da Asymmetric imidazole-4,5-dicarboxamide derivatives as SARS-CoV-2 main protease inhibitors: design, synthesis and biological evaluation By pubs.rsc.org Published On :: RSC Med. Chem., 2024, 15,3880-3888DOI: 10.1039/D4MD00414K, Research ArticlePhuong Nguyen Hoai Huynh, Phatcharin Khamplong, Minh-Hoang Phan, Thanh-Phuc Nguyen, Phuong Ngoc Lan Vu, Quang-Vinh Tang, Phumin Chamsodsai, Supaphorn Seetaha, Truong Lam Tuong, Thien Y. Vu, Duc-Duy Vo, Kiattawee Choowongkomon, Cam-Van T. VoNovel asymmetric imidazole-4,5-dicarboxamide derivatives were synthesized, evaluated for SARS-CoV-2 MPro inhibitory activity in vitro, and investigated for binding ability in silico.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
da Novel PROTAC probes targeting KDM3 degradation to eliminate colorectal cancer stem cells through inhibition of Wnt/β-catenin signaling By pubs.rsc.org Published On :: RSC Med. Chem., 2024, 15,3746-3758DOI: 10.1039/D4MD00122B, Research Article Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Shadid U. Zaman, Piyusha P. Pagare, Hongguang Ma, Rosalie G. Hoyle, Yan Zhang, Jiong LiWe designed and synthesized novel IOX1-based PROTACs, which can selectively degrade KDM3A and KDM3B to eliminate colorectal cancer stem cells through inhibition of Wnt signaling.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
da Correction: computational design, synthesis, and assessment of 3-(4-(4-(1,3,4-oxadiazol-2-yl)-1H-imidazol-2-yl)phenyl)-1,2,4-oxadiazole derivatives as effective epidermal growth factor receptor inhibitors: a prospective strategy for anticancer therapy By pubs.rsc.org Published On :: RSC Med. Chem., 2024, 15,3912-3912DOI: 10.1039/D4MD90040E, Correction Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Nilesh Raghunath Khedkar, Milind Sindkhedkar, Alex JosephThe content of this RSS Feed (c) The Royal Society of Chemistry Full Article
da Advances in Detecting Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) Using Molecular Receptors and Nanostructured Assemblies By pubs.rsc.org Published On :: RSC Med. Chem., 2024, Accepted ManuscriptDOI: 10.1039/D4MD00661E, Review ArticleAvijit Kumar DasThe detection and quantification of non-steroidal anti-inflammatory drugs (NSAIDs) are crucial due to their widespread use and potential impact on human health and the environment. This review provides a comprehensive...The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
da IIT Madras to conduct two-day summit on extended reality By www.thehindu.com Published On :: Wed, 13 Nov 2024 13:19:23 +0530 The aim is to develop academic partnership programmes to boost research in XR or extended reality Full Article Chennai
da IIT-M students develop robot for O.P. Jindal university’s Constitution Museum By www.thehindu.com Published On :: Wed, 13 Nov 2024 19:44:27 +0530 It is trained to respond to questions from visitors in Hindi and English, IIT-M professor says Full Article Tamil Nadu
da Vodafone Idea narrows Q2 loss to ₹7,176 crore By www.thehindu.com Published On :: Wed, 13 Nov 2024 20:56:55 +0530 Full Article Business
da Fervour marks ‘Kaisika Dwadasi’ at Tirumala By www.thehindu.com Published On :: Wed, 13 Nov 2024 18:22:52 +0530 Full Article Andhra Pradesh
da New counters opened at Tirumala for issuing Srivani darshan tickets By www.thehindu.com Published On :: Wed, 13 Nov 2024 18:45:53 +0530 Decision to open new counters taken following reports of devotees experiencing discomfort in queue at the previous counter, particularly during inclement weather, says TTD Additional EO Full Article Andhra Pradesh
da Target is to to make 30,000 MT of sand available every day in East Godavari district, says Collector By www.thehindu.com Published On :: Wed, 13 Nov 2024 19:25:35 +0530 P. Prasanthi warns boatmen associations of stringent action if they attempt to prevent vehicles transporting sand from the sand reaches Full Article Andhra Pradesh
da All set for Urus festival at Pedda Dargah in Kadapa By www.thehindu.com Published On :: Wed, 13 Nov 2024 19:44:11 +0530 Thousands of devotees from across Andhra Pradesh, Tamil Nadu, Karnataka and Maharashtra expected to converge at the famous Sufi shrine for the week-long event starting on November 16 Full Article Andhra Pradesh
da RLDA invites bids for commercial land use in Tirupati railway station By www.thehindu.com Published On :: Wed, 13 Nov 2024 20:29:31 +0530 The station is being developed on a massive scale, providing commuting area on the southern side, in view of the crammed locality on the northern side Full Article Andhra Pradesh
da Andhra Pradesh Govt. weighing options on how to utilise Mahila Samrakshana Karyadarshis, says Home Minister By www.thehindu.com Published On :: Wed, 13 Nov 2024 20:30:46 +0530 Ambiguity in overall control of their duties and service matters resulted in immense distress for the MSKs, says Home Minister Full Article Andhra Pradesh
da 117 applications received at Kuppam’s first ‘Praja Darbar’ By www.thehindu.com Published On :: Wed, 13 Nov 2024 20:37:24 +0530 Full Article Andhra Pradesh
da Jagan dares govt. to arrest him, says will continue to ‘expose failures’ By www.thehindu.com Published On :: Wed, 13 Nov 2024 21:16:05 +0530 Full Article Andhra Pradesh
da Peddapalli goods train derailment: Several trains cancelled or diverted By www.thehindu.com Published On :: Wed, 13 Nov 2024 13:43:36 +0530 Three railway lines were affected in the derailment. Some trains skipped stoppages. Full Article Telangana
da Affordable generics will stay relevant amid a premiumisation trend: Bhushan Akshikar By www.thehindu.com Published On :: Wed, 13 Nov 2024 10:50:51 +0530 GSK will keep its existing portfolios while entering areas like oncology, said company officials at its centenary celebrations Full Article Health
da 29th Climate Conference (COP) tracker | Day 2 LIVE: Key speeches, UK NDC, and India’s reaction at 5 p.m. on November 13 By www.thehindu.com Published On :: Wed, 13 Nov 2024 17:01:23 +0530 Vibhuti Garg, an Associate and Senior Energy Specialist with over 13 years of experience in the energy sector, will guide us through the implications of these financial negotiations and the potential impacts on global energy transitions and climate commitments at 5 p.m. on November 13 Full Article Environment
da Synthesis and evaluation of photoaffinity labeling reagents for identifying binding sites of sulfated neurosteroids on NMDA and GABAA receptors By pubs.rsc.org Published On :: RSC Adv., 2024, 14,36352-36369DOI: 10.1039/D4RA07074G, Paper Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Mingxing Qian, Yuanjian Xu, Hong-Jin Shu, Zi-Wei Chen, Lei Wang, Charles F. Zorumski, Alex S. Evers, Steven Mennerick, Douglas F. CoveyPhotoaffinity labels (PALs) for sulfated steroid binding sites on GABAA and NMDA receptors. The PALs have varying profiles of positive and negative modulatory (PAM and NAM) actions.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
da Synthesis of MOF-supported Pt catalyst with high electrochemical oxidation activity for methanol oxidation By pubs.rsc.org Published On :: RSC Adv., 2024, 14,36370-36377DOI: 10.1039/D4RA06393G, Paper Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Merve Akin, Hatice Kars, Muhammed Bekmezci, Aysenur Aygun, Mert Gul, Guray Kaya, Fatih SenIn this study, Pt and Pt@Ti-MOF NPs catalysts were synthesized by chemical reduction method. Ti-MOF structure was synthesized using the solvothermal method, and the effect of Ti-MOF on methanol oxidation was investigated.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
da Karnataka Chief Minister Siddaramaiah says no proposal to ease night traffic ban through Bandipur By www.thehindu.com Published On :: Wed, 13 Nov 2024 14:45:12 +0530 Deputy Chief Minister D.K. Shivakumar had stated, in Wayanad in Kerala, that the government would take all possible measures to lift night traffic ban through Bandipur, which had riled wildlife conservationists in Karnataka Full Article Karnataka
da Here are the big stories from Karnataka today By www.thehindu.com Published On :: Wed, 13 Nov 2024 18:28:16 +0530 Welcome to the Karnataka Today newsletter, your guide from The Hindu on the major news stories to follow today. Curated and written by Nalme Nachiyar. Full Article Karnataka Today
da ED’s investigation into MUDA case is based on false allegations, says Siddaramaiah By www.thehindu.com Published On :: Wed, 13 Nov 2024 19:12:55 +0530 Full Article Karnataka
da PUCL condemns opposition to Dalits’ entry into temple in Mandya village By www.thehindu.com Published On :: Wed, 13 Nov 2024 19:16:27 +0530 Full Article Karnataka
da Only education can empower women: Siddaramaiah By www.thehindu.com Published On :: Wed, 13 Nov 2024 19:33:50 +0530 Full Article Karnataka
da MUDA ‘scam’: Raichur MP Kumar Naik, CM’s PA questioned by ED By www.thehindu.com Published On :: Wed, 13 Nov 2024 19:52:50 +0530 Full Article Karnataka
da Kannada has survived because of native speakers from North Karnataka: Horatti By www.thehindu.com Published On :: Wed, 13 Nov 2024 21:05:42 +0530 Full Article Karnataka
da Comeback man Shami hogs the spotlight as MP takes honours on opening day against Bengal By www.thehindu.com Published On :: Wed, 13 Nov 2024 19:38:38 +0530 Full Article Sport
da Sharandeep grinds out a half-century on a slow-moving opening day By www.thehindu.com Published On :: Wed, 13 Nov 2024 19:43:55 +0530 The Jharkhand opener exhibits ample patience and a tight defence Full Article Cricket
da Daylight assault on doctor inside Chennai hospital leaves medical fraternity in shock By www.thehindu.com Published On :: Wed, 13 Nov 2024 20:20:29 +0530 The attacker, Vignesh, was reportedly frustrated over the treatment given to his mother, who was diagnosed with Hodgkin’s Lymphoma in an advanced stage Full Article Chennai
da Students to take oath on mental health on Children’s Day By www.thehindu.com Published On :: Wed, 13 Nov 2024 21:37:39 +0530 Full Article Kochi
da Jairam Tiger Mahto stands in the way in tough battle for NDA and INDIA blocs in Jharkhand By www.thehindu.com Published On :: Wed, 13 Nov 2024 22:26:16 +0530 Known for raising local issues, the 30-year-old leader hails from Kurmi (Mahtos) community that comprise 22% of the total population, the largest chunk after tribals and plays a decisive role in at least 30 seats Full Article Jharkhand Assembly
da Gokaldas Exports posts 19% growth in Q2 net profit By www.thehindu.com Published On :: Wed, 13 Nov 2024 22:28:34 +0530 Full Article Business
da Sharandeep grinds out a half-century on a slow-moving opening day By www.thehindu.com Published On :: Wed, 13 Nov 2024 22:59:37 +0530 The opener exhibits ample patience and a tight defence as Jharkhand reached 136 for three in the 55 overs that were possible after the start of play was delayed by two hours Full Article Cricket
da Villagers oppose proposal for quarry near Sathanur dam at a public hearing By www.thehindu.com Published On :: Wed, 13 Nov 2024 21:59:03 +0530 Tiruvannamalai Collector D. Bhaskara Pandian chaired the hearing organised by the TNPCB on Wednesday. The black granite quarry is proposed to be set up on about 8.46 hectares of government land in Sathanur Full Article Tamil Nadu
da Year-long action plan to combat diabetes to be launched on World Diabetes Day By www.thehindu.com Published On :: Wed, 13 Nov 2024 22:03:33 +0530 Full Article Kerala
da South India science drama festival on Thursday and Friday By www.thehindu.com Published On :: Wed, 13 Nov 2024 22:04:59 +0530 Full Article Bengaluru
da Stray dog menace grips Vijayawada By www.thehindu.com Published On :: Wed, 13 Nov 2024 22:08:06 +0530 Up to 100 dog bite cases reported in city every day, claims Coporators; shortage of kennels hits street dog sterilisation programme, says VMC official Full Article Andhra Pradesh
da Nagamohan Das to head panel to suggest internal reservation among SC communities By www.thehindu.com Published On :: Wed, 13 Nov 2024 22:24:18 +0530 Full Article Karnataka
da UPPSC aspirants protest continues for third day over exam format By www.thehindu.com Published On :: Wed, 13 Nov 2024 22:35:28 +0530 The job aspirants protest multiple shifts and score normalisation in exams, demanding a fair and unified testing process Full Article Uttar Pradesh
da Pedal boating begins at Sarovaram Biopark in Kozhikode By www.thehindu.com Published On :: Wed, 13 Nov 2024 23:37:01 +0530 Full Article Kerala
da Hackathon in database technology to be held By www.thehindu.com Published On :: Thu, 14 Nov 2024 00:01:49 +0530 IIT-M Pravartak Technologies invites applications from engineers, developers for the hackathon Full Article Tamil Nadu
da Yellow alert for eight districts on Thursday By www.thehindu.com Published On :: Thu, 14 Nov 2024 00:28:41 +0530 Full Article Kerala
da Police arrest man for employing, abusing 11-year-old domestic help in Noida society By www.thehindu.com Published On :: Thu, 14 Nov 2024 00:58:38 +0530 Full Article Delhi
da In Beed, Independent candidates on strong footing against party nominees By www.thehindu.com Published On :: Thu, 14 Nov 2024 05:43:54 +0530 Candidates who rebelled against party diktat stand out with strong support at the ground level and also have high chances of winning the seat Full Article Maharashtra Assembly
da 1,052 graduates to receive degrees during Nitte convocation on Saturday By www.thehindu.com Published On :: Thu, 14 Nov 2024 07:00:00 +0530 Full Article Mangaluru
da Teachers should inculcate reading habit among students, says Swami Jithakamananda By www.thehindu.com Published On :: Thu, 14 Nov 2024 07:00:00 +0530 Full Article Mangaluru
da If 23andMe goes bust, what happens to its DNA database? By www.thehindu.com Published On :: Wed, 13 Nov 2024 17:54:51 +0530 Millions of people have used 23andMe’s simple genetic testing service, which involves ordering a saliva test, spitting into a tube, and sending it back to the company for a detailed DNA analysis Full Article Science
da Visakhapatnam-Gunupur express to be cancelled on some days from November 13 owing to traffic blocks By www.thehindu.com Published On :: Wed, 13 Nov 2024 15:53:57 +0530 The cancellation is owing to traffic blocks in the Naupada-Gunupur section of Waltair Division Full Article Visakhapatnam
da Sri Kanaka Mahalakshmi temple hundi collection crosses ₹39 lakh in 63 days in Visakhapatnam By www.thehindu.com Published On :: Wed, 13 Nov 2024 18:35:50 +0530 Full Article Visakhapatnam