This article presents the capability of the QMAX furnace, devoted to reciprocal space mapping through X-ray scattering at high temperature up to 2000 K.

Have you ever had a pet that seemed just a little bit crazy or odd? Can you be sure that it was in control of […]

The post Crazy eyes and mind control – the power of parasites appeared first on Smithsonian Insider.

Only the Wing is a new book by Russell Lee that recounts Horten's epic quest to stabalize and control the all-wing aircraft.

The post New Book: “Only the Wing: Reimar Horten’s Epic Quest to Stabilize and Control the All-Wing Aircraft” appeared first on Smithsonian Insider.

Osiris Martinez-Guzman, Mathilda M. Willoughby, Arushi Saini, Jonathan V. Dietz, Iryna Bohovych, Amy E. Medlock, Oleh Khalimonchuk, and Amit R. Reddi

Heme is a cofactor and signaling molecule that is essential for much of aerobic life. All heme-dependent processes in eukaryotes require that heme is trafficked from its site of synthesis in the mitochondria to hemoproteins located throughout the cell. However, the mechanisms governing the mobilization of heme out of the mitochondria, and the spatio-temporal dynamics of these processes, are poorly understood. Herein, using genetically encoded fluorescent heme sensors, we developed a live cell assay to monitor heme distribution dynamics between the mitochondrial inner-membrane, where heme is synthesized, and the mitochondrial matrix, cytosol, and nucleus. Surprisingly, heme trafficking to the nucleus is ~25% faster than to the cytosol or mitochondrial matrix, which are nearly identical, potentially supporting a role for heme as a mitochondrial-nuclear retrograde signal. Moreover, we discovered that the heme synthetic enzyme, 5-aminolevulinic acid synthase (ALAS), and GTPases in control of the mitochondrial dynamics machinery, Mgm1 and Dnm1, and ER contact sites, Gem1, regulate the flow of heme between the mitochondria and nucleus. Overall, our results indicate that there are parallel pathways for the distribution of bioavailable heme.

Aline A. Alves, Heloisa B. Gabriel, Maria J. R. Bezerra, Wanderley de Souza, Sue Vaughan, Narcisa L. Cunha-e-Silva, and Jack D. Sunter

Eukaryotic flagella are complex microtubule based organelles and in many organisms there are extra-axonemal structures present, including the outer dense fibres of mammalian sperm and the paraflagellar rod (PFR) of trypanosomes. Flagellum assembly is a complex process occurring across three main compartments, the cytoplasm, the transition fibre-transition zone, and the flagellum. It begins with translation of protein components, followed by their sorting and trafficking into the flagellum, transport to the assembly site and then incorporation. Flagella are formed from over 500 proteins; the principles governing axonemal component assembly are relatively clear. However, the coordination and sites of extra-axonemal structure assembly processes are less clear.

We have discovered two cytoplasmic proteins in T. brucei that are required for PFR formation, PFR assembly factors 1 and 2. Deletion of either PFR-AF1 or PFR-AF2 dramatically disrupted PFR formation and caused a reduction in the amount of major PFR proteins. The presence of cytoplasmic factors required for PFR formation aligns with the concept of processes occurring across multiple compartments to facilitate axoneme assembly and this is likely a common theme for extra-axonemal structure assembly.

Aline A. Alves
Apr 15, 2020; 0:jcs.242271v1-jcs.242271
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National Science Foundation (NSF)-funded researchers from North Carolina State and Elon universities have developed a technique that allows them to remotely control the movement of soft robots, lock them into position for as long as needed and later reconfigure the robots into new shapes. The technique relies on light and magnetic fields. "By engineering the properties of the material, we can control the soft robot's movement remotely; we can get it to hold a given shape; we can then return the robot to its original shape or further modify its movement; and we can do this repeatedly. All of those things are valuable, in terms of this technology's utility in biomedical or aerospace applications," says Joe Tracy, a professor of materials science and engineering at NC State and corresponding author of a paper on the work. In experimental testing, the researchers demonstrated that the soft robots could be used to form "grabbers" for lifting and transporting objects. The soft robots could also be used as cantilevers or folded into "flowers" with petals that bend in different directions. "We are not limited to binary configurations, such as a grabber being either open or closed," says Jessica Liu, first author of the paper and a Ph.D. student at NC State. "We can control the light to ensure that a robot will hold its shape at any point."

Image credit: Jessica A.C. Liu

More targeted aircraft testing and simulation should be conducted to uncover design characteristics in new flight control systems that -- in rare circumstances -- may mislead pilots and result in unstable or dangerous flight conditions, says a new report by a National Research Council committee.

The U.S. Environmental Protection Agency (EPA) carries out experiments in which volunteer participants agree to be intentionally exposed by inhalation to specific pollutants at restricted concentrations over short periods to obtain important information about the effects of outdoor air pollution on human health.

Current cancer control efforts in the United States typically are fragmented and uncoordinated, but taking a systems approach to establish a U.S. National Cancer Control Plan would address the challenge more holistically, says a new report from the National Academies of Sciences, Engineering, and Medicine.

PFAS, or perfluoroalkyl and polyfluoroalkyl substances, are ubiquitous fluorinated organic compounds found widely in manufactured products, from firefighting foam to stain-resistant carpets. These water- and oil-repellent compounds are known to degrade slowly over time, and have been found in humans, drinking water, and even in Arctic ecosystems.

A new report from the National Academies of Sciences, Engineering, and Medicine finds new and innovative approaches to dust control are needed at Owens Lake, California, to improve air quality, reduce water use, and preserve habitats.

In light of the present situation in the U.S., we believe that it is essential to explore a wide range of options for treating the increasing numbers of very ill patients with COVID-19 respiratory illness.

On Broad Beach in Malibu, high tide not only wets sand but also retaining walls and broken down rock revetments. What happens next in homeowners' efforts to get sand trucked in here will go to the State Lands Commission - and the next Controller likely will weigh in on the problem. ; Credit: Molly Peterson/KPCC

The most common question I’ve been asked about the statewide Controller race this election year is the same question I get every four years. “Wait, we have one?”

The inevitable follow-up question: “What does this person do?” Down-ballot races in California’s state election can seem like a tedious part of a the voting process. Most of us just don't take the time to research them. In 2010, the last time we elected statewide executives, 435,308 of those people who voted for Governor just didn’t bother to vote for anybody in the Controller race. 

But in addition to being the chief fiscal officer of the 8th-largest economy in the world, the Controller sits on something like 80 state commissions and boards. And if you’re interested in California’s environment, a biggie there is the State Lands Commission.

The State Lands Commission oversees roughly 4 million acres of submerged land and tidelands, holding them in trust for the public. Right now it's looking at policy alternatives to respond to sea level rise. It manage the state's offshore oil-drilling leases. It even gets authority over historical shipwrecks! 

Three issues coming before to the Lands Commission mean the Controller matters:  

• Coastal Access and Martin’s Beach: At the end of September, Governor Jerry Brown signed a law requiring the State Lands Commission to negotiate with Vinod Khlosa, a private property owner who famously shut down coastal access over his land this year. The commission has all of next year to negotiate with Khlosa. If no deal is reached, it can use eminent domain authority to force public access – something that would represent a big break in historical practice, because that authority hasn’t ever been used in the 76 years that the commission has existed.
• Malibu’s Broad Beach has been rapidly eroding under pressure of waves and storms worsened by climate change, and very rich homeowners there have been seeking to add sand in front of their houses to combat the risk of damage to very expensive properties. Earlier this year, those homeowners successfully completed an application to the State Lands Commission, and the commission was expected to decide on it in October. The decision’s been put over till after the election.
• Fracking: Offshore oil made news late last year and earlier this year when some operators didn’t report that they were using drilling and production techniques collectively referred to as hydraulic fracturing. The news prompted the EPA to require chemical disclosures for drilling operations it oversees.  The state agencies that should be overseeing these issues – the Coastal Commission and the Lands Commission – are considering their next moves too.

Positions on these issues don’t really come up when it comes to the Controller race, though both Betty Yee and Ashley Swearengin have gone on the record to say they’re against fracking. 

This content is from Southern California Public Radio. View the original story at SCPR.org.

Nuns with the Little Sisters of The Poor, including Sister Celestine, left, and Sister Jeanne Veronique, center, rally outside the Supreme Court in Washington on March 23, 2016.; Credit: Jacquelyn Martin/AP

The birth-control wars return to the Supreme Court Wednesday, and it is likely that the five-justice conservative majority will make it more difficult for women to get birth control if they work for religiously affiliated institutions like hospitals, charities and universities.

At issue in the case is a Trump administration rule that significantly cuts back on access to birth control under the Affordable Care Act. Obamacare, the massive overhaul of the health care system, sought to equalize preventive health care coverage for women and men by requiring employers to include free birth control in their health care plans.

Listen to the arguments live beginning at 10 a.m. ET.

Houses of worship like churches and synagogues were automatically exempted from the provision, but religiously affiliated nonprofits like universities, charities and hospitals were not. Such organizations employ millions of people, many of whom want access to birth control for themselves and their family members. But many of these institutions say they have a religious objection to providing birth control for employees.

For these nonprofits, the Obama administration enacted rules providing a work-around to accommodate employers' religious objections. The workaround was that an employer was to notify the government, or the insurance company, or the plan administrator, that, for religious reasons, it would not be providing birth-control coverage to its employees. Then, the insurance company could provide free birth-control options to individual employees separately from the employer's plan.

But some religiously affiliated groups still objected, saying the work-around was not good enough, and sued. They contended that signing an opt-out form amounted to authorizing the use of their plan for birth control. Among those objectors was the Little Sisters of the Poor, an order of Catholic nuns that runs homes for the elderly poor.

The Supreme Court punted in 2016

The Little Sisters sued, and their case first reached the Supreme Court in 2016. At the time, Sister Constance Viet explained why she refused to sign any opt-out form, saying that "the religious burden is what that signifies and the fact that the government would ... be inserting services that we object into our plan. And it would still carry our name."

Back then, when the Little Sisters' case got to the Supreme Court, the justices basically punted, telling the government and the sisters to work together to try to reach a compromise that would still provide "seamless birth control" coverage for employees who want it, without burdening the Sisters' religious beliefs. Although the Little Sisters did eventually get relief from the lower courts, the fight over the accommodations rules continued right up to the end of the Obama administration.

But when President Trump came into office, the administration issued new rules that would give broad exemptions to nonprofits and some for-profit companies that have objections to providing birth-control coverage for their employees. And the new rules expanded the category of employers who would be exempt from the birth-control mandate to include not just those with religious objections, but those with moral objections, too.

New rules

Those new rules, currently blocked by lower courts, are what is at issue Wednesday in the Supreme Court.

"Many states are suing and none of them can find a single actual woman who claims she's been harmed," says Mark Reinezi, president of the Becket Fund for Religious Liberty, which is defending the Trump rules against challenges brought by Pennsylvania and other states.

And, he adds, "there are many other ways to provide contraceptive coverage to people if they happen to work for religious objectors."

Rienzi says that employees who work for birth-control objectors can get coverage from their spouse's insurance plan, or by switching to a different insurance plan on an Obamacare exchange. And he says that birth control is also available under a program known as Title X, which gives money to state and local governments to provide health care for women.

But Brigitte Amiri, the deputy director the of ACLU's Reproductive Freedom project, says the idea that Title X could make up for the lost coverage is "a joke." Amiri notes that the Title X program has been underfunded for years, and the Trump administration has issued new regulations that in her words "decimated the program."

According to Amiri, "the Trump administration and Vice President [Mike] Pence have long wanted to ... take away coverage for contraception. They want to block access to birth control. They want to block access to abortion ... so this is all part and parcel of the overall attack on access to reproductive health care."

Potential consequences

She maintains that if the expanded Trump rules are upheld for religious objectors, hundreds of thousands of women across the country will lose their contraceptive coverage. Ultimately, Amiri says, there just is no way to maintain birth-control coverage for employees who work for religiously affiliated institutions unless that employer, as she puts it, is willing to "raise their hand" to opt out.

A break in birth-control coverage that big could have serious consequences, say say birth-control advocates. They note that the National Academy of Medicine, a health policy nonprofit, recommended the original rules because birth control is prescribed not just to avoid pregnancy but also to treat various female medical conditions. In fact, it is the most frequently taken drug for women ages 15-60. And it is expensive, $30 a month and more for pills, and as much as $1,000 for buying and having an IUD inserted.

Birth-control advocates say that's the very reason that a broad requirement to cover birth control in insurance was included in Obamacare. They say the new Trump rule improperly undermines that mandate.

But selling that argument to the Supreme Court will be hard. When the court last considered this issue in 2016, its makeup was far less conservative than it is now. Since then, two Trump appointees have been added to the court. And both of those appointees — Neil Gorsuch and Brett Kavanaugh — have already indicated strong support for the notion that religious rights may often trump other rights.

This content is from Southern California Public Radio. View the original story at SCPR.org.

Birth control pills in 1976 in New York. The birth control pill was approved by the FDA 60 years ago this week.; Credit: /Bettmann/Getty Images

Updated at 9:44 a.m. ET

As a young woman growing up in a poor farming community in Virginia in the 1940 and '50s, with little information about sex or contraception, sexuality was a frightening thing for Carole Cato and her female friends.

"We lived in constant fear, I mean all of us," she said. "It was like a tightrope. always wondering, is this going to be the time [I get pregnant]?"

Cato, 78, now lives in Columbia, S.C. She grew up in the years before the birth control pill was approved by the U.S. Food and Drug Administration, on May 9, 1960. She said teenage girls in her community were told very little about how their bodies worked.

"I was very fortunate; I did not get pregnant, but a lot of my friends did. And of course, they just got married and went into their little farmhouses," she said. "But I just felt I just had to get out."

At 23, Cato married a widower who already had seven children. They decided seven was enough.

By that time, Cato said, the pill allowed the couple to avoid having more babies — and she eventually was able to go on to college.

"It was just like going from night to day, as far as the freedom of it," Cato said. "And to know that I had control, that I had choice, that I controlled my body. It gave me a whole new lease on life."

Loretta Ross, an activist and visiting women's studies professor at Smith College, was among the first generation of young women to have access to the birth control pill throughout their reproductive years.

Ross, now 66, said by the time she came of age around 1970, the pill was giving young women more control over their fertility than previous generations had enjoyed.

"We could talk about having sex – not without consequences, because there were still STDS ... but at the same time, with more freedom than our foremothers had," Ross said. "So it changed the world."

For all it's done for women, Ross said that the pill has a complex and controversial history; it was first tested on low-income women in Puerto Rico. Ross said the pill also has limitations; she'd like to see it made available over the counter, as it is in some countries – not to mention, a pill for men.

When the pill was approved in 1960, women had few relatively few contraceptive options, and the pill offered more reliability and convenience than methods like condoms or diaphragms, said Dr. Eve Espey, chair of the Department of Ob/Gyn and Family Planning at the University of New Mexico.

"There was a huge, pent-up desire for a truly effective form of contraception, which had been lacking up to that point," Espey said.

By 1965, she said, 40% of young married women were on the pill.

For Pat Fishback, now 80 and living in Richmond, Va., the newly-available pill allowed her to delay having children in her early 20s until she'd been married for a couple of years.

"It also made having children a positive experience," Fishback said. "Because we had actually, emotionally and intellectually, gotten to the point where we really desired to have children."

It took a bit longer for unmarried women to gain widespread access to the pill and other forms of contraception: Linda Gordon, 80, a historian at New York University, remembers the stigma around single women and contraception at the time.

"When I was in college, a number of women had a wedding ring – a gold ring –that we would pass around and use when we wanted to go see a doctor to get fitted for a diaphragm," Gordon said. "In other words, there were people finding their way to do that, even then."

The pill also gave rise to a variety of other forms of hormonal contraception, many of which are popular today, Gordon said. According to the Centers for Disease Control and Prevention, nearly 13% of American women of reproductive age use the pill — making it the second most popular form of contraception, after female sterilization.

Gordon said that 60 years after the pill's approval, contraception remains a contentious political issue.

Just this week, the U.S. Supreme Court heard arguments in a case involving the birth control mandate in the Affordable Care Act. A decision on whether some institutions with religious or moral objections can deny contraceptive coverage to their employees is expected in the months to come.

This content is from Southern California Public Radio. View the original story at SCPR.org.

Full Text:

National Science Foundation (NSF)-funded researchers from North Carolina State and Elon universities have developed a technique that allows them to remotely control the movement of soft robots, lock them into position for as long as needed and later reconfigure the robots into new shapes. The technique relies on light and magnetic fields. "By engineering the properties of the material, we can control the soft robot's movement remotely; we can get it to hold a given shape; we can then return the robot to its original shape or further modify its movement; and we can do this repeatedly. All of those things are valuable, in terms of this technology's utility in biomedical or aerospace applications," says Joe Tracy, a professor of materials science and engineering at NC State and corresponding author of a paper on the work. In experimental testing, the researchers demonstrated that the soft robots could be used to form "grabbers" for lifting and transporting objects. The soft robots could also be used as cantilevers or folded into "flowers" with petals that bend in different directions. "We are not limited to binary configurations, such as a grabber being either open or closed," says Jessica Liu, first author of the paper and a Ph.D. student at NC State. "We can control the light to ensure that a robot will hold its shape at any point."

Image credit: Jessica A.C. Liu

Assessing the potential of new environmental management tools often brings an ???innovation dilemma???: is it better to stick with what is known to work, or to implement new measures that are potentially more effective, but also more uncertain? Researchers have proposed an approach to deal with these dilemmas, and applied it to the case study of an invasive species programme in the US.

A fungus could offer an alternative to chemical pesticides for the control of biting midges that spread livestock diseases, including Bluetongue and African horse sickness, according to new research.

Natural predators of agricultural pests are influenced by the type and range of habitats within a farming landscape. A new study has developed an approach which predicts the risk of pest infestation and natural predation according to landscape features, to help land managers structure landscapes that encourage natural pest control.

Crane fly larvae cause considerable damage to agricultural crops and young trees throughout Europe. New research has demonstrated that certain strains of fungi have significant potential to control crane fly infestations, thus reducing the use of chemical insecticides and enabling more environmentally-friendly strategies for pest control.

Controlling pests using their natural enemies can be an environmentally sound alternative to pesticides. However, the complex interactions between different pest control species and the landscape itself can affect the efficiency of such biological pest control, research suggests.

Greenhouse gas (GHG) emissions from municipal waste in Europe could be reduced by 62 million tonnes, or 1.23% of total emissions in 2008, by 2020 if the diversion targets of the EU Landfill Directive are fully met, according to a recent report. This could be largely achieved through reducing methane emissions from landfill and increased recycling levels.

The North American pine wood nematode (PWN), Bursaphelenchus xylophilus, is a pest worm species that causes a disease known as pine wilt. It was discovered for the first time in the EU in Portuguese forests in 1999. Today, the entire territory of Portugal is demarcated for the presence of PWN, with a 20 km buffer zone, free from the pest, established along the Spanish border with the aim of preventing its further spread. The spread and establishment of PWN in the rest of EU territory is very likely if no strict measures are taken, as required by Decision 2012/535/EU of the European Commission, with serious economic and environmental consequences. To date, Spain has experienced five outbreaks of PWN, three of which have been successfully eradicated thanks to the EU measures and the effective work of the Spanish forest administration; and two outbreaks are currently being eradicated.

Locally managed carbon budgets for housing and transport could be highly effective in reducing greenhouse gas (GHG) emissions, according to researchers. They have suggested a policy framework with standardised methods to monitor city carbon budgets with local flexibility for remaining within these budgets.

Assessing the potential of new environmental management tools often brings an ‘innovation dilemma’: is it better to stick with what is known to work, or to implement new measures that are potentially more effective, but also more uncertain? Researchers have proposed an approach to deal with these dilemmas, and applied it to the case study of an invasive species programme in the US.

Researchers have developed an online tool to help water managers find effective ways of tackling eutrophication, an excess growth of weeds and algae that suffocates life in rivers, lakes and seas. They describe the tool as quick and easy to use and understand. Users can compare the likely effects of different strategies for cutting nutrient pollution in surface waters via an interactive map-based system; this is currently available for Sweden and Europe as a whole.

Controlled fires could help the regeneration capacity of some insects in regions of intensively managed forests, according to a recent study of Finnish forests that are part of an EU LIFE restoration project. Results indicated that fire can be an effective conservation measure but its impact depends on the region???s history and context.

Pollination and pest control are essential to global food production. This study shows that — as well as their individual benefits — they have synergistic effects on yield. Their joint effect increased the yield of oilseed rape by 23%, and the economic benefit from their combined effects was almost twice that of their individual contributions. These findings have implications for sustainable agricultural policy.

Use of the rodenticide bromadiolone to control water voles in France may also result in population declines of the near-threatened red kite, a new study suggests. The researchers propose a range of alternative forms of controlling vole populations, limiting the need for environmentally-damaging poisons.

Combining steam with heat-producing chemicals could control pathogenic viruses in soil, finds new research. The study examined how effective different forms of heat sterilisation of soil were at inactivating three plant viruses. While steam alone was enough to eradicate two of the viruses, the highly resilient tobacco mosaic virus required the addition of exothermic chemicals to reduce it by 97%.

Controls on pharmaceutical production in the EU should be changed to guard against the spread of antibiotic resistance, protect wildlife and improve transparency in the industry, a team of scientists from Sweden and the UK recommends. The scientists propose 10 changes to the environmental risk assessment (ERA) of pharmaceuticals.

Growing sugar beet varieties which are resistant to their pest, the cyst nematode, is the best way to achieve high sugar yields in northern Germany, recent research has concluded. The researchers say this method is better than growing trap crops or using pesticides to control the pests.

Measures to control methane and black carbon (soot) emissions could improve air quality and public health, in addition to slowing the rate of climate change, according to recent research. By 2030, the reduced pollution could prevent between 700,000 and 4.7 million premature deaths each year, with 80% of the benefits occurring in Asia.

Switching to the best available emission control technologies could eliminate 99% of particulate matter pollution 'hotspots', a new study suggests. The researchers reached this conclusion by expanding the local-scale capabilities of an existing computer model that estimates the effects of air pollution policies and control measures.

Pollution is the world’s largest environmental cause of disease and premature death. The Lancet Commission on pollution and health brought together leaders, researchers and practitioners from the fields of pollution management, environmental health and sustainable development to elucidate the full health and economic costs of air, water, chemical and soil pollution worldwide. By analysing existing and emerging data, the Commission reveals that pollution makes a significant and underreported contribution to the global burden of disease, particularly in low- and middle-income countries. The Commission also provides six recommendations to policymakers and other stakeholders looking for efficient, cost-effective and actionable approaches to pollution mitigation and prevention.

New research suggests that fungi could be used to control insect-borne diseases common in livestock. The study shows for the first time that a fungus can effectively kill adult midges in the family of insects that carry bluetongue virus (BTV). Bluetongue outbreaks have caused significant losses on European farms in recent years, and the study indicates that using the fungus as a means of biological control could help reduce reliance on chemical insecticides, in the absence of effective vaccines.

Crane fly larvae cause considerable damage to agricultural crops and young trees throughout Europe. New research has demonstrated that certain strains of fungi have significant potential to control crane fly infestations, thus reducing the use of chemical insecticides and enabling more environmentally-friendly strategies for pest control.

Pests that cause millions of euros in damage to Europe’s forests every year could be controlled using fungi. A new study finds that certain strains and formulations of fungi are extremely effective in killing large pine weevils. Control of the weevils using fungi may provide forest managers with an alternative to chemical pesticides.

A new study from Poland has confirmed the potential of fungal Trichoderma species to control diseases of oilseed rape crops. The use of Trichoderma can reduce the growth of disease-causing oilseed rape pathogens, which may allow a decrease in the use of harmful pesticides.

Keeping sperm from being ejaculated may provide the key to creating a birth control drug for men.

Multi-university project asks how organic farmers can control these pests and protect their crops.

Keep the pets but ditch the mess with this handy guide.

New hi-tech Environ thermostat allows you to remotely monitor and control your home energy use.

The research reveals genetic clues about the insects' behavior, making it possible to target specific attributes.