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Therapeutic upregulation of DNA repair pathways: strategies and small molecule activators

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00673A, Review Article
Juhyung Song, Cheoljun Park, Francis E. B. Cabanting, Yong Woong Jun
Potential therapeutic target proteins for upregulating DNA repair system are reviewed, along with reported small-molecule activators.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry




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S-MGBs bearing amidine tail groups are potent, selective antiplasmodial agents

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00619D, Research Article
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Marina Perieteanu, Tayner Rodriguez Garzon, Leah M. C. McGee, Abedawn I. Khalaf, Colin J. Suckling, Rebecca Beveridge, Vicky M. Avery, Fraser J. Scott
25 S-MGBs, including those bearing an amidine tail group, were investigated for their antiplasmodial, in vitro activity against 3D7 and Dd2 strains of P. falciparum. Several potent, and selective, hit compounds were identified.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Synthesis of cationic N-acylated thiazolidine for selective activity against Gram-positive bacteria and evaluation of N-acylation's role in membrane-disrupting activity

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00626G, Research Article
Aleena Pious, Vignesh Venkatasubramanian, Dharshini Karnan Singaravelu, Subburethinam Ramesh, Fuad Ameen, Anbazhagan Veerappan
Lipidation modulates the Gram-selective antibacterial activity of QPyNATh.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry




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TNSTC Kumbakonam Division mops up ₹17.13 crore in four days




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Pumping stations to be set up in eight low-lying areas in Tiruchi to prevent inundation




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Ernakulam Express to stop at Muthupettai during Kandhoori festival




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Bids invited for setting up International Dugong Conservation Centre at Manora

The proposed centre, to be set up at an estimate of ₹41 crore, is being established to conserve endangered Dugong species and its habitat in the Palk Bay




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Small-scale handloom park to come up at Sengunthapuram

Ministers R. Gandhi and S.S. Sivashankar inspect the 13,205 sq. ft. site belonging to the Tamil Nadu Cotton Corporation at Sengunthapuram




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Uppiliyapuram, gateway to scenic Pachamalai, lacks bus stand with passengers left to fight the elements

Buses stop at a busy junction making it difficult for commuters as well as local businessmen; a site is yet to be identified for the bus stand




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EPS’s dream of AIADMK staging a comeback in 2026 election will not materialise: Law Minister Regupathy




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Two doctors posted at Uppiliyapuram UPHC




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Library to hold Group II-A Mains, Group IV TNPSC model test




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Art and literary contests lined up for District Central Library’s National Library Week




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542: Breaking Up with CSS-in-JS, Mastodon, and Stories on the Web

We're talking CSS-in-JS, Token CSS, Matuzo being suspended from Twitter, trying out Mastodon, testing out stable diffusion, stories on the web, and Jake Albaugh's new social network.




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568: Display Contents, Passkeys Follow Up, Yellow Fade Technique, and TOTK Talk

Macho Man Randy Standards stops by for a quick chat, Passkeys follow up, discussing the safety of Display: contents, the yellow fade technique, how hot CSS is right now (so hot), and a check in on how everyone's doing with Tears of the Kingdom.




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578: Customer Support, P3 Color, Dave on Productivity, and Mobile vs Desktop

Is Apple's Numbers amazing or the worst? Customer support at various levels of software, Figma and P3 color, imagining a colorspace property in CSS, what's Dave doing for productivity, how has offloading CSS Tricks affected Chris, and should we build different websites for mobile vs desktop?




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610: TypeScript in 2024, Signals, Productivity Sniped, and Follow Up

Dave's about to be eclipsed, the state of TypeScript in 2024, signals stage zero proposal, corrections on accessibility in frameworks (thanks!), web apps for better collaborative writing, getting productivity sniped, the problem with email may be you, indieweb follow up, and ultimate guitar tab apps.




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611: React! TypeScript! Jobification! Drupal!

Dave & Chris and thoughts on career advice that worked 3 years ago but isn't as helpful now, marking tests with ChatGPT, is taking a Drupal job in 2024 a good idea, Chris got #gear sniped, P3 color follow up, the confusing File System APIs, and where did all the lightboxes go?




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621: Setting Up Prettier and Linting, Comparing Colors, and Accessibility Overlays

We've got follow up on Cloudflare and Cara from last episode, a question about setting up Prettier and auto linting, a cool tool from a listener on comparing colors, a question about using tooling like Craft or more user friendly apps like Webflow when working with clients, and our takes on accessibility overlays.




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622: Website Rendering, Updating Software, and Edge Gets Faster

We're talking website rendering, server side rendering, Astro's server islands, perf hits for navigation elements, updating software because the docs aren't available for older versions, and a new Microsoft Edge was released.




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630: Frostapalooza Recap, Follow Up, and Messy Codebases

Chris has a birthday today 🎉, we recap our Frostapalooza experience celebrating Brad Frost's birthday, do all codebases become a mess, Mermaid, TLDraw, and Figjam thoughts, making tiny games, where's the follow up in web and world news, and what's the current state of CMS' on the web?




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641: Passkey Usage, Writing Code with a Bot, and What’s Up With Java?

We've got a few leftovers from Halloween to process, what's been happening with Passkeys in late 2024, have you tried to write HTML faster than a bot can suggest it to you, CSS anchor positioning and popover polyfills, scroll driven animation thoughts, CSS nesting, and what's the reason for Java?




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Setting up shop in Chennai

As businesses head to the city, the lack of large format office spaces is pushing them towards peripheral locations.




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The pros and cons of spouses teaming up as co-founders

How do married co-founders navigate the personal and professional ties at work




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Startups join the party with craft mixers

How non-alcoholic mixers, handcrafted by small players, are edging out sugary soft drinks, sodas in cocktail glasses




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How ‘priority sector’ status can rev up Jan Dhan banking

How regulation can nudge private banks to promote financial inclusion




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Superlative Class

The EQS SUV reinvigorates Mercedes-Benz’s game in the all-electric segment




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Cargo companies upsize for new business

Booming demand for ecommerce delivery spurs freight handlers to open more centres, digitise for efficiency




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Bengaluru startup develops new tech for battery recycling, begins production

Li-ion battery recycler Metastable Materials launches commercial ops




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Keeping track of Scope-3 emissions from supply chains

Gurgaon-based startup OnlyGood FutureTech helps companies measure emissions generated by supply partners




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Delhi L-G lied in Supreme Court about tree felling: Bharadwaj




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Never asked people to pick up weapons: Tahir Hussain to court




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Congress gears up for Delhi poll battle with month-long ‘Nyay Yatra’

Maken, Sukhu flag off foot march; Kharge, Rahul expected to join at different junctures; yatra scheduled to end on Dec. 4; people won’t forget Cong.’s tie-up with AAP in Lok Sabha election: BJP




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Three juveniles held for murder in Delhi; political row erupts over city’s crime rate




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Security upped outside Canadian High Commission due to protest against temple attack

The Hindu Sikh Global Forum members are marching towards the High Commission in the Chanakyapuri area




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The K7RA Solar Update

Key solar indicators were lower this week, with average daily solar
flux down from 194.3 to 170.5 and average daily sunspot numbers
declining from 129.3 to 127.7.

On October 22, Spaceweather.com reported:

"THE SUN IS TAKING A QUICK BREAK: Solar Max is hard work. Just ask
the Sun. After flaring almost without pause for the past 10 months,
the Sun is taking a quick break. Solar activity has been low fo...




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ARRL VEC Services Update During Systems Disruption

Updated 10/30/2024

ARRL previously reported that we are responding to a serious incident involving access to our network and headquarters-based systems. Several services have been affected, including those administered by the ARRL Volunteer Examiner Coordinator (ARRL VEC).

Exam Registrations and Materials. ARRL Volunteer Examiners (VEs) should continue to submit exam registrations and material re...




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The K7RA Solar Update

Solar activity increased this week. Average daily sunspot number
went from 127.7 to 197.4 and average solar flux from 170.5 to 240.2.

Predicted solar flux is 270 on November 1-2, 265 and 260 on November
3-4, 250 on November 5-7, 214, 195 and 182 on November 8-10, 172,
168, 174 and 165 on November 11-14, and 162 on November 15-16.

Predicted planetary A index is 5, 8, 15, and 10 on November 1-4, 5
on N...




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Hurricane Rafael - Storm Updates

Tuesday, November 5, 2024, 11:00 AM Eastern Update:

The following information is from the Hurricane Watch Net:

The Hurricane Watch Net will be activated today, Tuesday, as planned, with one minor update. After further review of the timing of the storm and the distance from land, we need to modify our plans. All will remain the same with the exception that we will now operate overnight

Activation P...




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Building up an Arsenal

The autobiography of a coach who revolutionised English football




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Book Review: Demystifying Leadership: Unveiling the Mahabharata Code by Asha Kaul and Vishal Gupta

The Mahabharata shows that leaders need to navigate moral codes that are as complex, varied, and subtle as the situations in which they find themselves 




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Start-up Compass: How Iconic Entrepreneurs got it Right

A relevant book for those about to embark on their entrepreneurial journey, or can serve as a useful resource for those who like to track the start-up ecosystem 




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My Farm, a farm-to-table set-up in Visakhapatnam, is an example of responsible farming

Locally-grown vegetables find their way to My Farm, a farm-to-table set-up near Visakhapatnam, that adopts permaculture to promote sustainability as a way of life




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Paddy varieties with protein, zinc content get thumbs up in Odisha’s tribal pocket

Paddy varieties have high protein (10.1%) and moderately high level of zinc (20 ppm) content




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Centre to provide 15,000 women self help groups with drones that can be rented out for agricultural purposes

The scheme will help in infusing advanced technology in agriculture for improved efficiency, enhance crop yield and reduced cost of operation for the benefit of farmers




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Over ₹13 crore funds needed to support farmers in drought-affected areas of Nellore, says Collector

Ten in the district have been declared as ‘drought mandals’ by the NDMA; over 50% of crop was lost in Sitaramapuram while 30-40% of crops were lost in the remaining nine mandals




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Paddy MSP up 5.35% to ₹2,300 per quintal as Cabinet clears MSP hikes for 14 kharif crops

MSPs for bajra, arhar dal, maize offer highest margins above production costs; Cabinet nod for Varanasi airport expansion, new Maharashtra port, wind energy projects in Gujarat and T.N., forensic infrastructure development




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‘Dairy dilemma’ engulfs women farmers in CM Chandrababu Naidu’s constituency Kuppam with sudden fall in milk price

Recently, the dairy industry has experienced a decrease of ₹5 per liter in the milk price, causing concern among the predominantly women farmers involved in the sector. 




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Cabinet clears new scheme to supply virus-free planting material

It will cover all farmers, regardless of their landholding size or socioeconomic status: Ministry




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Taking roots in Tirupati, ‘Konark’ set to reach the kitchens of Odisha and Bengal