Bharat scheme

Extension of free health coverage to all over 70 years is good, but more needs to be done  




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Pivot to watch: On the U.S. Fed’s rate reduction, its impact




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Politicising the laddu: On the Tirupati laddu and its ‘adulteration’

The Tirupati laddu issue should be limited to one of quality control




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Sweet and sour: On the laddu ‘adulteration’ case  

The inquiry into laddu adulteration must not be communalised




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A Korean win: On the 2024 Nobel Prize in Literature

A Nobel raises Korean prose to success levels of its drama and music 




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​Allow for deliberation: On the legitimate demands of Ladakh

The lack of a legislature and regional autonomy in Ladakh has led to the current protests




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​Celebration and vigil: On India, kala-azar and trachoma

India must not let its guard down on kala-azar




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Why Kriti Is So Grateful

Kriti Kharbanda took a trip down memory lane when her rom-com Shaadi Mein Zaroor Aana clocked seven years since its release.




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Pathogenesis of Alzheimer's disease and therapeutic strategies involving traditional Chinese medicine

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00660G, Review Article
Shutang Li, Jinfei Yang
As research on AD has progressed, TCM and its active ingredients have increasingly played a crucial role in clinical treatment. This article summarizes extracts from TCM and briefly elucidates their pharmacological mechanisms against AD.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Integrating amino acids into Bcr-Abl inhibitors: design, synthesis, biological evaluation, and in silico studies

RSC Med. Chem., 2024, 15,3507-3528
DOI: 10.1039/D4MD00417E, Research Article
Yuying Liu, Zeyu Yang, Jie Zhang, Na Guo, Nanxin Liu, Qingqing Zhang, Xintao Dang, Yanchen Li, Jie Zhang, Xiaoyan Pan
In continuation of our previous research, a series of novel Bcr-AblT315I inhibitors with tert-leucine or serine as a flexible linker were developed and biological evaluation was performed in vitro.
The content of this RSS Feed (c) The Royal Society of Chemistry




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SLL-1A-16 suppresses proliferation and induces autophagy in non-small-cell lung cancer cells via the AKT/mTOR signaling pathway

RSC Med. Chem., 2024, 15,3460-3468
DOI: 10.1039/D4MD00405A, Research Article
Xiaoqin Luo, Jin Wang, Ruichang Wang, Jiabing Lian, Mengnan Guo, Hongrui Zhou, Mengxue Zhang, Zhe Yang, Xiaolong Li, Xianran He, Xiuli Bi
Schematic of proposed mechanism for the treatment of the SLL-1A-16 inhibiting the proliferation in NSCLC.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Next-generation EGFR tyrosine kinase inhibitors to overcome C797S mutation in non-small cell lung cancer (2019–2024)

RSC Med. Chem., 2024, 15,3371-3394
DOI: 10.1039/D4MD00384E, Review Article
Debasis Das, Lingzhi Xie, Jian Hong
Prospects of novel fourth-generation EGFR-TKIs overcoming C797S-mediated resistance in non-small cell lung cancer.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Rationally modified SNX-class Hsp90 inhibitors disrupt extracellular fibronectin assembly without intracellular Hsp90 activity

RSC Med. Chem., 2024, 15,3609-3615
DOI: 10.1039/D4MD00501E, Research Article
Open Access
Gciniwe S. Mathenjwa, Abir Chakraborty, Abantika Chakraborty, Ronel Muller, Mathew P. Akerman, Moira L. Bode, Adrienne L. Edkins, Clinton G. L. Veale
Rationally modified Hsp90 inhibitors which retained of on-target activity but showed no engagement of intracellular Hsp90, or stimulation of the heat shock response, were found to significantly alter the extracellular fibronectin network.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Rational design and in vitro testing of new urease inhibitors to prevent urinary catheter blockage

RSC Med. Chem., 2024, 15,3597-3608
DOI: 10.1039/D4MD00378K, Research Article
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Rachel A. Heylen, Nicola Cusick, Tom White, Emily J. Owen, Bethany L. Patenall, Martin Alm, Peter Thomsen, Maisem Laabei, A. Toby A. Jenkins
In silico identification of urease inhibitors based on thiourea, tested to determine IC50 and tested on a catheterised in vitro bladder model, showing efficacy in reducing catheter blockage.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Exploring 7β-amino-6-nitrocholestens as COVID-19 antivirals: in silico, synthesis, evaluation, and integration of artificial intelligence (AI) in drug design: assessing the cytotoxicity and antioxidant activity of 3β-acetoxynitrocholestane

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00257A, Research Article
Shahabuddin, Uzma, Mohammad Azam, Mehtab Parveen, Nurul Huda Abd Kadir, Kim Min, Mahboob Alam
In light of the ongoing pandemic caused by SARS-CoV-2, effective and clinically translatable treatments are desperately needed for COVID-19 and its emerging variants.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Therapeutic upregulation of DNA repair pathways: strategies and small molecule activators

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00673A, Review Article
Juhyung Song, Cheoljun Park, Francis E. B. Cabanting, Yong Woong Jun
Potential therapeutic target proteins for upregulating DNA repair system are reviewed, along with reported small-molecule activators.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Generation and capture of naphthoquinonynes: a new frontier in the development of trypanocidal quinones via aryne chemistry

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00558A, Research Article
Laura P. R. Figueroa, Renato L. de Carvalho, Renata G. Almeida, Esther R. S. Paz, Emilay B. T. Diogo, Maria H. Araujo, Warley S. Borges, Victor F. S. Ramos, Rubem F. S. Menna-Barreto, James M. Wood, John F. Bower, Eufrânio N. da Silva Júnior
This article presents A-ring functionalized quinones via a modern and efficient new strategy involving the generation and capture of benzyne quinones and their evaluation against Trypanosoma cruzi.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Adjuvant strategies to tackle mcr-mediated polymyxin resistance

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00654B, Review Article
Madison R. Nuske, Junlang Zhong, Renjie Huang, Vijayalekshmi Sarojini, Jack L. Y. Chen, Christopher J. Squire, Mark A. T. Blaskovich, Ivanhoe K. H. Leung
The emergence of the mobile colistin resistance (mcr) gene is a significant threat contributing to the worldwide antibiotic resistance crisis. This review discusses adjuvant strategies to restore polymyxin sensitivity in these resistant bacteria.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Deputy CM releases commemorative flag of Bharat Scouts and Guides




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Tiruchi Corporation embarks on special drive at night to capture and sterilise street dogs

About 125 stray dogs have been caught and sterilised at Tiruchi animal birth control centres in the last 10 days after the Corporation launched the special drive




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Tiruchi Corporation office expansion plan witnesses more delay




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‘State should retain primary agricultural cooperative societies under its purview’




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607: Astro Launches an Integrated Database

Fred K. Schott stops by to talk about Astro announcement of Astro DB, the pluses and minuses of it, whether you have to always use the database with Astro DB, how to migrate data, seeding your database, upgrading the database, and what about Astro DB pricing?




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624: Blogging, In App Browsers are Bad, and Teaching CSS from Scratch

On this epsiode we're talking about the current state of blogging and social media, the polyfill hack, whether in app browsers should be banned, web components and the difficulty of front end web dev, and how we would go about teaching CSS from scratch in 2024.




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How Ratan Tata pushed for evidence-led ayurveda 

Ratan Tata sought to promote research that could validate ayurveda through contemporary science




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Corporates look to tread the India Way  

Business leaders are realising that longevity may be a better marker for growth than shareholder value maximisation




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Delhi L-G inspects Gole Market restoration project




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Issue of infiltration in Santhal Pargana was raised, Hemant did not listen: Champai Soren

The longtime JMM-loyalist, who has now switched to the BJP, adds that decisions he had taken as CM — on tribal language education, PESA implementation, and jump-starting state recruitments — have been put on hold now




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Provide medical aid to jailed separatist leader Yasin Malik: Delhi HC to Tihar jail

In his plea before the high court, Malik claimed to be a patient of “serious cardiac and kidney ailments”, currently facing a “life and death situation”




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Delhi | The DAG is hosting an exhibition that celebrates MF Husain and his enduring legacy 

An exhibition in New Delhi’s DAG covers pivotal moments of legendary artist and painter MF Husain’s artistic journey 




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Three juveniles held for murder in Delhi; political row erupts over city’s crime rate




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Man stabs mother in Delhi’s Badarpur for not ‘allowing him’ to migrate to Canada




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BharatPe fraud case: Delhi HC quashes lookout circular against Ashneer Grover, wife




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2024 Pacificon Inspires Next Generation of Radio Amateurs




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Handbook 101: A New Generation of Amateur Radio




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Desecration of a way of life

A story of how China ripped into the genteel charm of the traditional Buddhist society in Tibet




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Strategies for an enduring legacy

How firms can thrive in an era of social tension, economic nationalism and tech revolution




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In love with operations management

The author brings aesthetics into a field obsessed with quantification




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Of crowds and irrational behaviour

The book unravels how people rationalise facts to fit them into their perceptions




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For people with aspirations

A book that focuses on an oft neglected aspect — soft skills




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Book Review: Demystifying Leadership: Unveiling the Mahabharata Code by Asha Kaul and Vishal Gupta

The Mahabharata shows that leaders need to navigate moral codes that are as complex, varied, and subtle as the situations in which they find themselves 




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CSIR-IICT demonstrates tech to turn dry leaves into soil conditioner

Using a method called accelerated anaerobic composting, a demonstration plant installed in a gated community in Hyderabad is turning dry leaves into bio-manure with recommended nitrogen and carbon content




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GI tag sought for the Senkanthal seed whose flower holds a special place in Tamil literature

Minister for Agriculture and Farmer’s Welfare M.R.K.Panneerselvam, while presenting the State’s Agriculture Budget, had said that Geographical Indication tag would be obtained for 10 agricultural products at a cost of ₹30 lakh




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First International Dairy Federation Asia-Pacific summit in Kochi from June 26 to 28




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Mangrove restoration in T.N. makes a small but steady progress

The Tamil Nadu Forest Department and non-governmental organisations are working to restore mangroves at various sites of the Ennore-Pulicat wetlands. In the meantime, the National Centre for Coastal Research has identified land available for restoration in Cuddalore, Tiruvarur, Thanjavur, Pudukkottai, Ramanathapuram, and Thoothukudi




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Virat Kohli remains India's most-valuable celebrity

Kohli remains the most valued celebrity for the fourth consecutive year with a steady brand value of $237.7 million in 2020 despite the pandemic




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Virat Kohli's 100th Test:All The Numbers

Rajneesh Gupta presents all the numbers you need to know about Virat Kohli in Test cricket.




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Happy 35th Virat! A look at his mind-boggling stats

Kohli has consistently dominated headlines with his extraordinary batting prowess.