Preclinical data have shown that ¹⁶¹Tb-labeled peptides targeting the somatostatin receptor are therapeutically more effective for peptide receptor radionuclide therapy than are their ¹⁷⁷Lu-labeled counterparts. To further substantiate this enhanced therapeutic effect, we performed cellular dosimetry to quantify the absorbed dose to the cell nucleus and compared dose–response curves to evaluate differences in relative biological effectiveness in vitro. Methods: CA20948 cell survival was assessed after treatment with [¹⁶¹Tb]Tb- and [¹⁷⁷Lu]Lu-DOTATATE (agonist) and with [¹⁶¹Tb]Tb- and [¹⁷⁷Lu]Lu-DOTA-LM3 (antagonist) via a clonogenic assay. Cell binding, internalization, and dissociation assays were performed up to 7 d to acquire time-integrated activity coefficients. Separate S values for each type of particle emission (Auger/internal conversion [IC] electrons and β^– particles) were computed via Monte Carlo simulations, while considering spheric cells. Once the absorbed dose to the cell nucleus was calculated, survival curves were fitted to the appropriate linear or linear-quadratic model and corresponding relative biological effectiveness was evaluated. Results: Although the radiopeptide uptake was independent of the radionuclide, [¹⁶¹Tb]Tb-DOTATATE and [¹⁶¹Tb]Tb-DOTA-LM3 delivered a 3.6 and 3.8 times higher dose to the nucleus, respectively, than their ¹⁷⁷Lu-labeled counterparts on saturated receptor binding. This increased nucleus-absorbed dose was mainly due to the additional emission of IC and not Auger electrons by ¹⁶¹Tb. When activity concentrations were considered, both [¹⁶¹Tb]Tb-DOTATATE and [¹⁶¹Tb]Tb-DOTA-LM3 showed a lower survival fraction than did labeling with ¹⁷⁷Lu. When the absorbed dose to the nucleus was considered, no significant difference could be observed between the dose–response curves for [¹⁶¹Tb]Tb- and [¹⁷⁷Lu]Lu-DOTATATE. [¹⁶¹Tb]Tb-DOTA-LM3 showed a linear-quadratic dose response, whereas [¹⁶¹Tb]Tb-DOTATATE showed only a linear dose response within the observed dose range, suggesting additional cell membrane damage by Auger electrons. Conclusion: The IC, rather than Auger, electrons emitted by ¹⁶¹Tb resulted in a higher absorbed dose to the cell nucleus and lower clonogenic survival for [¹⁶¹Tb]Tb-DOTATATE and [¹⁶¹Tb]Tb-DOTA-LM3 than for the ¹⁷⁷Lu-labeled analogs. In contrast, [¹⁶¹Tb]Tb-DOTATATE showed no higher dose response than [¹⁷⁷Lu]Lu-DOTATATE, whereas for [¹⁶¹Tb]Tb-DOTA-LM3 an additional quadratic response was observed. Because of this quadratic response, potentially caused by cell membrane damage, [¹⁶¹Tb]Tb-DOTA-LM3 is a more effective radiopeptide than [¹⁶¹Tb]Tb-DOTATATE for labeling with ¹⁶¹Tb.

McKesson Medical-Surgical Inc. entered into an agreement with the Labor Department on Monday resolving employment discrimination issues involving nearly 900 Black, Hispanic, and White applicants at a distribution center

More than 500,000 space heaters from GoveeLife and GoveeSmart Electric are being recalled because of safety issues, according to the U.S. Consumer Product Safety Commission.

The Dallas Cowboys agreed to trade a fourth-round pick in the 2025 NFL Draft to the Carolina Panthers in exchange for wide receiver Jonathan Mingo and a seventh-round pick, a league source told UPI on Tuesday.

Discover why more content isn’t solving your boredom but making it worse.

The therapy helps the brain work more efficiently and lifts depression.

“Nothing travels faster than the speed of light, with the possible exception of bad news, which obeys its own special laws.” ― Douglas Adams, Mostly Harmless

We are so beholden to the 'arrow of time', moving us inevitably from the past into the future, that we hardly notice it.

Two things which make you look more intelligent that you can do right now.

Study of workplace stress finds there's a better way to cope than relaxation.

Social psychologist Jonathan Haidt's latest book, "The Anxious Generation," is shaping cultural conversations and sparking fierce debates about the role of smartphones in society. In this timely conversation, he investigates how a smartphone-based childhood, amplified by overprotective parenting, is driving the mental health crisis among young people. He also explores the push for phone bans in schools and the concrete steps we can take to improve the mental health of young people around the world. (This conversation was hosted by Elise Hu, the host of TED Talks Daily. Visit ted.com/membership to support TED today and join more exclusive events like this one.)

TED Fellow and chemosensory researcher Paule Joseph unveils the hidden power of a sense that's too often overlooked: smell. She delves into the science behind smell — from how it evokes memory and emotion to its potential for early disease detection — and advocates for the creation of a baseline test for taste and smell that could open the door to more comprehensive health care.

An increasing number of schools are replacing snow days with remote learning, but some plan to stick with the snow day tradition for now.

It's pretty obvious by now that many Democrats are growing increasingly uncomfortable supporting charter schools. But New Hampshire lawmakers have taken the unusual step of rejecting federal charter school grant money.

Jonathan Lekkerimäki will make his NHL debut when the Vancouver Canucks take on the Calgary Flames on Tuesday night.

Fadel Zeidan
Nov 18, 2015; 35:15307-15325
BehavioralSystemsCognitive

Over 100 professional vacancies are in the process of being released and opened for applications. They cover mainly technical areas of work in headquarters and regional offices.

In addition, global calls [...]

Riders--who will descend in inflatable rafts of four rather than alone--will reach speeds of more than 65 miles per hour

It looks like a fairly nondescript plank of wood, found in the fields of Star Carr. But from an archaeological perspective, it’s far more significant: It’s the oldest piece of carpentry found anywhere in Europe.

So what exactly factors into how we end up being right or left-handed? In this one-minute video, Ask Smithsonian host Eric Schulze breaks down the science of being a southpaw.

The holiday was used as a call for freedom during the civil rights movement and as a day of mourning by Native Americans.

In 1918, Lulu Hunt Peters—one of the first women in America to earn a medical doctorate—published the best seller Diet and Health With Key to the Calories, making a name for herself as an apostle for weight reduction in an era when malnutrition was a far greater public health threat than obesity. She pioneered the idea of measuring food intake via the calorie, which at the time was an obscure unit of measurement familiar only to chemists.  A century later, the Centers for Disease Control and Prevention reports (https://www.cdc.gov/nchs/products/databriefs/db360.htm) that 42 percent of American adults are clinically obese and that Type 2 diabetes is on the rise (https://www.cdc.gov/media/releases/2022/p1229-future-diabetes-surge.html) . With those who can afford it now turning to pharmaceuticals to help them lose weight, we’ll examine why and how calorie counting has failed to help Americans maintain a “healthy” weight.  In this episode of “There’s More to That,” we hear from food historian Michelle Stacey about Peters’ legacy—and from Ronald Young Jr., creator and host of the critically acclaimed podcast “Weight For It (https://www.radiotopia.fm/podcasts/weight-for-it) ,” about how American society continues to stigmatize what he calls “fat folks” for reasons that have nothing to do with public, or even individual, health. A transcript is below. To subscribe to “There’s More to That,” and to listen to past episodes on the complex legacy of Sojourner Truth (https://www.smithsonianmag.com/history/how-to-separate-fact-from-myth-in-the-extraordinary-story-of-sojourner-truth-180983820/) , how Joan Baez opened the door for Taylor Swift (https://www.smithsonianmag.com/arts-culture/before-beyonce-taylor-swift-ran-world-joan-baez-180983893/) , how machine learning is helping archeologists to read scrolls (https://www.smithsonianmag.com/history/how-artificial-intelligence-is-making-2000-year-old-scrolls-readable-again-180984264/) buried by the eruption of Mount Vesuvius nearly 2,000 years ago and more, find us on Apple Podcasts (https://podcasts.apple.com/us/podcast/theres-more-to-that/id1694965155?ign-itscg=30200&ign-itsct=podcast_box_player) , Spotify (https://open.spotify.com/show/4NYRCRxkYJTLjW71sqYOFv?si=08fa62c3e59d450f&nd=1) or wherever you get your podcasts. Read Michelle Stacey's story about Dr. Lulu Hunt Peters in the June 2024 issue of Smithsonian here (https://www.smithsonianmag.com/science-nature/doctor-pioneered-counting-calories-century-ago-were-still-dealing-with-consequences-180984282/) . Listen to Ronald Young, Jr.'s podcast "Weight For It" here (https://www.radiotopia.fm/podcasts/weight-for-it) . Find prior episodes of our show here (https://www.smithsonianmag.com/podcast/) . There’s More to That is a production of Smithsonian magazine and PRX Productions. From the magazine, our team is Chris Klimek, Debra Rosenberg and Brian Wolly. From PRX, our team is Jessica Miller, Adriana Rosas Rivera, Genevieve Sponsler, Rye Dorsey, and Edwin Ochoa. The Executive Producer of PRX Productions is Jocelyn Gonzales. Fact-checking by Stephanie Abramson. Episode artwork by Emily Lankiewicz. Music by APM Music.

Follow us to the very first Thanksgiving celebration, where the Pilgrims and the Wampanoag came together for a historic feast.

Scientists identified traces of the drug in the brain tissue of two individuals buried in the crypt of a hospital in Milan

The baby pygmy hippopotamus in a Thailand zoo has taken the internet by storm, and keepers hope she will help gain momentum for conservation efforts

The wild canines have the same muscles used by domestic dogs to create the wide-eyed, pleading look that captures humans' hearts

Scientists used EEG headsets, MRI machines and eye trackers to study volunteers' responses to five paintings housed at the Mauritshuis museum in the Netherlands

Identified as an Arctic fox, the animal is believed to have been kept in captivity far from its native habitat in the tundra. Now, it's receiving care from wildlife officials

New research traces the genetic underpinnings of the enzyme amylase, which helps humans digest starches and sugars

Created in London in the 1960s, the tracks are heading to auction as part of a larger collection of memorabilia connected to the famous American guitarist

Called M136279841, the value belongs to a rare class of prime numbers called Mersenne primes and was found using a supercomputer system spread across 17 countries

An assessment from the International Union for Conservation of Nature paints a grim picture of the extinction risk of the world's trees

A century on, the country’s most beloved Thursday spectacle reaches new heights

Newspaper editor Horace Greeley unsuccessfully ran against incumbent Ulysses S. Grant in November 1872. Twenty-four days later, he died of unknown causes at a private mental health facility

Canadians hear the Last Post every year during Remembrance Day ceremonies. Warrant Officer Jeremy Maitland breaks down what it takes to play the melody perfectly.

The Regina Rams won the Hardy Cup showdown against the Saskatchewan Huskies Saturday, in the first finals clash between the two teams in 22 years.

The Surrey Police Service is less than three weeks from taking over from the RCMP to manage policing in British Columbia's second most populous municipality, but there's still no formal deal on how responsibilities will be split between the two forces.

Nathan Chen has accomplished just about everything that one can accomplish in the sport of figure skating. The only thing he's yet to accomplish? Winning Olympic gold.

The high cost of pet care can be an unfair burden to place on your family when you’re gone. Experts say you should set aside cash pet care expenses, and make sure you have a trusted beneficiary in your will.

World Cup Champion Noelle Pikus-Pace Turns To Local Metal Shop – And Her Husband – For Innovative New Sled

Newest Version of Leading 3D CAD Software Eliminates Traditional Performance/Functionality Tradeoffs

Space tourism pioneer Burt Rutan, developer of the world's first privately manned spacecraft, to discuss the role of 3D design tools in shaping the future

Faced with soaring material costs, LeBARON Foundry streamlined designs, lightening manhole covers and frames by as much as 50 pounds

Schools combine SOLIDWORKS 3D CAD software with 3D scanning and printing to enrich student learning

Nearly 100,000 visitors experimented with forward-looking tools and services in first year

Automotive aftermarket manufacturer designs failure points out of parts with 3D CAD software