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Asymmetric imidazole-4,5-dicarboxamide derivatives as SARS-CoV-2 main protease inhibitors: design, synthesis and biological evaluation

RSC Med. Chem., 2024, 15,3880-3888
DOI: 10.1039/D4MD00414K, Research Article
Phuong Nguyen Hoai Huynh, Phatcharin Khamplong, Minh-Hoang Phan, Thanh-Phuc Nguyen, Phuong Ngoc Lan Vu, Quang-Vinh Tang, Phumin Chamsodsai, Supaphorn Seetaha, Truong Lam Tuong, Thien Y. Vu, Duc-Duy Vo, Kiattawee Choowongkomon, Cam-Van T. Vo
Novel asymmetric imidazole-4,5-dicarboxamide derivatives were synthesized, evaluated for SARS-CoV-2 MPro inhibitory activity in vitro, and investigated for binding ability in silico.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Novel PROTAC probes targeting KDM3 degradation to eliminate colorectal cancer stem cells through inhibition of Wnt/β-catenin signaling

RSC Med. Chem., 2024, 15,3746-3758
DOI: 10.1039/D4MD00122B, Research Article
Open Access
Shadid U. Zaman, Piyusha P. Pagare, Hongguang Ma, Rosalie G. Hoyle, Yan Zhang, Jiong Li
We designed and synthesized novel IOX1-based PROTACs, which can selectively degrade KDM3A and KDM3B to eliminate colorectal cancer stem cells through inhibition of Wnt signaling.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Correction: computational design, synthesis, and assessment of 3-(4-(4-(1,3,4-oxadiazol-2-yl)-1H-imidazol-2-yl)phenyl)-1,2,4-oxadiazole derivatives as effective epidermal growth factor receptor inhibitors: a prospective strategy for anticancer therapy

RSC Med. Chem., 2024, 15,3912-3912
DOI: 10.1039/D4MD90040E, Correction
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Nilesh Raghunath Khedkar, Milind Sindkhedkar, Alex Joseph
The content of this RSS Feed (c) The Royal Society of Chemistry




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Advances in Detecting Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) Using Molecular Receptors and Nanostructured Assemblies

RSC Med. Chem., 2024, Accepted Manuscript
DOI: 10.1039/D4MD00661E, Review Article
Avijit Kumar Das
The detection and quantification of non-steroidal anti-inflammatory drugs (NSAIDs) are crucial due to their widespread use and potential impact on human health and the environment. This review provides a comprehensive...
The content of this RSS Feed (c) The Royal Society of Chemistry




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IIT Madras to conduct two-day summit on extended reality

The aim is to develop academic partnership programmes to boost research in XR or extended reality




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IIT-M students develop robot for O.P. Jindal university’s Constitution Museum

It is trained to respond to questions from visitors in Hindi and English, IIT-M professor says




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Vodafone Idea narrows Q2 loss to ₹7,176 crore




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Fervour marks ‘Kaisika Dwadasi’ at Tirumala




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New counters opened at Tirumala for issuing Srivani darshan tickets

Decision to open new counters taken following reports of devotees experiencing discomfort in queue at the previous counter, particularly during inclement weather, says TTD Additional EO




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Target is to to make 30,000 MT of sand available every day in East Godavari district, says Collector

P. Prasanthi warns boatmen associations of stringent action if they attempt to prevent vehicles transporting sand from the sand reaches




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All set for Urus festival at Pedda Dargah in Kadapa

Thousands of devotees from across Andhra Pradesh, Tamil Nadu, Karnataka and Maharashtra expected to converge at the famous Sufi shrine for the week-long event starting on November 16




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RLDA invites bids for commercial land use in Tirupati railway station

The station is being developed on a massive scale, providing commuting area on the southern side, in view of the crammed locality on the northern side




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Andhra Pradesh Govt. weighing options on how to utilise Mahila Samrakshana Karyadarshis, says Home Minister 

Ambiguity in overall control of their duties and service matters resulted in immense distress for the MSKs, says Home Minister




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117 applications received at Kuppam’s first ‘Praja Darbar’




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Jagan dares govt. to arrest him, says will continue to ‘expose failures’




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Peddapalli goods train derailment: Several trains cancelled or diverted

Three railway lines were affected in the derailment. Some trains skipped stoppages.




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Affordable generics will stay relevant amid a premiumisation trend: Bhushan Akshikar

GSK will keep its existing portfolios while entering areas like oncology, said company officials at its centenary celebrations




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29th Climate Conference (COP) tracker | Day 2 LIVE: Key speeches, UK NDC, and India’s reaction at 5 p.m. on November 13

Vibhuti Garg, an Associate and Senior Energy Specialist with over 13 years of experience in the energy sector, will guide us through the implications of these financial negotiations and the potential impacts on global energy transitions and climate commitments at 5 p.m. on November 13




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Synthesis and evaluation of photoaffinity labeling reagents for identifying binding sites of sulfated neurosteroids on NMDA and GABAA receptors

RSC Adv., 2024, 14,36352-36369
DOI: 10.1039/D4RA07074G, Paper
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Mingxing Qian, Yuanjian Xu, Hong-Jin Shu, Zi-Wei Chen, Lei Wang, Charles F. Zorumski, Alex S. Evers, Steven Mennerick, Douglas F. Covey
Photoaffinity labels (PALs) for sulfated steroid binding sites on GABAA and NMDA receptors. The PALs have varying profiles of positive and negative modulatory (PAM and NAM) actions.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Synthesis of MOF-supported Pt catalyst with high electrochemical oxidation activity for methanol oxidation

RSC Adv., 2024, 14,36370-36377
DOI: 10.1039/D4RA06393G, Paper
Open Access
Merve Akin, Hatice Kars, Muhammed Bekmezci, Aysenur Aygun, Mert Gul, Guray Kaya, Fatih Sen
In this study, Pt and Pt@Ti-MOF NPs catalysts were synthesized by chemical reduction method. Ti-MOF structure was synthesized using the solvothermal method, and the effect of Ti-MOF on methanol oxidation was investigated.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Karnataka Chief Minister Siddaramaiah says no proposal to ease night traffic ban through Bandipur

Deputy Chief Minister D.K. Shivakumar had stated, in Wayanad in Kerala, that the government would take all possible measures to lift night traffic ban through Bandipur, which had riled wildlife conservationists in Karnataka




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Here are the big stories from Karnataka today

Welcome to the Karnataka Today newsletter, your guide from The Hindu on the major news stories to follow today. Curated and written by Nalme Nachiyar.




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ED’s investigation into MUDA case is based on false allegations, says Siddaramaiah




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PUCL condemns opposition to Dalits’ entry into temple in Mandya village




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Only education can empower women: Siddaramaiah




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MUDA ‘scam’: Raichur MP Kumar Naik, CM’s PA questioned by ED




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Kannada has survived because of native speakers from North Karnataka: Horatti




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Comeback man Shami hogs the spotlight as MP takes honours on opening day against Bengal




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Sharandeep grinds out a half-century on a slow-moving opening day

The Jharkhand opener exhibits ample patience and a tight defence




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Daylight assault on doctor inside Chennai hospital leaves medical fraternity in shock

The attacker, Vignesh, was reportedly frustrated over the treatment given to his mother, who was diagnosed with Hodgkin’s Lymphoma in an advanced stage




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Students to take oath on mental health on Children’s Day




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Jairam Tiger Mahto stands in the way in tough battle for NDA and INDIA blocs in Jharkhand

Known for raising local issues, the 30-year-old leader hails from Kurmi (Mahtos) community that comprise 22% of the total population, the largest chunk after tribals and plays a decisive role in at least 30 seats




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Gokaldas Exports posts 19% growth in Q2 net profit




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Sharandeep grinds out a half-century on a slow-moving opening day

The opener exhibits ample patience and a tight defence as Jharkhand reached 136 for three in the 55 overs that were possible after the start of play was delayed by two hours




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Villagers oppose proposal for quarry near Sathanur dam at a public hearing

Tiruvannamalai Collector D. Bhaskara Pandian chaired the hearing organised by the TNPCB on Wednesday. The black granite quarry is proposed to be set up on about 8.46 hectares of government land in Sathanur




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Year-long action plan to combat diabetes to be launched on World Diabetes Day




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South India science drama festival on Thursday and Friday




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Stray dog menace grips Vijayawada

Up to 100 dog bite cases reported in city every day, claims Coporators; shortage of kennels hits street dog sterilisation programme, says VMC official




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Nagamohan Das to head panel to suggest internal reservation among SC communities




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UPPSC aspirants protest continues for third day over exam format 

The job aspirants protest multiple shifts and score normalisation in exams, demanding a fair and unified testing process




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Pedal boating begins at Sarovaram Biopark in Kozhikode




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Hackathon in database technology to be held

IIT-M Pravartak Technologies invites applications from engineers, developers for the hackathon




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Yellow alert for eight districts on Thursday




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Police arrest man for employing, abusing 11-year-old domestic help in Noida society




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In Beed, Independent candidates on strong footing against party nominees

Candidates who rebelled against party diktat stand out with strong support at the ground level and also have high chances of winning the seat




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1,052 graduates to receive degrees during Nitte convocation on Saturday




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Teachers should inculcate reading habit among students, says Swami Jithakamananda




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If 23andMe goes bust, what happens to its DNA database?

Millions of people have used 23andMe’s simple genetic testing service, which involves ordering a saliva test, spitting into a tube, and sending it back to the company for a detailed DNA analysis




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Visakhapatnam-Gunupur express to be cancelled on some days from November 13 owing to traffic blocks

The cancellation is owing to traffic blocks in the Naupada-Gunupur section of Waltair Division




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Sri Kanaka Mahalakshmi temple hundi collection crosses ₹39 lakh in 63 days in Visakhapatnam