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Optimizing lentiviral vector transduction of hematopoietic stem cells for gene therapy




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Albumin fusion with granulocyte-macrophage colony-stimulating factor acts as an immunotherapy against chronic tuberculosis




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Natural genetic variation in Stim1 creates stroke in the spontaneously hypertensive rat




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Back in Time

Astronomers have found some of the most distant galaxies in the universe, opening a window on a previously unknown period of cosmic history




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Time for Women Leaders

The gender gap in leadership narrows when groups spend more time together




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Daily briefing: How desperate measures might shorten the coronavirus vaccine timeline — and at what risk




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Novel sGC stimulator improves outcomes in patients with HFrEF




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Real-time observation of CRISPR spacer acquisition by Cas1–Cas2 integrase




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Exposure to direct-to-consumer advertising is associated with overestimation of benefits regarding ultrahypofractionated radiation therapy for prostate cancer




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Tumor-selective delivery of antisense oligomers (antimiRs) against oncogenic microRNAs

miRNA-targeted antimiRs conjugated to a peptide with a low pH–induced transmembrane structure (pHLIP) could help treat solid tumors.




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Angiopoietin 2 (ANG2; ANGPT2); placental growth factor (PGF; PlGF); tissue inhibitor of metalloproteinases 3 (TIMP3)

Mouse studies suggest inhibiting PGF could help treat hypertension.




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Immunostimulatory oncolytic virotherapy for multiple myeloma targeting 4-1BB and/or CD40




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A more accurate incidence of acute spinal cord injury in South Korea can be estimated by the national health insurance system




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Associations of interruptions to leisure-time sedentary behaviour with symptoms of depression and anxiety




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The Cities That Shaped Gandhi, The Cities That Gandhi Shaped, Hindustan Times

Mahatma Gandhi famously claimed that ‘India lives in her villages’. The focus of his political and social work, and his philosophical writings, was that India was essentially an agrarian civilization, and that it must remain that way. In fact, India had always lived in her towns too. Our epics spoke of the fabled cities of [...]




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From Indo-Pak to Chindia and Back Again to Indo-Pak, Hindustan Times

On 26th January 2006, the New York Times ran a story headlined ‘India Everywhere in the Alps’. The story began: ‘Delhi swept into Davos on Wednesday, with an extravagant public relations campaign by India intended to promote the country as the world's next economic superstar, and as a democratic alternative to China for the affections [...]




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The Fourth Crisis of The Republic, Hindustan Times

As I have written before, if India had been a start-up in August 1947 not even the most venturesome of venture capitalists would have invested in it. No new nation was born in more inhospitable circumstances. The Partition of the country had been awful enough, in the scale of its violence and the mass displacement [...]




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Standing With Gandhi in Ahmedabad, Hindustan Times

On 30th January I was in Ahmedabad, a city that was central to Mahatma Gandhi’s life and work. It was here that he established the most celebrated of his ashrams, on the banks of the Sabarmati River; here that he revised and refined his moral and political philosophy; here that he conceived and planned the [...]




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Get The Best Minds on Board, Hindustan Times

Years ago, working in the archives in New Delhi, I came across a brief, handwritten, letter from Jawaharlal Nehru to C. Rajagopalachari. It was dated 30th July 1947, and it read: ‘My dear Rajaji, This is to remind you that you have to approach Shanmukham Chetty—this must be done soon. I have seen Ambedkar and [...]




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Changing trends of ocular trauma in the time of COVID-19 pandemic




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Cutoff point estimation for serum vitamin D concentrations to predict cardiometabolic risk in Brazilian children




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Central catheter removal timing and growth patterns in preterm infants




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Project on Managing the Atom Seeking Full-Time Research Associate

The Managing the Atom (MTA) project at the Harvard Kennedy School is seeking a full-time Research Associate to support research projects directed by Professor Matthew Bunn on a range of nuclear policy topics including strategic stability and the future of nuclear arms control, reducing the risks of nuclear theft and terrorism worldwide, stemming the spread of nuclear weapons, and addressing key constraints on and risks of nuclear energy. Reporting to the MTA co-principal investigator Prof. Matthew Bunn, the Research Associate will play a major role in researching and writing papers and reports in these areas. 




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Noticias sobre Covid-19 y 2019-nCoV en medios de comunicación de España: el papel de los medios digitales en tiempos de confinamiento // News on Covid-19 and 2019-nCoV in Spanish media: The role of digital media in times of confinement

Lázaro-Rodríguez, Pedro and Herrera-Viedma, Enrique Noticias sobre Covid-19 y 2019-nCoV en medios de comunicación de España: el papel de los medios digitales en tiempos de confinamiento // News on Covid-19 and 2019-nCoV in Spanish media: The role of digital media in times of confinement. El profesional de la información, 2020, vol. 29, n. 3. [Journal article (Unpaginated)]




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Public Testimony on Trump Administration Funding for Nuclear Theft Preventing Programs

A nuclear explosion detonated anywhere by a terrorist group would be a global humanitarian, economic, and political catastrophe. The current COVID-19 pandemic reminds us not to ignore prevention of and preparation for low-probability, high-consequence disasters. For nuclear terrorism, while preparation is important, prevention must be the top priority. The most effective strategy for keeping nuclear weapons out of the hands of terrorists is to ensure that nuclear materials and facilities around the world have strong and sustainable security. Every president for more than two decades has made strengthening nuclear security around the globe a priority. This includes the Trump administration, whose 2018 Nuclear Posture Review states: “[n]uclear terrorism remains among the most significant threats to the security of the United States, allies, and partners.”




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Considering Public Purpose in the Time of COVID-19

In this piece, we will look at the various public purpose considerations as they relate to the development of diagnostics, therapeutics, and vaccines for coronavirus. We explore the foreseeable risks to public safety of loosened regulation, ultimately arguing that even in times of crisis, accountable science and technology development is a choice we can make to protect the public and yield beneficial results, while considering both short- and long-term impacts. 




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Considering Public Purpose in the Time of COVID-19

In this piece, we will look at the various public purpose considerations as they relate to the development of diagnostics, therapeutics, and vaccines for coronavirus. We explore the foreseeable risks to public safety of loosened regulation, ultimately arguing that even in times of crisis, accountable science and technology development is a choice we can make to protect the public and yield beneficial results, while considering both short- and long-term impacts. 




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Considering Public Purpose in the Time of COVID-19

In this piece, we will look at the various public purpose considerations as they relate to the development of diagnostics, therapeutics, and vaccines for coronavirus. We explore the foreseeable risks to public safety of loosened regulation, ultimately arguing that even in times of crisis, accountable science and technology development is a choice we can make to protect the public and yield beneficial results, while considering both short- and long-term impacts. 




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French media takes China to task reflecting sentiments in key European power

French commentators initially praised the ability of China’s regime to impose lockdown to fight Covid. But the French mood changed in late March, says Marc Julienne, China researcher at the French Institute for International Relations (IFRI).




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Considering Public Purpose in the Time of COVID-19

In this piece, we will look at the various public purpose considerations as they relate to the development of diagnostics, therapeutics, and vaccines for coronavirus. We explore the foreseeable risks to public safety of loosened regulation, ultimately arguing that even in times of crisis, accountable science and technology development is a choice we can make to protect the public and yield beneficial results, while considering both short- and long-term impacts. 




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Adobe Edge Animate Runtime API

The Adobe Edge Animate Runtime API is a companion to Adobe Edge Animate. Bind code to document, timeline and element, and execute your code at a specific position.




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Considering Public Purpose in the Time of COVID-19

In this piece, we will look at the various public purpose considerations as they relate to the development of diagnostics, therapeutics, and vaccines for coronavirus. We explore the foreseeable risks to public safety of loosened regulation, ultimately arguing that even in times of crisis, accountable science and technology development is a choice we can make to protect the public and yield beneficial results, while considering both short- and long-term impacts. 




tim

Public Testimony on Trump Administration Funding for Nuclear Theft Preventing Programs

A nuclear explosion detonated anywhere by a terrorist group would be a global humanitarian, economic, and political catastrophe. The current COVID-19 pandemic reminds us not to ignore prevention of and preparation for low-probability, high-consequence disasters. For nuclear terrorism, while preparation is important, prevention must be the top priority. The most effective strategy for keeping nuclear weapons out of the hands of terrorists is to ensure that nuclear materials and facilities around the world have strong and sustainable security. Every president for more than two decades has made strengthening nuclear security around the globe a priority. This includes the Trump administration, whose 2018 Nuclear Posture Review states: “[n]uclear terrorism remains among the most significant threats to the security of the United States, allies, and partners.”




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We May Be Dramatically Overestimating China’s Capabilities

The outbreak in Wuhan of the novel coronavirus shows how ragged and disorderly the Chinese police state was in the initial weeks of the pandemic. Beijing’s response was to suppress and manipulate information, at home and abroad. Trump administration officials have painted this as a Chinese plot against the West, but it looks more like a frantic effort by a one-party state to survive a domestic crisis.




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Greener Stimulus? Economic Recovery and Climate Policy

In this edition of Columbia Energy Exchange, host Jason Bordoff and Professor Joseph Aldy explore the role of climate-change and broader environmental policy in the U.S. federal government’s emergency economic stimulus funding package.




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Considering Public Purpose in the Time of COVID-19

In this piece, we will look at the various public purpose considerations as they relate to the development of diagnostics, therapeutics, and vaccines for coronavirus. We explore the foreseeable risks to public safety of loosened regulation, ultimately arguing that even in times of crisis, accountable science and technology development is a choice we can make to protect the public and yield beneficial results, while considering both short- and long-term impacts. 




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Considering Public Purpose in the Time of COVID-19

In this piece, we will look at the various public purpose considerations as they relate to the development of diagnostics, therapeutics, and vaccines for coronavirus. We explore the foreseeable risks to public safety of loosened regulation, ultimately arguing that even in times of crisis, accountable science and technology development is a choice we can make to protect the public and yield beneficial results, while considering both short- and long-term impacts. 




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Considering Public Purpose in the Time of COVID-19

In this piece, we will look at the various public purpose considerations as they relate to the development of diagnostics, therapeutics, and vaccines for coronavirus. We explore the foreseeable risks to public safety of loosened regulation, ultimately arguing that even in times of crisis, accountable science and technology development is a choice we can make to protect the public and yield beneficial results, while considering both short- and long-term impacts. 




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Considering Public Purpose in the Time of COVID-19

In this piece, we will look at the various public purpose considerations as they relate to the development of diagnostics, therapeutics, and vaccines for coronavirus. We explore the foreseeable risks to public safety of loosened regulation, ultimately arguing that even in times of crisis, accountable science and technology development is a choice we can make to protect the public and yield beneficial results, while considering both short- and long-term impacts. 




tim

Considering Public Purpose in the Time of COVID-19

In this piece, we will look at the various public purpose considerations as they relate to the development of diagnostics, therapeutics, and vaccines for coronavirus. We explore the foreseeable risks to public safety of loosened regulation, ultimately arguing that even in times of crisis, accountable science and technology development is a choice we can make to protect the public and yield beneficial results, while considering both short- and long-term impacts. 




tim

We May Be Dramatically Overestimating China’s Capabilities

The outbreak in Wuhan of the novel coronavirus shows how ragged and disorderly the Chinese police state was in the initial weeks of the pandemic. Beijing’s response was to suppress and manipulate information, at home and abroad. Trump administration officials have painted this as a Chinese plot against the West, but it looks more like a frantic effort by a one-party state to survive a domestic crisis.




tim

Greener Stimulus? Economic Recovery and Climate Policy

In this edition of Columbia Energy Exchange, host Jason Bordoff and Professor Joseph Aldy explore the role of climate-change and broader environmental policy in the U.S. federal government’s emergency economic stimulus funding package.




tim

We May Be Dramatically Overestimating China’s Capabilities

The outbreak in Wuhan of the novel coronavirus shows how ragged and disorderly the Chinese police state was in the initial weeks of the pandemic. Beijing’s response was to suppress and manipulate information, at home and abroad. Trump administration officials have painted this as a Chinese plot against the West, but it looks more like a frantic effort by a one-party state to survive a domestic crisis.




tim

Considering Public Purpose in the Time of COVID-19

In this piece, we will look at the various public purpose considerations as they relate to the development of diagnostics, therapeutics, and vaccines for coronavirus. We explore the foreseeable risks to public safety of loosened regulation, ultimately arguing that even in times of crisis, accountable science and technology development is a choice we can make to protect the public and yield beneficial results, while considering both short- and long-term impacts. 




tim

Considering Public Purpose in the Time of COVID-19

In this piece, we will look at the various public purpose considerations as they relate to the development of diagnostics, therapeutics, and vaccines for coronavirus. We explore the foreseeable risks to public safety of loosened regulation, ultimately arguing that even in times of crisis, accountable science and technology development is a choice we can make to protect the public and yield beneficial results, while considering both short- and long-term impacts. 





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How to Lead in a Time of Pandemic

The world has never before confronted a crisis quite like COVID-19, one that has simultaneously tested both the limits of public health systems everywhere and the ability of countries to work together on a shared challenge. But it is in just such moments of crisis that, under all prior U.S. presidents since World War II, the institutions of U.S. foreign policy mobilize for leadership. They call nations to action. They set the agenda for what needs to be done. They chart a path beyond the point of crisis.




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Raikkonen needs time to acclimatise, says Watson

Former grand prix winner John Watson says that Kimi Raikkonen will need time to familiarise himself with the new technicalities of the sport when he returns to drive for Lotus Renault for the 2012 season




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Liuzzi optimistic despite crash

Tonio Liuzzi is optimistic he can still have a good race despite crashing out of qualifying for the German Grand Prix




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It's time to stop reducing taxes on the wealthy


House Republicans recently approved the “Death Tax Repeal Act of 2015.”  If we care about our debt obligations, social mobility, or equality of opportunity, we should consider doing just the opposite: raising the tax and applying it to more of the super-wealthy.

Currently, the estate tax doesn't touch the first $5.43 million of an individual’s assets and the first $10.86 million of couples’ assets. The tax kicks in after that amount, eventually rising to a top rate of 40 percent.  

Proponents of repeal make a number of claims to make their case. Let’s examine the most common.

  1. The estate tax affects a significant portion of Americans. Only about 5,400 estates will pay any estate tax this year. That’s about 0.2% of all estates – that’s right, just two tenths of one percent.  That’s a fortieth of the 1970’s share. Americans worried about the Estate Tax have nothing to fear but fear itself. 
  2. The estate tax hurts small farms and businesses. In fact, the estate tax touches virtually no small farms or businesses. The Urban-Brookings Tax Policy estimated how many farm and business estates worth under $5 million paid any tax in 2013. Twenty did. Twenty small farms and businesses paid any estate tax in 2013. And those 20 estates faced an average tax rate of 4.9%. Only 660 farm estates—of any size—paid the tax in 2013, and 100 of those farms had assets worth over $20 million. The USDA estimates that 0.6% of all farm estates owed federal estate tax in 2013. This is because families who farm for a living have access to generous deductions: up to $1 million for continuing to farm the land for the next 10 years and up to $500,000 for adopting conservation easements. They can also delay payment and lighten their tax liability by gifting their land to heirs. Small businesses have similarly generous carve-out.
  3. Repealing the estate tax doesn't affect the budget, because it’s a small share of federal revenue. In 2014, the estate tax represented 0.6% of federal collections, or roughly $20 billion annually, according to the Joint Committee on Taxation. But part of the reason that’s so low is because Congress has increased the exemption and lowered the rate in recent years; in 2001, the top rate was 55% and the exemption was only $675,000. Still, even today, repealing the tax is costly. The JCT estimates that repeal would cost the government $269 billion over the next decade.
  4. The estate tax represents double taxation. Well, maybe. It is true that people  pay taxes on their income when earned and then may have to pay again when they pass it on to their heirs.  However, because the super-wealthy keep much of their assets as unrealized capital gains (55% for those estates worth over $100 million), the estate tax is the only way, right now, to tax these capital gains. In that sense it can be viewed as a partial corrective within our funhouse of a tax system. Some capital gains, to be sure, are the fruits of hard work and entrepreneurial creativity but a lot are simply the result of gains among those wealthy enough to participate in speculative ventures. 

One thing is true: repeal would mean a large tax break for the wealthiest 0.2% of the population. The 1,336 families with estates worth more than $20 million would get almost three-fourths of the benefit from the repeal and enjoy an average windfall of $10 million each, according to the Center on Budget and Policy Priorities. The 318 families with estates worth more than $50 million would see an average windfall of $20 million each.

These facts are often obscured by our penchant for individual stories. One Washington Post story for example, acknowledges many of the statistics above, but then goes on to give two examples of farmers who had to sell land to meet their tax burden, one of which is several decades old, when the exemption was much lower. Elected officials love these kinds of stories and tell them often. Are they unaware of the generous special provisions for this group?  Do they truly believe that very wealthy families are the ones we should be helping? Or are they thinking about who is going to finance their next campaign?

The estate tax is one of the most progressive aspects of our tax system. In a time of increasing inequality, it provides a way to counteract the formation of a “permanent ownership class.” If anything, we should consider raising the rate and lowering the exemption to pay down debt and invest in opportunities for the unlucky children at the bottom of the wealth ladder. We could start by closing the stepped-up basis loophole and raising the estate tax to Clinton-era levels. We could do so in a way that protects real farmers and small business owners. Wealthy heirs, meanwhile, will still do very well, much better than the rest of America. A serious estate tax would allow us to come closer to our national ideal, in which no child is born a prince, and every child can become as rich as a king.

Note: An earlier version of this post said that the estate tax only applies to assets in excess of the exemption, which is incorrect. The estate tax is levied on the entire estate but is offset by a credit equal to the tax on the first $5.43 million. This version is corrected.

Authors

Publication: Real Clear Markets
Image Source: © Tami Chappell / Reuters