Title: Smoking, Drinking a Double Whammy for Teens' Arteries: Study
Category: Health News
Created: 8/29/2018 12:00:00 AM
Last Editorial Review: 8/29/2018 12:00:00 AM

Title: Caw-lesterol? Fatty City Food Hits Crows' Arteries
Category: Health News
Created: 8/26/2019 12:00:00 AM
Last Editorial Review: 8/26/2019 12:00:00 AM

Title: Is a Charter School the Right Choice for Your Child?
Category: Health News
Created: 8/29/2019 12:00:00 AM
Last Editorial Review: 8/29/2019 12:00:00 AM

Title: Heavy Drinking in Youth Could Harm Arteries
Category: Health News
Created: 8/24/2021 12:00:00 AM
Last Editorial Review: 8/24/2021 12:00:00 AM

Title: AHA News: What Goes Into a Mediterranean Diet, and How to Get Started
Category: Health News
Created: 8/23/2022 12:00:00 AM
Last Editorial Review: 8/23/2022 12:00:00 AM

Title: Can Your Smartphone Spot a Narrowed Neck Artery?
Category: Health News
Created: 8/17/2022 12:00:00 AM
Last Editorial Review: 8/17/2022 12:00:00 AM

Two decades into the era of Electronic Health Records (EHRs), the promise of streamlining clinical care, reducing burden, and improving patient outcomes has yet to be realized. A cross-sectional family physician census conducted by the American Board of Family Medicine in 2022 and 2023 included self-reported physician EHR satisfaction. Of the nearly 10,000 responding family physicians, only one-in-four (26.2%) report being very satisfied and one-in-three (33.8%) were not satisfied. These low levels of satisfaction point to the need for greater transparency in the marketplace and pressure to increase user-centric EHR design.

BACKGROUND AND PURPOSE:

Hemangioblastoma is a rare vascular tumor that occurs within the central nervous system in children. Differentiating hemangioblastoma from other posterior fossa tumors can be challenging on imaging, and preoperative diagnosis can change the neurosurgical approach. We hypothesize that a "lightbulb sign" on the arterial spin-labeling (ASL) sequence (diffuse homogeneous intense hyperperfusion within the solid component of the tumor) will provide additional imaging finding to differentiate hemangioblastoma from other posterior fossa tumors.

MATERIALS AND METHODS:

In this retrospective comparative observational study, we only included pathology-proved cases of hemangioblastoma, while the control group consisted of other randomly selected pathology-proved posterior fossa tumors from January 2022 to January 2024. Two blinded neuroradiologists analyzed all applicable MRI sequences, including ASL sequence if available. ASL was analyzed for the lightbulb sign. Disagreements between the radiologists were resolved by a third pediatric neuroradiologist. ² and Fisher exact test were used to analyze the data.

RESULTS:

Ninety-five patients were enrolled in the study; 57 (60%) were boys. The median age at diagnosis was 8 years old (interquartile range: 3–14). Of the enrolled patients, 8 had hemangioblastoma, and 87 had other posterior fossa tumors, including medulloblastoma (n = 31), pilocytic astrocytoma (n = 23), posterior fossa ependymoma type A (n = 16), and other tumors (n = 17). The comparison of hemangioblastoma versus nonhemangioblastoma showed that peripheral edema (P = .02) and T2-flow void (P = .02) favor hemangioblastoma, whereas reduced diffusion (low ADC) (P = .002) and ventricular system extension (P = .001) favor nonhemangioblastoma tumors. Forty-two cases also had ASL perfusion sequences. While high perfusion favors hemangioblastoma (P = .03), the lightbulb sign shows a complete distinction because all the ASL series of hemangioblastoma cases (n = 4) showed the lightbulb sign, whereas none of the nonhemangioblastoma cases (n = 38) showed the sign (P < .001).

CONCLUSIONS:

Lightbulb-like intense and homogeneous hyperperfusion patterns on ASL are helpful in diagnosing posterior fossa hemangioblastoma in children.

BACKGROUND AND PURPOSE:

Vertebrobasilar artery stent placement (VBS) is potentially effective in preventing recurrent posterior circulation strokes; however, the incidences of in-stent restenosis and stented-territory ischemic events based on the location of stent placement have rarely been investigated. We aimed to investigate the characteristics and prognosis of VBS between intracranial and extracranial.

MATERIALS AND METHODS:

This study was single-center retrospective cohort study, and we obtained medical records of patients who underwent VBS. We compared clinical and periprocedural factors between extracranial and intracranial VBS. The primary outcomes included the incidence of in-stent restenosis (>50% reduction in lumen diameter) and stented-territory ischemic events. We compared the incidence of in-stent restenosis and stented-territory ischemic events by using Kaplan-Meier curves.

RESULTS:

Of the 105 patients, 41 (39.0%) underwent extracranial VBS, and 64 (61.0%) underwent intracranial VBS. During the follow-up, the incidences of in-stent restenosis and stented-territory ischemic events were 15.2% and 22.9%, respectively. The procedure time was longer (47.7 ± 19.5 minutes versus 74.5 ± 35.2 minutes, P < .001), and the rate of residual stenosis (≥30%) just after VBS was higher (2 [4.9%] versus 24 [37.5%], P < .001) in intracranial VBS than in extracranial VBS. Also, the incidences of in-stent restenosis were significantly higher in intracranial VBS than in extracranial VBS (4.9% versus 21.9%, P = .037). On the other hand, the incidences of stented-territory ischemic events (7.3% versus 32.8%, P < .001) were significantly higher in intracranial VBS than in extracranial VBS. The main mechanisms of stroke were artery-to-artery embolism (2 [66.7%]) in extracranial VBS, and artery-to-artery embolism (9 [42.9%]) and branch atheromatous disease (8 [38.1%]) in intracranial VBS. The Kaplan-Meier curve demonstrated a higher incidence of in-stent restenosis and stented-territory ischemic events in intracranial VBS than in extracranial VBS (P = .008 and P = .002, respectively).

CONCLUSIONS:

During the follow-up, the incidence of in-stent restenosis and stented-territory ischemic events was higher in patients with intracranial VBS than in those with extracranial VBS. The higher rates of postprocedural residual stenosis might have contributed to the increased risk of in-stent restenosis. Furthermore, prolonged procedure time and additional stroke mechanism, including branch atheromatous disease, might be associated with a higher risk of stented-territory ischemic events in intracranial VBS.

BACKGROUND AND PURPOSE:

Alterations of the basilar artery (BA) anatomy have been suggested as a possible MRA feature of Fabry disease (FD). Nonetheless, no information about their clinical or pathophysiologic correlates is available, limiting our comprehension of the real impact of vessel remodeling in FD.

MATERIALS AND METHODS:

Brain MRIs of 53 subjects with FD (mean age, 40.7 [SD, 12.4] years; male/female ratio = 23:30) were collected in this single-center study. Mean BA diameter and its tortuosity index were calculated on MRA. Possible correlations between these metrics and clinical, laboratory, and advanced imaging variables of the posterior circulation were tested. In a subgroup of 20 subjects, a 2-year clinical and imaging follow-up was available, and possible longitudinal changes of these metrics and their ability to predict clinical scores were also probed.

RESULTS:

No significant association was found between MRA metrics and any clinical, laboratory, or advanced imaging variable (P values ranging from –0.006 to 0.32). At the follow-up examination, no changes were observed with time for the mean BA diameter (P = .84) and the tortuosity index (P = .70). Finally, baseline MRA variables failed to predict the clinical status of patients with FD at follow-up (P = .42 and 0.66, respectively).

CONCLUSIONS:

Alterations of the BA in FD lack of any meaningful association with clinical, laboratory, or advanced imaging findings collected in this study. Furthermore, this lack of correlation seems constant across time, suggesting stability over time. Taken together, these results suggest that the role of BA dolichoectasia in FD should be reconsidered.

A new Nordic-style Open Kindergarten will be trialled in part of Scotland ahead of a potential roll-out across the country.

Disaster was averted at a Kentucky hospital when an ostensibly deceased organ donor began “thrashing” around in the operating theater, a preservationist tells NPR.

“He was moving around,” Natasha Miller recalled of the patient, whom NPR identified as Anthony Thomas “TJ” Hoover II. “He was crying visibly.”

The two surgeons assigned to the transplant naturally refused to go through with the procedure, which was reportedly scheduled to take place at Baptist Health Richmond Hospital in October 2021. But when her colleague called Kentucky Organ Donor Affiliates, which coordinated the harvest, Miller said the supervisor told them they “were going to do the case” and needed to “find another doctor.”

Read more at The Daily Beast.

I have zero archaeology experience or knowledge, but I bet archaeologists really love their jobs (for the most part). They get to analyse and discover cool artefacts and educate us on the histories of forgotten civilisations. That's dreamy stuff, that is. But I do wonder what it's like for archaeologists to discover and study something they shouldn't have; something with a disturbing secret - a curse, maybe. Bite-sized horror game The Children Of Clay explores this idea and I'd like more of it, please.

Read more

Apple recently announced its new lineup of Macs and rolled out Apple Intelligence, its latest artificial intelligence-powered feature for its products.

Prince Turki bin Faisal al-Saud, former Saudi ambassador to the United States, has written an open letter to President-elect Donald Trump asking him to “finish what you started the last time you occupied the White House” with respect to Middle Eastern affairs.

The post Saudi Royals Ask Trump to ‘Finish What You Started’ in Middle East appeared first on Breitbart.

Los Angeles Dodgers star Shohei Ohtani is a finalist for his first National League MVP award after winning the AL honor twice, joined among the top three in NL voting by New York Mets shortstop Francisco Lindor and Arizona second baseman Ketel Marte.

Canada will be without captain Alphonso Davies for its upcoming CONCACAF Nations League quarterfinal against Suriname. Canada Soccer says the Bayern Munich star has withdrawn as a "precautionary measure due to physical fatigue."

The contract software company closed a $110 million Series D round in 2023, one of the largest venture capital deals in Washington last year.

Neurosurgeon Vitor Mendes Pereira has grown accustomed to treating brain aneurysms with only blurry images for guidance.

Equipped with a rough picture of the labyrinthine network of arteries in the brain, he does his best to insert mesh stents or coils of platinum wire—interventions intended to promote clotting and to seal off a bulging blood vessel.

The results are not always perfect. Without a precise window into the arterial architecture at the aneurysm site, Pereira says that he and other neurovascular specialists occasionally misplace these implants, leaving patients at a heightened risk of stroke, clotting, inflammation, and life-threatening ruptures. But a new fiber-optic imaging probe offers hope for improved outcomes.

Pereira et al./Science Translational Medicine

According to Pereira’s early clinical experience, the technology—a tiny snake-like device that winds its way through the intricate maze of brain arteries and, using spirals of light, captures high-resolution images from the inside-out—provides an unprecedented level of structural detail that enhances the ability of clinicians to troubleshoot implant placement and better manage disease complications.

“We can see a lot more information that was not accessible before,” says Pereira, director of endovascular research and innovation at St. Michael’s Hospital in Toronto. “This is, for us, an incredible step forward.”

And not just for brain aneurysms. In a report published today in Science Translational Medicine, Pereira and his colleagues describe their first-in-human experience using the platform to guide treatment for 32 people with strokes, artery hardening, and various other conditions arising from aberrant blood vessels in the brain.

Whereas before, with technologies such as CT scans, MRIs, ultrasounds, and x-rays, clinicians had a satellite-like view of the brain’s vascular network, now they have a Google Street View-like perspective, complete with in-depth views of artery walls, plaques, immune cell aggregates, implanted device positions, and more.

“The amount of detail you could get you would never ever see with any other imaging modality,” says Adnan Siddiqui, a neurosurgeon at the University at Buffalo, who was not involved in the research. “This technology holds promise to be able to really transform the way we evaluate success or failure of our procedures, as well as to diagnose complications before they occur.”

A Decade of Innovation

The new fiber-optic probe is flexible enough to snake through the body’s arteries and provide previously unavailable information to surgeons.Pereira et al./Science Translational Medicine

The new imaging platform is the brainchild of Giovanni Ughi, a biomedical engineer at the University of Massachusetts’ Chan Medical School in Worcester. About a decade ago, he set out to adapt a technique called optical coherence tomography (OCT) for imaging inside the brain’s arteries.

OCT relies on the backscattering of near-infrared light to create cross-sectional images with micrometer-scale spatial resolution. Although OCT had long been used in clinical settings to generate pictures from the back of the eye and from inside the arteries that supply blood to the heart, the technology had proven difficult to adapt for brain applications owing to several technical challenges.

One major challenge is that the fiber-optic probes used in the technology are typically quite stiff, making them too rigid to twist and bend through the convoluted passageways of the brain’s vasculature. Additionally, the torque cables—traditionally used to rotate the OCT lens to image surrounding vessels and devices in three dimensions as the probe retracts—were too large to fit inside the catheters that are telescopically advanced into the brain’s arteries to address blockages or other vascular issues.

“We had to invent a new technology,” Ughi explains. “Our probe had to be very, very flexible, but also very, very small to be compatible with the clinical workflow.”

To achieve these design criteria, Ughi and his colleagues altered the properties of the glass at the heart of their fiber-optic cables, devised a new system of rotational control that does away with torque cables, miniaturized the imaging lens, and made a number of other engineering innovations.

The end result: a slender probe, about the size of a fine wire, that spins 250 times per second, snapping images as it glides back through the blood vessel. Researchers flush out blood cells with a tablespoon of liquid, then manually or automatically retract the probe, revealing a section of the artery about the length of a lip balm tube.

St. Michael’s Foundation

Clinical Confirmation

After initial testing in rabbits, dogs, pigs, and human cadavers, Ughi’s team sent the device to two clinical groups: Pereira’s in Toronto and Pedro Lylyk’s at the Sagrada Familia Clinic in Buenos Aires, Argentina. Across the two groups, neurosurgeons treated the 32 participants in the latest study, snaking the imaging probe through the patients’ groins or wrists and into their brains.

The procedure was safe and well-tolerated across different anatomies, underlying disease conditions, and the complexity of prior interventions. Moreover, the information provided frequently led to actionable insights—in one case, prompting clinicians to prescribe anti-platelet drugs when hidden clots were discovered; in another, aiding in the proper placement of stents that were not flush against the arterial wall.

“We were successful in every single case,” Ughi says. “So, this was a huge confirmation that the technology is ready to move forward.”

“We can see a lot more information that was not accessible before.” —Vitor Mendes Pereira, St. Michael’s Hospital

A startup called Spryte Medical aims to do just that. According to founder and CEO David Kolstad, the company is in discussions with regulatory authorities in Europe, Japan, and the United States to determine the steps necessary to bring the imaging probe to market.

At the same time, Spryte—with Ughi as senior director of advanced development and software engineering—is working on machine learning software to automate the image analysis process, thus simplifying diagnostics and treatment planning for clinicians.

Bolstered by the latest data, cerebrovascular specialists like Siddiqui now say they are chomping at the bit to get their hands on the imaging probe once it clears regulatory approval.

“I’m really impressed,” Siddiqui says. “This is a tool that many of us who do these procedures wish they had.”

CEPSA's logo installation

La French Touch by Martell

SMASHD Labs Season 2 is a 10-week accelerator program based out of Los Angeles talent firm Atom Factory. We are inviting companies at the intersection of entertainment, technology, and culture to work alongside our team to accelerate their growth. Join us and our roster of world-class mentors for a masterclass in hustle.

Imagine, if you will: an entire wargame, with strategic depth and intriguing possibilities . . . and the rules fit on one page.

If you're a long-time fan of Steve Jackson Games (or you saw the Daily Illuminator post from a couple of weeks ago), you know where we're going with this. One-Page Bulge – originally released in 1980 – did exactly what its title suggests, with Steve Jackson flexing his inimitable game-design skills to deliver a Battle of the Bulge wargame where the rules fit on one sheet of 8.5" × 11" double-sided paper.

This classic game is back with a new edition: One-Page Bulge Second Edition – in time for the 80th anniversary of the pivotal battle itself!

Thanks to Kickstarter (and fans like you), this updated version funded in 40 minutes! In honor of that success, we're providing a few more details about what makes it worth checking out.

One-Page Bulge Second Edition is being updated by Steve Jackson and wargame designer Dana Lombardy – two Hall of Fame designers working together to bring this classic game to a modern era. Find their behind-the-scenes insight about the new version on YouTube!

Some highlights of this edition include:

• New Random Event cards, with exciting events to represent unexpected battlefield surprises.
• A full-color mounted map.
• High-quality components, with two styles of counter sets to choose from (or get them both!).

An illustrated historical guide is also part of this project, bringing this landmark moment to life.

Suitable for solo gaming or two players, One-Page Bulge Second Edition is history in the making. But hurry! The Kickstarter ends in 10 days, on November 14!

– Steven Marsh

Warehouse 23 News: So Real, And Yet So Not

Not everything that's impossible is magical; sometimes it's just really impractical. GURPS Fantasy-Tech 1: The Edge of Reality is an assortment of pre-modern tech that never existed (probably), but might have, or was believed to exist, or was close to working but didn't. Grab a gun-sword, peruse Leonardo da Vinci's sketches, and download the impossible today from Warehouse 23!

This piece of literary mayhem is exclusive to Smart Bitches After Dark, but fret not. If you'd like to join, we'd love to have you! Have a look at our membership options, and come join the fun! If you want to have a little extra fun, be a little more yourself, and be part of keeping the site open for everyone in the future, we can’t wait to see you in our new subscription-based section … Continue reading Sign Up for Quarterly Book Recommendations! →

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Texas law enforcement said the shootout was between factions of the Gulf Cartel.

Rusty marsh dart (Ceriagrion olivaceum) (Male here) is a species of damselfly found in south and southeast Asia. Two subspecies are mentioned. Ceriagrion olivaceum olivaceum and Ceriagrion olivaceum aurantiacum.C. o. olivaceum is widespread in India and Southeast Asia and probably the one here C. o. aurantiacum is only known from southwest India. It is a medium-sized damselfly with olivaceous brown capped greenish eyes. Its thorax is olive green, paler on the sides. Female is similar to the male. Female @ http://www.indianaturewatch.net/displayimage.php?id=662987

The French tax authority has confirmed new rules regarding the calculation of VAT on pleasure yacht charters.

To ensure Har Khet Ko Pani, GoI should emulate irrigation policies followed by Gujarat and Madhya Pradesh, say researchers.

The post Press Release: Smarter irrigation can help avert water crises first appeared on International Water Management Institute (IWMI).

The Prime Minister was received by IWMI’s Management Team and staff, which was followed by an overview of IWMI’s ongoing work in Sri Lanka in the areas of irrigation and productivity, groundwater management, climate resilience, waste management and wetlands conservation.

The post Prime Minister of Sri Lanka, Hon. Dinesh Gunawardena, visits IWMI Headquarters in Colombo first appeared on International Water Management Institute (IWMI).

Arterial stiffness increases blood pressure via an update in insulin resistance but not via an increase in body fat, a paper published in Frontiers in Cardiovascular Medicine concludes.

Gentiva(R) Health Services Reports First Quarter 2010 Results

Quest Diagnostics Declares Quarterly Cash Dividend

Amicus Therapeutics Announces First Quarter 2010 Financial Results and Product Pipeline Advancements

ThermoGenesis Reports Fiscal 2010 Third Quarter Results

Emdeon Reports First Quarter 2010 Results

Luminex Corporation Reports First Quarter 2010 Results

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Oncothyreon reports full year and fourth quarter 2009 financial results

Sequenom Reports First Quarter 2010 Financial Results